Skip to main content

Articles

Page 110 of 155

  1. Inhibition of tumour necrosis factor (TNF)-alpha with biological molecules has proven an effective treatment for rheumatoid arthritis, achieving a 20% improvement in American College of Rheumatology score in u...

    Authors: David Gould, Nasim Yousaf, Rewas Fatah, Maria Cristina Subang and Yuti Chernajovsky
    Citation: Arthritis Research & Therapy 2007 9:R7
    Content type: Research article Published on:

  2. Innervation of the joint with thinly myelinated and unmyelinated sensory nerve fibres is crucial for the occurrence of joint pain. During inflammation in the joint, sensory fibres show changes in the expressio...

    Authors: Gisela Segond von Banchet, Jonny Richter, Marion Hückel, Christina Rose, Rolf Bräuer and Hans-Georg Schaible
    Citation: Arthritis Research & Therapy 2007 9:R6
    Content type: Research article Published on:

  3. We have recently demonstrated that the rheumatoid arthritis (RA) shared epitope (SE) acts as a ligand that triggers nitric oxide (NO) signaling in opposite cells. Given the known pro-oxidative effect of NO and...

    Authors: Song Ling, Zhanguo Li, Olga Borschukova, Liqun Xiao, Paul Pumpens and Joseph Holoshitz
    Citation: Arthritis Research & Therapy 2007 9:R5
    Content type: Research article Published on:

  4. Both selective cyclooxygenase (COX)-2 inhibitors and non-steroidal anti-inflammatory drugs (NSAIDs) have been beneficial pharmacological agents for many patients suffering from arthritis pain and inflammation....

    Authors: Edwin SL Chan, Hongwei Zhang, Patricia Fernandez, Sari D Edelman, Michael H Pillinger, Louis Ragolia, Thomas Palaia, Steven Carsons and Allison B Reiss
    Citation: Arthritis Research & Therapy 2007 9:R4
    Content type: Research article Published on:

  5. Quantitative traits such as complex diseases are controlled by many small-effect genes that are difficult to identify. Here we present a novel strategy to identify the candidate genes for small-effect quantita...

    Authors: Xinhua Yu, Kristin Bauer, Dirk Koczan, Hans-Jürgen Thiesen and Saleh M Ibrahim
    Citation: Arthritis Research & Therapy 2007 9:R3
    Content type: Research article Published on:

  6. People exposed to sunlight can develop erythema, DNA damage, and photoimmunosupression. Extended exposure of normal epidermis to sunlight will induce dysmorphic keratinocytes with pyknotic nuclei scattered thr...

    Authors: Melanie K Kuechle and Keith B Elkon
    Citation: Arthritis Research & Therapy 2007 9:101
    Content type: Editorial Published on:

  7. Rheumatoid arthritis (RA) is a chronic autoimmune disease of unknown etiology. Effective treatment of this disorder has been hampered by the lack of availability of agents that selectively target affected join...

    Authors: Dong Wang, Scott C Miller, Xin-Ming Liu, Brian Anderson, Xu Sherry Wang and Steven R Goldring
    Citation: Arthritis Research & Therapy 2007 9:R2
    Content type: Research article Published on:

  10. Numerous investigations have reported the efficacy of exogenous hyaluronan (HA) in modulating acute and chronic inflammation. The current study was performed to determine the in vitro effects of lower and higher ...

    Authors: Kelly S Santangelo, Amanda L Johnson, Amy S Ruppert and Alicia L Bertone
    Citation: Arthritis Research & Therapy 2007 9:R1
    Content type: Research article Published on:

  11. Vascular endothelial growth factor (VEGF) promotes cartilage-degrading pathways, and there is evidence for the involvement of reactive oxygen species (ROS) in cartilage degeneration. However, a relationship be...

    Authors: Jakob Fay, Deike Varoga, Christoph J Wruck, Bodo Kurz, Mary B Goldring and Thomas Pufe
    Citation: Arthritis Research & Therapy 2006 8:R189
    Content type: Research article Published on:

  12. Previous studies have shown a generalised increase in bone mass in patients with osteoarthritis (OA). Using molecular histomorphometry, this study examined the in vivo expression of mRNA encoding bone anabolic fa...

