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  1. Interleukin-1β (IL-1β) and nerve growth factor (NGF) are key regulators in the pathogenesis of inflammatory arthritis; specifically, IL-1β is involved in tissue degeneration and NGF is involved in joint pain. ...

    Authors: Yangzi Jiang, Changchang Hu, Shuting Yu, Junwei Yan, Hsuan Peng, Hong Wei Ouyang and Rocky S. Tuan
    Citation: Arthritis Research & Therapy 2015 17:327
    Content type: Research article Published on:

  2. This 28-week, phase IIIb study assessed safety and maintenance of response to certolizumab pegol (CZP) in a diverse population of rheumatoid arthritis (RA) patients, stratified by prior anti-TNF exposure, conc...

    Authors: Michael E. Weinblatt, Roy Fleischmann, Ronald F. van Vollenhoven, Paul Emery, Tom WJ Huizinga, Maurizio Cutolo, Désirée van der Heijde, Benjamin Duncan, Owen Davies, Kristel Luijtens and Maxime Dougados
    Citation: Arthritis Research & Therapy 2015 17:325
    Content type: Research article Published on:

  3. Gout is a common metabolic disorder characterized by hyperuricemia and chronic inflammation. Previous studies show that hyperuricemia accelerates the occurrence and worsening of cardiovascular disease due to L...

    Authors: Jing-Chi Lin, Chun-Liang Lin, Mien-Cheng Chen, Pey-Jium Chang, Shih-Tai Chang, Chang-Min Chung and Kuo-Li Pan
    Citation: Arthritis Research & Therapy 2015 17:323
    Content type: Research article Published on:

  4. Centralized intake is integral to healthcare systems to support timely access to appropriate health services. The aim of this study was to develop key performance indicators (KPIs) to evaluate centralized inta...

    Authors: Claire E. Barber, Jatin N. Patel, Linda Woodhouse, Christopher Smith, Stephen Weiss, Joanne Homik, Sharon LeClercq, Dianne Mosher, Tanya Christiansen, Jane Squire Howden, Tracy Wasylak, James Greenwood-Lee, Andrea Emrick, Esther Suter, Barb Kathol, Dmitry Khodyakov…
    Citation: Arthritis Research & Therapy 2015 17:322
    Content type: Research article Published on:

  5. The endocannabinoid system modulates function of immune cells and mesenchymal cells such as fibroblasts, which contribute to cartilage destruction in rheumatoid arthritis (RA). The aim of the study was to dete...

    Authors: Torsten Lowin, Martin Apitz, Sven Anders and Rainer H. Straub
    Citation: Arthritis Research & Therapy 2015 17:321
    Content type: Research article Published on:

  6. Lesional skin of patients with discoid lupus erythematosus (DLE) contains macrophages, whose polarization has yet to be investigated. To test our hypothesis that M1 macrophages would be increased in DLE skin, ...

    Authors: Benjamin F. Chong, Lin-chiang Tseng, Gregory A. Hosler, Noelle M. Teske, Song Zhang, David R. Karp, Nancy J. Olsen and Chandra Mohan
    Citation: Arthritis Research & Therapy 2015 17:324
    Content type: Research article Published on:

  7. Fibronectin fragments (FN-fs) are increased in the cartilage of patients with osteoarthritis (OA) and have a potent chondrolytic effect. However, little is known about the cellular receptors and signaling mech...

    Authors: Hyun Sook Hwang, Su Jin Park, Eun Jeong Cheon, Mi Hyun Lee and Hyun Ah Kim
    Citation: Arthritis Research & Therapy 2015 17:320
    Content type: Research article Published on:

  8. Interstitial lung disease (ILD) is a common extra-articular condition in rheumatoid arthritis (RA), but few studies have systematically investigated its incidence and risk factors in patients receiving anti-tu...

