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  1. The multifunctional nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-γ) has potent anti-fibrotic effects, and its expression and activity are impaired in patients with systemic sclerosis...

    Authors: Roberta Goncalves Marangoni, Benjamin D Korman, Yannick Allanore, Philippe Dieude, Loren L Armstrong, Margarita Rzhetskaya, Monique Hinchcliff, Mary Carns, Sofia Podlusky, Sanjiv J Shah, Barbara Ruiz, Eric Hachulla, Kiet Tiev, Jean-Luc Cracowski, John Varga and M Geoffrey Hayes
    Citation: Arthritis Research & Therapy 2015 17:128
    Content type: Research article Published on:

  2. The development of biomarkers for autoimmune diseases has been hampered by a lack of understanding of disease etiopathogenesis and of the mechanisms underlying the induction and maintenance of inflammation, wh...

    Authors: Nitya Nair, Henrik E Mei, Shih-Yu Chen, Matthew Hale, Garry P Nolan, Holden T Maecker, Mark Genovese, C Garrison Fathman and Chan C Whiting
    Citation: Arthritis Research & Therapy 2015 17:127
    Content type: Review Published on:

  4. Engagement of the homotypic cell-to-cell adhesion molecule cadherin-11 on rheumatoid arthritis (RA) synovial fibroblasts with a chimeric molecule containing the cadherin-11 extracellular binding domain stimula...

    Authors: Erika H Noss, Gerald FM Watts, Davide Zocco, Tracy L Keller, Malcolm Whitman, Carl P Blobel, David M Lee and Michael B Brenner
    Citation: Arthritis Research & Therapy 2015 17:126
    Content type: Research article Published on:

  6. Impairment in the ability of the inflamed synovium to generate cortisol has been proposed to be a factor in the persistence and severity of inflammatory arthritis. In the inflamed synovium, cortisol is generat...

    Authors: Dominika E Nanus, Andrew D Filer, Lorraine Yeo, Dagmar Scheel-Toellner, Rowan Hardy, Gareth G Lavery, Paul M Stewart, Christopher D Buckley, Jeremy W Tomlinson, Mark S Cooper and Karim Raza
    Citation: Arthritis Research & Therapy 2015 17:121
    Content type: Research article Published on:

  7. To assess the comparative effectiveness of febuxostat and allopurinol in reducing serum urate (sUA) levels in a real-world U.S. managed care setting.

    Authors: Jasvinder A Singh, Kasem S Akhras and Aki Shiozawa
    Citation: Arthritis Research & Therapy 2015 17:120
    Content type: Research article Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2015 17:236

  8. The transcription factor activating enhancer binding protein 2 epsilon (AP-2ε) was recently shown to be expressed during chondrogenesis as well as in articular chondrocytes of humans and mice. Furthermore, exp...

    Authors: Stephan Niebler, Thomas Schubert, Ernst B Hunziker and Anja K Bosserhoff
    Citation: Arthritis Research & Therapy 2015 17:119
    Content type: Research article Published on:

  9. Prevalence estimates of ankylosing spondylitis vary considerably, and there are few nationwide estimates. The present study aimed to describe the national prevalence of clinically diagnosed ankylosing spondyli...

    Authors: Sofia Exarchou, Ulf Lindström, Johan Askling, Jonas K Eriksson, Helena Forsblad-d’Elia, Martin Neovius, Carl Turesson, Lars Erik Kristensen and Lennart TH Jacobsson
    Citation: Arthritis Research & Therapy 2015 17:118
    Content type: Research article Published on:

  10. GlycA is a novel inflammatory biomarker measured using nuclear magnetic resonance (NMR). Its NMR signal primarily represents glycosylated acute phase proteins. GlycA was associated with inflammation and develo...

    Authors: Michelle J. Ormseth, Cecilia P. Chung, Annette M. Oeser, Margery A. Connelly, Tuulikki Sokka, Paolo Raggi, Joseph F. Solus, James D. Otvos and C. Michael Stein
    Citation: Arthritis Research & Therapy 2015 17:117
    Content type: Research article Published on:

  12. This review focuses on the genetic features of psoriatic arthritis (PsA) and their relationship to phenotypic heterogeneity in the disease, and addresses three questions: what do the recent studies on human le...

