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  1. Ankylosing spondylitis (AS) is an autoimmune rheumatic disease mostly affecting the axial skeleton. Currently, anti-tumour necrosis factor α (anti-TNF-α) represents an effective treatment for AS that may delay...

    Authors: Wei Wang, Gen-jin Yang, Ju Zhang, Chen Chen, Zhen-yu Jia, Jia Li and Wei-dong Xu
    Citation: Arthritis Research & Therapy 2016 18:244
    Content type: Research article Published on:

  2. Since the precise mechanism for the pathogenesis of systemic lupus erythematosus (SLE) is unknown, no targeted therapies in addition to immunosuppression are available so far. We recently demonstrated that adm...

    Authors: Andreas Keil, Sean R. Hall, Meike Körner, Martin Herrmann, Ralph A. Schmid and Steffen Frese
    Citation: Arthritis Research & Therapy 2016 18:243
    Content type: Research article Published on:

  3. Evidence suggests that the presence of peptidyl arginine deiminase type 4 (PAD4) antibodies is associated with radiographic-severity rheumatoid arthritis (RA) among Caucasian patients. The presence of anti-PAD...

    Authors: Iris Navarro-Millán, Erika Darrah, Andrew O. Westfall, Ted R. Mikuls, Richard J. Reynolds, Maria I. Danila, Jeffrey R. Curtis, Antony Rosen and S. Louis Bridges Jr
    Citation: Arthritis Research & Therapy 2016 18:241
    Content type: Research article Published on:

  4. Seropositive rheumatoid arthritis (RA) is characterized by autoantibodies binding to citrullinated and homocitrullinated proteins. We wanted to study the expression patterns of these disease-associated protein...

    Authors: Sanna Turunen, Johanna Huhtakangas, Tomi Nousiainen, Maarit Valkealahti, Jukka Melkko, Juha Risteli and Petri Lehenkari
    Citation: Arthritis Research & Therapy 2016 18:239
    Content type: Research article Published on:

  6. The aim of this study was to investigate subgroups of magnetic resonance imaging (MRI) findings for the spine and sacroiliac joints (SIJs) using latent class analysis (LCA), and to investigate whether these su...

    Authors: Bodil Arnbak, Rikke Krüger Jensen, Claus Manniche, Oliver Hendricks, Peter Kent, Anne Grethe Jurik and Tue Secher Jensen
    Citation: Arthritis Research & Therapy 2016 18:237
    Content type: Research article Published on:

  7. Authors: Jeffrey N. Miner, Philip K. Tan, David Hyndman, Sha Liu, Cory Iverson, Payal Nanavati, David T. Hagerty, Kimberly Manhard, Zancong Shen, Jean-Luc Girardet, Li-Tain Yeh, Robert Terkeltaub and Barry Quart
    Citation: Arthritis Research & Therapy 2016 18:236
    Content type: Erratum Published on:

    The original article was published in Arthritis Research & Therapy 2016 18:214

  8. The aim was to identify novel diagnostic autoantibody candidates for rheumatoid arthritis (RA) by comprehensive screening for autoreactivity.

    Authors: Stefan Vordenbäumen, Angelika Lueking, Petra Budde, Hans-Dieter Zucht, Heike Goehler, Ralph Brinks, Rebecca Fischer-Betz, Jutta Richter, Ellen Bleck, Jacqueline Detert, Hans-Eckhard Langer, Anne Sörgel, Gerd-Rüdiger Burmester, Peter Schulz-Knappe and Matthias Schneider
    Citation: Arthritis Research & Therapy 2016 18:235
    Content type: Research article Published on:

  9. There are few clinical and epidemiological studies reporting the association between abnormal changes within the IPFP and knee osteoarthritic changes. This study aims to describe the associations between hypoi...

    Authors: Weiyu Han, Dawn Aitken, Zhaohua Zhu, Andrew Halliday, Xia Wang, Benny Antony, Flavia Cicuttini, Graeme Jones and Changhai Ding
    Citation: Arthritis Research & Therapy 2016 18:234
    Content type: Research article Published on:

  10. Patented crystalline glucosamine sulfate (pCGS) and diacerein monotherapy have been recommended for treatment of mild to moderate osteoarthritis (OA), but evidence of efficacy for combined treatments is lackin...

