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  1. Antibodies against type II collagen (CII) are important in the development of collagen-induced arthritis (CIA) and possibly also in rheumatoid arthritis. We have determined the fine specificity and arthritogen...

    Authors: Estelle Bajtner, Kutty S Nandakumar, Åke Engström and Rikard Holmdahl
    Citation: Arthritis Research & Therapy 2005 7:R1148
    Content type: Research article Published on:

  2. There has been some evidence that Behçet's disease (BD) has a significant autoimmune component but the molecular identity of putative autoantigens has not been well characterized. In the initial analysis of th...

    Authors: Yu Lu, Ping Ye, Shun-le Chen, Eng M Tan and Edward KL Chan
    Citation: Arthritis Research & Therapy 2005 7:R1133
    Content type: Research article Published on:

  4. Sex hormones seem to modulate the immune/inflammatory responses by different mechanisms in female and male rheumatoid arthritis patients. The effects of 17β-oestradiol and of testosterone were tested on the cu...

    Authors: Maurizio Cutolo, Silvia Capellino, Paola Montagna, Paola Ghiorzo, Alberto Sulli and Barbara Villaggio
    Citation: Arthritis Research & Therapy 2005 7:R1124
    Content type: Research article Published on:

  5. The mechanisms by which microvascular damage leads to dermal fibrosis in diffuse cutaneous systemic sclerosis (dcSSc) are unclear. We hypothesized that microvascular pericytes constitute a cellular link betwee...

    Authors: Vineeth S Rajkumar, Kevin Howell, Katalin Csiszar, Christopher P Denton, Carol M Black and David J Abraham
    Citation: Arthritis Research & Therapy 2005 7:R1113
    Content type: Research article Published on:

  6. Accurate and sensitive measurement techniques are a key issue in the quantification of the microvascular and endothelial dysfunction in systemic sclerosis (SSc). Thermal hyperhemia comprises two separate mecha...

    Authors: Aude Boignard, Muriel Salvat-Melis, Patrick H Carpentier, Christopher T Minson, Laurent Grange, Catherine Duc, Françoise Sarrot-Reynauld and Jean-Luc Cracowski
    Citation: Arthritis Research & Therapy 2005 7:R1103
    Content type: Research article Published on:

  7. This study sought to evaluate the levels of mRNA expression and protein synthesis of MMP-13, cathepsin K, aggrecanase-1 (ADAMTS-4), aggrecanase-2 (ADAMTS-5) and 5-lipoxygenase (5-LOX) in cartilage in the exper...

    Authors: Jean-Pierre Pelletier, Christelle Boileau, Martin Boily, Julie Brunet, François Mineau, Changshen Geng, Pascal Reboul, Stefan Laufer, Daniel Lajeunesse and Johanne Martel-Pelletier
    Citation: Arthritis Research & Therapy 2005 7:R1091
    Content type: Research article Published on:

  8. Periarticular calcification is a common attendant symptom of generalized arterial calcification of infancy, a rare Mendelian disorder caused by mutations of the gene coding for ectonucleotide pyrophosphatase/p...

    Authors: Eun-Kyung Suk, Ida Malkin, Stefan Dahm, Leonid Kalichman, Nico Ruf, Eugene Kobyliansky, Mohammad Toliat, Frank Rutsch, Peter Nürnberg and Gregory Livshits
    Citation: Arthritis Research & Therapy 2005 7:R1082
    Content type: Research article Published on:

  9. Clinical and serological profiles of idiopathic and drug-induced autoimmune diseases can be very similar. We compared data from idiopathic and antithyroid drug (ATD)-induced antineutrophil cytoplasmic antibody...

    Authors: Branka Bonaci-Nikolic, Milos M Nikolic, Sladjana Andrejevic, Svetlana Zoric and Mirjana Bukilica
    Citation: Arthritis Research & Therapy 2005 7:R1072
    Content type: Research article Published on:

  10. This study is based on an expanded access program in which 511 patients suffering from active refractory rheumatoid arthritis (RA) were treated with intravenous infusions of infliximab (3 mg/kg+methotrexate (M...

