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  1. Pathogenesis and aetiology of systemic sclerosis (SSc) are currently unclear, thus rendering disease prognosis, diagnosis and treatment challenging. The aim of this study was to use paired skin biopsy samples ...

    Authors: Paraskevi Chairta, Paschalis Nicolaou, Kleitos Sokratous, Christine Galant, Frédéric Houssiau, Anastasis Oulas, George M. Spyrou, Marta E. Alarcon-Riquelme, Bernard R. Lauwerys and Kyproula Christodoulou
    Citation: Arthritis Research & Therapy 2020 22:107
  2. The tumor necrosis factor (TNF) superfamily cytokine TNF-like protein 1A (TL1A) and its receptor DR3 are essential for diverse animal models of autoimmune disease and may be pathogenic in rheumatoid arthritis ...

    Authors: Yun-Jeong Song, In Ah. Choi, Françoise Meylan, M. Kristen Demoruelle, Taylor Farley, Arianne C. Richard, Eric Hawley, John Botson, Yoo Jin Hong, Eun Young Lee, Sabina R. Mian, Bartlett C. Hamilton, Geoffrey M. Thiele, Ted R. Mikuls, Naveen Gara, Chris D. Ward…
    Citation: Arthritis Research & Therapy 2020 22:106
  3. Calprotectin (S100A8/S100A9 protein) is known as a damage-associated molecular pattern (DAMP) protein and reflects mainly neutrophil activation. Serum calprotectin levels might be a good alternative to acute-p...

    Authors: Matthias Jarlborg, Delphine S. Courvoisier, Céline Lamacchia, Laura Martinez Prat, Michael Mahler, Chelsea Bentow, Axel Finckh, Cem Gabay and Michael J. Nissen
    Citation: Arthritis Research & Therapy 2020 22:105
  4. Soluble urate has been shown to serve as an antioxidant, especially in the central nervous system. Although there are intriguing data suggesting that low levels of serum urate are associated with worse outcome...

    Authors: Woo-Joong Kim, Hye Ri Kim, Jung Soo Song and Sang Tae Choi
    Citation: Arthritis Research & Therapy 2020 22:104
  5. Large vessels could be involved in immunoglobulin (Ig)-G4-related disease (IgG4-RD). This study aimed to clarify the clinical features and evaluate the treatment efficacy for IgG4-RD with aortitis/periaortitis...

    Authors: Linyi Peng, Panpan Zhang, Jieqiong Li, Zheng Liu, Hui Lu, Liang Zhu, Xiaorong Wang, Fei Teng, Xuemei Li, Huifang Guo, Yunyun Fei, Wen Zhang, Yan Zhao, Xiaofeng Zeng and Fengchun Zhang
    Citation: Arthritis Research & Therapy 2020 22:103
  6. Elevated B lymphocyte stimulator (BLyS) levels in patients with systemic lupus erythematosus (SLE) correlate positively with disease activity; BLyS expression is directly linked to interferon (IFN) pathway act...

    Authors: Christel Wilkinson, Robert B. Henderson, Angela R. Jones-Leone, Shaun M. Flint, Mark Lennon, Roger A. Levy, Beulah Ji, Damon L. Bass and David Roth
    Citation: Arthritis Research & Therapy 2020 22:102
  7. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Debbie M. Boeters and Annette H. M. van der Helm–van Mil
    Citation: Arthritis Research & Therapy 2020 22:101

    The original article was published in Arthritis Research & Therapy 2020 22:55

  8. Overlapping Sjogren’s syndrome (SS) is not uncommon in rheumatoid arthritis (RA) and considered as a probable detrimental factor of RA. But data on the impact of overlapping SS on RA therapeutic response is li...

    Authors: Huijuan Zhang, Haoze Zhang, Dai Gao, Wenhui Xie, Yan Geng and Zhuoli Zhang
    Citation: Arthritis Research & Therapy 2020 22:100
  9. Due to the lack of research on the pathological mechanism of temporomandibular joint osteoarthritis (TMJOA), there are few effective treatment measures in the clinic. In recent years, microRNAs (miRs) have bee...

