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  1. Patient-reported outcomes (PROs) are important when evaluating treatment benefits in rheumatoid arthritis (RA). We compared upadacitinib, an oral, selective JAK-1 inhibitor, with placebo to assess clinically m...

    Authors: Vibeke Strand, Michael Schiff, Namita Tundia, Alan Friedman, Sebastian Meerwein, Aileen Pangan, Arijit Ganguli, Mahesh Fuldeore, Yan Song and Janet Pope
    Citation: Arthritis Research & Therapy 2019 21:263
    Content type: Research article Published on:

  2. Lupus nephritis (LN) is a common and serious complication of systemic lupus erythematosus. Anti-double-stranded (ds) DNA immunoglobulin G (IgG) plays a pivotal role in the pathogenesis of LN. Currently, there ...

    Authors: Huixia Wang, Mei Lu, Siyue Zhai, Kunyi Wu, Lingling Peng, Jie Yang and Yumin Xia
    Citation: Arthritis Research & Therapy 2019 21:261
    Content type: Research article Published on:

  3. Patients with incomplete systemic lupus erythematosus (iSLE) have lupus features, but do not meet classification criteria for SLE. Type I interferons (IFN) are important early mediators in SLE, and IFN upregul...

    Authors: Wietske M. Lambers, Karina de Leeuw, Berber Doornbos-van der Meer, Gilles F.H. Diercks, Hendrika Bootsma and Johanna Westra
    Citation: Arthritis Research & Therapy 2019 21:260
    Content type: Research article Published on:

  4. Immune complexes are of importance in systemic lupus erythematosus pathogenesis, and autoantibodies are believed to participate in immune complex formation. Quantification of autoantibody levels in circulating...

    Authors: Azita Sohrabian, Ioannis Parodis, Nellie Carlströmer-Berthén, Martina Frodlund, Andreas Jönsen, Agneta Zickert, Christopher Sjöwall, Anders A. Bengtsson, Iva Gunnarsson and Johan Rönnelid
    Citation: Arthritis Research & Therapy 2019 21:259
    Content type: Research article Published on:

  5. In previous studies, we demonstrated that the NEMO score, i.e. the cumulative number of microhaemorrhages (MHEs) and microthromboses (MTs), observed in nailfold videocapillaroscopy was a good indicator of the ...

    Authors: Francesca Pignataro, Wanda Maglione, Antonina Minniti, Domenico Sambataro, Gianluca Sambataro, Francesco Campanaro, Gabriele Valentini, Claudio Vitali and Nicoletta Del Papa
    Citation: Arthritis Research & Therapy 2019 21:258
    Content type: Research article Published on:

  6. In well-controlled rheumatoid arthritis (RA) without significant joint damage, a substantial proportion of patients complain of persistent pain. Previous studies have identified different pain phenotypes in RA...

    Authors: P. M. ten Klooster, N. de Graaf and H. E. Vonkeman
    Citation: Arthritis Research & Therapy 2019 21:257
    Content type: Research article Published on:

  7. To identify a therapeutic target interval for certolizumab pegol drug levels and examine the influence of anti-drug antibodies in patients with inflammatory joint diseases.

    Authors: Johanna Elin Gehin, Guro Løvik Goll, David John Warren, Silje Watterdal Syversen, Joseph Sexton, Eldri Kveine Strand, Tore Kristian Kvien, Nils Bolstad and Elisabeth Lie
    Citation: Arthritis Research & Therapy 2019 21:256
    Content type: Research article Published on:

  8. The prophylaxis for hepatitis B virus (HBV) reactivation assumes that hepatic injury after reactivation is often rapidly progressive and can evoke fulminant hepatitis. The incidence and prognosis of reactivati...

    Authors: Wataru Fukuda, Tadamasa Hanyu, Masaki Katayama, Shinichi Mizuki, Akitomo Okada, Masayuki Miyata, Yuichi Handa, Masatoshi Hayashi, Yoshinobu Koyama, Kaoru Arii, Toshiyuki Kitaori, Hiroyuki Hagiyama, Yoshinori Urushidani, Takahito Yamasaki, Yoshihiko Ikeno, Takeshi Suzuki…
    Citation: Arthritis Research & Therapy 2019 21:255
    Content type: Research article Published on:

  9. Osteoarthritis is increasingly recognized as the result of a complex interplay between inflammation, chrondrodegeneration, and pain. Joint mast cells are considered to play a key role in orchestrating this det...