    Authors: Jeffrey R. Curtis, Khaled Sarsour, Pavel Napalkov, Laurie A. Costa and Kathy L. Schulman
    Citation: Arthritis Research & Therapy 2015 17:319
    Content type: Research article Published on:

  9. The infrapatellar fat pad (IPFP) is commonly resected during knee joint arthroplasty, but the ramifications of doing so are unclear. This longitudinal study determined whether the size of the IPFP (maximum cro...

    Authors: Andrew J. Teichtahl, Ema Wulidasari, Sharmayne R. E. Brady, Yuanyuan Wang, Anita E. Wluka, Changhai Ding, Graham G. Giles and Flavia M. Cicuttini
    Citation: Arthritis Research & Therapy 2015 17:318
    Content type: Research article Published on:

  10. Osteoarthritis (OA) is a multifactorial disease, and recent studies have suggested that cell cycle–related proteins play a role in OA pathology. p21 was initially identified as a potent inhibitor of cell cycle...

    Authors: Shinya Hayashi, Takaaki Fujishiro, Shingo Hashimoto, Noriyuki Kanzaki, Nobuaki Chinzei, Shinsuke Kihara, Koji Takayama, Tomoyuki Matsumoto, Kotaro Nishida, Masahiro Kurosaka and Ryosuke Kuroda
    Citation: Arthritis Research & Therapy 2015 17:314
    Content type: Research article Published on:

  11. Whether low socioeconomic status (SES) is associated with worse rheumatoid arthritis (RA) outcomes in countries with general tax-financed healthcare systems (such as Sweden) remains to be elucidated. Our aim w...

    Authors: Xia Jiang, Maria E. C. Sandberg, Saedis Saevarsdottir, Lars Klareskog, Lars Alfredsson and Camilla Bengtsson
    Citation: Arthritis Research & Therapy 2015 17:317
    Content type: Research article Published on:

  12. Osteoarthritis (OA) is a leading cause of disability, but despite the high unmet clinical need and extensive research seeking dependable therapeutic interventions, no proven disease-modifying treatment for OA ...

    Authors: Cedo M. Bagi, Edwin Berryman, David E. Zakur, Dean Wilkie and Catharine J. Andresen
    Citation: Arthritis Research & Therapy 2015 17:315
    Content type: Research article Published on:

  14. Oxidative stress has been reported to be involved in numerous human diseases, including musculoskeletal disorders such as osteoarthritis. However, the interaction between intervertebral disc (IVD) degeneration...

    Authors: Satoshi Suzuki, Nobuyuki Fujita, Naobumi Hosogane, Kota Watanabe, Ken Ishii, Yoshiaki Toyama, Keiyo Takubo, Keisuke Horiuchi, Takeshi Miyamoto, Masaya Nakamura and Morio Matsumoto
    Citation: Arthritis Research & Therapy 2015 17:316
    Content type: Research article Published on:

  15. People with rheumatoid arthritis (RA) frequently suffer from compromised physical and psychological health, however, little is known about positive indicators of health, due to a lack of validated outcome meas...

    Authors: Peter C. Rouse, Jet J. J. C. S. Veldhuijzen Van Zanten, Nikos Ntoumanis, George S. Metsios, Chen-an Yu, George D. Kitas and Joan L. Duda
    Citation: Arthritis Research & Therapy 2015 17:312
    Content type: Research article Published on:

  16. Prostaglandin E receptor 4 (PTGER4) is implicated in immune regulation and bone metabolism. The aim of this study was to analyze its role in radiological joint damage in rheumatoid arthritis (RA).

    Authors: Luis Rodriguez-Rodriguez, Jose Ivorra-Cortes, F. David Carmona, Javier Martín, Alejandro Balsa, Hanna W. van Steenbergen, Annette H. M. van der Helm-van Mil, Isidoro González-Álvaro and Benjamín Fernandez-Gutiérrez
    Citation: Arthritis Research & Therapy 2015 17:306
    Content type: Research article Published on:

  17. Authors: Jian-Da Ma, Xiu-Ning Wei, Dong-Hui Zheng, Ying-Qian Mo, Le-Feng Chen, Xiang Zhang, Jin-Hua Li and Lie Dai
    Citation: Arthritis Research & Therapy 2015 17:311
    Content type: Erratum Published on:

    The original article was published in Arthritis Research & Therapy 2015 17:289

  18. The transcription factor nuclear factor-kappa B (NF-κB) is highly involved in regulation of a number of cellular processes, including production of inflammatory mediators. Thus, this transcription factor plays...