    Authors: Bert Vander Cruyssen, Stijn Van Looy, Bart Wyns, Rene Westhovens, Patrick Durez, Filip Van den Bosch, Eric M Veys, Herman Mielants, Luc De Clerck, Anne Peretz, Michel Malaise, Leon Verbruggen, Nathan Vastesaeger, Anja Geldhof, Luc Boullart and Filip De Keyser
    Citation: Arthritis Research & Therapy 2005 7:R1063
    Content type: Research article Published on:

  11. Recent data suggest a critical role for dendritic cells (DCs) in the generation of immunoglobulin-secreting plasma cells. In the work reported herein, we analyzed the frequency of peripheral blood plasmacytoid...

    Authors: Jean-François Viallard, Fabrice Camou, Marc André, François Liferman, Jean-François Moreau, Jean-Luc Pellegrin and Patrick Blanco
    Citation: Arthritis Research & Therapy 2005 7:R1052
    Content type: Research article Published on:

  12. Tumour necrosis factor (TNF)-α plays a key role in the pathogenesis of rheumatoid arthritis (RA). It binds to two receptors, namely TNF receptor (TNFR)I and TNFRII. Several studies have suggested an associatio...

    Authors: Vincent Goëb, Philippe Dieudé, Olivier Vittecoq, Othmane Mejjad, Jean-François Ménard, Marlène Thomas, Danièle Gilbert, Patrick Boumier, Sophie Pouplin, Alain Daragon, Patrice Fardellone, François Tron, François Cornélis and Xavier Le Loët
    Citation: Arthritis Research & Therapy 2005 7:R1056
    Content type: Research article Published on:

  13. The risk for cardiovascular (CV) disease is increased in rheumatoid arthritis (RA) but data on the burden of coronary atherosclerosis in patients with RA are lacking. We conducted a retrospective case-control ...

    Authors: Kenneth J Warrington, Peter D Kent, Robert L Frye, James F Lymp, Stephen L Kopecky, Jörg J Goronzy and Cornelia M Weyand
    Citation: Arthritis Research & Therapy 2005 7:R984
    Content type: Research article Published on:

  14. Adverse events of opioids may restrict their use in non-cancer pain. Analysis of the incidence of common adverse events in trials conducted in non-cancer pain has usually been limited to opioids used to treat ...

    Authors: R Andrew Moore and Henry J McQuay
    Citation: Arthritis Research & Therapy 2005 7:R1046
    Content type: Research article Published on:

  15. Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology, characterized by the presence of inflammatory synovitis accompanied by destruction of joint cartilage and bone. Treatment with vasoactive...

    Authors: Yasmina Juarranz, Catalina Abad, Carmen Martinez, Alicia Arranz, Irene Gutierrez-Cañas, Florencia Rosignoli, Rosa P Gomariz and Javier Leceta
    Citation: Arthritis Research & Therapy 2005 7:R1034
    Content type: Research article Published on:

  16. Monocytes/macrophages play an important role in rheumatoid arthritis (RA) pathogenesis. They can activate fibroblasts through many molecules, including IL-1 and tumor necrosis factor-alpha, but there have been...

    Authors: Ping Zhu, Jin Ding, Jun Zhou, Wei-Jia Dong, Chun-Mei Fan and Zhi-Nan Chen
    Citation: Arthritis Research & Therapy 2005 7:R1023
    Content type: Research article Published on:

  18. Tissue inhibitors of matrix metalloproteinases (TIMPs) regulate the breakdown of extracellular matrix components and play an important role in tissue remodelling and growth, in both physiological and pathologi...

    Authors: Maria Bokarewa, Leif Dahlberg and Andrej Tarkowski
    Citation: Arthritis Research & Therapy 2005 7:R1014
    Content type: Research article Published on:

  19. Chemokines and their receptors are essential in the recruitment and positioning of lymphocytes. To address the question of B cell migration into the inflamed synovial tissue of patients with rheumatoid arthrit...

