Skip to main content

Articles

Page 114 of 155

  1. The 54 kDa subunit of the signal recognition particle (SRP54) binds to the signal sequences of nascent secretory and membrane proteins and it contributes to the targeting of these precursors to the membrane of...

    Authors: Karin Römisch, Frederick W Miller, Bernhard Dobberstein and Stephen High
    Citation: Arthritis Research & Therapy 2006 8:R39
    Content type: Research article Published on:

  2. As a consequence of the avascular nature of cartilage the microenvironment in which chondrocytes must exist is characterized by hostile conditions, most prominently very low levels of oxygen (hypoxia). In rece...

    Authors: David Pfander, Bernd Swoboda and Thorsten Cramer
    Citation: Arthritis Research & Therapy 2006 8:104
    Content type: Commentary Published on:

  4. The pathogenetic role of anticardiolipin antibodies (aCLs) in patients with neuropsychiatric systemic lupus erythematosus (NPSLE) without cerebral infarcts remains elusive. Magnetization transfer imaging (MTI)...

    Authors: Stefan CA Steens, Gerlof PTh Bosma, Gerda M Steup-Beekman, Saskia le Cessie, Tom WJ Huizinga and Mark A van Buchem
    Citation: Arthritis Research & Therapy 2006 8:R38
    Content type: Research article Published on:

  5. One of the hallmarks of osteoarthritic cartilage is the loss of chondrocyte cellularity due to cell death. However, considerable controversy has recently arisen surrounding the extent of apoptotic cell death i...

    Authors: Lei Wei, Xiao-juan Sun, Zhengke Wang and Qian Chen
    Citation: Arthritis Research & Therapy 2006 8:R37
    Content type: Research article Published on:

  6. CCN2 is encoded by an immediate-early gene induced in mesenchymal cells during the formation of blood vessels, bone and connective tissue. It plays key roles in cell adhesion and migration, as well as matrix r...

    Authors: Jonathan P Van Beek, Laura Kennedy, Jason S Rockel, Suzanne M Bernier and Andrew Leask
    Citation: Arthritis Research & Therapy 2006 8:R36
    Content type: Research article Published on:

  7. Cyclo-oxygenase-2 selective inhibitors are frequently used to manage osteoarthritis. We compared the analgesic efficacy of the novel cyclo-oxygenase-2 selective inhibitor lumiracoxib (Prexige®) versus placebo and...

    Authors: Ralf H Wittenberg, Ernest Schell, Gerhard Krehan, Roland Maeumbaed, Hans Runge, Peter Schlüter, Taiwo OA Fashola, Helen J Thurston, Klaus J Burger and Ulrich Trechsel
    Citation: Arthritis Research & Therapy 2006 8:R35
    Content type: Research article Published on:

  8. Peptidylarginine deiminase type 4 (PADI4) genotypes were shown to influence susceptibility to rheumatoid arthritis (RA) in the Japanese population. Such an association could not previously be confirmed in differe...

    Authors: Berthold Hoppe, Thomas Häupl, Rudolf Gruber, Holger Kiesewetter, Gerd R Burmester, Abdulgabar Salama and Thomas Dörner
    Citation: Arthritis Research & Therapy 2006 8:R34
    Content type: Research article Published on:

  9. The anti-inflammatory effect of adenosine was previously found to be mediated via activation of the A3 adenosine receptor (A3AR). The aim of the present study was to decipher the molecular mechanism involved with...

    Authors: Pnina Fishman, Sara Bar-Yehuda, Lea Madi, Lea Rath-Wolfson, Avivit Ochaion, Shira Cohen and Ehud Baharav
    Citation: Arthritis Research & Therapy 2006 8:R33
    Content type: Research article Published on:

  10. In order to selectively block nuclear factor κB (NF-κB)-dependent signal transduction in angiogenic endothelial cells, we constructed an αvβ3 integrin specific adenovirus encoding dominant negative IκB (dnIκB)...