    Authors: Jatupon Kongtharvonskul, Patarawan Woratanarat, Mark McEvoy, John Attia, Siwadol Wongsak, Viroj Kawinwonggowit and Ammarin Thakkinstian
    Citation: Arthritis Research & Therapy 2016 18:233
    Content type: Research article Published on:

  11. The cause of premature cardiovascular disease (CVD) in inflammatory rheumatic diseases (IRDs) has not been fully elucidated. As inflammation may play a role, we wanted to compare the occurrence and extent of i...

    Authors: Jacqueline K. Andersen, Ingvild Oma, Richard A. Prayson, Ingjerd Lien Kvelstad, Sven Martin Almdahl, Morten Wang Fagerland and Ivana Hollan
    Citation: Arthritis Research & Therapy 2016 18:232
    Content type: Research article Published on:

  12. Systemic sclerosis (SSc) is a rare and devastating disease affecting skin and internal organs. Familial aggregation of SSc and co-aggregation with other autoimmune diseases is rarely reported.

    Authors: Chang-Fu Kuo, Shue-Fen Luo, Kuang-Hui Yu, Lai-Chu See, Weiya Zhang and Michael Doherty
    Citation: Arthritis Research & Therapy 2016 18:231
    Content type: Research article Published on:

  13. Interleukin-7 receptor alpha (IL-7Rα) represents a biomarker with potential applications in rheumatoid arthritis (RA) diagnosis and therapy. We have therefore searched by phage display potential IL-7Rα specifi...

    Authors: Carmen Burtea, Sophie Laurent, Tuba Sanli, Deborah Fanfone, Aude Devalckeneer, Sébastien Sauvage, Marie-Claire Beckers, Sandrine Rorive, Isabelle Salmon, Luce Vander Elst, Bernard R. Lauwerys and Robert N. Muller
    Citation: Arthritis Research & Therapy 2016 18:230
    Content type: Research article Published on:

  14. In the present study, we investigated whether thymosin β (Tβ) in saliva and in minor salivary glands is differentially expressed in patients with primary Sjögren’s syndrome (pSS) and patients with autoimmune d...

    Authors: Silvia Bosello, Giusy Peluso, Federica Iavarone, Barbara Tolusso, Irene Messana, Gavino Faa, Massimo Castagnola and Gianfranco Ferraccioli
    Citation: Arthritis Research & Therapy 2016 18:229
    Content type: Research article Published on:

  15. Systemic sclerosis (SSc) is characterized by early vascular abnormalities and subsequent fibroblast activation to myofibroblasts, leading to fibrosis. Recently, endothelial-to-mesenchymal transition (EndoMT), ...

    Authors: Claudio Corallo, Maurizio Cutolo, Bashar Kahaleh, Gianluca Pecetti, Antonio Montella, Chiara Chirico, Stefano Soldano, Ranuccio Nuti and Nicola Giordano
    Citation: Arthritis Research & Therapy 2016 18:228
    Content type: Research article Published on:

  16. Long noncoding RNAs (lncRNAs) have recently received wide attention as key molecules that mediate a variety of physiological and pathological processes by regulating gene expression; however, knowledge of lncR...

    Authors: Yu Zhang, Yu-Zhong Xu, Ning Sun, Jian-Hong Liu, Fang-Fang Chen, Xiao-Long Guan, Ang Li, Fei Wang, Qin-Fei Zhao, Hai-Yong Wang, Shu-Sheng Song, Wei Yu, Jian-Ning Zhao and Xiao-Jun Li
    Citation: Arthritis Research & Therapy 2016 18:227
    Content type: Research article Published on:

  17. Autoantibodies such as anti-citrullinated protein antibodies (ACPA) are major risk factors for articular bone destruction from the earliest phases of rheumatoid arthritis (RA). The aim of the current study was...

