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  1. The accumulation of advanced glycation endproducts in articular cartilage has been suggested as an etiologic factor in the development and progression of knee osteoarthritis (KOA).

    Authors: Charles B. Eaton, Maria Sayeed, Syeda Ameernaz, Mary B. Roberts, John D. Maynard, Jeffrey B. Driban and Timothy E. McAlindon
    Citation: Arthritis Research & Therapy 2017 19:36
    Content type: Research article Published on:

  2. It has been hypothesized that chronic inflammatory diseases such as rheumatoid arthritis (RA) may be caused by a failure of negative feedback mechanisms. This study sought to examine negative feedback mechanis...

    Authors: Thomas Crowley, John D. O’Neil, Holly Adams, Andrew M. Thomas, Andrew Filer, Christopher D. Buckley and Andrew R. Clark
    Citation: Arthritis Research & Therapy 2017 19:35
    Content type: Research article Published on:

  3. Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) result in severe joint destruction and functional disability if left untreated. We aim to develop tools that help patients with RA and PsA to understand ...

    Authors: Arnd Kleyer, Laura Beyer, Christoph Simon, Fabian Stemmler, Matthias Englbrecht, Christian Beyer, Jürgen Rech, Bernhard Manger, Gerhard Krönke, Georg Schett and Axel J. Hueber
    Citation: Arthritis Research & Therapy 2017 19:34
    Content type: Research article Published on:

  4. The aim was to describe the regulatory B and T cells (Breg and Treg) and T helper 17 (Th17) lymphocytes before and under treatment with biologic drugs, and to assess their potential predictive value as biomark...

    Authors: Sarah Salomon, Caroline Guignant, Pierre Morel, Gauthier Flahaut, Clément Brault, Clément Gourguechon, Patrice Fardellone, Jean-Pierre Marolleau, Brigitte Gubler and Vincent Goëb
    Citation: Arthritis Research & Therapy 2017 19:33
    Content type: Research article Published on:

  5. Symmetric (SDMA) and asymmetric (ADMA) dimethylarginines have emerged as novel biomarkers of cardiovascular disease (CVD) in several disease settings associated with atherosclerosis. Rheumatoid arthritis (RA) ...

    Authors: Theodoros Dimitroulas, James Hodson, Aamer Sandoo, Jacqueline Smith and George D. Kitas
    Citation: Arthritis Research & Therapy 2017 19:32
    Content type: Research article Published on:

  6. Electrocardiogram (ECG) cardiovascular disease (CVD) abnormalities (ECG-CVD) are predictive of subsequent CVD events in the general population. Systemic lupus erythematosus (SLE) patients are vulnerable to CVD...

    Authors: Hanan Al Rayes, Paula J. Harvey, Dafna D. Gladman, Jiandong Su, Arthy Sabapathy, Murray B. Urowitz and Zahi Touma
    Citation: Arthritis Research & Therapy 2017 19:31
    Content type: Research article Published on:

  7. Ultrasound is increasingly used to evaluate shoulder pain, but the benefits of this are unclear. In this study, we examined whether ultrasound-defined pathologies have implications for clinical outcomes.

    Authors: Gui Tran, Elizabeth M. A. Hensor, Aaron Ray, Sarah R. Kingsbury, Philip O’Connor and Philip G. Conaghan
    Citation: Arthritis Research & Therapy 2017 19:30
    Content type: Research article Published on:

  8. The importance of diseases to mankind is very similar worldwide. However, social and environmental issues, not to mention political and individual aspects, affect the prevalence and management of diseases and ...

    Authors: Francisco Airton Castro Rocha
    Citation: Arthritis Research & Therapy 2017 19:29
    Content type: Commentary Published on:

  9. Three different subsets of circulating human monocytes, CD14brightCD16- (classical), CD14brightCD16+ (intermediate), and CD14dimCD16+ (non-classical) have been recently identified. It has been reported that CD14b...