    Authors: Marika Cordaro, Rosalba Siracusa, Daniela Impellizzeri, Ramona D’ Amico, Alessio Filippo Peritore, Rosalia Crupi, Enrico Gugliandolo, Roberta Fusco, Rosanna Di Paola, Carlo Schievano and Salvatore Cuzzocrea
    Citation: Arthritis Research & Therapy 2019 21:254
    Content type: Research article Published on:

  10. While microangiopathy is well-documented in systemic sclerosis (SSc), a potential link between SSc and macrovascular disease is highly debated and remains to be established. The aim of the present study is to ...

    Authors: Stergios Soulaidopoulos, Eleni Pagkopoulou, Niki Katsiki, Eva Triantafyllidou, Asterios Karagiannis, Alexandros Garyfallos, George D. Kitas and Theodoros Dimitroulas
    Citation: Arthritis Research & Therapy 2019 21:253
    Content type: Research article Published on:

  11. Intra-articular adipose tissues (IAATs) are involved in osteoarthritis (OA) pathophysiology. We hypothesize that mesenchymal cells residing in IAATs may account for the specific inflammatory and metabolic patt...

    Authors: Florent Eymard, Audrey Pigenet, Cindy Rose, Anouchka Bories, Charles-Henri Flouzat-Lachaniette, Francis Berenbaum, Xavier Chevalier, Xavier Houard and Geoffroy Nourissat
    Citation: Arthritis Research & Therapy 2019 21:252
    Content type: Research article Published on:

  12. Primary Sjögren’s syndrome (pSS) is associated with dental caries. Pilocarpine, a salivary stimulant, can improve the amount and flow rate of saliva in patients with pSS. This study aimed to assess whether the...

    Authors: Chung-Yuan Hsu, Kuo-Chun Hung, Ming-Shyan Lin, Chi-Hua Ko, Yu-Sheng Lin, Tien-Hsing Chen, Chun-Yu Lin and Ying-Chou Chen
    Citation: Arthritis Research & Therapy 2019 21:251
    Content type: Research article Published on:

  13. Hydroxychloroquine (HCQ) is used for the treatment of patients with rheumatic diseases. We tested the hypothesis that HCQ affects the NLRP3 inflammasome, which is involved in autoinflammation.

    Authors: Yuya Fujita, Naoki Matsuoka, Jumpei Temmoku, Makiko Yashiro Furuya, Tomoyuki Asano, Shuzo Sato, Hiroko Kobayashi, Hiroshi Watanabe, Eiji Suzuki, Takeshi Urano, Hideko Kozuru, Hiroshi Yatsuhashi, Tomohiro Koga, Atsushi Kawakami and Kiyoshi Migita
    Citation: Arthritis Research & Therapy 2019 21:250
    Content type: Research article Published on:

  14. Based on a unique cohort of clinically suspect arthralgia (CSA) patients, we analysed which combinations of MRI features at onset were predictive for rheumatoid arthritis (RA) development. This was done to inc...

    Authors: Xanthe M. E. Matthijssen, Fenne Wouters, Debbie M. Boeters, Aleid C. Boer, Yousra J. Dakkak, Ellis Niemantsverdriet and Annette H. M. van der Helm-van Mil
    Citation: Arthritis Research & Therapy 2019 21:249
    Content type: Research article Published on:

  15. Ankylosing spondylitis (AS) shares many characteristics with inflammatory bowel disease (IBD). Intestinal microbiota most likely plays an important role in the development of IBDs and may also be involved in t...

    Authors: Eva Klingberg, Maria K. Magnusson, Hans Strid, Anna Deminger, Arne Ståhl, Johanna Sundin, Magnus Simrén, Hans Carlsten, Lena Öhman and Helena Forsblad-d’Elia
    Citation: Arthritis Research & Therapy 2019 21:248
    Content type: Research article Published on:

  16. Both loss- and gain-of-function of Wnt/β-catenin signaling in chondrocytes result in exacerbation of osteoarthritis (OA). Here, we examined the activity and roles of Wnt/β-catenin signaling in the superficial ...