    Authors: Patricia R. Wardwell, Martin B. Forstner and Rebecca A. Bader
    Citation: Arthritis Research & Therapy 2015 17:310
    Content type: Research article Published on:

  19. Current methods for early diagnosis of osteoarthritis (OA) are limited. We assessed whether in vivo detection of chondrocyte death by ApoPep-1 (CQRPPR), a peptide that binds to histone H1 of apoptotic and necr...

    Authors: Xiangguo Che, Lianhua Chi, Clara Yongjoo Park, Gyoung-Ho Cho, Narae Park, Seong-Gon Kim, Byung-Heon Lee and Je-Yong Choi
    Citation: Arthritis Research & Therapy 2015 17:309
    Content type: Research article Published on:

  20. Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis.

    Authors: Vibeke Strand, Joel Kremer, Gene Wallenstein, Keith S. Kanik, Carol Connell, David Gruben, Samuel H. Zwillich and Roy Fleischmann
    Citation: Arthritis Research & Therapy 2015 17:307
    Content type: Research article Published on:

  21. Vascular adhesion protein-1 (VAP-1) is an adhesion molecule, which upon inflammation is rapidly translocated from intracellular sources to the endothelial cell surface. We have recently discovered that sialic ...

    Authors: Helena Virtanen, Anu Autio, Riikka Siitonen, Heidi Liljenbäck, Tiina Saanijoki, Petteri Lankinen, Jussi Mäkilä, Meeri Käkelä, Jarmo Teuho, Nina Savisto, Kimmo Jaakkola, Sirpa Jalkanen and Anne Roivainen
    Citation: Arthritis Research & Therapy 2015 17:308
    Content type: Research article Published on:

  22. Current systemic therapies are rarely curative for patients with severe life-threatening forms of autoimmune diseases (ADs). During the past 15 years, autologous hematopoietic stem cell transplantation has bee...

    Authors: Audrey Cras, Dominique Farge, Thierry Carmoi, Jean-Jacques Lataillade, Dan Dan Wang and Lingyun Sun
    Citation: Arthritis Research & Therapy 2015 17:301
    Content type: Review Published on:

  23. This study aims to elucidate the prognosis and the effectiveness of current treatments for Japanese patients with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA).

    Authors: Ken-ei Sada, Masahiro Yamamura, Masayoshi Harigai, Takao Fujii, Yoshinari Takasaki, Koichi Amano, Shouichi Fujimoto, Eri Muso, Yohko Murakawa, Yoshihiro Arimura and Hirofumi Makino
    Citation: Arthritis Research & Therapy 2015 17:305
    Content type: Research article Published on:

  24. There is increasing evidence that both hyperuricemia and gout increase the risk of cardiovascular morbidity and mortality. Whether urate crystal precipitation confers a particular risk above what is already in...

    Authors: Kasper Søltoft Larsen, Anton Pottegård, Hanne Lindegaard and Jesper Hallas
    Citation: Arthritis Research & Therapy 2015 17:304
    Content type: Research article Published on:

  25. Pannus formation and resulting cartilage destruction during rheumatoid arthritis (RA) depends on the migration of synoviocytes to cartilage tissue. Here, we focused on the role of hypoxia-inducible factor (HIF...

    Authors: Yun Hyun Huh, Gyuseok Lee, Keun-Bae Lee, Jeong-Tae Koh, Jang-Soo Chun and Je-Hwang Ryu
    Citation: Arthritis Research & Therapy 2015 17:302
    Content type: Research article Published on:

  27. Both clinical experience and experimental evidence have suggested that Adrenocorticotropic hormone (ACTH) might directly exert immunomodulatory effects not dependent on adrenal steroidogenesis.