    Authors: Maren Henneken, Thomas Dörner, Gerd-Rüdiger Burmester and Claudia Berek
    Citation: Arthritis Research & Therapy 2005 7:R1001
    Content type: Research article Published on:

  21. In clinic studies, altered hypothalamic-pituitary-adrenal (HPA) axis function has been associated with fibromyalgia, a syndrome characterised by chronic widespread body pain. These results may be explained by ...

    Authors: John McBeth, Yee H Chiu, Alan J Silman, David Ray, Richard Morriss, Chris Dickens, Anindya Gupta and Gary J Macfarlane
    Citation: Arthritis Research & Therapy 2005 7:R992
    Content type: Research article Published on:

  22. Studies of cytokine expression in rheumatoid arthritis have provided key insights into the pathogenesis of disease and have offered clues for effective therapy. Patterns of T-cell products in chronic rheumatoi...

    Authors: Gary S Firestein
    Citation: Arthritis Research & Therapy 2005 7:157
    Content type: Commentary Published on:

  24. The selectins, along with very late antigen-4 and CD44, have been implicated in mediating leukocyte rolling interactions that lead to joint recruitment and inflammation during the pathogenesis of rheumatoid ar...

    Authors: Jeffrey H Ruth, M Asif Amin, James M Woods, Xiaodong He, Sharon Samuel, Nengjun Yi, Christian S Haas, Alisa E Koch and Daniel C Bullard
    Citation: Arthritis Research & Therapy 2005 7:R959
    Content type: Research article Published on:

  25. Antibodies to citrullinated proteins (anti-cyclic-citrullinated peptide [anti-CCP] antibodies) are highly specific for rheumatoid arthritis (RA) and precede the onset of disease symptoms, indicating a pathogen...

    Authors: Annette HM van der Helm-van Mil, Kirsten N Verpoort, Ferdinand C Breedveld, René EM Toes and Tom WJ Huizinga
    Citation: Arthritis Research & Therapy 2005 7:R949
    Content type: Research article Published on:

    The Editorial to this article has been published in Arthritis Research & Therapy 2019 21:227

  26. When purified under rigorous conditions, some murine anti-double-stranded-DNA (anti-dsDNA) antibodies actually bind chromatin rather than dsDNA. This suggests that they may actually be antinucleosome antibodie...

    Authors: Lesley J Mason, Anastasia Lambrianides, Joanna D Haley, Jessica J Manson, David S Latchman, David A Isenberg and Anisur Rahman
    Citation: Arthritis Research & Therapy 2005 7:R971
    Content type: Research article Published on:

  27. In synovial cells of patients with osteoarthritis (OA) and rheumatoid arthritis (RA), conversion products of major anti-inflammatory androgens are as yet unknown but may be proinflammatory. Therefore, therapy ...

    Authors: Martin Schmidt, Claudia Weidler, Heidrun Naumann, Sven Anders, Jürgen Schölmerich and Rainer H Straub
    Citation: Arthritis Research & Therapy 2005 7:R938
    Content type: Research article Published on:

  28. Models of rheumatoid arthritis (RA) in laboratory animals are important tools for research into pathogenic mechanisms and the development of effective, safe therapies. Rodent models (rats and mice) have provid...

    Authors: Michel PM Vierboom, Margreet Jonker, Ronald E Bontrop and Bert 't Hart
    Citation: Arthritis Research & Therapy 2005 7:145
    Content type: Review Published on:

  29. Certain monoclonal antibodies (mAbs) to type II collagen (CII) induce arthritis in vivo after passive transfer and have adverse effects on chondrocyte cultures and inhibit self assembly of collagen fibrils in vit...

    Authors: Duncan E Crombie, Muhammed Turer, Beltzane Biurrun Zuasti, Bayden Wood, Don McNaughton, Kutty Selva Nandakumar, Rikard Holmdahl, Marie-Paule Van Damme and Merrill J Rowley
    Citation: Arthritis Research & Therapy 2005 7:R927
    Content type: Research article Published on:

  30. The receptor for advanced glycation endproducts (RAGE) interacts with distinct ligand families linked to the inflammatory response. Studies in animal models suggest that RAGE is upregulated in the inflamed joi...