    Authors: Fengjun Xuan, Fumiko Yano, Daisuke Mori, Ryota Chijimatsu, Yuji Maenohara, Hideki Nakamoto, Yoshifumi Mori, Yuma Makii, Takeshi Oichi, Makoto Mark Taketo, Hironori Hojo, Shinsuke Ohba, Ung-il Chung, Sakae Tanaka and Taku Saito
    Citation: Arthritis Research & Therapy 2019 21:247
    Content type: Research article Published on:

  17. Anti-citrullinated protein antibodies (ACPA) are central to rheumatoid arthritis (RA) pathogenesis and may develop at inflamed mucosa. We investigated whether asthma, a disease of airway mucosal inflammation, ...

    Authors: Alessandra Zaccardelli, Xinyi Liu, Julia A. Ford, Jing Cui, Bing Lu, Su H. Chu, Peter H. Schur, Cameron B. Speyer, Karen H. Costenbader, William H. Robinson, Jeremy Sokolove, Elizabeth W. Karlson, Carlos A. Camargo Jr and Jeffrey A. Sparks
    Citation: Arthritis Research & Therapy 2019 21:246
    Content type: Research article Published on:

  18. Circulating endothelial progenitor cells (EPCs) are biologic markers of endothelial function. In patients with systemic lupus erythematosus (SLE), the numerical reduction and functional impairment of EPCs cont...

    Authors: Francesca Romana Spinelli, Cristiana Barbati, Fulvia Cecarelli, Francesca Morello, Tania Colasanti, Marta Vomero, Laura Massaro, Valeria Orefice, Cristiano Alessandri, Guido Valesini and Fabrizio Conti
    Citation: Arthritis Research & Therapy 2019 21:245
    Content type: Research article Published on:

  20. Early seronegative rheumatoid arthritis (RA) is considered a specific entity, especially regarding diagnostic issues and prognosis. Little is known about its potentially different initial clinical presentation...

    Authors: Cédric Lukas, Julia Mary, Michel Debandt, Claire Daïen, Jacques Morel, Alain Cantagrel, Bruno Fautrel and Bernard Combe
    Citation: Arthritis Research & Therapy 2019 21:243
    Content type: Research article Published on:

  22. The collaborative initiative of the European Network of Pregnancy Registers in Rheumatology (EuNeP) aims to combine data available in nationwide pregnancy registers to increase knowledge on pregnancy outcomes ...

    Authors: Yvette Meissner, Anja Strangfeld, Nathalie Costedoat-Chalumeau, Frauke Förger, Doreen Goll, Anna Molto, Rebecca Özdemir, Marianne Wallenius and Rebecca Fischer-Betz
    Citation: Arthritis Research & Therapy 2019 21:241
    Content type: Research article Published on:

  23. A pivotal effect of lymphatic vessel (LV) function in joint homeostasis was identified in the tumor necrosis factor-transgenic (TNF-Tg) mouse model of rheumatoid arthritis (RA). Specifically, loss of LV contra...

    Authors: Richard D. Bell, Pamelia N. Slattery, Emily K. Wu, Lianping Xing, Christopher T. Ritchlin and Edward M. Schwarz
    Citation: Arthritis Research & Therapy 2019 21:240
    Content type: Research article Published on:

  24. Bone marrow mesenchymal stem cells (BM-MSCs) can dampen inflammation in animal models of inflammatory rheumatisms and human osteoarthritis. They are expected to be a solution for numerous human conditions. How...

    Authors: Jean-Marie Berthelot, Benoit Le Goff and Yves Maugars
    Citation: Arthritis Research & Therapy 2019 21:239
    Content type: Review Published on:

  25. Most in vitro studies of potential osteoarthritis (OA) therapies have used cartilage monocultures, even though synovium is a key player in mediating joint inflammation and, thereby, cartilage degeneration. In ...

    Authors: Shikhar Mehta, Sumayyah Akhtar, Ryan M. Porter, Patrik Önnerfjord and Ambika G. Bajpayee
    Citation: Arthritis Research & Therapy 2019 21:238
    Content type: Research article Published on:

  26. The aim of this retrospective study was to examine the longitudinal association between disease activity and radiographic damage in a cohort of patients with early RA (symptom onset < 1 year) treated according...

    Authors: Peter M. ten Klooster, Letty G. A. Versteeg, Martijn A. H. Oude Voshaar, Inmaculada de la Torre, Francesco De Leonardis, Walid Fakhouri, Liliana Zaremba-Pechmann and Mart van de Laar
    Citation: Arthritis Research & Therapy 2019 21:237
    Content type: Research article Published on:

  27. Blau syndrome (BS) is a rare dominantly inherited autoinflammatory disorder associated with mutations in the nucleotide-binding oligomerization domain containing 2 (NOD2) gene. Biologic therapy of BS yielded dive...

