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  1. The aim of this study was to investigate the influence of symptom duration on treatment response and on the correlation between improvements in patient reported outcomes (PRO) and objective inflammation in pat...

    Authors: Anja Weiß, In-Ho Song, Hildrun Haibel, Joachim Listing and Joachim Sieper
    Citation: Arthritis Research & Therapy 2014 16:R35
    Content type: Research article Published on:

  2. Both genetic variation in ATP-binding cassette sub-family G member 2 (ABCG2) and intake of fructose-containing beverages are major risk factors for hyperuricemia and gout. This study aimed to test the hypothesis ...

    Authors: Nicola Dalbeth, Meaghan E House, Gregory D Gamble, Bregina Pool, Anne Horne, Lauren Purvis, Angela Stewart, Marilyn Merriman, Murray Cadzow, Amanda Phipps-Green and Tony R Merriman
    Citation: Arthritis Research & Therapy 2014 16:R34
    Content type: Research article Published on:

  3. Cartilage damage impacts on patient disability in rheumatoid arthritis (RA). The aims of this magnetic resonance imaging (MRI) study were to investigate cartilage damage over three years and determine predicti...

    Authors: Fiona M McQueen, Alexandra McHaffie, Andrew Clarke, Arier C Lee, Quentin Reeves, Barbara Curteis and Nicola Dalbeth
    Citation: Arthritis Research & Therapy 2014 16:R33
    Content type: Research article Published on:

  4. Citrullination and the immune response to citrullinated proteins have been fundamental for the early recognition of rheumatoid arthritis by serological tests and a better understanding of its pathophysiology. ...

    Authors: Walther J van Venrooij and Ger JM Pruijn
    Citation: Arthritis Research & Therapy 2014 16:103
    Content type: Commentary Published on:

  5. Articular cartilage needs sulfated-glycosaminoglycans (sGAGs) to withstand high pressures while mechanically loaded. Chondrocyte sGAG synthesis is regulated by exposure to compressive forces. Moderate physical...

    Authors: Michiel Siebelt, Harald C Groen, Stuart J Koelewijn, Erik de Blois, Marjan Sandker, Jan H Waarsing, Cristina Müller, Gerjo JVM van Osch, Marion de Jong and Harrie Weinans
    Citation: Arthritis Research & Therapy 2014 16:R32
    Content type: Research article Published on:

  6. The intervertebral disc has a complex structure originating developmentally from both the mesenchyme and notochord. Notochordal cells disappear during adolescence, which is also when human discs begin to show ...

    Authors: Takashi Yurube, Hiroaki Hirata, Kenichiro Kakutani, Koichiro Maeno, Toru Takada, Zhongying Zhang, Koji Takayama, Takehiko Matsushita, Ryosuke Kuroda, Masahiro Kurosaka and Kotaro Nishida
    Citation: Arthritis Research & Therapy 2014 16:R31
    Content type: Research article Published on:

  7. Disease-modifying antirheumatic drugs (DMARDs) have become the treatment standard for patients with rheumatoid arthritis (RA). Although several general-population studies document that a large population of pa...

    Authors: Erika M Brown, Katie L Garneau, Hsun Tsao and Daniel H Solomon
    Citation: Arthritis Research & Therapy 2014 16:R30
    Content type: Research article Published on:

  8. Vasculopathy, inflammatory fibrosis and functional autoantibodies (Abs) are major manifestations of systemic sclerosis (SSc). Abs directed against the angiotensin II type 1 receptor (AT1R) and endothelin-1 type A...

    Authors: Angela Kill, Christoph Tabeling, Reinmar Undeutsch, Anja A Kühl, Jeannine Günther, Mislav Radic, Mike O Becker, Harald Heidecke, Margitta Worm, Martin Witzenrath, Gerd-Rüdiger Burmester, Duska Dragun and Gabriela Riemekasten
    Citation: Arthritis Research & Therapy 2014 16:R29
    Content type: Research article Published on:

  9. We previously reported that sialyl Lewisy, synthesized by fucosyltransferases, is involved in angiogenesis. Fucosyltransferase 1 (fut1) is an α(1,2)-fucosyltransferase responsible for synthesis of the H blood gro...