    Authors: Oliver FitzGerald, Muhammad Haroon, Jon T Giles and Robert Winchester
    Citation: Arthritis Research & Therapy 2015 17:115
    Content type: Review Published on:

  13. Although physical inactivity has been associated with numerous chronic musculoskeletal complaints, few studies have examined its associations with spinal structures. Moreover, previously reported associations ...

    Authors: Andrew J Teichtahl, Donna M Urquhart, Yuanyuan Wang, Anita E Wluka, Richard O’Sullivan, Graeme Jones and Flavia M Cicuttini
    Citation: Arthritis Research & Therapy 2015 17:114
    Content type: Research article Published on:

  15. The mechanism by which obesity increases the risk of hip osteoarthritis is unclear. One possibility may be by mediating abnormalities in bony geometry, which may in turn be associated with early structural abn...

    Authors: Andrew J Teichtahl, Yuanyuan Wang, Sam Smith, Anita E Wluka, Michael Zhu, Donna Urquhart, Graham G Giles, Richard O’Sullivan and Flavia M Cicuttini
    Citation: Arthritis Research & Therapy 2015 17:112
    Content type: Research article Published on:

  17. Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with diverse manifestations. Although the approval of new therapies includes only one agent in 50 years, a number of promising new drugs are ...

    Authors: Kristin M Corapi, Mary Anne Dooley and William F Pendergraft III
    Citation: Arthritis Research & Therapy 2015 17:110
    Content type: Review Published on:

  18. Renal involvement is a severe complication in systemic lupus erythematosus (SLE). Moreover, a subset of SLE patients develop the anti-phospholipid syndrome (APS), characterised by the occurrence of anti-phosph...

    Authors: Jakob Gerhardsson, Birgitta Sundelin, Agneta Zickert, Leonid Padyukov, Elisabet Svenungsson and Iva Gunnarsson
    Citation: Arthritis Research & Therapy 2015 17:109
    Content type: Research article Published on:

  19. Morning stiffness is assessed daily in the diagnostic process of arthralgia and arthritis, but large-scale studies on the discriminative ability are absent. This study explored the diagnostic value of morning ...

    Authors: Jessica AB van Nies, Celina Alves, Audrey LS Radix-Bloemen, Cécile Gaujoux-Viala, Tom WJ Huizinga, Johanna MW Hazes, Elisabeth Brouwer, Bruno Fautrel and Annette HM van der Helm-van Mil
    Citation: Arthritis Research & Therapy 2015 17:108
    Content type: Research article Published on:

  20. Although obesity is a risk factor for hip osteoarthritis (OA), the role of body composition, if any, is unclear. This study examines whether the body mass index (BMI) and body composition are associated with h...

    Authors: Andrew J Teichtahl, Yuanyuan Wang, Sam Smith, Anita E Wluka, Donna Urquhart, Graham G Giles, Sultana Monira Hussain and Flavia M Cicuttini
    Citation: Arthritis Research & Therapy 2015 17:107
    Content type: Research article Published on:

  22. Differentiation of T helper 17 cells is dependent on the expression of transcription retinoid-related orphan receptor gamma t (RORγt). The purpose of our study is to determine the role of RORγt expression in T...

    Authors: Yuya Kondo, Zhaojin Yao, Masahiro Tahara, Mana Iizuka, Masahiro Yokosawa, Shunta Kaneko, Seiji Segawa, Hiroto Tsuboi, Keigyou Yoh, Satoru Takahashi, Isao Matsumoto and Takayuki Sumida
    Citation: Arthritis Research & Therapy 2015 17:105
    Content type: Research article Published on:

  23. Although susceptibility genes for anti-citrullinated peptide/protein antibodies (ACPA)-positive rheumatoid arthritis (RA) have been successfully discovered by genome-wide association studies (GWAS), little is ...

    Authors: Chikashi Terao, Koichiro Ohmura, Yuta Kochi, Katsunori Ikari, Yukinori Okada, Masakazu Shimizu, Naoshi Nishina, Akari Suzuki, Keiko Myouzen, Takahisa Kawaguchi, Meiko Takahashi, Kiyoshi Takasugi, Akira Murasawa, Shinichi Mizuki, Mitsuhiro Iwahashi, Keiko Funahashi…
    Citation: Arthritis Research & Therapy 2015 17:104
    Content type: Research article Published on:

  24. Systemic lupus erythematosus is associated with a persistent circulation of modified autoantigen-containing apoptotic debris that might be capable of breaking tolerance. We aimed to evaluate apoptotic microves...

