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  1. Adalimumab is a fully human anti–tumor necrosis factor α (anti-TNFα) monoclonal antibody that specifically blocks the interaction of TNFα with its receptors. It binds both soluble and transmembrane TNFα. We hy...

    Authors: Carlos Zamora-Atenza, Cesar Diaz-Torne, Carme Geli, Cesar Diaz-Lopez, M Angels Ortiz, Patricia Moya, Ivan Castellví, Juan C Nieto, Elisabet Cantó, Jordi Casademont, Candido Juarez, Josep M Llobet and Silvia Vidal
    Citation: Arthritis Research & Therapy 2014 16:R153
    Content type: Research article Published on:

  2. We previously showed that type X collagen, a marker of late stage chondrocyte hypertrophy (associated with endochondral ossification), is constitutively expressed by mesenchymal stem cells (MSCs) from osteoart...

    Authors: Omar Salem, Hong Tian Wang, Abdulrahman M Alaseem, Ovidiu Ciobanu, Insaf Hadjab, Rahul Gawri, John Antoniou and Fackson Mwale
    Citation: Arthritis Research & Therapy 2014 16:R152
    Content type: Research article Published on:

  3. We previously demonstrated that a single-chain fragment variable (scFv) specific to collagen type II (CII) posttranslationally modified by reactive oxygen species (ROS) can be used to target anti-inflammatory ...

    Authors: Chris Hughes, Angelica Sette, Michael Seed, Fulvio D’Acquisto, Antonio Manzo, Tonia L Vincent, Ngee Han Lim and Ahuva Nissim
    Citation: Arthritis Research & Therapy 2014 16:R151
    Content type: Research article Published on:

  4. Estrogen (E2) delays onset and decreases severity of experimental arthritis. The aim of this study was to investigate the importance of total estrogen receptor alpha (ERα) expression and cartilage-specific ERα...

    Authors: Cecilia Engdahl, Anna E Börjesson, Huamei F Forsman, Annica Andersson, Alexandra Stubelius, Andree Krust, Pierre Chambon, Ulrika Islander, Claes Ohlsson, Hans Carlsten and Marie K Lagerquist
    Citation: Arthritis Research & Therapy 2014 16:R150
    Content type: Research article Published on:

  5. There is increasing evidence to suggest that bone marrow lesions (BMLs) play a key role in the pathogenesis of osteoarthritis (OA). However, there is a lack of long term data. The aim of this study was to desc...

    Authors: Yi Chao Foong, Hussain Ijaz Khan, Leigh Blizzard, Changhai Ding, Flavia Cicuttini, Graeme Jones and Dawn Aitken
    Citation: Arthritis Research & Therapy 2014 16:R149
    Content type: Research article Published on:

  6. Syndecans are heparan sulphate proteoglycans expressed by endothelial cells. Syndecan-3 is expressed by synovial endothelial cells of rheumatoid arthritis (RA) patients where it binds chemokines, suggesting a ...

    Authors: Oksana Kehoe, Neena Kalia, Sophie King, Andrew Eustace, Charlotte Boyes, Ofer Reizes, Anwen Williams, Angela Patterson and Jim Middleton
    Citation: Arthritis Research & Therapy 2014 16:R148
    Content type: Research article Published on:

  7. Our objectives were to examine mononuclear cell gene expression profiles in patients with systemic lupus erythematosus (SLE) and healthy controls and to compare subsets with and without atherosclerosis to dete...

    Authors: Benjamin D Korman, Chiang-Ching Huang, Carly Skamra, Peggy Wu, Renee Koessler, David Yao, Qi Quan Huang, William Pearce, Kim Sutton-Tyrrell, George Kondos, Daniel Edmundowicz, Richard Pope and Rosalind Ramsey-Goldman
    Citation: Arthritis Research & Therapy 2014 16:R147
    Content type: Research article Published on:

  8. Rheumatoid arthritis (RA) is a complex polygenic inflammatory disease associated with accelerated atherosclerosis and increased cardiovascular (CV) disease risk. Interferon regulatory factor 5 (IRF5) is a regu...