    Authors: Serena Bugatti, Laura Bogliolo, Barbara Vitolo, Antonio Manzo, Carlomaurizio Montecucco and Roberto Caporali
    Citation: Arthritis Research & Therapy 2016 18:226
    Content type: Research article Published on:

  18. Interleukin 6 (IL-6) signaling plays a key role in the pathophysiology of rheumatoid arthritis (RA) and is inhibited by sarilumab, a human monoclonal antibody blocking the IL-6 receptor alpha (IL-6Rα). The eff...

    Authors: Anita Boyapati, Jérôme Msihid, Stefano Fiore, Janet van Adelsberg, Neil M. H. Graham and Jennifer D. Hamilton
    Citation: Arthritis Research & Therapy 2016 18:225
    Content type: Research article Published on:

  19. Increased expression of toll-like receptor 4 (TLR4) and its endogenous ligands, is characteristic of rheumatoid arthritis (RA) synovitis. In this study, we evaluated how these TLR4 ligands may drive pathogenic...

    Authors: Eric Hatterer, Limin Shang, Pierre Simonet, Suzanne Herren, Bruno Daubeuf, Stéphanie Teixeira, James Reilly, Greg Elson, Robert Nelson, Cem Gabay, Jeremy Sokolove, Iain B. McInnes, Marie Kosco-Vilbois, Walter Ferlin, Emmanuel Monnet and Cristina De Min
    Citation: Arthritis Research & Therapy 2016 18:224
    Content type: Research article Published on:

  20. The complement system is suggested to be involved in the pathogenesis of osteoarthritis (OA), and proinflammatory cytokines may play a role in OA development by inducing proteases. The association between comp...

    Authors: André Struglics, Marcin Okroj, Per Swärd, Richard Frobell, Tore Saxne, L. Stefan Lohmander and Anna M. Blom
    Citation: Arthritis Research & Therapy 2016 18:223
    Content type: Research article Published on:

  21. The aim was to determine the accuracy of high-resolution ultrasonography (US) for detecting erosion in the metacarpophalangeal (MCP) and wrist joints of patients with different subtypes of systemic lupus eryth...

    Authors: Matteo Piga, Luca Saba, Alessandra Gabba, Mattia Congia, Antonella Balestrieri, Alessandro Mathieu and Alberto Cauli
    Citation: Arthritis Research & Therapy 2016 18:222
    Content type: Research article Published on:

  22. Toll-like receptor (TLR) family members are key players in inflammation. TLR10 has been poorly studied in chronic inflammatory disorders, and its clinical relevance in rheumatoid arthritis (RA) is as yet unkno...

    Authors: Silvia Torices, Antonio Julia, Pedro Muñoz, Ignacio Varela, Alejandro Balsa, Sara Marsal, Antonio Fernández-Nebro, Francisco Blanco, Marcos López-Hoyos, Víctor Martinez-Taboada and Jose L. Fernández-Luna
    Citation: Arthritis Research & Therapy 2016 18:221
    Content type: Research article Published on:

  23. The detection of anti-dsDNA antibodies is critical for the diagnosis and follow-up of systemic lupus erythematosus (SLE) patients. The presently available assays are characterized by a non-optimal specificity ...

    Authors: Filomena Panza, Maria Claudia Alcaro, Fiorella Petrelli, Francesca Angelotti, Federico Pratesi, Paolo Rovero and Paola Migliorini
    Citation: Arthritis Research & Therapy 2016 18:220
    Content type: Research article Published on:

  24. Glucocorticoid-induced leucine zipper (GILZ) is a mediator of the anti-inflammatory activities of glucocorticoids. However, GILZ deletion does not impair the anti-inflammatory activities of exogenous glucocort...

    Authors: Olivier Malaise, Biserka Relic, Edith Charlier, Mustapha Zeddou, Sophie Neuville, Céline Deroyer, Philippe Gillet, Edouard Louis, Michel G. Malaise and Dominique de Seny
    Citation: Arthritis Research & Therapy 2016 18:219
    Content type: Research article Published on:

  25. Management of lupus nephritis (LN) would be greatly aided by the discovery of biomarkers that accurately reflect changes in disease activity. Here, we used a proteomics approach to identify potential urinary b...

