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  1. The aim was to examine if structural factors could affect response to intra-articular steroid injections (IASI) in knee osteoarthritis (OA).

    Authors: Nasimah Maricar, Matthew J. Parkes, Michael J. Callaghan, Charles E. Hutchinson, Andrew D. Gait, Richard Hodgson, David T. Felson and Terence W. O’Neill
    Citation: Arthritis Research & Therapy 2017 19:88
    Content type: Research article Published on:

  2. Early diagnosis of rheumatoid arthritis (RA) is crucial to providing effective therapy and often hampered by unspecific clinical manifestations. Elevated levels of extracellular circulating DNA (cirDNA) in pat...

    Authors: Elena Rykova, Aleksey Sizikov, Dirk Roggenbuck, Oksana Antonenko, Leonid Bryzgalov, Evgeniy Morozkin, Kseniya Skvortsova, Valentin Vlassov, Pavel Laktionov and Vladimir Kozlov
    Citation: Arthritis Research & Therapy 2017 19:85
    Content type: Research article Published on:

  3. Enthesitis-related arthritis (ERA) is a specific subtype of juvenile idiopathic arthritis (JIA) defined according to the International League of Associations for Rheumatology (ILAR) criteria. We aimed to chara...

    Authors: Sabrina Gmuca, Rui Xiao, Timothy G. Brandon, Ilaria Pagnini, Tracey B. Wright, Timothy Beukelman, Esi M. Morgan and Pamela F. Weiss
    Citation: Arthritis Research & Therapy 2017 19:84
    Content type: Research article Published on:

  4. Previous studies have revealed that ankylosing spondylitis (AS), as the progenitor of axial spondyloarthritis (AxSpA), has been characterized by the insidiously progressive nature of sacroiliitis and spondylit...

    Authors: Junqing Zhu, Aiwu Li, Ertao Jia, Yi Zhou, Juan Xu, Shixian Chen, Yinger Huang, Xiang Xiao and Juan Li
    Citation: Arthritis Research & Therapy 2017 19:83
    Content type: Research article Published on:

    The Letter to this article has been published in Arthritis Research & Therapy 2018 20:28

  6. We examined models to predict disease activity transitions from moderate to low or severe and associated factors in patients with rheumatoid arthritis (RA).

    Authors: George W. Reed, David H. Collier, Andrew S. Koenig, Katherine C. Saunders, Dimitrios A. Pappas, Heather J. Litman, Joel M. Kremer and Sameer Kotak
    Citation: Arthritis Research & Therapy 2017 19:81
    Content type: Research article Published on:

  7. Undifferentiated arthritis (UA) is a label applied to patients with joint complaints which cannot be classified according to current criteria, which implies a need for precision diagnostic technologies. We stu...

    Authors: Saida Farah Issa, Anne Duer, Mikkel Østergaard, Kim Hørslev-Petersen, Merete L. Hetland, Michael Sejer Hansen, Kirsten Junker, Hanne M. Lindegaard, Jakob M. Møller and Peter Junker
    Citation: Arthritis Research & Therapy 2017 19:80
    Content type: Research article Published on:

  8. Calgizzarin (S100A11) is a member of the S100 protein family that acts in different tumors by regulating a number of biologic functions. Recent data suggest its association with low-grade inflammation in osteo...

    Authors: Lucie Andrés Cerezo, Barbora Šumová, Klára Prajzlerová, David Veigl, Dres Damgaard, Claus Henrik Nielsen, Karel Pavelka, Jiří Vencovský and Ladislav Šenolt
    Citation: Arthritis Research & Therapy 2017 19:79
    Content type: Research article Published on:

  9. Current guidelines suggest reduction of DMARDs can be considered in RA patients in remission. Objectives were (1) to estimate the relative importance of patient characteristics rheumatologists consider in thei...

