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  1. Diseases associated with human cartilage, including rheumatoid arthritis (RA) and osteoarthritis (OA) have manifested age, mechanical stresses and inflammation as the leading risk factors. Although inflammator...

    Authors: Jieun Lee, Piera Smeriglio, Jason Dragoo, William J. Maloney and Nidhi Bhutani
    Citation: Arthritis Research & Therapy 2016 18:292
    Content type: Research article Published on:

  2. Osteoarthritis (OA) is a degenerative joint disease produced by a cascade of events that can ultimately lead to joint damage. The aim of this study was to evaluate the effect of adelmidrol, a synthetic palmito...

    Authors: Rosanna Di Paola, Roberta Fusco, Daniela Impellizzeri, Marika Cordaro, Domenico Britti, Valeria Maria Morittu, Maurizio Evangelista and Salvatore Cuzzocrea
    Citation: Arthritis Research & Therapy 2016 18:291
    Content type: Research article Published on:

  3. A peripheral blood interferon (IFN) signature (i.e., elevated type I interferon response gene [IRG] expression) has been described in a subset of patients with rheumatoid arthritis (RA). In the present study, ...

    Authors: Tamarah D. de Jong, Marjolein Blits, Sander de Ridder, Saskia Vosslamber, Gertjan Wolbink, Mike T. Nurmohamed and Cornelis L. Verweij
    Citation: Arthritis Research & Therapy 2016 18:290
    Content type: Research article Published on:

  4. Articular manifestations are common in systemic lupus erythematosus (SLE) whereas erosive disease is not. Antibodies to cyclic citrullinated peptide (anti-CCP) are citrulline-dependent in rheumatoid arthritis ...

    Authors: Michael Ziegelasch, Myrthe A. M. van Delft, Philip Wallin, Thomas Skogh, César Magro-Checa, Gerda M. Steup-Beekman, Leendert A. Trouw, Alf Kastbom and Christopher Sjöwall
    Citation: Arthritis Research & Therapy 2016 18:289
    Content type: Research article Published on:

  5. To prevent debilitating and irreversible joint damage, rheumatoid arthritis (RA) is often treated with tumor necrosis factor inhibitor (TNFi), but many patients do not respond to this costly therapy. Few predi...

    Authors: Xia Jiang, Johan Askling, Saedis Saevarsdottir, Leonid Padyukov, Lars Alfredsson, Sebastien Viatte and Thomas Frisell
    Citation: Arthritis Research & Therapy 2016 18:288
    Content type: Research article Published on:

  6. Blockade of granulocyte macrophage colony-stimulating factor (GM-CSF) and its receptor (GM-CSFRα) is being successfully tested in trials in rheumatoid arthritis (RA) with clinical results equivalent to those f...

    Authors: Andrew D. Cook, Cynthia Louis, Matthew J. Robinson, Reem Saleh, Matthew A. Sleeman and John A. Hamilton
    Citation: Arthritis Research & Therapy 2016 18:287
    Content type: Research article Published on:

  7. Osteoarthritis (OA) and rheumatoid arthritis (RA) are both debilitating diseases that cause significant morbidity in the US population. Extracellular vesicles (EVs), including exosomes and microvesicles, are n...

    Authors: Joseph Withrow, Cameron Murphy, Yutao Liu, Monte Hunter, Sadanand Fulzele and Mark W. Hamrick
    Citation: Arthritis Research & Therapy 2016 18:286
    Content type: Review Published on:

  8. The contribution of smoking to rheumatoid arthritis (RA) is hypothesized to be mediated through formation of anti-citrullinated protein antibodies (ACPA). In RA, however, autoantibodies such as ACPA, rheumatoi...

    Authors: Tineke J. van Wesemael, Sofia Ajeganova, Jennifer Humphreys, Chikashi Terao, Ammar Muhammad, Deborah P. M. Symmons, Alex J. MacGregor, Ingiäld Hafström, Leendert A. Trouw, Annette H. M. van der Helm-van Mil, Tom W. J. Huizinga, Tsuneyo Mimori, René E. M. Toes, Fumihiko Matsuda, Björn Svensson, Suzanne M. M. Verstappen…
    Citation: Arthritis Research & Therapy 2016 18:285
    Content type: Research article Published on:

  9. Antibodies against citrullinated proteins (ACPA) are common in patients with rheumatoid arthritis (RA). ACPA can appear before disease onset and target many self-antigens. Citrullinated fibrin/fibrinogen repre...

