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  1. Rheumatoid arthritis (RA) treat-to-target (T2T) regimens often use the disease activity score (28 joints) incorporating C-reactive protein (DAS28CRP) as an outcome measure. We compared changes in the DAS28CRP wit...

    Authors: Fiona M. McQueen, Peter Chapman, Terina Pollock, Dena D’Souza, Arier C. Lee, Nicola Dalbeth, Lisa Stamp, Karen Lindsay and Anthony Doyle
    Citation: Arthritis Research & Therapy 2017 19:241
  2. Individualising biologic disease-modifying anti-rheumatic drugs (bDMARDs) to maximise outcomes and deliver safe and cost-effective care is a key goal in the management of rheumatoid arthritis (RA). Investigati...

    Authors: Vasco C. Romão, Edward M. Vital, João Eurico Fonseca and Maya H. Buch
    Citation: Arthritis Research & Therapy 2017 19:239
  3. Studies have suggested that soluble factors in plasma from patients with active (aBD) and inactive (iBD) Behçet’s disease (BD) stimulate neutrophil function. Soluble CD40 ligand (sCD40L) is an important mediat...

    Authors: Sandro Félix Perazzio, Paulo Vitor Soeiro-Pereira, Viviane Cardoso dos Santos, Marlon Vilela de Brito, Bruno Salu, Maria Luiza Vilela Oliva, Anne Margherite Stevens, Alexandre Wagner Silva de Souza, Hans D. Ochs, Troy R. Torgerson, Antonio Condino-Neto and Luis Eduardo Coelho Andrade
    Citation: Arthritis Research & Therapy 2017 19:235
  4. Interferon-α (IFN-α) is increased and plays an important role in the pathogenesis of systemic lupus erythematosus (SLE). Plasmacytoid dendritic cells (pDCs) are the main producer of IFN-α, but their IFN-α prod...

    Authors: Goh Murayama, Nanako Furusawa, Asako Chiba, Ken Yamaji, Naoto Tamura and Sachiko Miyake
    Citation: Arthritis Research & Therapy 2017 19:234
  5. Valid detection of arthritis is essential in differential diagnosis of joint pain. Indocyanin green (ICG)-enhanced fluorescence optical imaging (FOI) is a new imaging method that visualizes inflammation in wri...

    Authors: Marisa Christin Beck, Anne-Marie Glimm, Sarah Ohrndorf, Kirsten Minden, Ralf Trauzeddel, Stephanie Gabriele Werner, Gerd Horneff, Marina Backhaus, Gerd Rüdiger Burmester, Tilmann Kallinich, Hermann Girschick and Jens Klotsche
    Citation: Arthritis Research & Therapy 2017 19:233
  6. Inflammatory arthritis (IA), including rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA), leads to increased cardiovascular disease occurrence probably due to atherosclerosis...

    Authors: Gia Deyab, Ingrid Hokstad, Jon Elling Whist, Milada Cvancarova Smastuen, Stefan Agewall, Torstein Lyberg, Nicoletta Ronda, Knut Mikkelsen, Gunnbjorg Hjeltnes and Ivana Hollan
    Citation: Arthritis Research & Therapy 2017 19:232
  7. Interleukin-6 (IL-6) transduces signals via phosphorylation of STAT3 (pSTAT3). Tocilizumab (TCZ) is an IL-6 receptor blocker, which, when administered intravenously every 4 weeks, efficiently ameliorates rheum...

    Authors: Shuntaro Saito, Katsuya Suzuki, Keiko Yoshimoto, Yuko Kaneko, Yoshihiro Matsumoto, Kunihiro Yamaoka and Tsutomu Takeuchi
    Citation: Arthritis Research & Therapy 2017 19:231
  8. The interaction of circulating microparticles (MPs) with immune cells in systemic lupus erythematosus (SLE) is sparsely investigated. We examined the ability of MPs from SLE patients to induce production of re...

    Authors: Line Kjær Winberg, Søren Jacobsen and Claus H. Nielsen
    Citation: Arthritis Research & Therapy 2017 19:230
  9. The precise mechanism linking systemic inflammation with insulin resistance (IR) in rheumatoid arthritis (RA) remains elusive. In the present study, we determined whether the incretin-insulin axis and incretin...