    Authors: T. Martijn Kuijper, Riëtte Folmer, Elly A. Stolk, Johanna M. W. Hazes and Jolanda J. Luime
    Citation: Arthritis Research & Therapy 2017 19:78
    Content type: Research article Published on:

  10. To aim was to investigate the additional value of incorporating the de Vlam cervical facet joint score in the modified ankylosing spondylitis (AS) spine score (mSASSS) for the evaluation of spinal radiographic...

    Authors: Fiona Maas, Suzanne Arends, Elisabeth Brouwer, Hendrika Bootsma, Reinhard Bos, Freke R. Wink and Anneke Spoorenberg
    Citation: Arthritis Research & Therapy 2017 19:77
    Content type: Research article Published on:

  11. The recent findings of cancer-specific metabolic changes, including increased glucose and glutamine consumption, have provided new therapeutic targets for consideration. Fibroblast-like synoviocytes (FLS) from...

    Authors: Soshi Takahashi, Jun Saegusa, Sho Sendo, Takaichi Okano, Kengo Akashi, Yasuhiro Irino and Akio Morinobu
    Citation: Arthritis Research & Therapy 2017 19:76
    Content type: Research article Published on:

  12. We found recently that baseline signal transducer and activator of transcription 3 phosphorylation in peripheral blood CD4+ T cells of patients with early rheumatoid arthritis (RA) is associated with treatment re...

    Authors: Krista Kuuliala, Antti Kuuliala, Riitta Koivuniemi, Hannu Kautiainen, Heikki Repo and Marjatta Leirisalo-Repo
    Citation: Arthritis Research & Therapy 2017 19:75
    Content type: Research article Published on:

  13. The efficacy and safety of direct-acting antiviral agents (DAAs) were evaluated in a cohort of prospectively enrolled patients with hepatitis C virus (HCV)-related mixed cryoglobulinaemia (MC), an immune compl...

    Authors: Gianfranco Lauletta, Sabino Russi, Fabio Pavone, Angelo Vacca and Franco Dammacco
    Citation: Arthritis Research & Therapy 2017 19:74
    Content type: Research article Published on:

  14. In patients with tender and swollen finger joints, the differential diagnosis between rheumatoid arthritis (RA) and osteoarthritis (OA) of the hands can be initially difficult. This prospective study (the TryC...

    Authors: Uta Kiltz, Christine von Zabern, Xenofon Baraliakos, Frank Heldmann, Bernd Mintrop, Michael Sarholz, Dietmar Krause, Friedrich Dybowski, Ludwig Kalthoff and Jürgen Braun
    Citation: Arthritis Research & Therapy 2017 19:73
    Content type: Research article Published on:

  15. Patients with psoriatic arthritis (PsA) experience functional impairment and reduced quality of life, and thus patient global assessment in PsA is explained mainly by the physical, but also by the psychologica...

    Authors: Rubén Queiro, Juan D. Cañete, Carlos Montilla, Miguel Abad, María Montoro, Susana Gómez and Ana Cábez
    Citation: Arthritis Research & Therapy 2017 19:72
    Content type: Research article Published on:

  16. Multiple factors, including interactions between genetic and environmental risks, are important in susceptibility to rheumatoid arthritis (RA). However, the underlying mechanism is not fully understood. This s...

    Authors: Weida Meng, Zaihua Zhu, Xia Jiang, Chun Lai Too, Steffen Uebe, Maja Jagodic, Ingrid Kockum, Shahnaz Murad, Luigi Ferrucci, Lars Alfredsson, Hejian Zou, Lars Klareskog, Andrew P. Feinberg, Tomas J. Ekström, Leonid Padyukov and Yun Liu
    Citation: Arthritis Research & Therapy 2017 19:71
    Content type: Research article Published on:

  17. Our aim is to study the existence of the TLR9/TGF-β1/PDGF-B pathway in healthy humans and patients with systemic lupus erythematosus (SLE), and to explore its possible involvement in the pathogenesis of lupus ...