    Authors: Vijay Joshua, Loes Schobers, Philip J. Titcombe, Lena Israelsson, Johan Rönnelid, Monika Hansson, Anca I. Catrina, Ger J. M. Pruijn and Vivianne Malmström
    Citation: Arthritis Research & Therapy 2016 18:284
    Content type: Research article Published on:

  10. Increasing vascular endothelial growth factor (VEGF) has been reported in remitting symmetrical seronegative synovitis with pitting edema (RS3PE) syndrome, rheumatoid arthritis (RA), polymyalgia rheumatica (PM...

    Authors: Perrine Smets, Valérie Devauchelle-Pensec, Paul-Olivier Rouzaire, Bruno Pereira, Marc Andre and Martin Soubrier
    Citation: Arthritis Research & Therapy 2016 18:283
    Content type: Research article Published on:

  11. Biologic therapies have revolutionised disease control in patients with rheumatoid arthritis (RA). Theoretically, they have the potential to influence co-morbid disease associated with RA through better contro...

    Authors: Jenny Humphreys, Kimme Hyrich and Deborah Symmons
    Citation: Arthritis Research & Therapy 2016 18:282
    Content type: Review Published on:

  12. Systemic lupus erythematosus (SLE) is a multi-system, complex disease in which the environment interacts with inherited genes to produce broad phenotypes with inter-individual variability. Of 46 single nucleot...

    Authors: Joyce S. Hui-Yuen, Lisha Zhu, Lai Ping Wong, Kaiyu Jiang, Yanmin Chen, Tao Liu and James N. Jarvis
    Citation: Arthritis Research & Therapy 2016 18:281
    Content type: Research article Published on:

  13. We compared the effectiveness of abatacept (ABA) vs tocilizumab (TCA) in tumor necrosis factor inhibitor (TNFi) experienced patients.

    Authors: Leslie R. Harrold, George W. Reed, Daniel H. Solomon, Jeffrey R. Curtis, Mei Liu, Jeffrey D. Greenberg and Joel M. Kremer
    Citation: Arthritis Research & Therapy 2016 18:280
    Content type: Research article Published on:

  14. Homeostatic bone remodelling becomes disturbed in a variety of pathologic conditions that affect the skeleton, including inflammatory diseases. Rheumatoid arthritis is the prototype of an inflammatory arthriti...

    Authors: Michelle Fennen, Thomas Pap and Berno Dankbar
    Citation: Arthritis Research & Therapy 2016 18:279
    Content type: Review Published on:

  15. Recent evidence suggests a link between autoimmunity and the intestinal microbial composition in several rheumatic diseases including systemic sclerosis (SSc). The objective of this study was to investigate th...

    Authors: Kristofer Andréasson, Zaid Alrawi, Anita Persson, Göran Jönsson and Jan Marsal
    Citation: Arthritis Research & Therapy 2016 18:278
    Content type: Research article Published on:

  16. The risk of development of rheumatoid arthritis (RA) could be affected by immune activation in obesity. Our objective was to evaluate the association between obesity in general, and abdominal obesity, and the ...

    Authors: Lotta Ljung and Solbritt Rantapää-Dahlqvist
    Citation: Arthritis Research & Therapy 2016 18:277
    Content type: Research article Published on:

  17. Antibodies against carbamylated proteins (anti-CarP) have been recently identified in the sera of patients with rheumatoid arthritis (RA). The objective of the study was to evaluate the prevalence, sensitivity...