    Authors: Beatriz Tejera-Segura, Raquel López-Mejías, María Jesús Domínguez-Luis, Antonia M. de Vera-González, Alejandra González-Delgado, Begoña Ubilla, José M. Olmos, José L. Hernández, Miguel A. González-Gay and Iván Ferraz-Amaro
    Citation: Arthritis Research & Therapy 2017 19:229
  10. Gout is a risk factor for cardiovascular disease, but associations with specific cardiovascular outcomes, myocardial infarction (MI), and stroke are unclear. Our objective in the present study was to assess wh...

    Authors: Jasvinder A. Singh, Rekha Ramachandaran, Shaohua Yu, Shuo Yang, Fenglong Xie, Huifeng Yun, Jie Zhang and Jeffrey R. Curtis
    Citation: Arthritis Research & Therapy 2017 19:228
  11. Behçet’s disease (BD) susceptibility had been associated with single-nucleotide polymorphisms (SNPs) in IL23R–IL12RB2, IL10, STAT4, or ERAP1 locus in Japanese, Turkish, Chinese, and other populations, but not in ...

    Authors: Eun Ha Kang, Sewon Kim, Min Young Park, Ji Yong Choi, In Ah Choi, Min Jung Kim, You-Jung Ha, Eun Young Lee, Yun Jong Lee, Eun Bong Lee, Changwon Kang and Yeong Wook Song
    Citation: Arthritis Research & Therapy 2017 19:227
  12. With expanding therapeutic possibilities for treatment of psoriatic arthritis (PsA) it will be increasingly important to determine residual disease and define when to adjust treatment. The rationale behind tre...

    Authors: Leonieke J. J. van Mens, Marleen G. H. van de Sande, Inka A. Fluri, Sadaf Atiqi, Arno W. R. van Kuijk and Dominique L. P. Baeten
    Citation: Arthritis Research & Therapy 2017 19:226
  13. A hallmark of systemic lupus erythematosus is high titers of circulating autoantibodies. Recently, a novel CD11c+ B-cell subset has been identified that is critical for the development of autoimmunity. However, t...

    Authors: Ya Liu, Shiyu Zhou, Jie Qian, Yan Wang, Xiang Yu, Dai Dai, Min Dai, Lingling Wu, Zhuojun Liao, Zhixin Xue, Jiehua Wang, Goujun Hou, Jianyang Ma, John B. Harley, Yuanjia Tang and Nan Shen
    Citation: Arthritis Research & Therapy 2017 19:225
  14. Caspase-8 is a well-established initiator of apoptosis and suppressor of necroptosis, but maintains functions beyond cell death that involve suppression of receptor-interacting serine-threonine kinases (RIPKs)...

    Authors: Salina Dominguez, Anna B. Montgomery, G. Kenneth Haines III, Christina L. Bloomfield and Carla M. Cuda
    Citation: Arthritis Research & Therapy 2017 19:224
  15. Immunoglobulin G4-related disease (IgG4-RD) is a newly recognized systemic condition characterized by high serum immunoglobulin G4 (IgG4) concentration and IgG4-bearing plasma cell infiltration in affected org...

    Authors: Makiko Ozawa, Yasunari Fujinaga, Junpei Asano, Akira Nakamura, Takayuki Watanabe, Tetsuya Ito, Takashi Muraki, Hideaki Hamano and Shigeyuki Kawa
    Citation: Arthritis Research & Therapy 2017 19:223
  16. Although one study showed minimal progression of erosions in patients with rheumatoid arthritis (RA) one year after TNFα inhibition therapy, no studies have investigated very early bone changes after initiatio...

    Authors: Tomohiro Shimizu, Hyo Jin Choi, Ursula Heilmeier, Matthew Tanaka, Andrew J. Burghardt, Jingshan Gong, Nattagan Chanchek, Thomas M. Link, Jonathan Graf, John B. Imboden and Xiaojuan Li
    Citation: Arthritis Research & Therapy 2017 19:222
  17. Ultrasound (US) is a sensitive method for detecting joint/tendon inflammation in patients with rheumatoid arthritis (RA). Subclinical inflammation is often found in patients with RA in composite score remissio...