    Authors: Ken-ichi Ogawara, Joanna M Kułdo, Koen Oosterhuis, Bart-Jan Kroesen, Marianne G Rots, Christian Trautwein, Toshikiro Kimura, Hidde J Haisma and Grietje Molema
    Citation: Arthritis Research & Therapy 2006 8:R32
    Content type: Research article Published on:

  11. The factors that trigger the development of extraarticular features of rheumatoid arthritis (RA) are still unknown. HLA-DR alleles such as HLA-DR4 and HLA-DR1 are associated with the risk to develop RA. A larg...

    Authors: Jean Roudier
    Citation: Arthritis Research & Therapy 2006 8:103
    Content type: Commentary Published on:

  13. The objective of this study was to determine whether serum biomarkers for degradation and synthesis of the extracellular matrix of cartilage are associated with, and can predict, radiographic damage in patient...

    Authors: SMM Verstappen, AR Poole, M Ionescu, LE King, M Abrahamowicz, DM Hofman, JWJ Bijlsma and FPJG Lafeber
    Citation: Arthritis Research & Therapy 2006 8:R31
    Content type: Research article Published on:

  14. Rheumatoid arthritis (RA) is a chronic debilitating autoimmune disease that results in joint destruction and subsequent loss of function. To better understand its pathogenesis and to facilitate the search for ...

    Authors: Jianyong Shou, Christopher M Bull, Li Li, Hui-Rong Qian, Tao Wei, Shuang Luo, Douglas Perkins, Patricia J Solenberg, Seng-Lai Tan, Xin-Yi Cynthia Chen, Neal W Roehm, Jeffrey A Wolos and Jude E Onyia
    Citation: Arthritis Research & Therapy 2006 8:R28
    Content type: Research article Published on:

  15. Polyclonal B cell activation might be related to pathogenic over-expression of B-cell-activating factor (BAFF) in primary Sjögren's syndrome (pSS) and other autoimmune diseases. We therefore investigated wheth...

    Authors: Jacques-Eric Gottenberg, Jérémie Sellam, Marc Ittah, Frédéric Lavie, Alexis Proust, Habib Zouali, Christelle Sordet, Jean Sibilia, Robert P Kimberly, Xavier Mariette and Corinne Miceli-Richard
    Citation: Arthritis Research & Therapy 2006 8:R30
    Content type: Research article Published on:

  16. The objective of this work is to analyze the survival of infliximab, etanercept and adalimumab in patients who have switched among tumor necrosis factor (TNF) antagonists for the treatment of chronic arthritis...

    Authors: Juan J Gomez-Reino and Loreto Carmona
    Citation: Arthritis Research & Therapy 2006 8:R29
    Content type: Research article Published on:

  17. Recent studies have implicated PTPN22 and tp53 in susceptibility to several autoimmune diseases, including rheumatoid arthritis, suggesting that these genes are important in maintaining immune homeostasis. Becaus...

    Authors: Christopher Butt, Lynette Peddle, Celia Greenwood, Sean Hamilton, Dafna Gladman and Proton Rahman
    Citation: Arthritis Research & Therapy 2006 8:R27
    Content type: Research article Published on:

  18. A major and early feature of cartilage degeneration is proteoglycan breakdown. Matrix metalloprotease (MMP)-13 plays an important role in cartilage degradation in osteoarthritis (OA). This MMP, in addition to ...

    Authors: Jordi Monfort, Ginette Tardif, Pascal Reboul, François Mineau, Peter Roughley, Jean-Pierre Pelletier and Johanne Martel-Pelletier
    Citation: Arthritis Research & Therapy 2006 8:R26
    Content type: Research article Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2013 15:401

  19. In order to determine whether there is a genetic component to hip or knee joint failure due to idiopathic osteoarthritis (OA), we invited patients (probands) undergoing hip or knee arthroplasty for management ...

    Authors: H Bukulmez, AL Matthews, CM Sullivan, C Chen, MJ Kraay, RC Elston, RW Moskowitz, VM Goldberg and ML Warman
    Citation: Arthritis Research & Therapy 2006 8:R25
    Content type: Research article Published on:

  20. This study was designed to examine the potential use of the ethyl acetate (EA) extract of Tripterygium wilfordii Hook F (TwHF), a Chinese herbal medicine, in the treatment of systemic lupus erythematosus. A total...