    Authors: Masako Tsukamoto, Noriyuki Seta, Keiko Yoshimoto, Katsuya Suzuki, Kunihiro Yamaoka and Tsutomu Takeuchi
    Citation: Arthritis Research & Therapy 2017 19:28
    Content type: Research article Published on:

  10. Systemic sclerosis (SSc) is characterized by endothelial cell (EC) apoptosis, impaired angiogenesis and peripheral microvasculopathy. Soluble α-Klotho (sKl) is a pleiotropic molecule with multiple effects on E...

    Authors: Celestina Mazzotta, Mirko Manetti, Irene Rosa, Eloisa Romano, Jelena Blagojevic, Silvia Bellando-Randone, Cosimo Bruni, Gemma Lepri, Serena Guiducci, Lidia Ibba-Manneschi and Marco Matucci-Cerinic
    Citation: Arthritis Research & Therapy 2017 19:27
    Content type: Research article Published on:

  11. Determining the association between body composition and low back pain (LBP) will improve our understanding of the mechanisms by which obesity affects LBP, and inform novel approaches to managing LBP. The aim ...

    Authors: Sultana Monira Hussain, Donna M. Urquhart, Yuanyuan Wang, Jonathan E. Shaw, Dianna J. Magliano, Anita E. Wluka and Flavia M. Cicuttini
    Citation: Arthritis Research & Therapy 2017 19:26
    Content type: Research article Published on:

  12. Immunoglobulin G4 (IgG4)-related disease (IgG4-RD) is a multisystem fibroinflammatory disease. We previously reported that a circulating cell population expressing CD19+CD24−CD38hi was increased in patients with ...

    Authors: Wei Lin, Panpan Zhang, Hua Chen, Yu Chen, Hongxian Yang, Wenjie Zheng, Xuan Zhang, Fengxiao Zhang, Wen Zhang and Peter E. Lipsky
    Citation: Arthritis Research & Therapy 2017 19:25
    Content type: Research article Published on:

  14. Osteoarthritis (OA) is a chronic debilitating joint disorder of particularly high prevalence in the elderly population. Intra-articular basic calcium phosphate (BCP) crystals are present in the majority of OA ...

    Authors: Emma M. Corr, Clare C. Cunningham, Laura Helbert, Geraldine M. McCarthy and Aisling Dunne
    Citation: Arthritis Research & Therapy 2017 19:23
    Content type: Research article Published on:

  15. Systemic sclerosis (SSc) is a connective tissues disease of unknown origin characterized by vascular damage and extensive fibrosis. Recently, we demonstrated that α2-antiplasmin (α2AP) is associated with the d...

    Authors: Yosuke Kanno, En Shu, Hiroyuki Kanoh, Ayaka Matsuda and Mariko Seishima
    Citation: Arthritis Research & Therapy 2017 19:22
    Content type: Research article Published on:

  16. Patients with ankylosing spondylitis (AS) are at increased risk of developing inflammatory bowel disease (IBD). We aimed to determine the variation in fecal calprotectin in AS over 5 years in relation to disea...

    Authors: Eva Klingberg, Hans Strid, Arne Ståhl, Anna Deminger, Hans Carlsten, Lena Öhman and Helena Forsblad-d’Elia
    Citation: Arthritis Research & Therapy 2017 19:21
    Content type: Research article Published on:

  17. We have recently analyzed the profile of T-cell subtypes based on chemokine receptor expression in blood from untreated early rheumatoid arthritis (ueRA) patients compared to healthy controls (HC). Here, we co...

    Authors: Jayesh M. Pandya, Anna-Carin Lundell, Kerstin Andersson, Inger Nordström, Elke Theander and Anna Rudin
    Citation: Arthritis Research & Therapy 2017 19:20
    Content type: Research article Published on:

  18. Here we integrate verified signals from previous genetic association studies with gene expression and pathway analysis for discovery of new candidate genes and signaling networks, relevant for rheumatoid arthr...

    Authors: Klementy Shchetynsky, Lina-Marcella Diaz-Gallo, Lasse Folkersen, Aase Haj Hensvold, Anca Irinel Catrina, Louise Berg, Lars Klareskog and Leonid Padyukov
    Citation: Arthritis Research & Therapy 2017 19:19
    Content type: Research article Published on:

  20. Magnetic resonance imaging (MRI) of thigh muscles is increasingly used to assess disease activity and damage extent in chronic myositis, but the validity of the findings is not clear. Here, the primary aim was...

