Ricklin D, Hajishengallis G, Yang K, Lambris JD. Complement: a key system for immune surveillance and homeostasis. Nat Immunol. 2010;11(9):785–97.
Article
CAS
PubMed
PubMed Central
Google Scholar
Merle NS, Church SE, Fremeaux-Bacchi V, Roumenina LT. Complement system part I –molecular mechanisms of activation and regulation. Front Immunol. 2015;6:262.
PubMed
PubMed Central
Google Scholar
Okroj M, Heinegård D, Holmdahl R, Blom AM. Rheumatoid arthritis and the complement system. Ann Med. 2007;39(7):517–30.
Article
CAS
PubMed
Google Scholar
Happonen KE, Heinegård D, Saxne T, Blom AM. Interactions of the complement system with molecules of extracellular matrix: relevance for joint diseases. Immunobiology. 2012;217(11):1088–96.
Article
CAS
PubMed
Google Scholar
Happonen KE, Saxne T, Aspberg A, Mörgelin M, Heinegård D, Blom AM. Regulation of complement by cartilage oligomeric matrix protein allows for a novel molecular diagnostic principle in rheumatoid arthritis. Arthritis Rheum. 2010;62(12):3574–83.
Article
CAS
PubMed
PubMed Central
Google Scholar
Melin Fürst C, Mörgelin M, Vadstrup K, Heinegård D, Aspberg A, Blom AM. The C-type lectin of the aggrecan G3 domain activates complement. PLoS One. 2013;8(4):e61407.
Article
PubMed
PubMed Central
Google Scholar
Sjöberg A, Onnerfjord P, Mörgelin M, Heinegård D, Blom AM. The extracellular matrix and inflammation: fibromodulin activates the classical pathway of complement by directly binding C1q. J Biol Chem. 2005;280(37):32301–8.
Article
PubMed
Google Scholar
Lohmander LS, Englund PM, Dahl LL, Roos EM. The long-term consequence of anterior cruciate ligament and meniscus injuries: osteoarthritis. Am J Sports Med. 2007;35(10):1756–69.
Article
PubMed
Google Scholar
Johnson DL, Urban Jr WP, Caborn DN, Vanarthos WJ, Carlson CS. Articular cartilage changes seen with magnetic resonance imaging-detected bone bruises associated with acute anterior cruciate ligament rupture. Am J Sports Med. 1998;26(3):409–14.
CAS
PubMed
Google Scholar
Tochigi Y, Zhang P, Rudert MJ, Baer TE, Martin JA, Hillis SL, et al. A novel impaction technique to create experimental articular fractures in large animal joints. Osteoarthritis Cartilage. 2013;21(1):200–8.
Article
CAS
PubMed
Google Scholar
Goldring MB. The role of the chondrocyte in osteoarthritis. Arthritis Rheum. 2000;43(9):1916–26.
Article
CAS
PubMed
Google Scholar
Huber-Lang M, Kovtun A, Ignatius A. The role of complement in trauma and fracture healing. Semin Immunol. 2013;25(1):73–8.
Article
CAS
PubMed
Google Scholar
Schmal H, Salzmann GM, Niemeyer P, Langenmair E, Guo R, Schneider C, et al. Early intra-articular complement activation in ankle fractures. Biomed Res Int. 2014;2014:426893.
Article
PubMed
PubMed Central
Google Scholar
Swärd P, Frobell R, Englund M, Roos H, Struglics A. Cartilage and bone markers and inflammatory cytokines are increased in synovial fluid in the acute phase of knee injury (hemarthrosis) – a cross-sectional analysis. Osteoarthritis Cartilage. 2012;20(11):1302–8.
Article
PubMed
Google Scholar
Larsson S, Lohmander LS, Struglics A. Synovial fluid level of aggrecan ARGS fragments is a more sensitive marker of joint disease than glycosaminoglycan or aggrecan levels: a cross-sectional study. Arthritis Res Ther. 2009;11(3):R92.
Article
PubMed
PubMed Central
Google Scholar
Lohmander LS, Atley LM, Pietka TA, Eyre DR. The release of crosslinked peptides from type II collagen into human synovial fluid is increased soon after joint injury and in osteoarthritis. Arthritis Rheum. 2003;48(11):3130–9.
Article
CAS
PubMed
Google Scholar
Lohmander LS, Ionescu M, Jugessur H, Poole AR. Changes in joint cartilage aggrecan after knee injury and in osteoarthritis. Arthritis Rheum. 1999;42(3):534–44.