    Authors: Mercedes García-Bermúdez, Raquel López-Mejías, Fernanda Genre, Santos Castañeda, Javier Llorca, Carlos González-Juanatey, Alfonso Corrales, Begoña Ubilla, José A Miranda-Filloy, Trinitario Pina, Carmen Gómez-Vaquero, Luis Rodríguez-Rodríguez, Benjamín Fernández-Gutiérrez, Alejandro Balsa, Dora Pascual-Salcedo, Francisco J López-Longo…
    Citation: Arthritis Research & Therapy 2014 16:R146
    Content type: Research article Published on:

  9. Recent studies regarding the infrapatellar fat pad (IPFP) mainly focus on the roles of the cells derived from the IPFP. There have been few clinical or epidemiological studies reporting on the association betw...

    Authors: Weiyu Han, Shiji Cai, Zhenhua Liu, Xingzhong Jin, Xia Wang, Benny Antony, Yuelong Cao, Dawn Aitken, Flavia Cicuttini, Graeme Jones and Changhai Ding
    Citation: Arthritis Research & Therapy 2014 16:R145
    Content type: Research article Published on:

  10. Pulmonary involvement represents a major cause of death of systemic sclerosis (SSc) patients. Recent data suggest that tyrosine kinase inhibitors, such as imatinib, may be a therapeutic option for SSc patients...

    Authors: Paolo Fraticelli, Barbara Gabrielli, Giovanni Pomponio, Gabriele Valentini, Silvia Bosello, Piersandro Riboldi, Maria Gerosa, Paola Faggioli, Roberto Giacomelli, Nicoletta Del Papa, Roberto Gerli, Claudio Lunardi, Stefano Bombardieri, Walter Malorni, Angelo Corvetta, Gianluca Moroncini…
    Citation: Arthritis Research & Therapy 2014 16:R144
    Content type: Research article Published on:

  11. Antibodies towards type II collagen (CII) are detected in patients with rheumatoid arthritis (RA) and in non-human primates and rodents with collagen induced arthritis (CIA). We have previously shown that anti...

    Authors: Ingrid Lindh, Omri Snir, Erik Lönnblom, Hüseyin Uysal, Ida Andersson, Kutty Selva Nandakumar, Michel Vierboom, Bert 't Hart, Vivianne Malmström and Rikard Holmdahl
    Citation: Arthritis Research & Therapy 2014 16:R143
    Content type: Research article Published on:

  12. C5a plays an crucial role in antineutrophil cytoplasmic antibody (ANCA)-mediated neutrophil recruitment and activation. The current study further investigated the interaction between C5a and sphingosine-1-phos...

    Authors: Jian Hao, Yi-Min Huang, Ming-Hui Zhao and Min Chen
    Citation: Arthritis Research & Therapy 2014 16:R142
    Content type: Research article Published on:

  13. In the present systematic review and meta-analysis, we assessed the effectiveness of different forms of balneotherapy (BT) and hydrotherapy (HT) in the management of fibromyalgia syndrome (FMS).

    Authors: Johannes Naumann and Catharina Sadaghiani
    Citation: Arthritis Research & Therapy 2014 16:R141
    Content type: Research article Published on:

  14. The novel arthritis-specific Work Productivity Survey (WPS) was developed to estimate patient productivity limitations associated with arthritis within and outside the home, which is an unmet need in psoriatic...

    Authors: Jane T Osterhaus and Oana Purcaru
    Citation: Arthritis Research & Therapy 2014 16:R140
    Content type: Research article Published on:

  16. The aim of this study was to define the frequency and associated clinical phenotype of anti-MDA5 autoantibodies in a large UK based, predominantly Caucasian, cohort of patients with juvenile dermatomyositis (J...

    Authors: Sarah L Tansley, Zoe E Betteridge, Harsha Gunawardena, Thomas S Jacques, Catherine M Owens, Clarissa Pilkington, Katie Arnold, Shireena Yasin, Elena Moraitis, Lucy R Wedderburn and Neil J McHugh
    Citation: Arthritis Research & Therapy 2014 16:R138
    Content type: Research article Published on:

  17. Our objective was to investigate whether a lack of frizzled-related protein B (FrzB), an extracellular antagonist of the Wnt signaling pathways, could enhance cartilage degradation by facilitating the expressi...