    Authors: Nancy J. Olsen, Dima A. Decker, Paul Higgins, Patrice M. Becker, Carl A. McAloose, Ann L. Benko and William J. Kovacs
    Citation: Arthritis Research & Therapy 2015 17:300
    Content type: Research article Published on:

  28. Pain in arthritis may be experienced in regions outside the affected joint, and hyperalgesia may even be widespread. The spread of pain is usually attributed to mechanisms in the central nervous system. We inv...

    Authors: Elisabeth Jochmann, Michael Karl Boettger, Praveen Anand and Hans-Georg Schaible
    Citation: Arthritis Research & Therapy 2015 17:299
    Content type: Research article Published on:

  29. Physical activity has been recommended to patients with knee osteoarthritis for improving their symptoms. However, it is still controversial if physical activity has effects on joint structures including carti...

    Authors: Benny Antony, Alison Venn, Flavia Cicuttini, Lyn March, Leigh Blizzard, Terence Dwyer, Marita Cross, Graeme Jones and Changhai Ding
    Citation: Arthritis Research & Therapy 2015 17:298
    Content type: Research article Published on:

  30. In this study, we determined: (1) the utility of an untimed sample of urine protein/creatinine ratio (PCR) as a screening test for proteinuria, (2) its ability to accurately measure proteinuria, and (3) cutoff...

    Authors: Jorge Medina-Rosas, Dafna D. Gladman, Jiandong Su, Arthy Sabapathy, Murray B. Urowitz and Zahi Touma
    Citation: Arthritis Research & Therapy 2015 17:296
    Content type: Research article Published on:

  31. Varied definitions of disc pathology exist in the literature. Magnetic Resonance Imaging (MRI) classification systems incorporate several qualitative features including disc appearance, the distinction between...

    Authors: Andrew J. Teichtahl, Donna M. Urquhart, Yuanyuan Wang, Anita E. Wluka, Stephane Heritier and Flavia M. Cicuttini
    Citation: Arthritis Research & Therapy 2015 17:297
    Content type: Research article Published on:

  32. Methotrexate (MTX) is a cornerstone of treatment in a wide variety of inflammatory conditions, including juvenile idiopathic arthritis (JIA) and juvenile dermatomyositis (JDM). However, owing to its narrow the...

    Authors: Ahmed F. Hawwa, AbdelQader AlBawab, Madeleine Rooney, Lucy R. Wedderburn, Michael W. Beresford and James C. McElnay
    Citation: Arthritis Research & Therapy 2015 17:295
    Content type: Research article Published on:

  33. An increased risk of vertebral fracture (VF) is one of the extra-articular manifestations of spondyloarthropathy (SpA). The prevalence of moderate to severe VFs visualized by radiography (Rx) in patients with ...

    Authors: Piet Geusens, Liesbeth De Winter, Dana Quaden, Johan Vanhoof, Debby Vosse, Joop van den Bergh and Veerle Somers
    Citation: Arthritis Research & Therapy 2015 17:294
    Content type: Research article Published on:

  34. While protective plasma cells (PCs) are an important part of the individual’s immune defense, autoreactive plasma cells such as dsDNA-specific plasma cells contribute to the pathogenesis of autoimmune diseases...

    Authors: Oliver Winter, Stephanie Musiol, Melissa Schablowsky, Qingyu Cheng, Laleh Khodadadi and Falk Hiepe
    Citation: Arthritis Research & Therapy 2015 17:293
    Content type: Research article Published on:

  35. Chronic peripheral inflammation in diseases such as rheumatoid arthritis leads to alterations in central pain processing and consequently to mood disorders resulting from sensitization within the central nervo...