    Authors: Yi Yuan, Mingyue Yang, Kuo Wang, Jing Sun, Lili Song, Xue Diao, Zhenyu Jiang, Genhong Cheng and Xiaosong Wang
    Citation: Arthritis Research & Therapy 2017 19:70
    Content type: Research article Published on:

  18. The effect of IL-1 blocking therapy on mucocutaneous manifestations of Behçet’s disease is incompletely understood.

    Authors: Peter C. Grayson, Yusuf Yazici, Melissa Merideth, H. Nida Sen, Michael Davis, Elaine Novakovich, Elizabeth Joyal, Raphaela Goldbach-Mansky and Cailin H. Sibley
    Citation: Arthritis Research & Therapy 2017 19:69
    Content type: Research article Published on:

  19. Prognostic factors are used for treatment decisions in rheumatoid arthritis (RA). High disease activity, the early presence of erosions, and autoantibody positivity are the most frequently used poor prognostic...

    Authors: Katinka Albrecht and Angela Zink
    Citation: Arthritis Research & Therapy 2017 19:68
    Content type: Review Published on:

  20. CD4+CD28− T cells exhibit autoreactive potential in autoimmune disorders, including rheumatoid arthritis (RA). It is not well known which costimulator functions as an alternative second signal in the activation o...

    Authors: Juean Jiang, Cuiping Liu, Mi Liu, Yu Shen, Xiaohan Hu, Qin Wang, Jian Wu, Min Wu, Qi Fang and Xueguang Zhang
    Citation: Arthritis Research & Therapy 2017 19:67
    Content type: Research article Published on:

  21. Physical function (PF) is a core patient-reported outcome domain in clinical trials in rheumatic diseases. Frequently used PF measures have ceiling effects, leading to large sample size requirements and low se...

    Authors: Gregor Liegl, Barbara Gandek, H. Felix Fischer, Jakob B. Bjorner, John E. Ware Jr., Matthias Rose, James F. Fries and Sandra Nolte
    Citation: Arthritis Research & Therapy 2017 19:66
    Content type: Research article Published on:

  22. HCMV phosphoprotein 65 (HCMVpp65) is a putative immunogen that acts as an accelerator, inducing autoantibody and exacerbating autoimmune response in susceptible animals. The immunity to pp65336-439 instigates aut...

    Authors: Ao HoHsieh, Chin Man Wang, Yeong-Jian Jan Wu, Albert Chen, Ming-I Chang and Ji-Yih Chen
    Citation: Arthritis Research & Therapy 2017 19:65
    Content type: Research article Published on:

  23. During pregnancy, patients with rheumatoid arthritis (RA) and axial spondyloarthritis (axSpA) can experience active disease, which might be influenced by adjustment of treatment around conception. The aim of t...

    Authors: Stephanie van den Brandt, Astrid Zbinden, Dominique Baeten, Peter M. Villiger, Monika Østensen and Frauke Förger
    Citation: Arthritis Research & Therapy 2017 19:64
    Content type: Research article Published on:

  25. Systemic lupus erythematosus (SLE) is associated with significant impairment of health-related quality of life (HR-QoL). Recently, meeting a definition of a lupus low disease activity state (LLDAS), analogous ...

    Authors: Vera Golder, Rangi Kandane-Rathnayake, Alberta Yik-Bun Hoi, Molla Huq, Worawit Louthrenoo, Yuan An, Zhan Guo Li, Shue Fen Luo, Sargunan Sockalingam, Chak Sing Lau, Mo Yin Mok, Aisha Lateef, Kate Franklyn, Susan Morton, Sandra Teresa V. Navarra, Leonid Zamora…
    Citation: Arthritis Research & Therapy 2017 19:62
    Content type: Research article Published on:

  26. The aim of the study was to detect by skin high-frequency ultrasound (US) possible subclinical skin involvement in patients affected by limited cutaneous systemic sclerosis (lcSSc), in those skin areas apparen...