    Authors: Carole Bougault, Sabrina Priam, Xavier Houard, Audrey Pigenet, Laure Sudre, Rik J Lories, Claire Jacques and Francis Berenbaum
    Citation: Arthritis Research & Therapy 2014 16:R137
    Content type: Research article Published on:

  18. The crucial role of innate immunity in the pathogenesis of systemic sclerosis (SSc) is well established, and in the past few years the hypothesis that Toll-like receptor 4 (TLR4) activation induced by endogeno...

    Authors: Giuseppina Stifano, Alsya J Affandi, Allison L Mathes, Lisa M Rice, Sashidhar Nakerakanti, Banafsheh Nazari, Jungeun Lee, Romy B Christmann and Robert Lafyatis
    Citation: Arthritis Research & Therapy 2014 16:R136
    Content type: Research article Published on:

  19. Relatively little is known about cellular subpopulations in the mature nucleus pulposus (NP). Detailed understanding of the ontogenetic, cellular and molecular characteristics of functional intervertebral disc...

    Authors: Guus GH van den Akker, Don AM Surtel, Andy Cremers, Ricardo Rodrigues-Pinto, Stephen M Richardson, Judith A Hoyland, Lodewijk W van Rhijn, Tim JM Welting and Jan Willem Voncken
    Citation: Arthritis Research & Therapy 2014 16:R135
    Content type: Research article Published on:

  23. Rheumatoid arthritis is a complex disease where predetermined and stochastic factors conspire to confer disease susceptibility. In light of the diverse responses to targeted therapies, rheumatoid arthritis mig...

    Authors: Gary S Firestein
    Citation: Arthritis Research & Therapy 2014 16:114
    Content type: Commentary Published on:

  25. Post-traumatic arthritis (PTA) is a progressive, degenerative response to joint injury, such as articular fracture. The pro-inflammatory cytokines, interleukin 1(IL-1) and tumor necrosis factor alpha (TNF-α), ...

    Authors: Bridgette D Furman, Daniel S Mangiapani, Evan Zeitler, Karsyn N Bailey, Phillip H Horne, Janet L Huebner, Virginia B Kraus, Farshid Guilak and Steven A Olson
    Citation: Arthritis Research & Therapy 2014 16:R134
    Content type: Research article Published on:

  26. Our objective was to compare the effectiveness and safety of traditional Chinese moxibustion to that of sham moxibustion in patients with chronic knee osteoarthritis (KOA) pain.

    Authors: Ling Zhao, Ke Cheng, Lizhen Wang, Fan Wu, Haiping Deng, Ming Tan, Lixing Lao and Xueyong Shen
    Citation: Arthritis Research & Therapy 2014 16:R133
    Content type: Research article Published on:

  28. Rheumatoid arthritis (RA) is a chronic disease causing recurring inflammatory joint attacks. These attacks are characterized by macrophage infiltration contributing to joint destruction. Studies have shown tha...

    Authors: Azza Gramoun, Lindsey A Crowe, Lionel Maurizi, Wolfgang Wirth, Frank Tobalem, Kerstin Grosdemange, Geraldine Coullerez, Felix Eckstein, Marije I Koenders, Wim B Van den Berg, Heinrich Hofmann and Jean-Paul Vallée
    Citation: Arthritis Research & Therapy 2014 16:R131
    Content type: Research article Published on:

  30. Intra-articular glucocorticoid treatment (IAGC) is widely used for symptom relief in arthritis. However, knowledge of factors predicting treatment outcome is limited. The aim of the present study was to identi...

    Authors: Tomas Weitoft, Johan Rönnelid, Ann Knight, Jörgen Lysholm, Tore Saxne and Anders Larsson
    Citation: Arthritis Research & Therapy 2014 16:R129
    Content type: Research article Published on:

  31. We aimed to replicate a recent study which showed higher genetic risk load at 15 loci in men than in women with systemic lupus erythematosus (SLE). This difference was very significant, and it was interpreted ...