    Authors: Jürgen Dieker, Luuk Hilbrands, Astrid Thielen, Henry Dijkman, Jo H Berden and Johan van der Vlag
    Citation: Arthritis Research & Therapy 2015 17:103
    Content type: Research article Published on:

  25. Microchimeric male fetal cells (MFCs) have been associated with systemic lupus erythematosus, and published studies have further correlated MFC with lupus nephritis (LN). In the present study, we evaluated the...

    Authors: Greiciane MS Florim, Heloisa C Caldas, Julio CR de Melo, Maria Alice SF Baptista, Ida MM Fernandes, Marcela Savoldi-Barbosa, Gustavo H Goldman and Mario Abbud-Filho
    Citation: Arthritis Research & Therapy 2015 17:101
    Content type: Research article Published on:

  26. A study was conducted to determine whether the human leukocyte antigen (HLA) B alleles are implicated in the susceptibility to Henoch-Schönlein purpura (HSP) in the largest series of Caucasian HSP patients eve...

    Authors: Raquel López-Mejías, Fernanda Genre, Belén Sevilla Pérez, Santos Castañeda, Norberto Ortego-Centeno, Javier Llorca, Begoña Ubilla, Sara Remuzgo-Martínez, Verónica Mijares, Trinitario Pina, Vanesa Calvo-Río, Ana Márquez, José A Miranda-Filloy, Antonio Navas Parejo, Marta Conde-Jaldón, Lourdes Ortiz-Fernández…
    Citation: Arthritis Research & Therapy 2015 17:102
    Content type: Research article Published on:

  27. Fibroblast-like synoviocytes (FLS) play an important role in the pathogenesis of rheumatoid arthritis (RA). This study aimed to investigate the role of glucose 6-phosphate isomerase (GPI) in the proliferation ...

    Authors: Ming Zong, Tianbao Lu, Shasha Fan, Hui Zhang, Ruhan Gong, Lishan Sun, Zhiyan Fu and Lieying Fan
    Citation: Arthritis Research & Therapy 2015 17:100
    Content type: Research article Published on:

  28. We conducted an external validation study to examine the correlation of a previously published claims-based index for rheumatoid arthritis severity (CIRAS) with disease activity score in 28 joints calculated b...

    Authors: Rishi J Desai, Daniel H Solomon, Michael E Weinblatt, Nancy Shadick and Seoyoung C Kim
    Citation: Arthritis Research & Therapy 2015 17:83
    Content type: Research article Published on:

  29. To determine the prevalence and clinical/laboratory associations of subclinical atherosclerosis and impaired bone health in primary Sjogren’s syndrome (SS).

    Authors: Fotini Gravani, Ioanna Papadaki, Eleni Antypa, Andrianos Nezos, Kyriaki Masselou, Dimitrios Ioakeimidis, Michael Koutsilieris, Haralampos M Moutsopoulos and Clio P Mavragani
    Citation: Arthritis Research & Therapy 2015 17:99
    Content type: Research article Published on:

  31. Considering a lack of efficacy data in patients with early rheumatoid arthritis (eRA) presenting without classical markers of poor prognosis, we compared methotrexate (MTX) with or without step-down glucocorti...

    Authors: Patrick Verschueren, Diederik De Cock, Luk Corluy, Rik Joos, Christine Langenaken, Veerle Taelman, Frank Raeman, Isabelle Ravelingien, Klaas Vandevyvere, Jan Lenaerts, Elke Geens, Piet Geusens, Johan Vanhoof, Anne Durnez, Jan Remans, Bert Vander Cruyssen…
    Citation: Arthritis Research & Therapy 2015 17:97
    Content type: Research article Published on:

  32. Authors: Yasuchika Aoki, Arata Nakajima, Seiji Ohtori, Hiroshi Takahashi, Fusako Watanabe, Masato Sonobe, Fumiaki Terajima, Masahiko Saito, Kazuhisa Takahashi, Tomoaki Toyone, Atsuya Watanabe, Takayuki Nakajima, Makoto Takazawa and Koichi Nakagawa
    Citation: Arthritis Research & Therapy 2015 17:96
    Content type: Letter Published on:

  33. Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). During the clinical development programme, increases in mean serum creatinine (SCr) of approximately 0.07 mg/dL and...