    Authors: Carolina Landolt-Marticorena, Stephenie D. Prokopec, Stacey Morrison, Babak Noamani, Dennisse Bonilla, Heather Reich, James Scholey, Carmen Avila-Casado, Paul R. Fortin, Paul C. Boutros and Joan Wither
    Citation: Arthritis Research & Therapy 2016 18:218
    Content type: Research article Published on:

  26. It has been suggested that the phenotypes of Behçet’s disease (BD) in Japan are changing. To ask whether the evolution of BD holds true in recent-onset cases in Japan, we performed a retrospective study.

    Authors: Yohei Kirino, Haruko Ideguchi, Mitsuhiro Takeno, Akiko Suda, Kana Higashitani, Yosuke Kunishita, Kaoru Takase-Minegishi, Maasa Tamura, Toshiyuki Watanabe, Yukiko Asami, Takeaki Uehara, Ryusuke Yoshimi, Tetsu Yamazaki, Akiko Sekiguchi, Atsushi Ihata, Shigeru Ohno…
    Citation: Arthritis Research & Therapy 2016 18:217
    Content type: Research article Published on:

  27. The ubiquitin-editing cytosolic enzyme A20, the major negative regulator of toll-like receptor (TLR)-mediated cellular inflammatory responses, has tight genetic linkage with systemic sclerosis (SSc). Because r...

    Authors: Swati Bhattacharyya, Wenxia Wang, Lauren Van Duyn Graham and John Varga
    Citation: Arthritis Research & Therapy 2016 18:216
    Content type: Research article Published on:

  28. Previous studies provide evidence that adipokine leptin increases production of catabolic and proinflammatory factors in chondrocytes and serves as a link between obesity and osteoarthritis (OA). However, the ...

    Authors: Anna Koskinen-Kolasa, Katriina Vuolteenaho, Riku Korhonen, Teemu Moilanen and Eeva Moilanen
    Citation: Arthritis Research & Therapy 2016 18:215
    Content type: Research article Published on:

  29. Excess body burden of uric acid promotes gout. Diminished renal clearance of uric acid causes hyperuricemia in most patients with gout, and the renal urate transporter (URAT)1 is important for regulation of se...

    Authors: Jeffrey N. Miner, Philip K. Tan, David Hyndman, Sha Liu, Cory Iverson, Payal Nanavati, David T. Hagerty, Kimberly Manhard, Zancong Shen, Jean-Luc Girardet, Li-Tain Yeh, Robert Terkeltaub and Barry Quart
    Citation: Arthritis Research & Therapy 2016 18:214
    Content type: Research article Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2016 18:236

  30. The aim of this project was to analyze and compare the educational experience in rheumatology specialty training programs across European countries, with a focus on self-reported ability.

    Authors: Francisca Sivera, Sofia Ramiro, Nada Cikes, Maurizio Cutolo, Maxime Dougados, Laure Gossec, Tore K. Kvien, Ingrid E. Lundberg, Peter Mandl, Arumugam Moorthy, Sonia Panchal, José A. P. da Silva and Johannes W. Bijlsma
    Citation: Arthritis Research & Therapy 2016 18:213
    Content type: Research article Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2016 18:300

  31. The detection of statistically significant reductions in radiographic progression during clinical studies in patients with rheumatoid arthritis (RA) has become increasingly difficult over the past decade due t...

    Authors: Robert B. M. Landewé, Carol A. Connell, John D. Bradley, Bethanie Wilkinson, David Gruben, Sander Strengholt and Désirée van der Heijde
    Citation: Arthritis Research & Therapy 2016 18:212
    Content type: Research article Published on:

  32. Previous studies in patients with rheumatoid arthritis (RA) have shown that switching to tocilizumab (TCZ) monotherapy (TCZMONO) or combination therapy (TCZCOMBI) with conventional synthetic disease-modifying ant...

    Authors: Xavier M. Teitsma, Anne Karien A. Marijnissen, Johannes W. J. Bijlsma, Floris P. J. Lafeber and Johannes W. G. Jacobs
    Citation: Arthritis Research & Therapy 2016 18:211
    Content type: Research article Published on:

  33. In the present study, we compared the incidence of hospitalized infection among children with juvenile idiopathic arthritis (JIA) following initiation of treatment with biologic agents versus methotrexate (MTX).