    Authors: Arbi Pecani, Cristiano Alessandri, Francesca Romana Spinelli, Roberta Priori, Valeria Riccieri, Manuela Di Franco, Fulvia Ceccarelli, Tania Colasanti, Monica Pendolino, Riccardo Mancini, Simona Truglia, Cristiana Barbati, Marta Vomero, Danilo Sabatinelli, Francesca Morello, Guido Valesini…
    Citation: Arthritis Research & Therapy 2016 18:276
    Content type: Research article Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2016 18:299

  18. The efficacy of exercise therapy for ankylosing spondylitis (AS) is well-documented, but dearth of information is for non-radiographic axial spondyloarthritis (nr-axSpA).

    Authors: Andrea Levitova, Hana Hulejova, Maja Spiritovic, Karel Pavelka, Ladislav Senolt and Marketa Husakova
    Citation: Arthritis Research & Therapy 2016 18:275
    Content type: Research article Published on:

  19. Changes in immunoglobulin G (IgG) constant domain (Fc) glycosylation are associated with changes in rheumatoid arthritis (RA) disease activity in response to pregnancy. Here, we sought to determine whether the...

    Authors: Albert Bondt, Manfred Wuhrer, T. Martijn Kuijper, Johanna M. W. Hazes and Radboud J. E. M. Dolhain
    Citation: Arthritis Research & Therapy 2016 18:274
    Content type: Research article Published on:

  20. In immunoglobulin G4-related kidney disease (IgG4-RKD), focal or diffuse renal cortical atrophy is often observed in the clinical course after glucocorticoid therapy. This study aimed to clarify the factors re...

    Authors: Ichiro Mizushima, Motohisa Yamamoto, Dai Inoue, Shinichi Nishi, Yoshinori Taniguchi, Yoshifumi Ubara, Shoko Matsui, Tetsuhiko Yasuno, Hitoshi Nakashima, Hiroki Takahashi, Kazunori Yamada, Hideki Nomura, Masakazu Yamagishi, Takao Saito and Mitsuhiro Kawano
    Citation: Arthritis Research & Therapy 2016 18:273
    Content type: Research article Published on:

  21. Treatment response, remission rates and compliance in patients with polyarticular juvenile idiopathic arthritis (polyJIA) treated with adalimumab, etanercept, or tocilizumab were analyzed in clinical practice.

    Authors: Gerd Horneff, Ariane Klein, Jens Klotsche, Kirsten Minden, Hans-Iko Huppertz, Frank Weller-Heinemann, Jasmin Kuemmerle-Deschner, Johannes-Peter Haas and Anton Hospach
    Citation: Arthritis Research & Therapy 2016 18:272
    Content type: Research article Published on:

  22. Dominant-negative somatic mutations of p53 has been identified in the synovium of patients with rheumatoid arthritis (RA), in which interleukin (IL)-6 has been established as a pivotal inflammatory cytokine. T...

    Authors: Ting Zhang, Huihua Li, Juan Shi, Sha Li, Muyuan Li, Lei Zhang, Leting Zheng, Dexian Zheng, Fulin Tang, Xuan Zhang, Fengchun Zhang and Xin You
    Citation: Arthritis Research & Therapy 2016 18:271
    Content type: Research article Published on:

  23. We investigated two distinct synovial fibroblast populations that were located preferentially in the lining or sub-lining layers and defined by their expression of either podoplanin (PDPN) or CD248, and explor...

    Authors: Adam P. Croft, Amy J. Naylor, Jennifer L. Marshall, Debbie L. Hardie, Birgit Zimmermann, Jason Turner, Guillaume Desanti, Holly Adams, Adrian I. Yemm, Ulf Müller-Ladner, Jean-Michel Dayer, Elena Neumann, Andrew Filer and Christopher D. Buckley
    Citation: Arthritis Research & Therapy 2016 18:270
    Content type: Research article Published on:

  24. Tendon disease is characterized by the development of fibrosis. Transforming growth factor beta (TGF-β), bone morphogenic proteins (BMPs) and connective tissue growth factor (CTGF) are key mediators in the pat...

    Authors: Wataru Morita, Sarah Jane Bothwell Snelling, Stephanie Georgina Dakin and Andrew Jonathan Carr
    Citation: Arthritis Research & Therapy 2016 18:269
    Content type: Research article Published on:

  25. Interleukin (IL)-37 has emerged as a fundamental inhibitor of innate immunity. Acute gout is a self-limiting inflammatory response to monosodium urate (MSU) crystals. In the current study, we assessed the prev...