    Authors: Shixing Ma, Aobo Zhang, Xiaole Li, Shizhou Zhang, Shaopeng Liu, Haoming Zhao, Shichao Wu, Lei Chen, Chuan Ma and Huaqiang Zhao
    Citation: Arthritis Research & Therapy 2020 22:99
  10. Fluorescence optical imaging (FOI) demonstrates enhanced microcirculation in finger joints as a sign of inflammation. We wanted to assess the validity and diagnostic performance of FOI measuring synovitis in p...

    Authors: Øystein Maugesten, Alexander Mathiessen, Hilde Berner Hammer, Sigrid Valen Hestetun, Tore Kristian Kvien, Till Uhlig, Sarah Ohrndorf and Ida Kristin Haugen
    Citation: Arthritis Research & Therapy 2020 22:98

    The Correction to this article has been published in Arthritis Research & Therapy 2021 23:87

  11. To systematically review the impact of tapering targeted therapies (bDMARDs or JAKis) on the risk of serious infections and severe adverse events (SAEs) in patients with rheumatoid arthritis (RA) or axial spon...

    Authors: D. Vinson, L. Molet-Benhamou, Y. Degboé, A. den Broeder, F. Ibrahim, C. Pontes, R. Westhovens, J. Závada, T. Pham, T. Barnetche, A. Constantin and A. Ruyssen-Witrand
    Citation: Arthritis Research & Therapy 2020 22:97
  12. Studies have demonstrated that rheumatoid arthritis (RA) patients who achieve low disease activity or remission are able to taper biological disease-modifying antirheumatic drugs (bDMARDs). The aim of this stu...

    Authors: Stéphanie Dierckx, Tatiana Sokolova, Bernard R. Lauwerys, Aleksandra Avramovska, Laurent Meric de Bellefon, Adrien Nzeusseu Toukap, Maria Stoenoiu, Frédéric A. Houssiau and Patrick Durez
    Citation: Arthritis Research & Therapy 2020 22:96
  13. CD4+ T cells play a central role during the early stages of rheumatoid arthritis (RA), but to which extent they are required for the perpetuation of the disease is still not fully understood. The aim of the curre...

    Authors: Jonatan Tuncel, Jens Holmberg, Sabrina Haag, Malin Hultqvist Hopkins, Lena Wester-Rosenlöf, Stefan Carlsen, Peter Olofsson and Rikard Holmdahl
    Citation: Arthritis Research & Therapy 2020 22:95
  14. The objective of this study was to compare in real life the occurrence of anterior uveitis in patients with spondyloarthritis (SpA), including psoriatic arthritis (PsA), treated with the soluble-receptor etane...

    Authors: Gisèle Khoury, Jacques Morel, Bernard Combe and Cédric Lukas
    Citation: Arthritis Research & Therapy 2020 22:94
  15. Systemic lupus erythematosus (SLE) is an autoimmune inflammatory rheumatic disease. SLE susceptibility is affected by multiple genetic elements, environmental factors, and their interactions. We aimed in this ...

    Authors: Taehyeung Kim, Sang-Cheol Bae and Changwon Kang
    Citation: Arthritis Research & Therapy 2020 22:93
  16. Patients with obstructive sleep apnea (OSA) might be at risk of gout because of pathophysiological mechanisms that can lead to hyperuricemia and eventually gout or because of shared risk factors between both d...

    Authors: Caroline van Durme, Bart Spaetgens, Johanna Driessen, Johannes Nielen, Manuel Sastry, Annelies Boonen and Frank de Vries
    Citation: Arthritis Research & Therapy 2020 22:92
  17. Systemic lupus erythematosus (SLE) is a complex multi-system disease, characterized by both autoimmune and autoinflammatory clinical and laboratory features. The role of type I interferon (IFN) in SLE has been...

    Authors: Alessandra Tesser, Luciana Martins de Carvalho, Paula Sandrin-Garcia, Alessia Pin, Serena Pastore, Andrea Taddio, Luciana Rodrigues Roberti, Rosane Gomes de Paula Queiroz, Virginia Paes Leme Ferriani, Sergio Crovella and Alberto Tommasini
    Citation: Arthritis Research & Therapy 2020 22:91
  18. In younger individuals, low absolute risk of cardiovascular disease (CVD) may conceal an increased risk age and relative risk of CVD. Calculation of risk age is proposed as an adjuvant to absolute CVD risk est...