    Authors: Bernhard Moser, Barry I Hudson and Ann Marie Schmidt
    Citation: Arthritis Research & Therapy 2005 7:142
    Content type: Commentary Published on:

  31. Basic calcium phosphate (BCP) crystals, including hydroxyapatite, octacalcium phosphate (OCP) and carbonate-apatite, have been associated with severe osteoarthritis and several degenerative arthropathies. Most...

    Authors: Hang-Korng Ea, Benjamin Uzan, Christian Rey and Frédéric Lioté
    Citation: Arthritis Research & Therapy 2005 7:R915
    Content type: Research article Published on:

  32. Transcription factor hypoxia-inducible factor (HIF)-1 protein accumulates and activates the transcription of genes that are of fundamental importance for oxygen homeostasis – including genes involved in energy...

    Authors: Kazuo Yudoh, Hiroshi Nakamura, Kayo Masuko-Hongo, Tomohiro Kato and Kusuki Nishioka
    Citation: Arthritis Research & Therapy 2005 7:R904
    Content type: Research article Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2005 7:225

  33. Spondyloarthropathies are inflammatory diseases closely associated with human leukocyte antigen (HLA)-B27 by unknown mechanisms. One of these diseases is reactive arthritis (ReA), which is typically triggered ...

    Authors: Sanna Vähämiko, Markus A Penttinen and Kaisa Granfors
    Citation: Arthritis Research & Therapy 2005 7:136
    Content type: Review Published on:

  34. Anti-endothelial-cell antibodies are associated with psychiatric manifestations in systemic lupus erythematosus (SLE). Our primary aim in this study was to seek and characterize molecules that behave as endoth...

    Authors: Paola Margutti, Maurizio Sorice, Fabrizio Conti, Federica Delunardo, Mauro Racaniello, Cristiano Alessandri, Alessandra Siracusano, Rachele Riganò, Elisabetta Profumo, Guido Valesini and Elena Ortona
    Citation: Arthritis Research & Therapy 2005 7:R896
    Content type: Research article Published on:

  35. In previous studies we have found that FcγRI determines chondrocyte death and matrix metalloproteinase (MMP)-mediated cartilage destruction during IFN-γ-regulated immune complex arthritis (ICA). Binding of imm...

    Authors: Peter LEM van Lent, Karin CAM Nabbe, Arjen B Blom, Annet Sloetjes, Astrid EM Holthuysen, Jay Kolls, Fons AJ Van De Loo, Steven M Holland and Wim B Van Den Berg
    Citation: Arthritis Research & Therapy 2005 7:R885
    Content type: Research article Published on:

  36. Collagen-induced arthritis (CIA), an approved animal model for rheumatoid arthritis, is thought to be a T cell-dependent disease. There is evidence that CD8+ T cells are a major subset controlling the pathogenesi...

    Authors: Kristin Bauer, Annika Knipper, Hoang Tu-Rapp, Dirk Koczan, Hans-Jürgen Kreutzer, Horst Nizze, Eilhard Mix, Hans-Juergen Thiesen, Rikard Holmdahl and Saleh M Ibrahim
    Citation: Arthritis Research & Therapy 2005 7:R877
    Content type: Research article Published on:

  38. Although the precise pathogenesis of rheumatoid arthritis (RA) remains unclear, many cell populations, including monocytes, macrophages, endothelial cells, fibroblasts and B cells, participate in the inflammat...

    Authors: Edward Keystone
    Citation: Arthritis Research & Therapy 2005 7(Suppl 3):S13
    Content type: Review Published on:

    This article is part of a Supplement: Volume 7 Supplement 3

  39. In rheumatoid arthritis, T cells, B cells, macrophages, and dendritic cells invade the synovial membranes, establishing complex microstructures that promote inflammatory/tissue destructive lesions. B cell invo...