    Authors: Le-Hoa Truong, Julia S Kuliwaba, Helen Tsangari and Nicola L Fazzalari
    Citation: Arthritis Research & Therapy 2006 8:R188
    Content type: Research article Published on:

  13. There is an increasing body of evidence that synovitis plays a role in the progression of osteoarthritis and that overproduction of cytokines and growth factors from the inflamed synovium can influence the pro...

    Authors: Jan Bondeson, Shane D Wainwright, Sarah Lauder, Nick Amos and Clare E Hughes
    Citation: Arthritis Research & Therapy 2006 8:R187
    Content type: Research article Published on:

  14. The prevalence of ischemic heart disease and atherosclerosis is increased in patients with rheumatoid arthritis (RA). In the general population, but not in patients with systemic lupus erythematosus, the Frami...

    Authors: Cecilia P Chung, Annette Oeser, Ingrid Avalos, Tebeb Gebretsadik, Ayumi Shintani, Paolo Raggi, Tuulikki Sokka, Theodore Pincus and C Michael Stein
    Citation: Arthritis Research & Therapy 2006 8:R186
    Content type: Research article Published on:

  15. The aim of the present study was to evaluate the relative contribution of human leukocyte antigen (HLA)-C locus alleles in determining the risk and the clinical expression of psoriatic arthritis (PsA). One hun...

    Authors: Ruben Queiro, Segundo Gonzalez, Carlos López-Larrea, Mercedes Alperi, Cristina Sarasqueta, Jose Luis Riestra and Javier Ballina
    Citation: Arthritis Research & Therapy 2006 8:R185
    Content type: Research article Published on:

  16. Infection imposes a serious burden on patients with systemic lupus erythematosus (SLE). The increased infection rate in SLE patients has been attributed in part to defects of immune defence. Recently, the lect...

    Authors: Irene EM Bultink, Dörte Hamann, Marc A Seelen, Margreet H Hart, Ben AC Dijkmans, Mohamed R Daha and Alexandre E Voskuyl
    Citation: Arthritis Research & Therapy 2006 8:R183
    Content type: Research article Published on:

  17. Mycophenolate mofetil (MMF) is an immunosuppressant drug being used for induction and maintenance of remission of lupus nephritis in systemic lupus erythematosus. Evidence about its use was sought from full pu...

    Authors: R Andrew Moore and Sheena Derry
    Citation: Arthritis Research & Therapy 2006 8:R182
    Content type: Research article Published on:

  18. Osteoarthritis (OA) is characterized by articular cartilage degradation and hypertrophic bone changes with osteophyte formation and abnormal bone remodeling. Two groups of OA patients were identified via the p...

    Authors: Kelitha Maxis, Aline Delalandre, Johanne Martel-Pelletier, Jean-Pierre Pelletier, Nicolas Duval and Daniel Lajeunesse
    Citation: Arthritis Research & Therapy 2006 8:R181
    Content type: Research article Published on:

  19. We have recently shown that cardiolipin (CL) and its metabolites move from mitochondria to other cellular membranes during death receptor-mediated apoptosis. In this study, we investigate the immunoreactivity ...

    Authors: Cristiano Alessandri, Maurizio Sorice, Michele Bombardieri, Paola Conigliaro, Agostina Longo, Tina Garofalo, Valeria Manganelli, Fabrizio Conti, Mauro Degli Esposti and Guido Valesini
    Citation: Arthritis Research & Therapy 2006 8:R180
    Content type: Research article Published on:

  22. We examined the gene expression profiles in arthroscopic biopsies retrieved from 10 rheumatoid arthritis patients before and after anti-TNF treatment with infliximab to investigate whether such profiles can be...

    Authors: Johan Lindberg, Erik af Klint, Anca Irinel Catrina, Peter Nilsson, Lars Klareskog, Ann-Kristin Ulfgren and Joakim Lundeberg
    Citation: Arthritis Research & Therapy 2006 8:R179
    Content type: Research article Published on:

  23. Juvenile idiopathic arthritis (JIA) is a heterogeneous autoimmune disease characterized by chronic joint inflammation. Knowing which antigens drive the autoreactive T-cell response in JIA is crucial for the un...