    Authors: Grunde Wibetoe, Joseph Sexton, Eirik Ikdahl, Silvia Rollefstad, George D. Kitas, Piet van Riel, Sherine Gabriel, Tore K. Kvien, Karen Douglas, Aamer Sandoo, Elke E. Arts, Solveig Wållberg-Jonsson, Solbritt Rantapää Dahlqvist, George Karpouzas, Patrick H. Dessein, Linda Tsang…
    Citation: Arthritis Research & Therapy 2020 22:90
  19. Pain persists in a moderate number of patients following hip or knee replacement surgery. Persistent pain may subsequently lead to the prolonged consumption of analgesics after surgery and expose patients to t...

    Authors: Tuomas Jaakko Rajamäki, Pia A. Puolakka, Aki Hietaharju, Teemu Moilanen and Esa Jämsen
    Citation: Arthritis Research & Therapy 2020 22:89
  20. Foxp3 is a marker for regulatory T cells (Treg cells), but recent studies have shown the plasticity and heterogeneity of CD4+Foxp3+ T cells. This study aimed to examine the phenotype and function of circulating C...

    Authors: Hironari Hanaoka, Tetsuya Nishimoto, Yuka Okazaki, Tsutomu Takeuchi and Masataka Kuwana
    Citation: Arthritis Research & Therapy 2020 22:88
  21. Missing clinical outcome data are a common occurrence in longitudinal studies. Data quality in clinical audit is a particular cause for concern. The relationship between departmental levels of missing clinical...

    Authors: Mark Yates, Katie Bechman, Elaine M. Dennison, Alexander J. MacGregor, Jo Ledingham, Sam Norton and James B. Galloway
    Citation: Arthritis Research & Therapy 2020 22:87
  22. Gout has been associated with a higher risk for coronary heart disease (CHD) and stroke in some prior studies. Few studies have assessed the association of gout with incident heart failure (HF).

    Authors: Lisandro D. Colantonio, Kenneth G. Saag, Jasvinder A. Singh, Ligong Chen, Richard J. Reynolds, Angelo Gaffo, Timothy B. Plante, Jeffrey R. Curtis, S. Louis Bridges Jr., Emily B. Levitan, Ninad S. Chaudhary, George Howard, Monika M. Safford, Paul Muntner and Marguerite Ryan Irvin
    Citation: Arthritis Research & Therapy 2020 22:86
  23. Authors: Bastiaan T. van Dijk, Leendert A. Trouw, Annette H. M. van der Helm-van Mil and Tom W. J. Huizinga
    Citation: Arthritis Research & Therapy 2020 22:85

    The original article was published in Arthritis Research & Therapy 2019 21:280

  24. Longitudinal evidence on change of serum urate level with mortality risk is limited as prior studies have a measurement of serum urate at a single time point. Further, the combined effect of serum urate and sy...

    Authors: Shanshan Li, Liufu Cui, Jin Cheng, Rong Shu, Shuohua Chen, Uyen-Sa Nguyen, Devyani Misra, Shouling Wu and Xiang Gao
    Citation: Arthritis Research & Therapy 2020 22:84
  25. Dietary fatty acid (FA) content has been shown to influence the development of post-traumatic osteoarthritis (PTOA) in obesity. We used the fat-1 transgenic mouse to examine the hypothesis that endogenous reducti...

    Authors: Kelly A. Kimmerling, Sara J. Oswald, Janet L. Huebner, Dianne Little, Virginia B. Kraus, Jing X. Kang, Chia-Lung Wu and Farshid Guilak
    Citation: Arthritis Research & Therapy 2020 22:83
  26. Patient-reported outcomes measures, such as those provided by the Psoriatic Arthritis Impact of Disease (PsAID) questionnaire, have been found to be a reliable indicator of change during treatment, predictive of ...