    Authors: Xuelian Tao, Fred Fan, Victoria Hoffmann, Nancy S Longo and Peter E Lipsky
    Citation: Arthritis Research & Therapy 2006 8:R24
    Content type: Research article Published on:

  21. Arthritis is characterised by the proteolytic degradation of articular cartilage leading to a loss of joint function. Articular cartilage is composed of an extracellular matrix of proteoglycans and collagens. ...

    Authors: Jennifer M Milner, Lara Kevorkian, David A Young, Debra Jones, Robin Wait, Simon T Donell, Emma Barksby, Angela M Patterson, Jim Middleton, Benjamin F Cravatt, Ian M Clark, Andrew D Rowan and Timothy E Cawston
    Citation: Arthritis Research & Therapy 2006 8:R23
    Content type: Research article Published on:

  22. Chronic arthritis typically leads to loss of periarticular bone, which results from an imbalance between bone formation and bone resorption. Recent research has focused on the role of osteoclastogenesis and bo...

    Authors: Jochen Zwerina, Birgit Tuerk, Kurt Redlich, Josef S Smolen and Georg Schett
    Citation: Arthritis Research & Therapy 2005 8:R22
    Content type: Research article Published on:

  23. The objective of this study was to further explore the cartilage volume changes in knee osteoarthritis (OA) over time using quantitative magnetic resonance imaging (qMRI). These were correlated with demographi...

    Authors: Jean-Pierre Raynauld, Johanne Martel-Pelletier, Marie-Josée Berthiaume, Gilles Beaudoin, Denis Choquette, Boulos Haraoui, Hyman Tannenbaum, Joan M Meyer, John F Beary, Gary A Cline and Jean-Pierre Pelletier
    Citation: Arthritis Research & Therapy 2005 8:R21
    Content type: Research article Published on:

  24. We examined whether polymorphisms of the vitamin D receptor (VDR) gene was associated with individual risk of hand osteoarthritis (OA). Radiographs of both hands of 295 dentists and of 248 teachers were examined ...

    Authors: Svetlana Solovieva, Ari Hirvonen, Päivi Siivola, Tapio Vehmas, Katariina Luoma, Hilkka Riihimäki and Päivi Leino-Arjas
    Citation: Arthritis Research & Therapy 2005 8:R20
    Content type: Research article Published on:

  25. The transcription factor STAT-1 (signal transducer and activator of transcription-1) plays a pivotal role in the expression of inflammatory gene products involved in the pathogenesis of arthritis such as vario...

    Authors: Marion Hückel, Uta Schurigt, Andreas H Wagner, Renate Stöckigt, Peter K Petrow, Klaus Thoss, Mieczyslaw Gajda, Steffen Henzgen, Markus Hecker and Rolf Bräuer
    Citation: Arthritis Research & Therapy 2005 8:R17
    Content type: Research article Published on:

  26. Blockade of tumour necrosis factor (TNF) is an effective treatment in rheumatoid arthritis (RA), but both non-responders and partial responders are quite frequent. This suggests that other pro-inflammatory cyt...

    Authors: Sofia Ernestam, Erik af Klint, Anca Irinel Catrina, Erik Sundberg, Marianne Engström, Lars Klareskog and Ann-Kristin Ulfgren
    Citation: Arthritis Research & Therapy 2005 8:R18
    Content type: Research article Published on:

  27. We analysed relationships between the PTPN22 1858 polymorphism and antibodies to cyclic citrullinated peptide (CCP), rheumatoid factors (RFs) and the shared epitope (SE) gene (HLA-DRB1*0404 or 0401) and determine...

    Authors: Martin Johansson, Lisbeth Ärlestig, Göran Hallmans and Solbritt Rantapää-Dahlqvist
    Citation: Arthritis Research & Therapy 2005 8:R19
    Content type: Research article Published on:

  28. There is a general belief among doctors, in part grounded in experience, that patients with arthritis need nonsteroidal anti-inflammatory drugs (NSAIDs). Implicit in this view is that these patients require th...