    Authors: Hilde Berner Hammer, Tore K. Kvien and Lene Terslev
    Citation: Arthritis Research & Therapy 2017 19:221
  18. It is recommended to optimise treatment as long as a predefined treatment target is not met, but should the aim be remission if patients are in low disease activity (LDA)? The aim of this study was to assess i...

    Authors: Sytske Anne Bergstra, Otto Olivas, Gülşah Akdemir, Naghmeh Riyazi, Gerard Collée, Johannes H. L. M. van Groenendael, Robert B. M. Landewé and Cornelia F. Allaart
    Citation: Arthritis Research & Therapy 2017 19:220
  19. Infection by common viruses has long been discussed in the aetiology of a number of autoimmune diseases, including rheumatoid arthritis (RA). However, studies investigating this hypothesis in RA show conflicti...

    Authors: Natalia Sherina, Hulda S. Hreggvidsdottir, Camilla Bengtsson, Monika Hansson, Lena Israelsson, Lars Alfredsson and Karin Lundberg
    Citation: Arthritis Research & Therapy 2017 19:219
  20. Targeted proteomics, which involves quantitative analysis of targeted proteins using selected reaction monitoring (SRM) mass spectrometry, has emerged as a new methodology for discovery of clinical biomarkers....

    Authors: Jun Ishizaki, Ayako Takemori, Koichiro Suemori, Takuya Matsumoto, Yoko Akita, Ken-ei Sada, Yukio Yuzawa, Koichi Amano, Yoshinari Takasaki, Masayoshi Harigai, Yoshihiro Arimura, Hirofumi Makino, Masaki Yasukawa, Nobuaki Takemori and Hitoshi Hasegawa
    Citation: Arthritis Research & Therapy 2017 19:218
  21. Monocytes are dominant cells present within the inflamed synovium during osteoarthritis (OA). In mice, two functionally distinct monocyte subsets are described: pro-inflammatory Ly6Chigh and patrolling Ly6Clow mo...

    Authors: Niels A. J. Cremers, Martijn H. J. van den Bosch, Stephanie van Dalen, Irene Di Ceglie, Giuliana Ascone, Fons van de Loo, Marije Koenders, Peter van der Kraan, Annet Sloetjes, Thomas Vogl, Johannes Roth, Edwin J. W. Geven, Arjen B. Blom and Peter L. E. M. van Lent
    Citation: Arthritis Research & Therapy 2017 19:217
  22. We aimed to explore whether country of residence or specific country characteristics are associated with work outcomes in rheumatoid arthritis (RA).

    Authors: Antje van der Zee-Neuen, Polina Putrik, Sofia Ramiro, Andras P. Keszei, Ihsane Hmamouchi, Maxime Dougados and Annelies Boonen
    Citation: Arthritis Research & Therapy 2017 19:216
  23. Comorbidities may contribute to disease activity and treatment response in rheumatoid arthritis (RA) patients. We defined a somatization comorbidity phenotype (SCP) and examined its influence on response to ce...

    Authors: Jeffrey R. Curtis, Christopher Herrem, ’Matladi N. Ndlovu, Cathy O’Brien and Yusuf Yazici
    Citation: Arthritis Research & Therapy 2017 19:215

    The Letter to this article has been published in Arthritis Research & Therapy 2019 21:65

  24. Stroke has been associated with rheumatoid arthritis (RA). We assessed patients with RA and healthy control subjects by transcranial Doppler (TCD), carotid ultrasonography and brain magnetic resonance imaging ...

    Authors: Csaba Oláh, Zsófia Kardos, Mariann Sepsi, Attila Sas, László Kostyál, Harjit Pal Bhattoa, Katalin Hodosi, György Kerekes, László Tamási, Attila Valikovics, Dániel Bereczki and Zoltán Szekanecz
    Citation: Arthritis Research & Therapy 2017 19:213
  25. Discordance between patients with rheumatoid arthritis (RA) and their rheumatology health care providers is a common and important problem. The objective of this study was to perform a comprehensive clinical e...