    Authors: Timothy Beukelman, Fenglong Xie, John W. Baddley, Lang Chen, Melissa L. Mannion, Kenneth G. Saag, Jie Zhang and Jeffrey R. Curtis
    Citation: Arthritis Research & Therapy 2016 18:210
    Content type: Research article Published on:

  35. It is currently unknown whether bone erosion in gout occurs through an ‘inside-out’ mechanism due to direct intra-osseous crystal deposition or through an ‘outside-in’ mechanism from the surface of bone. The a...

    Authors: Patapong Towiwat, Anthony J. Doyle, Gregory D. Gamble, Paul Tan, Opetaia Aati, Anne Horne, Lisa K. Stamp and Nicola Dalbeth
    Citation: Arthritis Research & Therapy 2016 18:208
    Content type: Research article Published on:

  36. Adipokines are related to knee osteoarthritis, but their exact role is not well known. The aim of this study was to evaluate the association between adipokines in synovial fluid and clinical severity in patien...

    Authors: Joan Calvet, Cristóbal Orellana, Jordi Gratacós, Antoni Berenguer-Llergo, Assumpta Caixàs, Juan José Chillarón, Juan Pedro-Botet, María García-Manrique, Noemí Navarro and Marta Larrosa
    Citation: Arthritis Research & Therapy 2016 18:207
    Content type: Research article Published on:

  37. Rituximab has broad and increasing application in rheumatic diseases. It is known from lymphoma studies that natural killer (NK) cells can lyse rituximab-coated transformed B cells. However, the role of NK cel...

    Authors: Wolfgang Merkt, Hanns-Martin Lorenz and Carsten Watzl
    Citation: Arthritis Research & Therapy 2016 18:206
    Content type: Research article Published on:

  38. Multiple lymphocyte subsets like T and B cells have been connected to joint infiltration and inflammation in rheumatoid arthritis (RA). Identification of leucocyte subsets that are dysregulated in arthritis de...

    Authors: Joyce Lübbers, Marian H. van Beers-Tas, Saskia Vosslamber, Samina A. Turk, Sander de Ridder, Elise Mantel, John G. Wesseling, Martine Reijm, Ingrid M. van Hoogstraten, Johannes W. Bijlsma, Dirkjan van Schaardenburg, Hetty J. Bontkes and Cornelis L. Verweij
    Citation: Arthritis Research & Therapy 2016 18:205
    Content type: Research article Published on:

  39. The role of natural killer (NK) cells in granulomatosis with polyangiitis (GPA) is poorly understood. We recently reported that peripheral blood NK cell percentages correlate with the suppression of GPA activi...

    Authors: Wolfgang Merkt, Maren Claus, Norbert Blank, Michael Hundemer, Adelheid Cerwenka, Hanns-Martin Lorenz and Carsten Watzl
    Citation: Arthritis Research & Therapy 2016 18:204
    Content type: Research article Published on:

  40. Osteoarthritis (OA) of the knee joint is a degenerative process resulting in cartilage loss. Recent evidence suggests that OA is not merely a disease of cartilage but a disease of the entire knee joint and tha...

    Authors: Vikrant Rai, Nicholas E. Dietz, Matthew F. Dilisio, Mohamed M. Radwan and Devendra K. Agrawal
    Citation: Arthritis Research & Therapy 2016 18:203
    Content type: Research article Published on:

  41. Osteoarthritis (OA) mainly affects older populations; however, it is possible that early life factors contribute to the development of OA in later life. The aim of this review is to describe the association be...

    Authors: Benny Antony, Graeme Jones, Xingzhong Jin and Changhai Ding
    Citation: Arthritis Research & Therapy 2016 18:202
    Content type: Review Published on:

  42. The periodontal pathogen Porphyromonas gingivalis is hypothesized to be important in rheumatoid arthritis (RA) aetiology by inducing production of anti-citrullinated protein antibodies (ACPA). We have shown that ...