    Authors: Leslie G Cleland, Michael J James and Susanna M Proudman
    Citation: Arthritis Research & Therapy 2005 8:202
    Content type: Review Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2006 8:402

  29. We demonstrated previously that local, intra-articular injection of an adenoviral vector expressing human tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in a rabbit knee model of inflammatory ...

    Authors: Qingping Yao, Dai-Wu Seol, Zhibao Mi and Paul D Robbins
    Citation: Arthritis Research & Therapy 2005 8:R16
    Content type: Research article Published on:

  30. Dendritic cells (DCs) comprise heterogeneous subsets of professional antigen-presenting cells, linking innate and adaptive immunity. Analysis of DC subsets has been hampered by a lack of specific DC markers an...

    Authors: Sarah L Jongbloed, M Cristina Lebre, Alasdair R Fraser, J Alastair Gracie, Roger D Sturrock, Paul P Tak and Iain B McInnes
    Citation: Arthritis Research & Therapy 2005 8:R15
    Content type: Research article Published on:

  32. Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear DNA-binding protein that participates in the regulation of DNA repair and maintenance of genomic integrity. In addition, PARP-1 has a role in several models ...

    Authors: Samuel García, Ana Bodaño, Antonio González, Jerónimo Forteza, Juan J Gómez-Reino and Carmen Conde
    Citation: Arthritis Research & Therapy 2005 8:R14
    Content type: Research article Published on:

  33. The aim of this study was to investigate HLA class II associations in polymyositis (PM) and dermatomyositis (DM), and to determine how these associations influence clinical and serological differences. DNA sam...

    Authors: Hector Chinoy, Fiona Salway, Noreen Fertig, Neil Shephard, Brian D Tait, Wendy Thomson, David A Isenberg, Chester V Oddis, Alan J Silman, William ER Ollier and Robert G Cooper
    Citation: Arthritis Research & Therapy 2005 8:R13
    Content type: Research article Published on:

  34. PEG-modified recombinant mammalian urate oxidase (PEG-uricase) is being developed as a treatment for patients with chronic gout who are intolerant of, or refractory to, available therapy for controlling hyperu...

    Authors: Nancy J Ganson, Susan J Kelly, Edna Scarlett, John S Sundy and Michael S Hershfield
    Citation: Arthritis Research & Therapy 2005 8:R12
    Content type: Research article Published on:

  35. To study the inter-reader reliability of detecting abnormalities of sacroiliac (SI) joints in patients with recent-onset inflammatory back pain by magnetic resonance imaging (MRI), and to study the prevalence ...

    Authors: Liesbeth Heuft-Dorenbosch, René Weijers, Robert Landewé, Sjef van der Linden and Désirée van der Heijde
    Citation: Arthritis Research & Therapy 2005 8:R11
    Content type: Research article Published on:

  36. The role of fibroblasts in inflammatory processes and their cross-talk with T cells is increasingly being recognized. Our aim was to explore the capacity of dermal fibroblasts to produce inflammatory chemokine...

    Authors: Carlo Chizzolini, Yann Parel, Agneta Scheja and Jean-Michel Dayer
    Citation: Arthritis Research & Therapy 2005 8:R10
    Content type: Research article Published on:

  38. Periarticular osteolysis, a crippling complication of rheumatoid arthritis, is the product of enhanced osteoclast recruitment and activation. The osteoclast, which is a member of the monocyte/macrophage family...

    Authors: Steven L Teitelbaum
    Citation: Arthritis Research & Therapy 2005 8:201
    Content type: Review Published on:

  40. To describe the differences in knee structure and non-knee structural factors between offspring having at least one parent with a total knee replacement for severe primary knee osteoarthritis and age- and sex-...

    Authors: Changhai Ding, Flavia Cicuttini, Leigh Blizzard and Graeme Jones
    Citation: Arthritis Research & Therapy 2005 8:R8
    Content type: Research article Published on:

  41. THR0921 is a novel peroxisome proliferator-activated receptor gamma (PPARγ) agonist with potent anti-diabetic properties. Because of the proposed role of PPARγ in inflammation, we investigated the potential of...