    Authors: Divya N. Challa, Zoran Kvrgic, Andrea L. Cheville, Cynthia S. Crowson, Tim Bongartz, Thomas G. Mason II, Eric L. Matteson, Clement J. Michet Jr, Scott T. Persellin, Daniel E. Schaffer, Theresa L. Wampler Muskardin, Kerry Wright and John M. Davis III
    Citation: Arthritis Research & Therapy 2017 19:212
  26. Systemic lupus erythematosus (SLE) is associated with B cell hyperactivity, and lupus nephritis (LN), in particular, is promoted by the production of autoantibodies and immune complex deposition. Bruton’s tyro...

    Authors: Yu-Yon Kim, Ki Tae Park, Sun Young Jang, Kyu Hang Lee, Joo-Yun Byun, Kwee Hyun Suh, Young-Mi Lee, Young Hoon Kim and Kwang Woo Hwang
    Citation: Arthritis Research & Therapy 2017 19:211
  27. A recent systematic review identified four candidate serum-soluble bone-turnover biomarkers (dickkopf-1, Dkk-1; macrophage-colony stimulating factor, M-CSF; matrix metalloproteinase-3, MMP-3; osteoprotegerin, ...

    Authors: Deepak R. Jadon, Raj Sengupta, Alison Nightingale, Hui Lu, Juliet Dunphy, Amelia Green, James T. Elder, Rajan P. Nair, Eleanor Korendowych, Mark A. Lindsay and Neil J. McHugh
    Citation: Arthritis Research & Therapy 2017 19:210
  28. Mechanical overloading can lead to disc degeneration. Nucleus pulposus (NP) cell senescence is aggravated within the degenerated disc. This study was designed to investigate the effects of high compression on ...

    Authors: Pei Li, Gang Hou, Ruijie Zhang, Yibo Gan, Yuan Xu, Lei Song and Qiang Zhou
    Citation: Arthritis Research & Therapy 2017 19:209
  29. This study evaluates patient-reported outcomes (PROs) in a double-blind, phase III study of baricitinib as monotherapy or combined with methotrexate (MTX) in patients with active rheumatoid arthritis (RA) with...

    Authors: Michael Schiff, Tsutomu Takeuchi, Roy Fleischmann, Carol L. Gaich, Amy M. DeLozier, Douglas Schlichting, Wen-Ling Kuo, Ji-Eon Won, Tara Carmack, Terence Rooney, Patrick Durez, Saeed Shaikh, Rodolfo Pardo Hidalgo, Ronald van Vollenhoven and Cristiano A. F. Zerbini
    Citation: Arthritis Research & Therapy 2017 19:208
  30. Endoplasmic reticulum (ER) stress has proinflammatory properties, and transgenic animal studies of rheumatoid arthritis (RA) indicate its relevance in the process of joint destruction. Because currently availa...

    Authors: Pawel A. Kabala, Chiara Angiolilli, Nataliya Yeremenko, Aleksander M. Grabiec, Barbara Giovannone, Desiree Pots, Timothy R. Radstake, Dominique Baeten and Kris A. Reedquist
    Citation: Arthritis Research & Therapy 2017 19:207
  31. Interstitial lung disease (ILD) is a major pulmonary manifestation of connective tissue disease (CTD), leading to significant morbidity and mortality. Chest high-resolution computed tomography (HRCT) is presen...

    Authors: YuKai Wang, Luna Gargani, Tatiana Barskova, Dan E. Furst and Marco Matucci Cerinic
    Citation: Arthritis Research & Therapy 2017 19:206
  32. Systemic sclerosis (SSc) is a pro-fibrotic condition with a poorly understood aetiology. Evidence presented by Artlett et al. in this issue suggests that the microRNA miR-155 is key, with its involvement depen...

    Authors: John Henderson and Steven O’Reilly
    Citation: Arthritis Research & Therapy 2017 19:205
  33. Gout is considered one of the most painful acute conditions caused by deposition of monosodium urate (MSU) crystals within joints. Recent studies have shown that interleukin (IL)-1β is a key inflammatory media...