    Authors: Sylvia Kamphuis, Kolbrún Hrafnkelsdóttir, Mark R Klein, Wilco de Jager, Margje H Haverkamp, Jolanda HM van Bilsen, Salvatore Albani, Wietse Kuis, Marca HM Wauben and Berent J Prakken
    Citation: Arthritis Research & Therapy 2006 8:R178
    Content type: Research article Published on:

  24. Insulin-like growth factor (IGF)-1 is a key factor in bone homeostasis and could be involved in bone tissue sclerosis as observed in osteoarthritis (OA). Here, we compare the key signaling pathways triggered i...

    Authors: Frédéric Massicotte, Isabelle Aubry, Johanne Martel-Pelletier, Jean-Pierre Pelletier, Julio Fernandes and Daniel Lajeunesse
    Citation: Arthritis Research & Therapy 2006 8:R177
    Content type: Research article Published on:

  25. Infections of body tissue by Staphylococcus aureus are quickly followed by degradation of connective tissue. Patients with rheumatoid arthritis are more prone to S. aureus-mediated septic arthritis. Various types...

    Authors: Siva Kanangat, Arnold Postlethwaite, Karen Hasty, Andrew Kang, Mark Smeltzer, Whitney Appling and Dennis Schaberg
    Citation: Arthritis Research & Therapy 2006 8:R176
    Content type: Research article Published on:

  26. Recently, autoantibodies to some citrullinated autoantigens have been reported to be specific for rheumatoid arthritis (RA). However, an entire profile of and autoimmunity of the citrullinated proteins have be...

    Authors: Kosuke Matsuo, Yang Xiang, Hiroshi Nakamura, Kayo Masuko, Kazuo Yudoh, Koji Noyori, Kusuki Nishioka, Tomoyuki Saito and Tomohiro Kato
    Citation: Arthritis Research & Therapy 2006 8:R175
    Content type: Research article Published on:

  27. The objective of this work is to compare the adherence to therapy of patients receiving etanercept and infliximab during first tumour necrosis factor (TNF)-blocking treatment course in rheumatoid arthritis. Sp...

    Authors: Lars Erik Kristensen, Tore Saxne, Jan-Ã…ke Nilsson and Pierre Geborek
    Citation: Arthritis Research & Therapy 2006 8:R174
    Content type: Research article Published on:

  28. The effects of exogenous glucosamine on the biology of articular chondrocytes were determined by examining global transcription patterns under normal culture conditions and following challenge with IL-1β. Chon...

    Authors: Jean-Noël Gouze, Elvire Gouze, Mick P Popp, Marsha L Bush, Emil A Dacanay, Jesse D Kay, Padraic P Levings, Kunal R Patel, Jeet-Paul S Saran, Rachael S Watson and Steven C Ghivizzani
    Citation: Arthritis Research & Therapy 2006 8:R173
    Content type: Research article Published on:

  29. The overgrowth of synovial tissues is critical in the pathogenesis of rheumatoid arthritis (RA). The expression of Synoviolin (SYN), an E3 ubiquitin ligase, is upregulated in arthritic synovial fibroblasts and...

    Authors: Beixue Gao, Karen Calhoun and Deyu Fang
    Citation: Arthritis Research & Therapy 2006 8:R172
    Content type: Research article Published on:

  30. Fibroblast activation protein (FAP), as described so far, is a type II cell surface serine protease expressed by fibroblastic cells in areas of active tissue remodelling such as tumour stroma or healing wounds...

    Authors: Stefan Bauer, Michael C Jendro, Andreas Wadle, Sascha Kleber, Frank Stenner, Robert Dinser, Anja Reich, Erica Faccin, Stefan Gödde, Harald Dinges, Ulf Müller-Ladner and Christoph Renner
    Citation: Arthritis Research & Therapy 2006 8:R171
    Content type: Research article Published on:

  31. Rheumatoid arthritis (RA) is an inflammatory autoimmune disease of unclear etiology. This study was conducted to identify critical factors involved in the synovial hyperplasia in RA pathology. We applied cDNA ...