    Authors: Elisa Alonso-Perez, Marian Suarez-Gestal, Manuel Calaza, Francisco J Blanco, Ana Suarez, Maria Jose Santos, Chryssa Papasteriades, Patricia Carreira, Rudolf Pullmann, Josep Ordi-Ros, Maurizio Marchini, Fotini N Skopouli, Marc Bijl, Nadia Barrizone, Gian Domenico Sebastiani, Sergio Migliaresi…
    Citation: Arthritis Research & Therapy 2014 16:R128
    Content type: Research article Published on:

  32. The elevated risk of ischaemic heart disease in patients with rheumatoid arthritis (RA) has been linked to inflammation and disease severity. Treatment with tumour necrosis factor inhibitors (TNFis) is often e...

    Authors: Lotta Ljung, Johan Askling, Solbritt Rantapää-Dahlqvist and Lennart Jacobsson
    Citation: Arthritis Research & Therapy 2014 16:R127
    Content type: Research article Published on:

  33. C-X-C motif chemokine 10 (CXCL10) is a chemokine that plays a critical role in the infiltration of T cells in autoimmune diseases and is reported to be expressed in muscle tissue of polymyositis. To determine ...

    Authors: Jinhyun Kim, Ji Yong Choi, Sung-Hye Park, Seung Hee Yang, Ji Ah Park, Kichul Shin, Eun Young Lee, Hiroshi Kawachi, Hitoshi Kohsaka and Yeong Wook Song
    Citation: Arthritis Research & Therapy 2014 16:R126
    Content type: Research article Published on:

  34. The aim was to investigate the frequency of neurological adverse events in patients with rheumatoid arthritis (RA) and spondylarthropathies (SpA) treated with tumor necrosis factor (TNF) α antagonists.

    Authors: Evripidis Kaltsonoudis, Anastasia K Zikou, Paraskevi V Voulgari, Spyridon Konitsiotis, Maria I Argyropoulou and Alexandros A Drosos
    Citation: Arthritis Research & Therapy 2014 16:R125
    Content type: Research article Published on:

  35. Ankylosing spondylitis (AS) is associated with an increased incidence of vertebral fractures (VFs); however the actual incidence and predictors of morphometric VFs are unknown. The present study examined the i...

    Authors: Kwi Young Kang, In Je Kim, Seung Min Jung, Seung-Ki Kwok, Ji Hyeon Ju, Kyung-Su Park, Yeon Sik Hong and Sung-Hwan Park
    Citation: Arthritis Research & Therapy 2014 16:R124
    Content type: Research article Published on:

  36. The aim of this study was to examine the associations of elevated serum C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) with change in muscle strength in patients with established knee osteoa...

    Authors: Diana C Sanchez-Ramirez, Marike van der Leeden, Martin van der Esch, Leo D Roorda, Sabine Verschueren, Jaap H van Dieën, Joost Dekker and Willem F Lems
    Citation: Arthritis Research & Therapy 2014 16:R123
    Content type: Research article Published on:

  37. Neutrophil extracellular traps (NETs) have recently been implicated in a number of autoimmune conditions, including rheumatoid arthritis (RA). We examined the underlying signaling pathways triggering enhanced ...

    Authors: Chanchal Sur Chowdhury, Stavros Giaglis, Ulrich A Walker, Andreas Buser, Sinuhe Hahn and Paul Hasler
    Citation: Arthritis Research & Therapy 2014 16:R122
    Content type: Research article Published on:

  39. Acid-sensing ion channel 3 (ASIC3) is expressed in synoviocytes, activated by decreases in pH, and reduces inflammation in animal models of inflammatory arthritis. The purpose of the current study was to chara...

    Authors: Weiyi Gong, Sandra J Kolker, Yuriy Usachev, Roxanne Y Walder, David L Boyle, Gary S Firestein and Kathleen A Sluka
    Citation: Arthritis Research & Therapy 2014 16:R121
    Content type: Research article Published on:

  41. Polymorphonuclear leukocytes (PMN) are main effector cells in the acute immune response. While the specific role of PMN in systemic lupus erythematosus (SLE) and autoimmunity is still unclear, their importance...