    Authors: Lei Liu, Yu Xue, Yingfeng Zhu, Dandan Xuan, Xue Yang, Minrui Liang, Juan Wang, Xiaoxia Zhu, Jiong Zhang and Hejian Zou
    Citation: Arthritis Research & Therapy 2016 18:268
    Content type: Research article Published on:

  26. The complement system has been implicated in pathogenesis of systemic sclerosis (SSc). The goal of the present study was to evaluate improved complement biomarkers in SSc.

    Authors: Marcin Okrój, Martin Johansson, Tore Saxne, Anna M. Blom and Roger Hesselstrand
    Citation: Arthritis Research & Therapy 2016 18:267
    Content type: Research article Published on:

  27. B cells are key players in the pathogenesis of rheumatoid arthritis (RA). Although successful in 50–60% of patients with RA, anti-B-cell therapy given as rituximab could be more efficient by identifying potent...

    Authors: Stefan Bruijnen, Michel Tsang-A-Sjoe, Hennie Raterman, Tamara Ramwadhdoebe, Daniëlle Vugts, Guus van Dongen, Marc Huisman, Otto Hoekstra, Paul-Peter Tak, Alexandre Voskuyl and Conny van der Laken
    Citation: Arthritis Research & Therapy 2016 18:266
    Content type: Research article Published on:

  28. Spondyloarthritis often affects young people, typically in their working years. The aim of our study was to investigate work productivity and its relationship with disease activity and physical functioning in ...

    Authors: Manouk de Hooge, Roberta Ramonda, Mariagrazia Lorenzin, Paola Frallonardo, Leonardo Punzi, Augusta Ortolan and Andrea Doria
    Citation: Arthritis Research & Therapy 2016 18:265
    Content type: Research article Published on:

  29. Exosomes are involved in intercellular communication. The aim of this study was to investigate whether circulating exosomes effectively contribute to the inflammatory response in systemic lupus erythematosus (...

    Authors: Joo Youn Lee, Jin Kyun Park, Eun Young Lee, Eun Bong Lee and Yeong Wook Song
    Citation: Arthritis Research & Therapy 2016 18:264
    Content type: Research article Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2020 22:109

  30. Recent studies have shown that alterations in the function of dendritic cells (DCs) are involved in the pathogenesis of systemic lupus erythematosus (SLE). However, the mechanism of the alteration remains uncl...

    Authors: Yilun Wang, Jun Liang, Haihong Qin, Yan Ge, Juan Du, Jinran Lin, Xiaohua Zhu, Jie Wang and Jinhua Xu
    Citation: Arthritis Research & Therapy 2016 18:263
    Content type: Research article Published on:

  32. The aim was to assess the influence of long-term treatment with tumor necrosis factor alpha (TNF-α) inhibitors on total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), high-density lipopro...

    Authors: Shadi Hassan, Uzi Milman, Joy Feld, Lihi Eder, Idit Lavi, Shai Cohen and Devy Zisman
    Citation: Arthritis Research & Therapy 2016 18:261
    Content type: Research article Published on:

  33. Systemic lupus erythematosus (SLE) is a chronic heterogeneous disease with considerable burden from disease activity and damage. A novel clinical treatment target in the form of the lupus low disease activity ...

    Authors: Vera Golder, Rangi Kandane-Rathnayake, Alberta Yik-Bun Hoi, Molla Huq, Worawit Louthrenoo, Yuan An, Zhan Guo Li, Shue Fen Luo, Sargunan Sockalingam, Chak Sing Lau, Alfred Lok Lee, Mo Yin Mok, Aisha Lateef, Kate Franklyn, Susan Morton, Sandra Teresa V. Navarra…
    Citation: Arthritis Research & Therapy 2016 18:260
    Content type: Research article Published on:

  34. Rheumatoid arthritis (RA) patients are treated with a mean of 3–4 conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) with or without glucocorticoids (GCs), before the first biologic prescr...