    Authors: Jinah Jang, Dae-Seog Lim, Young-Eun Choi, Yong Jeong, Seung-Ah Yoo, Wan-Uk Kim and Yong-Soo Bae
    Citation: Arthritis Research & Therapy 2006 8:R170
    Content type: Research article Published on:

  32. Methotrexate (MTX) exerts an anti-inflammatory effect via its metabolite adenosine, which activates adenosine receptors. The A3 adenosine receptor (A3AR) was found to be highly expressed in inflammatory tissues a...

    Authors: Avivit Ochaion, Sara Bar-Yehuda, Shira Cohn, Luis Del Valle, Georginia Perez-Liz, Lea Madi, Faina Barer, Motti Farbstein, Sari Fishman-Furman, Tatiana Reitblat, Alexander Reitblat, Howard Amital, Yair Levi, Yair Molad, Reuven Mader, Moshe Tishler…
    Citation: Arthritis Research & Therapy 2006 8:R169
    Content type: Research article Published on:

  33. We and others have reported that rheumatoid arthritis (RA) synovial T cells can activate human monocytes/macrophages in a contact-dependent manner to induce the expression of inflammatory cytokines, including ...

    Authors: Jonathan T Beech, Evangelos Andreakos, Cathleen J Ciesielski, Patricia Green, Brian MJ Foxwell and Fionula M Brennan
    Citation: Arthritis Research & Therapy 2006 8:R168
    Content type: Research article Published on:

  34. Arthritis pain affects millions of people worldwide yet we still have only a limited understanding of what makes our joints ache. This review examines the sensory innervation of diarthroidal joints and discuss...

    Authors: Jason J McDougall
    Citation: Arthritis Research & Therapy 2006 8:220
    Content type: Review Published on:

  35. The objective of this study was to investigate the interaction between levels of BAFF (B-cell activation factor of the tumour necrosis factor [TNF] family) and APRIL (a proliferation-inducing ligand) and B-cel...

    Authors: Therese Vallerskog, Mikael Heimbürger, Iva Gunnarsson, Wei Zhou, Marie Wahren-Herlenius, Christina Trollmo and Vivianne Malmström
    Citation: Arthritis Research & Therapy 2006 8:R167
    Content type: Research article Published on:

  36. IL-32 is a newly described cytokine in the human found to be an in vitro inducer of tumor necrosis factor alpha (TNFα). We examined the in vivo relationship between IL-32 and TNFα, and the pathologic role of IL-3...

    Authors: Hirofumi Shoda, Keishi Fujio, Yumi Yamaguchi, Akiko Okamoto, Tetsuji Sawada, Yuta Kochi and Kazuhiko Yamamoto
    Citation: Arthritis Research & Therapy 2006 8:R166
    Content type: Research article Published on:

  37. The healthy synovial lining layer consists of a single cell layer that regulates the transport between the joint cavity and the surrounding tissue. It has been suggested that abnormalities such as somatic muta...

    Authors: Marjan MC Steenvoorden, Tanja CA Tolboom, Gabri van der Pluijm, Clemens Löwik, Cornelis PJ Visser, Jeroen DeGroot, Adriana C Gittenberger-DeGroot, Marco C DeRuiter, Bert J Wisse, Tom WJ Huizinga and René EM Toes
    Citation: Arthritis Research & Therapy 2006 8:R165
    Content type: Research article Published on:

  38. Ank is a multipass transmembrane protein that regulates the cellular transport of inorganic pyrophosphate. In the progressive ankylosis (ank) mouse, a premature termination mutation at glutamic acid 440 results i...

    Authors: Raihana Zaka, David Stokes, Arnold S Dion, Anna Kusnierz, Fei Han and Charlene J Williams
    Citation: Arthritis Research & Therapy 2006 8:R164
    Content type: Research article Published on:

  39. The PD-1 (programmed death 1) molecule is a negative regulator of T cells. PDCD1 (programmed cell death 1) has been reported to have a genetic association in systemic lupus erythematosus and rheumatoid arthritis ...