    Authors: Weidong Zhou, Ying Wang, Rongfeng Wu, Yan He, Qun Su and Guixiu Shi
    Citation: Arthritis Research & Therapy 2017 19:203
  34. To decrease the burden of disease of rheumatoid arthritis (RA), patients at risk for RA need to be identified as early as possible, preferably when no clinically apparent synovitis can be detected. Up to now, ...

    Authors: Myrthe van der Ven, M. van der Veer-Meerkerk, D. F. Ten Cate, N. Rasappu, M. R. Kok, D. Csakvari, J. M. W. Hazes, A. H. Gerards and J. J. Luime
    Citation: Arthritis Research & Therapy 2017 19:202
  35. Medial meniscal extrusion (MME) is associated with progression of medial knee osteoarthritis (OA), but no or little information is available for relationships between MME and osteophytes, which are found in ca...

    Authors: Shinnosuke Hada, Muneaki Ishijima, Haruka Kaneko, Mayuko Kinoshita, Lizu Liu, Ryo Sadatsuki, Ippei Futami, Anwajan Yusup, Tomohiro Takamura, Hitoshi Arita, Jun Shiozawa, Takako Aoki, Yuji Takazawa, Hiroshi Ikeda, Shigeki Aoki, Hisashi Kurosawa…
    Citation: Arthritis Research & Therapy 2017 19:201
  36. Our objective was to examine the relationships between proximal tibial trabecular (epiphyseal and metaphyseal) bone mineral density (BMD) and osteoarthritis (OA)-related pain in patients with severe knee OA.

    Authors: Wadena D. Burnett, Saija A. Kontulainen, Christine E. McLennan, Diane Hazel, Carl Talmo, David R. Wilson, David J. Hunter and James D. Johnston
    Citation: Arthritis Research & Therapy 2017 19:200
  37. HLA-DRB1 alleles are major determinants of genetic predisposition to rheumatic diseases. We assessed whether DRB1 alleles are associated with susceptibility to particular clinical feat...

    Authors: Tomoyuki Asano, Hiroshi Furukawa, Shuzo Sato, Makiko Yashiro, Hiroko Kobayashi, Hiroshi Watanabe, Eiji Suzuki, Tomoyuki Ito, Yoshifumi Ubara, Daisuke Kobayashi, Nozomi Iwanaga, Yasumori Izumi, Keita Fujikawa, Satoshi Yamasaki, Tadashi Nakamura, Tomohiro Koga…
    Citation: Arthritis Research & Therapy 2017 19:199
  38. Ankylosing spondylitis (AS) is a male-predominant disease, and radiographic evidence of damage is also more severe in males. Estrogen modulates immune-related processes such as T cell differentiation and cytok...

    Authors: Hyemin Jeong, Eun-Kyung Bae, Hunnyun Kim, Yeong Hee Eun, In Young Kim, Hyungjin Kim, Jaejoon Lee, Chan Hong Jeon, Eun-Mi Koh and Hoon-Suk Cha
    Citation: Arthritis Research & Therapy 2017 19:198
  39. A previous study revealed the association between susceptibility to Takayasu arteritis (TAK) and a single nucleotide polymorphism (SNP) rs6871626 located in IL12B, which encodes interleukin (IL)-12p40, a common c...

    Authors: Toshiki Nakajima, Hajime Yoshifuji, Masakazu Shimizu, Koji Kitagori, Kosaku Murakami, Ran Nakashima, Yoshitaka Imura, Masao Tanaka, Koichiro Ohmura, Fumihiko Matsuda, Chikashi Terao and Tsuneyo Mimori
    Citation: Arthritis Research & Therapy 2017 19:197
  40. The Central European Congress of Rheumatology (CECR) has been organized by seven Central European countries: Austria, Croatia, Czech Republic, Hungary, Poland, Slovakia, and Slovenia. These countries have lots...

    Authors: Zoltán Szekanecz, Branimir Anic, Gábor Héjj, Iztok Holc, Aniella Hunka, Eugene Kucharz, Klaus Machold, Miroslav Mayer, Artur Pahor, Rudolf Puchner, Jozef Rovensky, Ladislav Senolt, Alena Tuchynova, Jiri Vencovsky and Josef S. Smolen
    Citation: Arthritis Research & Therapy 2017 19:196
  41. Periarticular osteopenia is an early sign of incipient joint injury in rheumatoid arthritis (RA), but cannot be accurately quantified using conventional radiography. Digital X-ray radiogrammetry (DXR) is a com...