    Authors: Blanca Hernández-Cruz, Esther Márquez-Saavedra, Rafael Caliz-Caliz and Federico Navarro-Sarabia
    Citation: Arthritis Research & Therapy 2016 18:259
    Content type: Research article Published on:

  35. Rheumatoid arthritis (RA) is the most common systemic autoimmune disease characterized by articular and extra-articular manifestations involving cardiovascular (CV) diseases. RA increases the CV mortality by u...

    Authors: Frank Verhoeven, Clément Prati, Katy Maguin-Gaté, Daniel Wendling and Céline Demougeot
    Citation: Arthritis Research & Therapy 2016 18:258
    Content type: Review Published on:

  36. Authors: Linda Johansson, Natalia Sherina, Nastya Kharlamova, Barbara Potempa, Barbro Larsson, Lena Israelsson, Jan Potempa, Solbritt Rantapää-Dahlqvist and Karin Lundberg
    Citation: Arthritis Research & Therapy 2016 18:257
    Content type: Erratum Published on:

    The original article was published in Arthritis Research & Therapy 2016 18:201

  37. In osteoarthritis (OA) treatment, although chondroitin sulfate (CS) was found in a number of studies using radiography to have a structure-modifying effect, to date CS use is still under debate. A clinical stu...

    Authors: Jean-Pierre Pelletier, Jean-Pierre Raynauld, André D. Beaulieu, Louis Bessette, Frédéric Morin, Artur J. de Brum-Fernandes, Philippe Delorme, Marc Dorais, Patrice Paiement, François Abram and Johanne Martel-Pelletier
    Citation: Arthritis Research & Therapy 2016 18:256
    Content type: Research article Published on:

  38. By altering muscular activation patterns, internal forces acting on the human body during dynamic activity may be manipulated. The magnitude of one of these forces, the medial knee joint reaction force (JRF), ...

    Authors: Lance Rane and Anthony Michael James Bull
    Citation: Arthritis Research & Therapy 2016 18:255
    Content type: Research article Published on:

  39. Presentation of citrullinated neo-epitopes by HLA-DRB1 molecules that carry the shared epitope (SE) sequence was proposed to explain the association between HLA and seropositive RA. Although it is shown that s...

    Authors: Arieke S. B. Kampstra, Jurgen van Heemst, Antonis K. Moustakas, George K. Papadopoulos, Tom W. J. Huizinga and René E. M. Toes
    Citation: Arthritis Research & Therapy 2016 18:254
    Content type: Research article Published on:

  40. Significant peripheral blood CD4+ T-cell depletion has been observed after a first cycle of rituximab, a monoclonal antibody directed against the CD20 antigen, which is currently used in rheumatoid arthritis. ...

    Authors: Matthieu Lavielle, Denis Mulleman, Philippe Goupille, Clément Bahuaud, Hsueh Cheng Sung, Hervé Watier and Gilles Thibault
    Citation: Arthritis Research & Therapy 2016 18:253
    Content type: Research article Published on:

  41. According to international guidelines, treatment of inflammatory arthritis should be based on a shared decision between patient and rheumatologist. Furthermore, patients with inflammatory arthritis have high n...

    Authors: Ingrid Nota, Constance H. C. Drossaert, Erik Taal, Harald E. Vonkeman, Cees J. Haagsma and Mart A. F. J. van de Laar
    Citation: Arthritis Research & Therapy 2016 18:252
    Content type: Research article Published on:

  42. Patient-reported outcomes (PROs) reflect the patient’s perspective and are used in rheumatoid arthritis (RA) routine clinical practice. Patient global assessment (PGA) is one of the most widely used PROs in RA...

    Authors: Elena Nikiphorou, Helga Radner, Katerina Chatzidionysiou, Carole Desthieux, Codruta Zabalan, Yvonne van Eijk-Hustings, William G. Dixon, Kimme L. Hyrich, Johan Askling and Laure Gossec
    Citation: Arthritis Research & Therapy 2016 18:251
    Content type: Review Published on:

  43. There is currently no blood-based test for detection of early-stage osteoarthritis (OA) and the anti-cyclic citrullinated peptide (CCP) antibody test for rheumatoid arthritis (RA) has relatively low sensitivit...