    Authors: Helena Andersson, Eva Kirkhus, Torhild Garen, Ragnhild Walle-Hansen, Else Merckoll and Øyvind Molberg
    Citation: Arthritis Research & Therapy 2017 19:17
    Content type: Research article Published on:

  21. Growing evidence supports a key role for inflammation in the onset and progression of tendinopathy. However, the effect of the inflammatory infiltrate on tendon cells is poorly understood.

    Authors: Stephanie G. Dakin, Christopher D. Buckley, Mohammad Hussein Al-Mossawi, Robert Hedley, Fernando O. Martinez, Kim Wheway, Bridget Watkins and Andrew J. Carr
    Citation: Arthritis Research & Therapy 2017 19:16
    Content type: Research article Published on:

  22. Pneumococcal pneumonia is the most frequent form of pneumonia. We herein assessed the effectiveness of the 23-valent pneumococcal polysaccharide vaccine (PPSV23) in the prevention of pneumonia overall in rheum...

    Authors: Yasumori Izumi, Manabu Akazawa, Yukihiro Akeda, Shigeto Tohma, Fuminori Hirano, Haruko Ideguchi, Ryutaro Matsumura, Tomoya Miyamura, Shunsuke Mori, Takahiro Fukui, Nozomi Iwanaga, Yuka Jiuchi, Hideko Kozuru, Hiroshi Tsutani, Kouichirou Saisyo, Takao Sugiyama…
    Citation: Arthritis Research & Therapy 2017 19:15
    Content type: Research article Published on:

  23. There is a long-lasting need for non-invasive, more accurate diagnostic techniques when evaluating primary Sjögren’s syndrome (pSS) patients. Incorporation of additional diagnostics involving screening for dis...

    Authors: Lara A. Aqrawi, Hilde Kanli Galtung, Beate Vestad, Reidun Øvstebø, Bernd Thiede, Shermin Rusthen, Alix Young, Eduarda M. Guerreiro, Tor Paaske Utheim, Xiangjun Chen, Øygunn Aass Utheim, Øyvind Palm and Janicke Liaaen Jensen
    Citation: Arthritis Research & Therapy 2017 19:14
    Content type: Research article Published on:

  24. Canakinumab is a human anti-interleukin-1β (IL-1β) monoclonal antibody neutralizing IL-1β-mediated pathways. We sought to characterize the molecular response to canakinumab and evaluate potential markers of re...

    Authors: Arndt H. Brachat, Alexei A. Grom, Nico Wulffraat, Hermine I. Brunner, Pierre Quartier, Riva Brik, Liza McCann, Huri Ozdogan, Lidia Rutkowska-Sak, Rayfel Schneider, Valeria Gerloni, Liora Harel, Maria Terreri, Kristin Houghton, Rik Joos, Daniel Kingsbury…
    Citation: Arthritis Research & Therapy 2017 19:13
    Content type: Research article Published on:

  25. To identify molecular alterations in skeletal muscle in rheumatoid arthritis (RA) that may contribute to ongoing disability in RA.

    Authors: Kim M. Huffman, Ryan Jessee, Brian Andonian, Brittany N. Davis, Rachel Narowski, Janet L. Huebner, Virginia B. Kraus, Julie McCracken, Brian F. Gilmore, K. Noelle Tune, Milton Campbell, Timothy R. Koves, Deborah M. Muoio, Monica J. Hubal and William E. Kraus
    Citation: Arthritis Research & Therapy 2017 19:12
    Content type: Research article Published on:

  26. Authors: Jérémie Sellam, Elodie Rivière, Alice Courties, Paul-Olivier Rouzaire, Barbara Tolusso, Edward M. Vital, Paul Emery, Gianfranco Ferraccioli, Martin Soubrier, Bineta Ly, Houria Hendel Chavez, Yassine Taoufik, Maxime Dougados and Xavier Mariette
    Citation: Arthritis Research & Therapy 2017 19:11
    Content type: Erratum Published on:

    The original article was published in Arthritis Research & Therapy 2016 18:294

  28. Macrophage activation is involved in the pathogenesis of polymyositis (PM)/dermatomyositis (DM). CD163, a scavenger receptor expressed on the surface of activated macrophages, mediates anti-inflammatory functi...