    Authors: Ruben Queiro, Juan D. Cañete, María Montoro, Susana Gómez and Ana Cábez
    Citation: Arthritis Research & Therapy 2020 22:82
  27. To analyze whether ANA-positive idiopathic anterior uveitis differs from JIA-associated uveitis concerning clinical course, response to treatment, and disease outcome.

    Authors: Arnd Heiligenhaus, Jens Klotsche, Martina Niewerth, Gerd Horneff, Gerd Ganser, Johannes-Peter Haas and Kirsten Minden
    Citation: Arthritis Research & Therapy 2020 22:81

    The Correspondence to this article has been published in Arthritis Research & Therapy 2023 25:41

    The Correspondence to this article has been published in Arthritis Research & Therapy 2023 25:52

  28. Galectin-9 (Gal-9) is involved in the regulatory process of immune responses or inflammation. The aim of the present study is to characterize circulating Gal-9 in patients with rheumatoid arthritis (RA) and it...

    Authors: Yuya Fujita, Tomoyuki Asano, Naoki Matsuoka, Jumpei Temmoku, Shuzo Sato, Haruki Matsumoto, Makiko Yashiro Furuya, Eiji Suzuki, Hiroshi Watanabe, Atsushi Kawakami and Kiyoshi Migita
    Citation: Arthritis Research & Therapy 2020 22:80
  29. Anti-TNF treatment may be useful for the treatment of patients with refractory juvenile dermatomyositis (JDM). The aim of this study was to describe the use of infliximab and adalimumab therapy in juvenile der...

    Authors: Raquel Campanilho-Marques, Claire T. Deakin, Stefania Simou, Charalampia Papadopoulou, Lucy R. Wedderburn and Clarissa A. Pilkington
    Citation: Arthritis Research & Therapy 2020 22:79
  30. For people with chronic autoimmune rheumatic diseases (AIRD), such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) or systemic sclerosis (SSc), normal cognitive functions are essential for per...

    Authors: Csaba Oláh, Noa Schwartz, Christopher Denton, Zsófia Kardos, Chaim Putterman and Zoltán Szekanecz
    Citation: Arthritis Research & Therapy 2020 22:78
  31. Rapamycin, an inhibitor of the serine/threonine protein kinase mTOR, is an immunosuppressant used to treat renal transplant recipients, but it can cause endothelial and mitochondrial dysfunction. Metformin is ...

    Authors: Eun Kyung Kim, Hong Ki Min, Seon-Yeong Lee, Da-Som Kim, Jun-Geol Ryu, Hyun Sik Na, Kyoung Ah Jung, Jeong Won Choi, Sung-Hwan Park and Mi-La Cho
    Citation: Arthritis Research & Therapy 2020 22:77
  32. Fibrotic diseases are characterized by tissue overgrowth, hardening, and/or scarring because of the excessive production, deposition, and contraction of the extracellular matrix (ECM). However, the detailed me...

    Authors: Yosuke Kanno, En Shu, Hirofumi Niwa, Hiroyuki Kanoh and Mariko Seishima
    Citation: Arthritis Research & Therapy 2020 22:76
  33. Spinal cord ischemia-reperfusion injury (SCIRI) often leads to neurological damage and mortality. In this regard, understanding the pathology of SCIRI and preventing its development are of great clinic value.

    Authors: Ran Li, Kunchi Zhao, Qing Ruan, Chunyang Meng and Fei Yin
    Citation: Arthritis Research & Therapy 2020 22:75
  34. The association of HLA-B*27 with AS is amongst the strongest of any known association of a common variant with any human disease. Nonetheless, there is strong evidence indicating that other HLA-B alleles are invo...

    Authors: Geng Wang, Tae-Hwan Kim, Zhixiu Li, Adrian Cortes, Kwangwoo Kim, So-Young Bang, Paul Leo, Matthew A. Brown and Huji Xu
    Citation: Arthritis Research & Therapy 2020 22:74
  35. Interleukin (IL)-16 is a T cell chemoattractant produced by peripheral mononuclear cells. We investigated whether IL-16 plays a pro- or an anti-inflammatory role in antineutrophil cytoplasmic antibody-associat...