    Authors: Usman Ahmed, Attia Anwar, Richard S. Savage, Paul J. Thornalley and Naila Rabbani
    Citation: Arthritis Research & Therapy 2016 18:250
    Content type: Research article Published on:

  44. The linkage between periodontal disease and rheumatoid arthritis is well established. Commonalities among the two are that both are chronic inflammatory diseases characterized by bone loss, an association with...

    Authors: Indra Sandal, Anastasios Karydis, Jiwen Luo, Amanda Prislovsky, Karen B. Whittington, Edward F. Rosloniec, Chen Dong, Deborah V. Novack, Piotr Mydel, Song Guo Zheng, Marko Z. Radic and David D. Brand
    Citation: Arthritis Research & Therapy 2016 18:249
    Content type: Research article Published on:

  45. BoneXpert (BX) is a newly developed medical device based on digital X-ray radiogrammetry to measure human cortical bone thickness. The aim of this study was to quantify cortical bone loss of the metacarpals in...

    Authors: Alexander Pfeil, Laura Krojniak, Diane M. Renz, Lisa Reinhardt, Marcus Franz, Peter Oelzner, Gunter Wolf and Joachim Böttcher
    Citation: Arthritis Research & Therapy 2016 18:248
    Content type: Research article Published on:

  46. Seronegative joint diseases are characterized by a lack of well-defined biomarkers since autoantibodies are not elevated. Calprotectin (S100A8/A9) is a damage-associated molecular pattern (DAMP) which is relea...

    Authors: Edwin J. W. Geven, Martijn H. J. van den Bosch, Irene Di Ceglie, Giuliana Ascone, Shahla Abdollahi-Roodsaz, Annet W. Sloetjes, Sven Hermann, Michael Schäfers, Fons A. J. van de Loo, Peter M. van der Kraan, Marije I. Koenders, Dirk Foell, Johannes Roth, Thomas Vogl and Peter L. E. M. van Lent
    Citation: Arthritis Research & Therapy 2016 18:247
    Content type: Research article Published on:

  47. In some rheumatic diseases such as systemic lupus erythematosus (SLE), low serum complement (‘hypocomplementaemia’) is a feature of active disease. However, the role of hypocomplementaemia in systemic sclerosi...

    Authors: James Esposito, Zoe Brown, Wendy Stevens, Joanne Sahhar, Candice Rabusa, Jane Zochling, Janet Roddy, Jennifer Walker, Susanna M. Proudman and Mandana Nikpour
    Citation: Arthritis Research & Therapy 2016 18:246
    Content type: Research article Published on:

  48. In the population a high body mass index (BMI) has been associated with slightly increased inflammatory markers. Within rheumatoid arthritis (RA), however, a high BMI has been associated with less radiographic...

    Authors: Lukas Mangnus, Wouter P. Nieuwenhuis, Hanna W. van Steenbergen, Tom W. J. Huizinga, Monique Reijnierse and Annette H. M. van der Helm-van Mil
    Citation: Arthritis Research & Therapy 2016 18:245
    Content type: Research article Published on:

  49. Emerging research on the mechanisms of disease chronicity in experimental arthritis has included a new focus on the draining lymph node (LN). Here, we combined clinical-serological analyses and power Doppler u...

    Authors: Antonio Manzo, Francesca Benaglio, Barbara Vitolo, Chandra Bortolotto, Francesca Zibera, Monica Todoerti, Claudia Alpini, Serena Bugatti, Roberto Caporali, Fabrizio Calliada and Carlomaurizio Montecucco
    Citation: Arthritis Research & Therapy 2016 18:242
    Content type: Research article Published on:

  50. The role of environmental exposures in the pathogenesis of ankylosing spondylitis (AS) remains unclear. In particular, two types of exposures have been suspected to play a role: mechanical stress and infection...

    Authors: Ulf Lindström, Sofia Exarchou, Elisabeth Lie, Mats Dehlin, Helena Forsblad-d’Elia, Johan Askling and Lennart Jacobsson
    Citation: Arthritis Research & Therapy 2016 18:240
    Content type: Research article Published on:
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Arthritis Research & Therapy

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