    Authors: Michael Ziegelasch, Kristina Forslind, Thomas Skogh, Katrine Riklund, Alf Kastbom and Ewa Berglin
    Citation: Arthritis Research & Therapy 2017 19:195
  42. Although both rheumatoid factor (RF) and anticyclic citrullinated peptide antibodies (anti-CCP) are useful for diagnosing rheumatoid arthritis (RA), the impact of these autoantibodies on the efficacy of tumor ...

    Authors: Tsutomu Takeuchi, Nobuyuki Miyasaka, Takashi Inui, Toshiro Yano, Toru Yoshinari, Tohru Abe and Takao Koike
    Citation: Arthritis Research & Therapy 2017 19:194
  43. Lupus pathogenesis is closely associated with interferon gamma (IFN-γ), which plays a central role in innate and adaptive immunity. The aim of this study was to evaluate the ex vivo production of IFN-γ after s...

    Authors: Sung Soo Ahn, Eun Seong Park, Joo Sung Shim, Sang-Jun Ha, Beom Seok Kim, Seung Min Jung, Sang-Won Lee, Yong-Beom Park and Jason Jungsik Song
    Citation: Arthritis Research & Therapy 2017 19:193
  44. Sjögren's syndrome (SS) shares many clinical and pathological similarities with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). These autoimmune diseases mostly affect women. In this study, c...

    Authors: Nirav R. Shah, Braxton D. Noll, Craig B. Stevens, Michael T. Brennan, Farah B. Mougeot and Jean-Luc C. Mougeot
    Citation: Arthritis Research & Therapy 2017 19:192
  45. To assess frequency and distribution of infusion reactions (IRs) in responders and nonresponders in randomized clinical trials (RCTs) of intravenous pegloticase and the utility of the National Institute of All...

    Authors: Leonard H. Calabrese, Arthur Kavanaugh, Anthony E. Yeo and Peter E. Lipsky
    Citation: Arthritis Research & Therapy 2017 19:191
  46. Anti-carbamylated protein (anti-CarP) antibodies have recently been reported to occur in around 45% of rheumatoid arthritis (RA) patients and to have prognostic and diagnostic properties. At present, the bread...

    Authors: Myrthe A. M. van Delft, Marije K. Verheul, Leonie E. Burgers, Veerle F. A. M. Derksen, Annette H. M. van der Helm-van Mil, Diane van der Woude, Tom W. J. Huizinga, René E. M. Toes and Leendert A. Trouw
    Citation: Arthritis Research & Therapy 2017 19:190
  47. To examine the association between sonographic enthesitis and the severity of radiographic features of damage in the peripheral and axial joints in psoriatic arthritis (PsA).

    Authors: Ari Polachek, Richard Cook, Vinod Chandran, Dafna D. Gladman and Lihi Eder
    Citation: Arthritis Research & Therapy 2017 19:189

    The Correction to this article has been published in Arthritis Research & Therapy 2019 21:20

  48. Age is an important risk factor for rheumatoid arthritis (RA), which often develops in middle age. However, how age-associated changes in immunity impact RA is poorly understood. Gut microbiota are known to be...

    Authors: Fei Teng, Krysta M. Felix, C. Pierce Bradley, Debdut Naskar, Heqing Ma, Walid A. Raslan and Hsin-Jung Joyce Wu
    Citation: Arthritis Research & Therapy 2017 19:188
  49. Bortezomib (Bz) is a proteasome inhibitor that directly targets antibody-producing plasma cells. We recently reported the first randomized control trial that evaluated the effects of Bz in patients with system...

    Authors: Tomoko Ikeda, Hiroshi Fujii, Masato Nose, Yukiko Kamogawa, Tsuyoshi Shirai, Yuko Shirota, Tomonori Ishii and Hideo Harigae
    Citation: Arthritis Research & Therapy 2017 19:187

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