    Authors: Yasunori Enomoto, Yuzo Suzuki, Hironao Hozumi, Kazutaka Mori, Masato Kono, Masato Karayama, Kazuki Furuhashi, Tomoyuki Fujisawa, Noriyuki Enomoto, Yutaro Nakamura, Naoki Inui, Daisuke Suzuki, Noriyoshi Ogawa, Ran Nakashima, Tsuneyo Mimori, Toshihide Iwashita…
    Citation: Arthritis Research & Therapy 2017 19:9
    Content type: Research article Published on:

  29. Systemic sclerosis (SSc) is a systemic autoimmune disease characterized by excessive production of extracellular matrix by fibroblasts on skin and internal organs. Although Th2 cells have been involved in fibr...

    Authors: Octavio Aravena, Ashley Ferrier, Madhvi Menon, Claudia Mauri, Juan Carlos Aguillón, Lilian Soto and Diego Catalán
    Citation: Arthritis Research & Therapy 2017 19:8
    Content type: Research article Published on:

  30. Sulfamethoxazole-trimethoprim (SMX/TMP) is a standard drug for the prophylaxis of Pneumocystis pneumonia (PJP) in immunosuppressed patients with systemic rheumatic diseases, but is sometimes discontinued due to a...

    Authors: Masako Utsunomiya, Hiroaki Dobashi, Toshio Odani, Kazuyoshi Saito, Naoto Yokogawa, Kenji Nagasaka, Kenchi Takenaka, Makoto Soejima, Takahiko Sugihara, Hiroyuki Hagiyama, Shinya Hirata, Kazuo Matsui, Yoshinori Nonomura, Masahiro Kondo, Fumihito Suzuki, Makoto Tomita…
    Citation: Arthritis Research & Therapy 2017 19:7
    Content type: Research article Published on:

  31. Gout is the most common inflammatory arthritic disease and is caused by crystal deposition secondary to persistent hyperuricemia. Etiological treatment with urate-lowering therapy (ULT) has been available sinc...

    Authors: Mats Dehlin, Emin Hoxha Ekström, Max Petzold, Ulf Strömberg, Gunilla Telg and Lennart T. H. Jacobsson
    Citation: Arthritis Research & Therapy 2017 19:6
    Content type: Research article Published on:

  32. Restoring normal physical functioning is a major therapeutic aim in the management of rheumatoid arthritis (RA). It is unknown, whether the extent of synovial inflammation quantified by musculoskeletal ultraso...

    Authors: Jakub Závada, Petra Hánová, Jana Hurňáková, Lenka Szczuková, Michal Uher, Šárka Forejtová, Martin Klein, Herman Mann, Marta Olejárová, Olga Růžičková, Olga Šléglová, Karel Hejduk and Karel Pavelka
    Citation: Arthritis Research & Therapy 2017 19:5
    Content type: Research article Published on:

  33. Lupus nephritis class III or IV is associated with a poor prognosis for both patient and renal survival. Recommendations for the management of lupus nephritis have recently been established, and changing thera...

    Authors: Hironari Hanaoka, Hidehiro Yamada, Tomofumi Kiyokawa, Harunobu Iida, Takeshi Suzuki, Yoshioki Yamasaki, Seido Ooka, Hiroko Nagafuchi, Takahiro Okazaki, Daisuke Ichikawa, Sayuri Shirai, Yugo Shibagaki, Junki Koike and Shoichi Ozaki
    Citation: Arthritis Research & Therapy 2017 19:4
    Content type: Research article Published on:

  34. Calprotectin (S100A8/A9 or MRP8/14) and S100A12 (leukocyte-derived proteins), interleukin 6 (IL-6) and vascular endothelial growth factor (VEGF) are markers of inflammation and angiogenesis. Ultrasound (US) is...