Article
CAS
PubMed
Google Scholar
Struglics A, Hansson M, Lohmander LS. Human aggrecanase generated synovial fluid fragment levels are elevated directly after knee injuries due to proteolysis both in the inter globular and chondroitin sulfate domains. Osteoarthritis Cartilage. 2011;19(8):1047–57.
Article
CAS
PubMed
Google Scholar
Swärd P, Struglics A, Englund M, Roos HP, Frobell RB. Soft tissue knee injury with concomitant osteochondral fracture is associated with higher degree of acute joint inflammation. Am J Sports Med. 2014;42(5):1096–102.
Article
PubMed
Google Scholar
Dahlberg L, Ryd L, Heinegård D, Lohmander LS. Proteoglycan fragments in joint fluid: influence of arthrosis and inflammation. Acta Orthop Scand. 1992;63(4):417–23.
Article
CAS
PubMed
Google Scholar
Blom AM, Osterborg A, Mollnes TE, Okroj M. Antibodies reactive to cleaved sites in complement proteins enable highly specific measurement of soluble markers of complement activation. Mol Immunol. 2015;66(2):164–70.
Article
CAS
PubMed
Google Scholar
Bergseth G, Ludviksen JK, Kirschfink M, Giclas PC, Nilsson B, Mollnes TE. An international serum standard for application in assays to detect human complement activation products. Mol Immunol. 2013;56(3):232–9.
Article
CAS
PubMed
Google Scholar
Kumahashi N, Sward P, Larsson S, Lohmander LS, Frobell R, Struglics A. Type II collagen C2C epitope in human synovial fluid and serum after knee injury – associations with molecular and structural markers of injury. Osteoarthritis Cartilage. 2015;23(9):1506–12.
Article
CAS
PubMed
Google Scholar
Frobell RB, Roos HP, Roos EM, Hellio Le Graverand MP, Buck R, Tamez-Pena J, et al. The acutely ACL injured knee assessed by MRI: are large volume traumatic bone marrow lesions a sign of severe compression injury? Osteoarthritis Cartilage. 2008;16(7):829–36.
Article
CAS
PubMed
Google Scholar
Gobezie R, Kho A, Krastins B, Sarracino DA, Thornhill TS, Chase M, et al. High abundance synovial fluid proteome: distinct profiles in health and osteoarthritis. Arthritis Res Ther. 2007;9(2):R36.
Article
PubMed
PubMed Central
Google Scholar
Ritter SY, Subbaiah R, Bebek G, Crish J, Scanzello CR, Krastins B, et al. Proteomic analysis of synovial fluid from the osteoarthritic knee: comparison with transcriptome analyses of joint tissues. Arthritis Rheum. 2013;65(4):981–92.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang Q, Rozelle AL, Lepus CM, Scanzello CR, Song JJ, Larsen DM, et al. Identification of a central role for complement in osteoarthritis. Nat Med. 2011;17(12):1674–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bradley K, North J, Saunders D, Schwaeble W, Jeziorska M, Woolley DE, et al. Synthesis of classical pathway complement components by chondrocytes. Immunology. 1996;88(4):648–56.
CAS
PubMed
PubMed Central
Google Scholar
Corvetta A, Pomponio G, Rinaldi N, Luchetti MM, Di Loreto C, Stramazzotti D. Terminal complement complex in synovial tissue from patients affected by rheumatoid arthritis, osteoarthritis and acute joint trauma. Clin Exp Rheumatol. 1992;10(5):433–8.
CAS
PubMed
Google Scholar
John T, Stahel PF, Morgan SJ, Schulze-Tanzil G. Impact of the complement cascade on posttraumatic cartilage inflammation and degradation. Histol Histopathol. 2007;22(7):781–90.
CAS
PubMed
Google Scholar
Sjöberg AP, Trouw LA, Blom AM. Complement activation and inhibition: a delicate balance. Trends Immunol. 2009;30(2):83–90.
Article
PubMed
Google Scholar
Huber-Lang M, Ignatius A, Brenner RE. Role of complement on broken surfaces after trauma. Adv Exp Med Biol. 2015;865:43–55.
Article
PubMed
Google Scholar
Ignatius A, Schoengraf P, Kreja L, Liedert A, Recknagel S, Kandert S, et al. Complement C3a and C5a modulate osteoclast formation and inflammatory response of osteoblasts in synergism with IL-1β. J Cell Biochem. 2011;112(9):2594–605.
Article
CAS
PubMed
PubMed Central
Google Scholar
Martin JA, Buckwalter JA. Post-traumatic osteoarthritis: the role of stress induced chondrocyte damage. Biorheology. 2006;43(3-4):517–21.