    Authors: Joel M Kremer, Alan J Kivitz, Jesus A Simon-Campos, Evgeny L Nasonov, Hans-Peter Tony, Soo-Kon Lee, Bonnie Vlahos, Constance Hammond, Jack Bukowski, Huihua Li, Seth L Schulman, Susan Raber, Andrea Zuckerman and John D Isaacs
    Citation: Arthritis Research & Therapy 2015 17:95
    Content type: Research article Published on:

  34. Urinary T cells represent a reliable noninvasive biomarker for proliferative Lupus nephritis (LN). Little is known about the presence of T cell subsets, B cells and macrophages in the urine although they may f...

    Authors: Katharina Kopetschke, Jan Klocke, Anna-Sophie Grießbach, Jens Y Humrich, Robert Biesen, Duska Dragun, Gerd-Rüdiger Burmester, Philipp Enghard and Gabriela Riemekasten
    Citation: Arthritis Research & Therapy 2015 17:94
    Content type: Research article Published on:

  35. Mutations in the TNFRSF1A gene, encoding tumor necrosis factor receptor 1 (TNF-R1), are associated with the autosomal dominant autoinflammatory disorder, called TNF receptor associated periodic syndrome (TRAPS). ...

    Authors: Eliana Greco, Ada Aita, Paola Galozzi, Alessandra Gava, Paolo Sfriso, Ola H Negm, Patrick Tighe, Francesco Caso, Filippo Navaglia, Emanuela Dazzo, Marzia De Bortoli, Alessandra Rampazzo, Laura Obici, Simona Donadei, Giampaolo Merlini, Mario Plebani…
    Citation: Arthritis Research & Therapy 2015 17:93
    Content type: Research article Published on:

  36. Disease activity and therapy show an impact on cellular and serological parameters in patients with systemic lupus erythematosus (SLE). This study was performed to compare the influence of mycophenolate mofeti...

    Authors: Till Fassbinder, Ute Saunders, Eva Mickholz, Elisabeth Jung, Heidemarie Becker, Bernhard Schlüter and Annett Marita Jacobi
    Citation: Arthritis Research & Therapy 2015 17:92
    Content type: Research article Published on:

  37. Our previous work has revealed that expression of follistatin-like protein 1 (FSTL1) is elevated in the synovial tissues from osteoarthritis (OA) patients. The aim of this study was to elucidate the underlying...

    Authors: Su Ni, Kaisong Miao, Xianju Zhou, Nanwei Xu, Chenkai Li, Ruixia Zhu, Rongbin Sun and Yuji Wang
    Citation: Arthritis Research & Therapy 2015 17:91
    Content type: Research article Published on:

  38. To determine the prevalence of chronic kidney disease and nephrolithiasis in people with gout, and the association between gout and prevalent or incident chronic kidney disease and nephrolithiasis.

    Authors: Matthew J Roughley, John Belcher, Christian D Mallen and Edward Roddy
    Citation: Arthritis Research & Therapy 2015 17:90
    Content type: Research article Published on:

  40. Mesenchymal stromal cells (MSCs) are considered to be promising agents for the treatment of immunological disease. Although originally identified as precursor cells for mesenchymal lineages, in vitro studies have...

    Authors: Martin J Hoogduijn
    Citation: Arthritis Research & Therapy 2015 17:88
    Content type: Review Published on:

  41. The nervous and immune systems are likely to be interacting in arthritis, with the possible involvement of both neural and non-neural cholinergic transmission. Centrally acting muscarinic agonists, electrical ...

    Authors: Robin M McAllen, Andrew D Cook, Hsu Wei Khiew, Davide Martelli and John A Hamilton
    Citation: Arthritis Research & Therapy 2015 17:87
    Content type: Review Published on:

  42. The evidence from published studies on the association between obesity and rheumatoid arthritis has been contradictory. To clarify the association between obesity and rheumatoid arthritis, we conducted a syste...

    Authors: Baodong Qin, Min Yang, Haitao Fu, Ning Ma, Tingting Wei, Qingqin Tang, Zhide Hu, Yan Liang, Zaixing Yang and Renqian Zhong
    Citation: Arthritis Research & Therapy 2015 17:86
    Content type: Research article Published on:

  43. Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease. Currently, numerous genetic loci of SLE have been confirmed. Here we try to further explore additional genes contributing to SLE suscepti...