    Authors: Taejun Yoon, Jung Yoon Pyo, Sung Soo Ahn, Jason Jungsik Song, Yong-Beom Park and Sang-Won Lee
    Citation: Arthritis Research & Therapy 2020 22:73
  36. Relapses frequently occur in giant cell arteritis (GCA), and long-term glucocorticoid therapy is required. The identification of associated factors with poor treatment outcomes is important to decide the treat...

    Authors: Takahiko Sugihara, Hitoshi Hasegawa, Haruhito A. Uchida, Hajime Yoshifuji, Yoshiko Watanabe, Eisuke Amiya, Yasuhiro Maejima, Masanori Konishi, Yohko Murakawa, Noriyoshi Ogawa, Shunsuke Furuta, Yasuhiro Katsumata, Yoshinori Komagata, Taio Naniwa, Takahiro Okazaki, Yoshiya Tanaka…
    Citation: Arthritis Research & Therapy 2020 22:72
  37. To derive a list of opportunistic infections (OI) through the analysis of the juvenile idiopathic arthritis (JIA) patients in the Pharmachild registry by an independent Safety Adjudication Committee (SAC).

    Authors: Gabriella Giancane, Joost F. Swart, Elio Castagnola, Andreas H. Groll, Gerd Horneff, Hans-Iko Huppertz, Daniel J. Lovell, Tom Wolfs, Troels Herlin, Pavla Dolezalova, Helga Sanner, Gordana Susic, Flavio Sztajnbok, Despoina Maritsi, Tamas Constantin, Veronika Vargova…
    Citation: Arthritis Research & Therapy 2020 22:71
  38. Interleukin-6 (IL-6) is a pleiotropic cytokine that plays a key role in the pathogenesis of rheumatoid arthritis. Sarilumab is a human monoclonal antibody that binds membrane-bound and soluble IL-6 receptor-α ...

    Authors: Cem Gabay, Gerd R. Burmester, Vibeke Strand, Jérôme Msihid, Moshe Zilberstein, Toshio Kimura, Hubert van Hoogstraten, Susan H. Boklage, Jonathan Sadeh, Neil M. H. Graham and Anita Boyapati
    Citation: Arthritis Research & Therapy 2020 22:70
  39. Juvenile dermatomyositis (JDM) is a systemic autoimmune disease with a prominent interferon (IFN) signature, but the pathogenesis of JDM and the etiology of its IFN signature remain unknown. The Mendelian auto...

    Authors: Hanna Kim, Fatima Gunter-Rahman, John A. McGrath, Esther Lee, Adriana A. de Jesus, Ira N. Targoff, Yan Huang, Terrance P. O’Hanlon, Wanxia L. Tsai, Massimo Gadina, Frederick W. Miller, Raphaela Goldbach-Mansky and Lisa G. Rider
    Citation: Arthritis Research & Therapy 2020 22:69
  40. Hemorrhagic arthritis (HA) is a common disease of the musculoskeletal system caused by hemorrhage in the joints, leading to damages in the synovium and cartilage. Pure platelet-rich plasma (P-PRP) has been rec...

    Authors: Yulun Xue, Xinlin Su, Miao Jiang, Ziqiang Yu, Huilin Yang, Ling Qin, Peter V. Giannoudis and Jiong Jiong Guo
    Citation: Arthritis Research & Therapy 2020 22:68
  41. The relationship between physical joint examination (PE) and MRI-detected inflammation in early inflammatory arthritis has mostly been studied in the hands. Physical examination of MTP joints is considered dif...

    Authors: Yousra J. Dakkak, Aleid C. Boer, Debbie M. Boeters, Ellis Niemantsverdriet, Monique Reijnierse and Annette H. M. van der Helm-van Mil
    Citation: Arthritis Research & Therapy 2020 22:67
  42. Systemic sclerosis (SSc) is a connective tissue disease with a significant morbidity and reduced survival of patients. Effective treatment and clinical control of the disease remain challenging. In particular,...