    Authors: Marina Sergeeva, Jürgen Rech, Georg Schett and Andreas Hess
    Citation: Arthritis Research & Therapy 2015 17:268
    Content type: Review Published on:

  36. Previously, we demonstrated that children with active systemic vasculitis (SV) have higher circulating CD34 + CD133 + KDR+ endothelial progenitor cells (EPC); the function of these EPCs, and their relationship...

    Authors: Ying Hong, Despina Eleftheriou, Nigel J. Klein and Paul A. Brogan
    Citation: Arthritis Research & Therapy 2015 17:292
    Content type: Research article Published on:

  37. Although caspase-8 is a well-established initiator of apoptosis and suppressor of necroptosis, recent evidence suggests that this enzyme maintains functions beyond its role in cell death. As cells of the innat...

    Authors: Carla M. Cuda, Alexander V. Misharin, Sonal Khare, Rana Saber, FuNien Tsai, Amy M. Archer, Philip J. Homan, G. Kenneth Haines III, Jack Hutcheson, Andrea Dorfleutner, G. R. Scott Budinger, Christian Stehlik and Harris Perlman
    Citation: Arthritis Research & Therapy 2015 17:291
    Content type: Research article Published on:

  39. Core disease activity indicators of rheumatoid arthritis (RA) have been found to be limited in predicting joint destruction progression. Matrix metalloproteinase (MMP) 3 plays an essential role in joint destru...

    Authors: Jian-Da Ma, Xiu-Ning Wei, Dong-Hui Zheng, Ying-Qian Mo, Le-Feng Chen, Xiang Zhang, Jin-Hua Li and Lie Dai
    Citation: Arthritis Research & Therapy 2015 17:289
    Content type: Research article Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2015 17:311

  40. After transection of the medial collateral ligament and medial meniscus (MCLT + MMT) in the rat, focal cartilage lesions develop over 4–6 weeks; however, sham surgery (MCLT alone) does not result in cartilage ...

    Authors: Heidi E. Kloefkorn, Brittany Y. Jacobs, Ayomiposi M. Loye and Kyle D. Allen
    Citation: Arthritis Research & Therapy 2015 17:287
    Content type: Research article Published on:

  41. The acute gout flare results from a localised self-limiting innate immune response to monosodium urate (MSU) crystals deposited in joints in hyperuricaemic individuals. Activation of the caspase recruitment do...

    Authors: Cushla McKinney, Lisa K. Stamp, Nicola Dalbeth, Ruth K. Topless, Richard O. Day, Diluk RW Kannangara, Kenneth M. Williams, Matthijs Janssen, Timothy L. Jansen, Leo A. Joosten, Timothy R. Radstake, Philip L. Riches, Anne-Kathrin Tausche, Frederic Lioté, Alexander So and Tony R. Merriman
    Citation: Arthritis Research & Therapy 2015 17:288
    Content type: Research article Published on:

  42. To determine whether the PTPN22 (protein tyrosine phosphatase nonreceptor 22)/CSK (c-src tyrosine kinase) pathway is implicated in the susceptibility and clinical heterogeneity of Henoch-Schönlein purpura (HSP...

    Authors: Raquel López-Mejías, Fernanda Genre, Sara Remuzgo-Martínez, Belén Sevilla Pérez, Santos Castañeda, Javier Llorca, Norberto Ortego-Centeno, Begoña Ubilla, Verónica Mijares, Trinitario Pina, Vanesa Calvo-Río, Natalia Palmou, José A. Miranda-Filloy, Antonio Navas Parejo, Diego Argila, Javier Sánchez-Pérez…
    Citation: Arthritis Research & Therapy 2015 17:286
    Content type: Research article Published on:

  43. BTB and CNC homology 1 (Bach1) is a transcriptional repressor of Heme oxygenase-1 (HO-1), which is cytoprotective through its antioxidant effects. The objective of this study was to define the role of Bach1 in...