    Authors: Tetsuya Tomita, Yoshimi Kakiuchi and Philip S Tsao
    Citation: Arthritis Research & Therapy 2005 8:R7
    Content type: Research article Published on:

  42. Considerable evidence points to a role for B lymphocyte stimulator (BLyS) overproduction in murine and human systemic lupus erythematosus (SLE). Nevertheless, the correlation between circulating levels of BLyS...

    Authors: Christopher E Collins, Amanda L Gavin, Thi-Sau Migone, David M Hilbert, David Nemazee and William Stohl
    Citation: Arthritis Research & Therapy 2005 8:R6
    Content type: Research article Published on:

  44. The Fcγ receptors play important roles in the initiation and regulation of many immunological and inflammatory processes, and genetic variants (FCGR) have been associated with numerous autoimmune and infectious d...

    Authors: Ann W Morgan, Jennifer H Barrett, Bridget Griffiths, Deepak Subramanian, Jim I Robinson, Viki H Keyte, Manir Ali, Elizabeth A Jones, Robert W Old, Frederique Ponchel, Arthur W Boylston, R Deva Situnayake, Alexander F Markham, Paul Emery and John D Isaacs
    Citation: Arthritis Research & Therapy 2005 8:R5
    Content type: Research article Published on:

  45. Studies on autoantibody production in patients treated with tumor necrosis factor-α (TNF-α) inhibitors reported contradictory results. We investigated in a prospective study the efficacy of a treatment with hu...

    Authors: Fabiola Atzeni, Piercarlo Sarzi-Puttini, Donata Dell' Acqua, Simona de Portu, Germana Cecchini, Carola Cruini, Mario Carrabba and Pier Luigi Meroni
    Citation: Arthritis Research & Therapy 2005 8:R3
    Content type: Research article Published on:

  46. Treatment of osteoarthritis (OA) with nonsteroidal anti-inflammatory drugs (NSAIDs) diminishes inflammation along with mediators of cartilage destruction. However, NSAIDs may exert adverse direct effects on ca...

    Authors: Simon C Mastbergen, Nathalie WD Jansen, Johannes WJ Bijlsma and Floris PJG Lafeber
    Citation: Arthritis Research & Therapy 2005 8:R2
    Content type: Research article Published on:

  47. Neonatal lupus erythematosus is a rare disorder caused by the transplacental passage of maternal autoantibodies. The 52-kDa Ro/SSA antigen (Ro52) ribonucleoprotein represents an antigenic target strongly assoc...

    Authors: Christine Fritsch, Johan Hoebeke, Hayet Dali, Vincent Ricchiuti, David A Isenberg, Olivier Meyer and Sylviane Muller
    Citation: Arthritis Research & Therapy 2005 8:R4
    Content type: Research article Published on:

  48. Many extracellular matrix (ECM) proteases seem to be important in rheumatoid arthritis (RA) and regulation of their transcription levels is a critical mechanism for controlling their activity. We have investig...

    Authors: Julio Rodriguez-Lopez, Eva Perez-Pampin, Juan J Gomez-Reino and Antonio Gonzalez
    Citation: Arthritis Research & Therapy 2005 8:R1
    Content type: Research article Published on:

  49. The 3rd International Meeting on Gene Therapy in Rheumatology and Orthopaedics was held in Boston, Massachusetts, USA in May 2004. Keystone lectures delivered by Drs Joseph Glorioso and Inder Verma provided co...

    Authors: Christopher H Evans, Steven C Ghivizzani, Elvire Gouze, John J Rediske, Edward M Schwarz and Paul D Robbins
    Citation: Arthritis Research & Therapy 2005 7:273
    Content type: Meeting report Published on:
  • Logo
Submit manuscript

Follow

Annual Journal Metrics

  • Citation Impact 2023
    Journal Impact Factor: 4.4
    5-year Journal Impact Factor: 4.9
    Source Normalized Impact per Paper (SNIP): 1.294
    SCImago Journal Rank (SJR): 1.518

    Speed 2023
    Submission to first editorial decision (median days): 9
    Submission to acceptance (median days): 111

    Usage 2023
    Downloads: 3,331,819
    Altmetric mentions: 1,885

Arthritis Research & Therapy

ISSN: 1478-6362

Contact us