    Authors: Yu-jun Sheng, Jian-hua Xu, Yong-gui Wu, Xian-bo Zuo, Jin-ping Gao, Yan Lin, Zheng-wei Zhu, Lei-lei Wen, Chao Yang, Lu Liu, Yu-yan Cheng, Yan Chang, Lu-lu Yang, Fu-sheng Zhou, Xian-fa Tang, Xiao-dong Zheng…
    Citation: Arthritis Research & Therapy 2015 17:85
    Content type: Research article Published on:

  44. As osteoporosis is reported to be associated with atherosclerosis in the general population we examined the relationship between bone mass and carotid measurements in patients with systemic lupus erythematosus...

    Authors: Sofia Ajeganova, Thomas Gustafsson, Tomas Jogestrand, Johan Frostegård and Ingiäld Hafström
    Citation: Arthritis Research & Therapy 2015 17:84
    Content type: Research article Published on:

  45. Gout is a chronic inflammatory disease the development of which is associated with obesity-induced metabolic abnormalities. However, a substantial number of non-obese patients (body mass index [BMI] <25 kg/m2) al...

    Authors: Jennifer Lee, Ji-Yeon Lee, Jae-Ho Lee, Seung-Min Jung, Young Sun Suh, Jung-Hee Koh, Seung-Ki Kwok, Ji Hyeon Ju, Kyung-Su Park and Sung-Hwan Park
    Citation: Arthritis Research & Therapy 2015 17:79
    Content type: Research article Published on:

  46. To evaluate the impact of meniscal extrusion (Ext) on knee osteoarthritis (OA) structural progression and on response to strontium ranelate (SrRan) treatment at 36 months in patients with (+) or without (-) Ex...

    Authors: Camille Roubille, Johanne Martel-Pelletier, Jean-Pierre Raynauld, François Abram, Marc Dorais, Philippe Delorme and Jean-Pierre Pelletier
    Citation: Arthritis Research & Therapy 2015 17:82
    Content type: Research article Published on:

  47. Elevated type I interferon (IFN) response gene (IRG) expression has proven clinical relevance in predicting rituximab non-response in rheumatoid arthritis (RA). Interference between glucocorticoids (GCs) and t...

    Authors: Tamarah D de Jong, Saskia Vosslamber, Marjolein Blits, Gertjan Wolbink, Mike T Nurmohamed, Conny J van der Laken, Gerrit Jansen, Alexandre E Voskuyl and Cornelis L Verweij
    Citation: Arthritis Research & Therapy 2015 17:78
    Content type: Research article Published on:

  48. The objective of this study was to directly compare the safety of tocilizumab (TCZ) and TNF inhibitors (TNFIs) in rheumatoid arthritis (RA) patients in clinical practice.

    Authors: Ryoko Sakai, Soo-Kyung Cho, Toshihiro Nanki, Kaori Watanabe, Hayato Yamazaki, Michi Tanaka, Ryuji Koike, Yoshiya Tanaka, Kazuyoshi Saito, Shintaro Hirata, Koichi Amano, Hayato Nagasawa, Takayuki Sumida, Taichi Hayashi, Takahiko Sugihara, Hiroaki Dobashi…
    Citation: Arthritis Research & Therapy 2015 17:74
    Content type: Research article Published on:

  49. Clinical diversity in systemic sclerosis (SSc) reflects multifaceted pathogenesis and the effect of key growth factors or cytokines operating within a disease-specific microenvironment. Dermal interstitial flu...

    Authors: Kristina EN Clark, Henry Lopez, Bahja Ahmed Abdi, Sandra G Guerra, Xu Shiwen, Korsa Khan, Oseme Etomi, George R Martin, David J Abraham, Christopher P Denton and Richard J Stratton
    Citation: Arthritis Research & Therapy 2015 17:73
    Content type: Research article Published on:

  50. We investigated how many patients, who presented with Raynaud’s phenomenon (RP) and who had not been classified as systemic sclerosis (SSc), would be reclassified as SSc, if the 2013 American College of Rheuma...

    Authors: Jin-Su Park, Min-Chan Park, Jason Jungsik Song, Yong-Beom Park, Soo-Kon Lee and Sang-Won Lee
    Citation: Arthritis Research & Therapy 2015 17:77
    Content type: Research article Published on:
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  • Citation Impact 2023
    Journal Impact Factor: 4.4
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Arthritis Research & Therapy

ISSN: 1478-6362

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