CAS
PubMed
Google Scholar
Martin M, Leffler J, Blom AM. Annexin A2 and A5 serve as new ligands for C1q on apoptotic cells. J Biol Chem. 2012;287(40):33733–44.
Article
CAS
PubMed
PubMed Central
Google Scholar
Amara U, Flierl MA, Rittirsch D, Klos A, Chen H, Acker B, et al. Molecular intercommunication between the complement and coagulation systems. J Immunol. 2010;185(9):5628–36.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lohmander LS, Saxne T, Heinegård DK. Release of cartilage oligomeric matrix protein (COMP) into joint fluid after knee injury and in osteoarthritis. Ann Rheum Dis. 1994;53(1):8–13.
Article
CAS
PubMed
PubMed Central
Google Scholar
Struglics A, Larsson S, Kumahashi N, Frobell R, Lohmander LS. Changes in cytokines and aggrecan ARGS neoepitope in synovial fluid and serum and in C-terminal crosslinking telopeptide of type II collagen and N-terminal crosslinking telopeptide of type I Collagen in urine over five years after anterior cruciate ligament rupture: an exploratory analysis in the knee anterior cruciate ligament, nonsurgical versus surgical treatment trial. Arthritis Rheumatol. 2015;67(7):1816–25.
Article
CAS
PubMed
Google Scholar
Sjöberg AP, Manderson GA, Mörgelin M, Day AJ, Heinegård D, Blom AM. Short leucine-rich glycoproteins of the extracellular matrix display diverse patterns of complement interaction and activation. Mol Immunol. 2009;46(5):830–9.
Article
PubMed
Google Scholar
Hanauske-Abel HM, Pontz BF, Schorlemmer HU. Cartilage specific collagen activates macrophages and the alternative pathway of complement: evidence for an immunopathogenic concept of rheumatoid arthritis. Ann Rheum Dis. 1982;41(2):168–76.
Article
CAS
PubMed
PubMed Central
Google Scholar
Happonen KE, Furst CM, Saxne T, Heinegård D, Blom AM. PRELP protein inhibits the formation of the complement membrane attack complex. J Biol Chem. 2012;287(11):8092–100.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kalchishkova N, Furst CM, Heinegård D, Blom AM. NC4 domain of cartilage-specific collagen IX inhibits complement directly due to attenuation of membrane attack formation and indirectly through binding and enhancing activity of complement inhibitors C4B-binding protein and factor H. J Biol Chem. 2011;286(32):27915–26.
Article
CAS
PubMed
PubMed Central
Google Scholar
Groeneveld TW, Oroszlan M, Owens RT, Faber-Krol MC, Bakker AC, Arlaud GJ, et al. Interactions of the extracellular matrix proteoglycans decorin and biglycan with C1q and collectins. J Immunol. 2005;175(7):4715–23.
Article
CAS
PubMed
Google Scholar
Higuchi H, Shirakura K, Kimura M, Terauchi M, Shinozaki T, Watanabe H, et al. Changes in biochemical parameters after anterior cruciate ligament injury. Int Orthop. 2006;30(1):43–7.
Article
CAS
PubMed
Google Scholar
Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP, Fahmi H. Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol. 2011;7(1):33–42.
Article
CAS
PubMed
Google Scholar
Sohn DH, Sokolove J, Sharpe O, Erhart JC, Chandra PE, Lahey LJ, et al. Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4. Arthritis Res Ther. 2012;14(1):R7.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bondeson J, Wainwright SD, Lauder S, Amos N, Hughes CE. The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis. Arthritis Res Ther. 2006;8(6):R187.
Article
PubMed
PubMed Central
Google Scholar
Moradi B, Rosshirt N, Tripel E, Kirsch J, Barie A, Zeifang F, et al. Unicompartmental and bicompartmental knee osteoarthritis show different patterns of mononuclear cell infiltration and cytokine release in the affected joints. Clin Exp Immunol. 2015;180(1):143–54.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sakiyama H, Inaba N, Toyoguchi T, Okada Y, Matsumoto M, Moriya H, et al. Immunolocalization of complement C1s and matrix metalloproteinase 9 (92 kDa gelatinase/type IV collagenase) in the primary ossification center of the human femur. Cell Tissue Res. 1994;277(2):239–45.
CAS
PubMed
Google Scholar
Yamaguchi K, Sakiyama H, Matsumoto M, Moriya H, Sakiyama S. Degradation of type I and II collagen by human activated C1-s. FEBS Lett. 1990;268(1):206–8.
Article
CAS
PubMed
Google Scholar