    Authors: Jing Chen, Yi Luo, Mengzhu Zhao, Di Wu, Yunjiao Yang, Wen Zhang and Min Shen
    Citation: Arthritis Research & Therapy 2019 21:236
    Content type: Research article Published on:

  29. Reduced renal clearance of uric acid is a major contributor to hyperuricemia. The aim of this study was to examine clinical and genetic variables associated with fractional excretion of uric acid (FEUA).

    Authors: Ravi K. Narang, Zoe Vincent, Amanda Phipps-Green, Lisa K. Stamp, Tony R. Merriman and Nicola Dalbeth
    Citation: Arthritis Research & Therapy 2019 21:234
    Content type: Research article Published on:

  31. Over the past 20 years, the rheumatoid arthritis (RA) treatment landscape has been continuously evolving. A range of novel biologic agents, different from the conventional therapies, became available. However,...

    Authors: Teresa A. Simon
    Citation: Arthritis Research & Therapy 2019 21:232
    Content type: Editorial Published on:

    The Research article to this article has been published in Arthritis Research & Therapy 2008 10:R45

  32. The ACR20 has been validated as the best discriminator of efficacy in placebo-controlled trials, but not in head-to-head trials comparing effective therapies in patients with rheumatoid arthritis (RA). We asse...

    Authors: Josef Smolen, Roy Fleischmann, Daniel Aletaha, Yihan Li, Yijie Zhou, Iain Sainsbury and Ivan Lagunes Galindo
    Citation: Arthritis Research & Therapy 2019 21:231
    Content type: Research article Published on:

  33. The response to treatment for juvenile idiopathic arthritis (JIA) can be staged using clinical features. However, objective laboratory biomarkers of remission are still lacking. In this study, we used machine ...

    Authors: Kerry E. Poppenberg, Kaiyu Jiang, Lu Li, Yijun Sun, Hui Meng, Carol A. Wallace, Teresa Hennon and James N. Jarvis
    Citation: Arthritis Research & Therapy 2019 21:230
    Content type: Research article Published on:

  34. For patients with recurrent flares of gout, tophi, urate crystal arthropathy, and renal stones, urate-lowering therapies (ULTs, including allopurinol and febuxostat) are the first-line treatment. Due to the wi...

    Authors: Amayelle Rey, Benjamin Batteux, Solène M. Laville, Justine Marienne, Kamel Masmoudi, Valérie Gras-Champel and Sophie Liabeuf
    Citation: Arthritis Research & Therapy 2019 21:229
    Content type: Research article Published on:

  35. Patients with rheumatoid arthritis (RA) are at an increased risk of developing certain cancers and infections compared with the general population. Biologic and targeted synthetic disease-modifying antirheumat...

    Authors: Teresa A. Simon, Maarten Boers, Marc Hochberg, Nicole Baker, Mary L. Skovron, Nitesh Ray, Sanket Singhal, Samy Suissa and Andres Gomez-Caminero
    Citation: Arthritis Research & Therapy 2019 21:228
    Content type: Research article Published on:

  37. A study by Raza et al., published in this journal in 2005, identified that RA patients, within 3 months of symptom onset, had a synovial fluid cytokine profile that was distinct from that of patients with othe...

    Authors: K. Raza
    Citation: Arthritis Research & Therapy 2019 21:226
    Content type: Editorial Published on:

    The Research article to this article has been published in Arthritis Research & Therapy 2005 7:R784

  38. A decade has passed since the publication on the comparison of the effect of adalimumab with data from a historic cohort on the progression of structural damage in the spine of patients with ankylosing spondyl...

    Authors: Désirée van der Heijde and Robert Landewé
    Citation: Arthritis Research & Therapy 2019 21:225
    Content type: Editorial Published on:

    The Research article to this article has been published in Arthritis Research & Therapy 2009 11:R127

  39. Identification of the optimal treatment for a given patient is of paramount importance. This is of particular relevance in osteoarthritis (OA) because of the high prevalence of the disease, extensive heterogen...

    Authors: Guangju Zhai, Jean-Pierre Pelletier, Ming Liu, Edward W. Randell, Proton Rahman and Johanne Martel-Pelletier
    Citation: Arthritis Research & Therapy 2019 21:224
    Content type: Research article Published on:

  40. Fatigue is a common symptom of systemic autoimmune rheumatic disease (SARD). Patients with SARD have a protracted pre-clinical phase during which progressive immunologic derangements occur culminating in disea...