    Authors: A. Sulli, B. Ruaro, V. Smith, S. Paolino, C. Pizzorni, G. Pesce and M. Cutolo
    Citation: Arthritis Research & Therapy 2017 19:61
    Content type: Research article Published on:

  27. The disruption of endothelial homeostasis is a major determinant in the pathogenesis of systemic sclerosis (SSc) and is reflected by soluble and cellular markers of activation, injury and repair. We aimed to p...

    Authors: Audrey Benyamine, Jérémy Magalon, Sylvie Cointe, Romaric Lacroix, Laurent Arnaud, Nathalie Bardin, Pascal Rossi, Yves Francès, Fanny Bernard-Guervilly, Gilles Kaplanski, Jean-Robert Harlé, Pierre-Jean Weiller, Philippe Berbis, David Braunstein, Elisabeth Jouve, Nathalie Lesavre…
    Citation: Arthritis Research & Therapy 2017 19:60
    Content type: Research article Published on:

  28. Twenty-five percent of the British population over the age of 50 years experiences knee pain. Knee pain can limit physical ability and cause distress and bears significant socioeconomic costs. The objectives o...

    Authors: G. S. Fernandes, A. Bhattacharya, D. F. McWilliams, S. L. Ingham, M. Doherty and W. Zhang
    Citation: Arthritis Research & Therapy 2017 19:59
    Content type: Research article Published on:

  29. Mucosal-associated invariant T (MAIT) cells are innate-like lymphocytes constituting a large proportion of peripheral blood T cells expressing αβ T-cell receptor in humans. In this study, we aimed to investiga...

    Authors: Asako Chiba, Naoto Tamura, Kazunori Yoshikiyo, Goh Murayama, Mie Kitagaichi, Ken Yamaji, Yoshinari Takasaki and Sachiko Miyake
    Citation: Arthritis Research & Therapy 2017 19:58
    Content type: Research article Published on:

  30. The transcriptomes of peripheral blood cells in children with juvenile idiopathic arthritis (JIA) have distinct transcriptional aberrations that suggest impairment of transcriptional regulation. To gain a bett...

    Authors: Lisha Zhu, Kaiyu Jiang, Karstin Webber, Laiping Wong, Tao Liu, Yanmin Chen and James N. Jarvis
    Citation: Arthritis Research & Therapy 2017 19:57
    Content type: Research article Published on:

  31. This study was conducted to evaluate the feasibility of long-term adalimumab (ADA) discontinuation after achievement of low disease activity (LDA) in Japanese patients with early rheumatoid arthritis (RA) and ...

    Authors: Yoshiya Tanaka, Hisashi Yamanaka, Naoki Ishiguro, Nobuyuki Miyasaka, Katsuyoshi Kawana, Junko Kimura, Naoki Agata and Tsutomu Takeuchi
    Citation: Arthritis Research & Therapy 2017 19:56
    Content type: Research article Published on:

  32. Magnetic resonance imaging (MRI) is increasingly used for research in hand osteoarthritis, but imaging the thin cartilage layers in the hand joints remains challenging. We therefore assessed the accuracy of MR...

    Authors: Michael S. Saltzherr, J. Henk Coert, Ruud W. Selles, Johan W. van Neck, Jean-Bart Jaquet, Gerjo J. V. M. van Osch, Edwin H. G. Oei, Jolanda J. Luime and Galied S. R. Muradin
    Citation: Arthritis Research & Therapy 2017 19:55
    Content type: Research article Published on:

  33. Systemic lupus erythematosus (SLE) is an autoimmune disease with few treatment options. Current therapies are not fully effective and show highly variable responses. In this regard, large efforts have focused ...

    Authors: Daniel Toro-Domínguez, Pedro Carmona-Sáez and Marta E. Alarcón-Riquelme
    Citation: Arthritis Research & Therapy 2017 19:54
    Content type: Research article Published on:

  34. Namilumab (AMG203) is an immunoglobulin G1 monoclonal antibody that binds with high affinity to the GM-CSF ligand. This was a phase 1b, randomized, double-blind study (PRIORA) to assess namilumab in active, mi...