    Authors: Tsuyoshi Takada, Shigeru Miyaki, Hiroyuki Ishitobi, Yuya Hirai, Tomoyuki Nakasa, Kazuhiko Igarashi, Martin K. Lotz and Mitsuo Ochi
    Citation: Arthritis Research & Therapy 2015 17:285
    Content type: Research article Published on:

  44. Environmental exposures, including smoking, hormone-related factors, and metabolic factors, have been implicated in the etiology of rheumatoid arthritis (RA). A previous study has indicated that blood lipid le...

    Authors: Carl Turesson, Ulf Bergström, Mitra Pikwer, Jan-Åke Nilsson and Lennart TH Jacobsson
    Citation: Arthritis Research & Therapy 2015 17:284
    Content type: Research article Published on:

  45. Serum hyaluronic acid (sHA) is a serum biomarker for knee osteoarthritis (OA). Although sHA concentration is elevated in patients with knee OA, the relationship between serum concentration and disease progress...

    Authors: Eiji Sasaki, Eiichi Tsuda, Yuji Yamamoto, Shugo Maeda, Ryo Inoue, Daisuke Chiba, Hiroshi Fujita, Ippei Takahashi, Takashi Umeda, Shigeyuki Nakaji and Yasuyuki Ishibashi
    Citation: Arthritis Research & Therapy 2015 17:283
    Content type: Research article Published on:

  46. Treat-to-target strategies to achieve low disease activity or clinical remission are key in the treatment of rheumatoid arthritis (RA). 14-3-3η is a joint-derived biomarker that is expressed at significantly h...

    Authors: Shintaro Hirata, Anthony Marotta, Yuan Gui, Kentaro Hanami and Yoshiya Tanaka
    Citation: Arthritis Research & Therapy 2015 17:280
    Content type: Research article Published on:

  47. Nerve growth factor plays a key role in the pathology of osteoarthritis (OA) related chronic pain. The aim of these studies was to evaluate the safety, tolerability, pharmacokinetics, and clinical response of ...

    Authors: Jason M. Gow, Wayne H. Tsuji, Gary J. Williams, Daniel Mytych, David Sciberras, Shawn L. Searle, Tim Mant and John P. Gibbs
    Citation: Arthritis Research & Therapy 2015 17:282
    Content type: Research article Published on:

  48. Non-adherence to disease-modifying antirheumatic drugs (DMARDs) hampers the targets of rheumatoid arthritis (RA) treatment, obtaining low disease activity and decreasing radiological progression. This study in...

    Authors: Annelieke Pasma, Charlotte V. Schenk, Reinier Timman, Jan J. V. Busschbach, Bart J.F. van den Bemt, Esmeralda Molenaar, Willemijn H. van der Laan, Saskia Schrauwen, Adriaan van’t Spijker and Johanna M. W. Hazes
    Citation: Arthritis Research & Therapy 2015 17:281
    Content type: Research article Published on:

  49. Endothelial dysfunction is an early step in the atherosclerotic process and can be quantified by flow-mediated vasodilation (FMD). Our aim was to investigate the effect of long-term rosuvastatin therapy on end...

    Authors: Eirik Ikdahl, Jonny Hisdal, Silvia Rollefstad, Inge C. Olsen, Tore K. Kvien, Terje R. Pedersen and Anne Grete Semb
    Citation: Arthritis Research & Therapy 2015 17:279
    Content type: Research article Published on:

  50. Low-intensity pulsed ultrasound (LIPUS) has been known to promote bone healing by nonthermal effects. In recent studies, LIPUS has been shown to reduce inflammation in injured soft tissues. Xerostomia is one o...

    Authors: Minami Sato, Shingo Kuroda, Karima Qurnia Mansjur, Ganzorig Khaliunaa, Kumiko Nagata, Shinya Horiuchi, Toshihiro Inubushi, Yoshiko Yamamura, Masayuki Azuma and Eiji Tanaka
    Citation: Arthritis Research & Therapy 2015 17:278
    Content type: Research article Published on:
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Arthritis Research & Therapy

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