    Authors: Waleed Hafiz, Rawad Nori, Ariana Bregasi, Babak Noamani, Dennisse Bonilla, Larissa Lisnevskaia, Earl Silverman, Arthur A. M. Bookman, Sindhu R. Johnson, Carolina Landolt-Marticorena and Joan Wither
    Citation: Arthritis Research & Therapy 2019 21:223
    Content type: Research article Published on:

  42. The aim of this study was to explore the impact of sex and disease classification on outcomes in axial spondyloarthritis (axSpA) patients, including both radiographic (r-) axSpA and non-radiographic (nr-) axSp...

    Authors: Rikke A. Andreasen, Lars E. Kristensen, Kenneth Egstrup, Xenofon Baraliakos, Vibeke Strand, Hans Christian Horn, Inger M. J. Hansen, Robin Christensen and Torkell Ellingsen
    Citation: Arthritis Research & Therapy 2019 21:221
    Content type: Research article Published on:

  43. CD38+ NK cells are overabundant in rheumatoid arthritis (RA). Cyanidin-3-O-glucoside (C3G) is an inhibitor of CD38. This study investigated the pathogenic role of CD38+ NK cells and the effect of C3G on RA.

    Authors: Hongxing Wang, Shutong Li, Guoqing Zhang, Hui Wu and Xiaotian Chang
    Citation: Arthritis Research & Therapy 2019 21:220
    Content type: Research article Published on:

  46. The objective of this randomized, placebo-controlled, double-blind, parallel group, trial was to assess the effect of ambrisentan on mean pulmonary arterial pressure (mPAP) in patients with systemic sclerosis ...

    Authors: Zixuan Pan, Alberto M. Marra, Nicola Benjamin, Christina A. Eichstaedt, Norbert Blank, Eduardo Bossone, Antonio Cittadini, Gerry Coghlan, Christopher P. Denton, Oliver Distler, Benjamin Egenlauf, Christine Fischer, Satenik Harutyunova, Panagiota Xanthouli, Hanns-Martin Lorenz and Ekkehard Grünig
    Citation: Arthritis Research & Therapy 2019 21:217
    Content type: Research article Published on:

  47. The goal of this study is to use comprehensive molecular profiling to characterize clinical response to anti-TNF therapy in a real-world setting and identify reproducible markers differentiating good responder...

    Authors: Victor Farutin, Thomas Prod’homme, Kevin McConnell, Nathaniel Washburn, Patrick Halvey, Carol J. Etzel, Jamey Guess, Jay Duffner, Kristen Getchell, Robin Meccariello, Bryan Gutierrez, Christopher Honan, Ganlin Zhao, Nicholas A. Cilfone, Nur Sibel Gunay, Jan L. Hillson…
    Citation: Arthritis Research & Therapy 2019 21:216
    Content type: Research article Published on:

  48. Patients with ankylosing spondylitis (AS) have a higher prevalence of depression compared to the general population. Comorbid depression in AS likely has a multifactorial origin. While several disease-related ...

    Authors: Casper Webers, Laura Vanhoof, Carsten Leue, Annelies Boonen and Sebastian Köhler
    Citation: Arthritis Research & Therapy 2019 21:215
    Content type: Research article Published on:

  49. The objective of this study was to evaluate early changes in magnetic resonance imaging (MRI) and clinical disease activity measures as predictors of later structural progression in early rheumatoid arthritis ...

    Authors: Philip G. Conaghan, Mikkel Østergaard, Orrin Troum, Michael A. Bowes, Gwenael Guillard, Bethanie Wilkinson, Zhiyong Xie, John Andrews, Amy Stein, Douglass Chapman and Andrew Koenig
    Citation: Arthritis Research & Therapy 2019 21:214
    Content type: Research article Published on:

  50. Intervertebral disc degeneration (IVDD)-related disorders are the major causes of low back pain. A previous study suggested that Notch activation serves as a protective mechanism and is a part of the compensat...

    Authors: Jun Long, Xiaobo Wang, Xianfa Du, Hehai Pan, Jianru Wang, Zemin Li, Hui Liu, Xudong Li and Zhaomin Zheng
    Citation: Arthritis Research & Therapy 2019 21:213
    Content type: Research article Published on:
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Arthritis Research & Therapy

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