    Authors: Hilde Haugedal Nordal, Karl Albert Brokstad, Magne Solheim, Anne-Kristine Halse, Tore K. Kvien and Hilde Berner Hammer
    Citation: Arthritis Research & Therapy 2017 19:3
    Content type: Research article Published on:

  36. A change of loading conditions in the knee causes changes in the subchondral bone and may be a cause of osteoarthritis (OA). However, quantification of trabecular architecture in vivo is difficult due to the l...

    Authors: Torsten Lowitz, Oleg Museyko, Valérie Bousson, Christine Chappard, Liess Laouisset, Jean-Denis Laredo and Klaus Engelke
    Citation: Arthritis Research & Therapy 2017 19:1
    Content type: Research article Published on:

  37. To examine the structural and oxidative properties of lipoproteins from patients with systemic lupus erythematosus (SLE).

    Authors: Jin Kyun Park, Jae-Yong Kim, Jin Young Moon, Eun Young Ahn, Eun Young Lee, Eun Bong Lee, Kyung-Hyun Cho and Yeong Wook Song
    Citation: Arthritis Research & Therapy 2016 18:306
    Content type: Research article Published on:

  38. Increased circulatory levels of the chemokine CXCL4 have been associated with the presence of interstitial lung disease (ILD) in an observational study of patients with systemic sclerosis (SSc). The purpose of...

    Authors: Elizabeth R. Volkmann, Donald P. Tashkin, Michael D. Roth, Philip J. Clements, Dinesh Khanna, Daniel E. Furst, Maureen Mayes, Julio Charles, Chi-Hong Tseng, Robert M. Elashoff and Shervin Assassi
    Citation: Arthritis Research & Therapy 2016 18:305
    Content type: Research article Published on:

  39. In the present study, we evaluated relationships between serum biomarkers and clinical/magnetic resonance imaging (MRI) findings in golimumab-treated patients with ankylosing spondylitis.

    Authors: Robert D. Inman, Xenofon Baraliakos, Kay-Geert A. Hermann, Jürgen Braun, Atul Deodhar, Désirée van der Heijde, Stephen Xu and Benjamin Hsu
    Citation: Arthritis Research & Therapy 2016 18:304
    Content type: Research article Published on:

  40. Anti-TNF agents have revolutionised rheumatoid arthritis (RA) treatment; however, a third of patients fail to achieve therapeutic responses. Unexpectedly, studies in murine and human arthritis have indicated t...

    Authors: Dobrina N. Hull, Helen Cooksley, Shilpa Chokshi, Richard O. Williams, Sonya Abraham and Peter C. Taylor
    Citation: Arthritis Research & Therapy 2016 18:303
    Content type: Research article Published on:

  41. Alemtuzumab, an anti-CD52 monoclonal antibody, was administered to patients with RA between 1991 and 1994. We have followed a cohort of recipients since that time and previously reported significant delays in ...

    Authors: Faye A. H. Cooles, Amy E. Anderson, Tracey Drayton, Rachel A. Harry, Julie Diboll, Lee Munro, Nishanthi Thalayasingham, Andrew J. K. Östör and John D. Isaacs
    Citation: Arthritis Research & Therapy 2016 18:302
    Content type: Research article Published on:

  42. Osteoarthritis (OA) is a common and debilitating chronic degenerative disease of the joints. Currently, cell-based therapy is being explored to address the repair of damaged articular cartilage in the knee joint.

    Authors: Pawan Kumar Gupta, Anoop Chullikana, Mathiyazhagan Rengasamy, Naresh Shetty, Vivek Pandey, Vikas Agarwal, Shrikant Yeshwant Wagh, Prasanth Kulapurathu Vellotare, Devi Damodaran, Pachaiyappan Viswanathan, Charan Thej, Sudha Balasubramanian and Anish Sen Majumdar
    Citation: Arthritis Research & Therapy 2016 18:301
    Content type: Research article Published on:

  43. Authors: Francisca Sivera, Sofia Ramiro, Nada Cikes, Maurizio Cutolo, Maxime Dougados, Laure Gossec, Tore K. Kvien, Ingrid E. Lundberg, Peter Mandl, Arumugam Moorthy, Sonia Panchal, José A. P. da Silva and Johannes W. Bijlsma
    Citation: Arthritis Research & Therapy 2016 18:300
    Content type: Erratum Published on:

    The original article was published in Arthritis Research & Therapy 2016 18:213

  44. Anti-CarP antibodies were detected in 117 patients with RA (37.9%), ACPA in 190 patients (61.4%) and RF in 202 patients (65.3%). Two (2.04%) of the NHS were positive for anti-CarP, one NHS (1.02%) was positive...