    Authors: Anders A Bengtsson, Ã…sa Pettersson, Stina Wichert, Birgitta Gullstrand, Markus Hansson, Thomas Hellmark and Ã…sa CM Johansson
    Citation: Arthritis Research & Therapy 2014 16:R120
    Content type: Research article Published on:

  42. Gelatinous Heberden’s nodes (HNs), also termed synovial cysts, are a common form of generalized osteoarthritis (OA). We sought to determine whether HN cases at clinical presentation contained multipotential st...

    Authors: Thomas G Baboolal, Sally A Boxall, Sarah M Churchman, Conor T Buckley, Elena Jones and Dennis McGonagle
    Citation: Arthritis Research & Therapy 2014 16:R119
    Content type: Research article Published on:

  43. Transgenic mice are used to study the roles of specific proteins in an intact living system. Use of transgenic mice to study processes in cartilage, however, poses some challenges. First of all, many factors i...

    Authors: Esmeralda N Blaney Davidson, Fons AJ van de Loo, Wim B van den Berg and Peter M van der Kraan
    Citation: Arthritis Research & Therapy 2014 16:210
    Content type: Review Published on:

  45. IgG4-related disease (IgG4-RD) is a multisystem-involved autoimmune disease. Abnormally activated and differentiated B cells may play important roles. Regulatory B cells (Breg) are newly defined B cell subgrou...

    Authors: Wei Lin, Lixia Jin, Hua Chen, Qingjun Wu, Yunyun Fei, Wenjie Zheng, Qian Wang, Ping Li, Yongzhe Li, Wen Zhang, Yan Zhao, Xiaofeng Zeng and Fengchun Zhang
    Citation: Arthritis Research & Therapy 2014 16:R118
    Content type: Research article Published on:

  46. Interleukin 27 (IL-27) is an important regulator of the proinflammatory T-cell response. In this study, we investigated its role in the pathogenesis of Behçet’s disease (BD).

    Authors: Chaokui Wang, Yuan Tian, Zi Ye, Aize Kijlstra, Yan Zhou and Peizeng Yang
    Citation: Arthritis Research & Therapy 2014 16:R117
    Content type: Research article Published on:

  47. Behçet’s disease (BD) as systemic vasculitis of unknown etiology is associated with HLA-B*51 in European and Asian populations. HLA-A*26 was claimed as an additional BD susceptibility marker in Japanese and Gr...

    Authors: Alexandr Borisovich Kuranov, Ina Kötter, Jörg Christoph Henes, Saule Tleubaevna Abisheva, Ingeborg Steiert, Florian Riewerts, Kuvat Temirgalievich Momynaliev and Claudia Anna Müller
    Citation: Arthritis Research & Therapy 2014 16:R116
    Content type: Research article Published on:

  48. While low levels of vitamin D can increase the risk for osteoporosis, excessive amounts of vitamin D may also be problematic. Hypercalcemia and hypercalcuria due to increased vitamin D activity occur in a sign...

    Authors: Robert P Baughman and Elyse E Lower
    Citation: Arthritis Research & Therapy 2014 16:111
    Content type: Editorial Published on:

  49. Regulatory T (Treg) cells play a crucial role in preventing autoimmune diseases and are an ideal target for the development of therapies designed to suppress inflammation in an antigen-specific manner. Type 1 ...

    Authors: Hélène Asnagli, Delphine Martire, Nathalie Belmonte, Julie Quentin, Hervé Bastian, Mathilde Boucard-Jourdin, Papa Babacar Fall, Anne-Laure Mausset-Bonnefont, Amélie Mantello-Moreau, Sandrine Rouquier, Irène Marchetti, Christian Jorgensen, Arnaud Foussat and Pascale Louis-Plence
    Citation: Arthritis Research & Therapy 2014 16:R115
    Content type: Research article Published on:

  50. The majority of the genetic variance of systemic lupus erythematosus (SLE) remains unexplained by the common disease-common variant hypothesis. Rare variants, which are not detectable by genome-wide associatio...

    Authors: Amy L Roberts, Ellen RA Thomas, Shriram Bhosle, Laurence Game, Olga Obraztsova, Timothy J Aitman, Timothy J Vyse and Benjamin Rhodes
    Citation: Arthritis Research & Therapy 2014 16:R114
    Content type: Research article Published on:
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Arthritis Research & Therapy

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