    Authors: Cornelia M Weyand, Thorsten M Seyler and Jörg J Goronzy
    Citation: Arthritis Research & Therapy 2005 7(Suppl 3):S9
    Content type: Review Published on:

    This article is part of a Supplement: Volume 7 Supplement 3

  40. Until the pathophysiology/etiology of rheumatoid arthritis (RA) is better understood, treatment strategies must focus on disease management. Early diagnosis and treatment with disease-modifying antirheumatic d...

    Authors: Larry Moreland
    Citation: Arthritis Research & Therapy 2005 7(Suppl 3):S2
    Content type: Review Published on:

    This article is part of a Supplement: Volume 7 Supplement 3

  42. A better understanding of the initial mechanisms that lead to arthritic disease could facilitate development of improved therapeutic strategies. We characterized the synovial microcirculation of knee joints in...

    Authors: Philip Gierer, Saleh Ibrahim, Thomas Mittlmeier, Dirk Koczan, Steffen Moeller, Jürgen Landes, Georg Gradl and Brigitte Vollmar
    Citation: Arthritis Research & Therapy 2005 7:R868
    Content type: Research article Published on:

  44. Analysis of biomarkers in synovial tissue is increasingly used in the evaluation of new targeted therapies for patients with rheumatoid arthritis (RA). This study determined the intrarater and inter-rater reli...

    Authors: Jasper J Haringman, Marjolein Vinkenoog, Danielle M Gerlag, Tom JM Smeets, Aeilko H Zwinderman and Paul P Tak
    Citation: Arthritis Research & Therapy 2005 7:R862
    Content type: Research article Published on:

  45. Osteoarthritis (OA), the commonest form of arthritis and a major cause of morbidity, is characterized by progressive degeneration of the articular cartilage. Along with increased production and activation of d...

    Authors: Allan A Young, Margaret M Smith, Susan M Smith, Martin A Cake, Peter Ghosh, Richard A Read, James Melrose, David H Sonnabend, Peter J Roughley and Christopher B Little
    Citation: Arthritis Research & Therapy 2005 7:R852
    Content type: Research article Published on:

  46. Somatic mutations have a role in the pathogenesis of a number of diseases, particularly cancers. Here we present data supporting a role of mitochondrial somatic mutations in an autoimmune disease, rheumatoid a...

    Authors: Tanya R Da Sylva, Alison Connor, Yvonne Mburu, Edward Keystone and Gillian E Wu
    Citation: Arthritis Research & Therapy 2005 7:R844
    Content type: Research article Published on:

  47. Generalized osteoporosis in postmenopausal rheumatoid arthritis (RA) is caused both by estrogen deficiency and by the inflammatory disease. The relative importance of each of these factors is unknown. The aim ...

    Authors: Caroline Jochems, Ulrika Islander, Malin Erlandsson, Margareta Verdrengh, Claes Ohlsson and Hans Carlsten
    Citation: Arthritis Research & Therapy 2005 7:R837
    Content type: Research article Published on:

  48. The disease category of early rheumatoid arthritis (RA) has been limited with respect to clinical criteria. Pathological manifestations of synovitis in patients whose disease is clinically classified as early ...

    Authors: Takahito Tsubaki, Norimasa Arita, Takuma Kawakami, Takayuki Shiratsuchi, Haruyasu Yamamoto, Nobuo Takubo, Kazuhito Yamada, Sanpei Nakata, Sumiki Yamamoto and Masato Nose
    Citation: Arthritis Research & Therapy 2005 7:R825
    Content type: Research article Published on:

  49. The receptor for advanced glycation end products (RAGE) is a member of the immunoglobulin superfamily being expressed as a cell surface molecule and binding a variety of ligands. One of these ligands is high-m...

    Authors: Rille Pullerits, Maria Bokarewa, Leif Dahlberg and Andrej Tarkowski
    Citation: Arthritis Research & Therapy 2005 7:R817
    Content type: Research article Published on:
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Arthritis Research & Therapy

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