    Authors: Arbi Pecani, Cristiano Alessandri, Francesca Romana Spinelli, Roberta Priori, Valeria Riccieri, Manuela Di Franco, Fulvia Ceccarelli, Tania Colasanti, Monica Pendolino, Riccardo Mancini, Simona Truglia, Cristiana Barbati, Marta Vomero, Danilo Sabatinelli, Francesca Morello, Guido Valesini…
    Citation: Arthritis Research & Therapy 2016 18:299
    Content type: Erratum Published on:

    The original article was published in Arthritis Research & Therapy 2016 18:276

  45. Authors: Sophie J. Bernelot Moens, Fleur M. van der Valk, Aart C. Strang, Jeffrey Kroon, Loek P. Smits, Eva L. Kneepkens, Hein J. Verberne, Jaap D. van Buul, Michael T. Nurmohamed and Erik S. G. Stroes
    Citation: Arthritis Research & Therapy 2016 18:298
    Content type: Erratum Published on:

    The original article was published in Arthritis Research & Therapy 2016 18:115

  46. In this study, we evaluated the impact of obesity and/or overweight on the achievement of minimal disease activity (MDA) in patients with psoriatic arthritis (PsA) and patients with rheumatoid arthritis (RA) r...

    Authors: Roberta Lupoli, Paolo Pizzicato, Antonella Scalera, Pasquale Ambrosino, Manuela Amato, Rosario Peluso and Matteo Nicola Dario Di Minno
    Citation: Arthritis Research & Therapy 2016 18:297
    Content type: Research article Published on:

  47. Psoriatic arthritis (PsA), an inflammatory musculoskeletal disease, develops in approximately 30% of patients with psoriasis. Previously, chemokine (C-X-C motif) ligand 10 (CXCL10) was identified as a predicti...

    Authors: Anastasiya Muntyanu, Fatima Abji, Kun Liang, Remy A. Pollock, Vinod Chandran and Dafna D. Gladman
    Citation: Arthritis Research & Therapy 2016 18:296
    Content type: Research article Published on:

  48. Rheumatoid arthritis (RA) disease activity is often measured using the 28-joint Disease Activity Score (DAS28). We aimed to identify and independently verify subgroups of people with RA that may be discordant ...

    Authors: Daniel F. McWilliams, Eamonn Ferguson, Adam Young, Patrick D. W. Kiely and David A. Walsh
    Citation: Arthritis Research & Therapy 2016 18:295
    Content type: Research article Published on:

  49. Recent works have suggested a possible link between interleukin (IL)-33 and B-cell biology. We aimed to study the possible association between serum IL-33 detection and response to rituximab (RTX) in rheumatoi...

    Authors: Jérémie Sellam, Elodie Rivière, Alice Courties, Paul-Olivier Rouzaire, Barbara Tolusso, Edward M. Vital, Paul Emery, Gianfranco Ferraccioli, Martin Soubrier, Bineta Ly, Houria Hendel Chavez, Yassine Taoufik, Maxime Dougados and Xavier Mariette
    Citation: Arthritis Research & Therapy 2016 18:294
    Content type: Research article Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2017 19:11

  50. The clinical characteristics of Takayasu arteritis (TAK) developing in individuals older than 40 years (TAK >40) are little-known.

    Authors: Shoichi Fukui, Naoki Iwamoto, Toshimasa Shimizu, Masataka Umeda, Ayako Nishino, Tomohiro Koga, Shin-ya Kawashiri, Kunihiro Ichinose, Yasuko Hirai, Mami Tamai, Hideki Nakamura, Toshiyuki Aramaki, Nozomi Iwanaga, Yasumori Izumi, Tomoki Origuchi, Kiyoshi Migita…
    Citation: Arthritis Research & Therapy 2016 18:293
    Content type: Research article Published on:
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Arthritis Research & Therapy

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