    Authors: Jakob Einhaus, Ann-Christin Pecher, Elisa Asteriti, Hannes Schmid, Kathy-Ann Secker, Silke Duerr-Stoerzer, Hildegard Keppeler, Reinhild Klein, Corina Schneidawind, Joerg Henes and Dominik Schneidawind
    Citation: Arthritis Research & Therapy 2020 22:66
  43. Iguratimod, a novel immunomodulatory agent for rheumatoid arthritis, has been shown to be effective against murine lupus. The aim of this study was to make a preliminary evaluation of the efficacy and safety o...

    Authors: Yuening Kang, Qingran Yan, Qiong Fu, Ran Wang, Min Dai, Fang Du, Qing Dai, Ping Ye, Chunmei Wu, Liangjing Lu and Chunde Bao
    Citation: Arthritis Research & Therapy 2020 22:65
  44. Cytotoxic T lymphocyte-associated antigen-4-Ig (CTLA-4-Ig) competes with CD28 for binding CD80/CD86 on antigen-presenting cells (APCs) to limit T cell activation. B cells are believed to be important APCs in t...

    Authors: Po-Chun Liu, Chih-Tai Ssu, Yen-Po Tsao, Teh-Ling Liou, Chang-Youh Tsai, Chung-Tei Chou, Ming-Han Chen and Chuen-Miin Leu
    Citation: Arthritis Research & Therapy 2020 22:64
  45. Innate lymphoid cells (ILCs) play an essential role in maintaining homeostasis; however, they can also cause chronic inflammation and autoimmune disease. This study aimed to identify the role of ILCs in the pa...

    Authors: Seungwon Ryu, Eun Young Lee, Dong Ki Kim, Yon Su Kim, Doo Hyun Chung, Ji Hyung Kim, Hajeong Lee and Hye Young Kim
    Citation: Arthritis Research & Therapy 2020 22:63
  46. Although increasing studies have demonstrated that chondrogenic progenitor cells (CPCs) remain present in human osteoarthritic cartilage, the biological alterations of the CPCs from the less diseased lateral t...

    Authors: Yu-Xing Wang, Zhi-Dong Zhao, Qian Wang, Zhong-Li Li, Ya Huang, Sen Zhao, Wei Hu, Jia-Wu Liang, Pei-Lin Li, Hua Wang, Ning Mao, Chu-Tse Wu and Heng Zhu
    Citation: Arthritis Research & Therapy 2020 22:62
  47. Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and joint stiffness, finally leading to tissue destruction. Connective tissue growth factor (CTGF) is a critical factor i...

    Authors: Weiwei Sun, Jinglan Ma, Han Zhao, Chipeng Xiao, Hao Zhong, Hanzhi Ling, Zhen Xie, Qingqing Tian, Huaijun Chen, Tingting Zhang, Mu Chen, Shengwei Jin and Jianguang Wang
    Citation: Arthritis Research & Therapy 2020 22:61
  48. ABP 710 is being developed as a biosimilar to infliximab reference product (RP). Analytical similarity and pharmacokinetic equivalence between the two have been previously demonstrated. Here we report results ...

    Authors: Mark C. Genovese, Juan Sanchez-Burson, MyungShin Oh, Eva Balazs, Jeffrey Neal, Andrea Everding, Tomas Hala, Rafal Wojciechowski, Gary Fanjiang and Stanley Cohen
    Citation: Arthritis Research & Therapy 2020 22:60
  49. The SPARCC sacroiliac joint inflammation (SIS) and structural (SSS) scores are reliable measures to quantify abnormalities in the pediatric sacroiliac joint. We aimed to evaluate the utility of online calibrat...

    Authors: Pamela F. Weiss, Walter P. Maksymowych, Rui Xiao, David M. Biko, Michael L. Francavilla, Robert G. Lambert, Jacob L. Jaremko, Merav Heshin-Bekenstein, Timothy G. Brandon and Nancy A. Chauvin
    Citation: Arthritis Research & Therapy 2020 22:58
  50. Post-traumatic osteoarthritis (PTOA) develops after joint injury. Specifically, patients with anterior cruciate ligament (ACL) injury have a high risk of developing PTOA. In this review, we outline the inciden...

    Authors: Li-Juan Wang, Ni Zeng, Zhi-Peng Yan, Jie-Ting Li and Guo-Xin Ni
    Citation: Arthritis Research & Therapy 2020 22:57

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