    Authors: T. W. J. Huizinga, A. Batalov, R. Stoilov, E. Lloyd, T. Wagner, D. Saurigny, B. Souberbielle and E. Esfandiari
    Citation: Arthritis Research & Therapy 2017 19:53
    Content type: Research article Published on:

  35. Programmed cell death protein 1 (PD-1) plays an important role in immune response regulation as a co-inhibitory signal during T cell activation. However, there is little known about the serum autoantibody prof...

    Authors: Hui Shi, Junna Ye, Jialin Teng, Yufeng Yin, Qiongyi Hu, Xinyao Wu, Honglei Liu, Xiaobing Cheng, Yutong Su, Mengru Liu, Juanfang Gu, Ting Lu, HaoJie Chen, Hui Zheng, Yue Sun and Chengde Yang
    Citation: Arthritis Research & Therapy 2017 19:52
    Content type: Research article Published on:

  37. Smoking is reported to affect the risk of a number of chronic disorders, including rheumatic diseases. Previous cross-sectional studies have shown a lower frequency of smoking in patients with primary Sjögren’...

    Authors: Peter Olsson, Carl Turesson, Thomas Mandl, Lennart Jacobsson and Elke Theander
    Citation: Arthritis Research & Therapy 2017 19:50
    Content type: Research article Published on:

  38. Africa faces many health challenges despite sustained growth and development over the past decade. Contributory factors are the lack of financial resources, an inadequate health professional workforce, a high ...

    Authors: Girish M. Mody
    Citation: Arthritis Research & Therapy 2017 19:49
    Content type: Commentary Published on:

  39. Social media may complement traditional data sources to answer comparative effectiveness/safety questions after medication licensure.

    Authors: Jeffrey R. Curtis, Lang Chen, Phillip Higginbotham, W. Benjamin Nowell, Ronit Gal-Levy, James Willig, Monika Safford, Joseph Coe, Kaitlin O’Hara and Roee Sa’adon
    Citation: Arthritis Research & Therapy 2017 19:48
    Content type: Research article Published on:

  40. The inhibition of pyrimidine biosynthesis by blocking the dihydroorotate dehydrogenase (DHODH) activity, the prime target of leflunomide (LEF), has been proven to be an effective strategy for rheumatoid arthri...

    Authors: Raphael S. Peres, Gabriela B. Santos, Nerry T. Cecilio, Valquíria A. P. Jabor, Michael Niehues, Bruna G. S. Torres, Gabriela Buqui, Carlos H. T. P. Silva, Teresa Dalla Costa, Norberto P. Lopes, Maria C. Nonato, Fernando S. Ramalho, Paulo Louzada-Júnior, Thiago M. Cunha, Fernando Q. Cunha, Flavio S. Emery…
    Citation: Arthritis Research & Therapy 2017 19:47
    Content type: Research article Published on:

  41. Specific HLA class II alleles are associated with systemic sclerosis (SSc) risk, clinical characteristics, and autoantibodies. HLA nomenclature initially developed with antibodies as typing reagents defining D...

    Authors: Coline A. Gentil, Hilary S. Gammill, Christine T. Luu, Maureen D. Mayes, Dan E. Furst and J. Lee Nelson
    Citation: Arthritis Research & Therapy 2017 19:46
    Content type: Research article Published on:

  42. Hyperimmune caprine serum (HICS) is a novel biological therapy with potential benefit for skin in established diffuse cutaneous systemic sclerosis. Here we report multiplex protein analysis of blood samples fr...

    Authors: Niamh Quillinan, Kristina E. N. Clark, Bryan Youl, Jeffrey Vernes, Deirdre McIntosh, Syed Haq and Christopher P. Denton
    Citation: Arthritis Research & Therapy 2017 19:45
    Content type: Research article Published on:

  43. The causes and mechanisms of late-onset neutropenia (LON) following rituximab treatment in patients with rheumatic diseases are not known. In this study, we aimed to investigate the role of established Fcγ rec...