    Authors: Sang-Hoon Lee, Yeon-Ah Lee, Doo-Hyun Woo, Ran Song, Eun-Kyung Park, Mi-Hyun Ryu, Young-Hoon Kim, Kyoung-Soo Kim, Seung-Jae Hong, Myung Chul Yoo and Hyung-In Yang
    Citation: Arthritis Research & Therapy 2006 8:R163
    Content type: Research article Published on:

  40. This study investigated the overall clinical impact of anti-α-actinin antibodies in patients with pre-selected autoimmune diseases and in a random group of anti-nuclear antibody (ANA)-positive individuals. The...

    Authors: Andrea Becker-Merok, Manar Kalaaji, Kaia Haugbro, Cathrin Nikolaisen, Kirsten Nilsen, Ole Petter Rekvig and Johannes C Nossent
    Citation: Arthritis Research & Therapy 2006 8:R162
    Content type: Research article Published on:

  41. The tight-skin (TSK/+) mouse, a genetic model of systemic sclerosis (SSc), develops cutaneous fibrosis and defects in pulmonary architecture. Because hepatocyte growth factor (HGF) is an important mitogen and ...

    Authors: Tsuyoshi Iwasaki, Takehito Imado, Sachie Kitano and Hajime Sano
    Citation: Arthritis Research & Therapy 2006 8:R161
    Content type: Research article Published on:

  43. Lung fibrosis is a major cause of mortality and morbidity in systemic sclerosis (SSc). However, its pathogenesis still needs to be elucidated. We examined whether the alteration of certain proteins in bronchoa...

    Authors: AM Fietta, AM Bardoni, R Salvini, I Passadore, M Morosini, L Cavagna, V Codullo, E Pozzi, F Meloni and C Montecucco
    Citation: Arthritis Research & Therapy 2006 8:R160
    Content type: Research article Published on:

  44. 4-Hydroxynonenal (HNE), a lipid peroxidation end product, is produced abundantly in osteoarthritic (OA) articular tissues, but its role in bone metabolism is ill-defined. In this study, we tested the hypothesi...

    Authors: Qin Shi, France Vaillancourt, Véronique Côté, Hassan Fahmi, Patrick Lavigne, Hassan Afif, John A Di Battista, Julio C Fernandes and Mohamed Benderdour
    Citation: Arthritis Research & Therapy 2006 8:R159
    Content type: Research article Published on:

  46. The molecular basis to mammalian osteoarthritis (OA) is unknown. We hypothesised that the expression of selected proteases, matrix molecules, and collagens believed to have a role in the pathogenesis of OA wou...

    Authors: Dylan N Clements, Stuart D Carter, John F Innes, William ER Ollier and Philip JR Day
    Citation: Arthritis Research & Therapy 2006 8:R158
    Content type: Research article Published on:

  49. Apoptotic cells are thought to play an essential role in the pathogenesis of systemic lupus erythematosus (SLE). We hypothesise that delayed or altered clearance of apoptotic cells after UV irradiation will le...

    Authors: Esther Reefman, Marcelus CJM de Jong, Hilde Kuiper, Marcel F Jonkman, Pieter C Limburg, Cees GM Kallenberg and Marc Bijl
    Citation: Arthritis Research & Therapy 2006 8:R156
    Content type: Research article Published on:

  50. Synovial tissue of rheumatoid arthritis (RA) patients is characterised by an influx and retention of CD97-positive inflammatory cells. The ligands of CD97, CD55, chondroitin sulfate B, and α5β1 (very late anti...

    Authors: Else N Kop, Janik Adriaansen, Tom JM Smeets, Margriet J Vervoordeldonk, René AW van Lier, Jörg Hamann and Paul P Tak
    Citation: Arthritis Research & Therapy 2006 8:R155
    Content type: Research article Published on:
  • Logo
Submit manuscript

Follow

Annual Journal Metrics

  • Citation Impact 2023
    Journal Impact Factor: 4.4
    5-year Journal Impact Factor: 4.9
    Source Normalized Impact per Paper (SNIP): 1.294
    SCImago Journal Rank (SJR): 1.518

    Speed 2023
    Submission to first editorial decision (median days): 9
    Submission to acceptance (median days): 111

    Usage 2023
    Downloads: 3,331,819
    Altmetric mentions: 1,885

Arthritis Research & Therapy

ISSN: 1478-6362

Contact us