    Authors: Linda Johansson, Natalia Sherina, Nastya Kharlamova, Barbara Potempa, Barbro Larsson, Lena Israelsson, Jan Potempa, Solbritt Rantapää-Dahlqvist and Karin Lundberg
    Citation: Arthritis Research & Therapy 2016 18:201
    Content type: Research article Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2016 18:257

  43. The aim was to characterise the sociodemographic, general health and polymyalgia rheumatica (PMR)-specific features of participants in a large inception cohort of patients with PMR diagnosed in UK primary care.

    Authors: Sara Muller, Samantha L. Hider, Toby Helliwell, Sarah Lawton, Kevin Barraclough, Bhaskar Dasgupta, Irena Zwierska and Christian D. Mallen
    Citation: Arthritis Research & Therapy 2016 18:200
    Content type: Research article Published on:

  44. Exercise is associated with major benefits in patients with rheumatic diseases for both cardiovascular and rheumatic status. However, information about exercise generally is not collected systematically in rou...

    Authors: Isabel Castrejón, Yusuf Yazici, Selda Celik and Theodore Pincus
    Citation: Arthritis Research & Therapy 2016 18:199
    Content type: Research article Published on:

  45. Sarilumab is a human monoclonal antibody directed against the alpha subunit of the interleukin-6 receptor complex. In the MOBILITY phase III randomized controlled trial (RCT), sarilumab + methotrexate (MTX) tr...

    Authors: Vibeke Strand, Mark Kosinski, Chieh-I Chen, George Joseph, Regina Rendas-Baum, Neil M. H. Graham, Hubert van Hoogstraten, Martha Bayliss, Chunpeng Fan, Tom Huizinga and Mark C. Genovese
    Citation: Arthritis Research & Therapy 2016 18:198
    Content type: Research article Published on:

  46. Decreased heart rate variability (HRV) is associated with adverse outcomes in cardiovascular diseases and has been observed in patients with systemic lupus erythematosus (SLE). We examined the relationship of ...

    Authors: Aikaterini Thanou, Stavros Stavrakis, John W. Dyer, Melissa E. Munroe, Judith A. James and Joan T. Merrill
    Citation: Arthritis Research & Therapy 2016 18:197
    Content type: Research article Published on:

  47. Peripheral disease (arthritis, enthesitis and dactylitis) and extra-articular disease (uveitis, psoriasis and inflammatory bowel disease) is common in ankylosing spondylitis (AS) and non-radiographic axial spo...

    Authors: Janneke J. de Winter, Leonieke J. van Mens, Désirée van der Heijde, Robert Landewé and Dominique L. Baeten
    Citation: Arthritis Research & Therapy 2016 18:196
    Content type: Research article Published on:

  48. Acute administration of the oral 5-HT1A receptor agonist buspirone, which is commonly used as an anxiolytic drug, may improve compromised lower esophageal sphincter function. In an open-label trial we assessed th...

    Authors: George P. Karamanolis, Stylianos Panopoulos, Konstantinos Denaxas, Anastasios Karlaftis, Alexandra Zorbala, Dimitrios Kamberoglou, Spiros D. Ladas and Petros P. Sfikakis
    Citation: Arthritis Research & Therapy 2016 18:195
    Content type: Research article Published on:

  49. Proliferation of draining lymphatic vessels coupled with dynamic changes in lymph node volume and flow are characteristic features in rheumatoid arthritis (RA). Furthermore, impaired lymph egress from inflamed...

    Authors: Homaira Rahimi, Richard Bell, Echoe M. Bouta, Ronald W. Wood, Lianping Xing, Christopher T. Ritchlin and Edward M. Schwarz
    Citation: Arthritis Research & Therapy 2016 18:194
    Content type: Review Published on:

  50. In the present study, we sought to generate hypotheses regarding the associations of serum levels of interleukin (IL)-17, adiponectin, and resistin with magnetic resonance imaging-measured infrapatellar fat pa...

    Authors: Kang Wang, Jianhua Xu, Jingyu Cai, Shuang Zheng, Weiyu Han, Benny Antony and Changhai Ding
    Citation: Arthritis Research & Therapy 2016 18:193
    Content type: Research article Published on:
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Arthritis Research & Therapy

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