    Authors: Sofia Ajeganova, Daniel Tesfa, Hans Hägglund, Bengt Fadeel, Inger Vedin, Anna Linda Zignego and Jan Palmblad
    Citation: Arthritis Research & Therapy 2017 19:44
    Content type: Research article Published on:

  44. Tophi contribute to musculoskeletal disability, joint damage and poor health-related quality of life in people with gout. The aim of this study was to examine the role of SLC2A9 and ABCG2 variants in tophaceous d...

    Authors: Wendy He, Amanda Phipps-Green, Lisa K. Stamp, Tony R. Merriman and Nicola Dalbeth
    Citation: Arthritis Research & Therapy 2017 19:43
    Content type: Research article Published on:

  45. Pulmonary arterial hypertension (PAH) is the leading cause of death in systemic sclerosis (SSc). Annual screening with echocardiogram (ECHO) is recommended. We present the methodological aspects of a PAH scree...

    Authors: Kathleen Morrisroe, Wendy Stevens, Joanne Sahhar, Candice Rabusa, Mandana Nikpour and Susanna Proudman
    Citation: Arthritis Research & Therapy 2017 19:42
    Content type: Research article Published on:

  46. Elevated levels of type I interferons (IFNs) are a characteristic feature of the systemic autoimmune rheumatic diseases (SARDs) and are thought to play an important pathogenic role. However, it is unknown whet...

    Authors: Joan Wither, Sindhu R. Johnson, Tony Liu, Babak Noamani, Dennisse Bonilla, Larissa Lisnevskaia, Earl Silverman, Arthur Bookman and Carolina Landolt-Marticorena
    Citation: Arthritis Research & Therapy 2017 19:41
    Content type: Research article Published on:

  47. Rheumatoid arthritis synovial fibroblasts (RASFs) are known to travel via the bloodstream from sites of cartilage destruction to new locations where they reinitiate the destructive processes at distant articul...

    Authors: Jan Hillen, Christiane Geyer, Marianne Heitzmann, Denise Beckmann, Annika Krause, Ina Winkler, Hermann Pavenstädt, Christoph Bremer, Thomas Pap and Adelheid Korb-Pap
    Citation: Arthritis Research & Therapy 2017 19:40
    Content type: Research article Published on:

  48. Monocytes/macrophages are activated in several autoimmune diseases, including systemic sclerosis (scleroderma; SSc), with increased expression of interferon (IFN)-regulatory genes and inflammatory cytokines, s...

    Authors: Antonella Farina, Giovanna Peruzzi, Valentina Lacconi, Stefania Lenna, Silvia Quarta, Edoardo Rosato, Anna Rita Vestri, Michael York, David H. Dreyfus, Alberto Faggioni, Stefania Morrone, Maria Trojanowska and G. Alessandra Farina
    Citation: Arthritis Research & Therapy 2017 19:39
    Content type: Research article Published on:

  49. Joint pain, including back pain, and arthritis are common conditions in the United States, affecting more than 100 million individuals and costing upwards of $200 billion each year. Although activity limitatio...

    Authors: Edith M. Williams, Rebekah J. Walker, Trevor Faith and Leonard E. Egede
    Citation: Arthritis Research & Therapy 2017 19:38
    Content type: Research article Published on:

  50. The aim of this study was to understand whether acupuncture can decrease the risk of coronary heart disease (CHD) in patients with fibromyalgia.

    Authors: Mei-Yao Wu, Ming-Cheng Huang, Jen-Huai Chiang, Mao-Feng Sun, Yu-Chen Lee and Hung-Rong Yen
    Citation: Arthritis Research & Therapy 2017 19:37
    Content type: Research article Published on:
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Arthritis Research & Therapy

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