    Authors: Takeo Isozaki, Jeffrey H Ruth, Mohammad A Amin, Phillip L Campbell, Pei-Suen Tsou, Christine M Ha, G Kenneth Haines III, Gautam Edhayan and Alisa E Koch
    Citation: Arthritis Research & Therapy 2014 16:R28
    Content type: Research article Published on:

  10. The meniscus has an important role in force transmission across the knee, but a detailed three-dimensional (3D) morphometric shape analysis of the lateral meniscus to elucidate subject-specific function has no...

    Authors: Kai Yu Zhang, Angela E Kedgley, Claire R Donoghue, Daniel Rueckert and Anthony MJ Bull
    Citation: Arthritis Research & Therapy 2014 16:R27
    Content type: Research article Published on:

  11. The aim of this study was to investigate the expression of tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor fibroblast growth factor-inducible 14 (Fn14) in patients with polymyosit...

    Authors: Qing-Lin Peng, Xiao-Ming Shu, Xiao-Lan Tian, Xin Lu and Guo-Chun Wang
    Citation: Arthritis Research & Therapy 2014 16:R26
    Content type: Research article Published on:

  12. Chondrocalcinosis (CC) most commonly results from calcium pyrophosphate crystal deposition (CPPD). The objective of this study is to examine the association between candidate single-nucleotide polymorphisms (S...

    Authors: Abhishek Abhishek, Sally Doherty, Rose Maciewicz, Kenneth Muir, Weiya Zhang, Michael Doherty and Anna M Valdes
    Citation: Arthritis Research & Therapy 2014 16:R25
    Content type: Research article Published on:

  13. Patients with active rheumatoid arthritis who had failed at least one disease-modifying anti-rheumatic drug (DMARD) were treated with adalimumab (ADA) in the ReAct study with the option to continue treatment f...

    Authors: Gerd R Burmester, Marco Matucci-Cerinic, Xavier Mariette, Francisco Navarro-Blasco, Sonja Kary, Kristina Unnebrink and Hartmut Kupper
    Citation: Arthritis Research & Therapy 2014 16:R24
    Content type: Research article Published on:

  14. Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease characterized by articular and extra-articular manifestations involving cardiovascular diseases (CVDs), which account for 30% to 50% of all ...

    Authors: Perle Totoson, Katy Maguin-Gaté, Clément Prati, Daniel Wendling and Céline Demougeot
    Citation: Arthritis Research & Therapy 2014 16:202
    Content type: Review Published on:

  15. Our recent data showed that signal transducers and activators of transcription 1 (STAT1), adenosine deaminase acting on RNA (ADAR), C-C motif chemokine ligand 2 (CCL2), and C-X-C motif chemokine 10 (CXCL10) we...

    Authors: Paul R Dominguez-Gutierrez, Angela Ceribelli, Minoru Satoh, Eric S Sobel, Westley H Reeves and Edward KL Chan
    Citation: Arthritis Research & Therapy 2014 16:R23
    Content type: Research article Published on:

  16. Excessive mechanical loading of intervertebral discs (IVDs) is thought to alter matrix properties and influence disc cell metabolism, contributing to degenerative disc disease and development of discogenic pai...

    Authors: Rahul Gawri, Derek H Rosenzweig, Emerson Krock, Jean A Ouellet, Laura S Stone, Thomas M Quinn and Lisbet Haglund
    Citation: Arthritis Research & Therapy 2014 16:R21
    Content type: Research article Published on:

  17. The present study examines the levels of recently reported biomarkers, adenosine deaminase acting on RNA (ADAR), C-C motif chemokine ligand 2 (CCL2), C-X-C motif chemokine 10 (CXCL10), signal transducers and a...

    Authors: Paul R Dominguez-Gutierrez, Angela Ceribelli, Minoru Satoh, Eric S Sobel, Westley H Reeves and Edward KL Chan
    Citation: Arthritis Research & Therapy 2014 16:R20
    Content type: Research article Published on:

  18. Obesity, usually characterized by the body mass index (BMI), is a risk factor for hand osteoarthritis (OA). We investigated whether adipose tissue and abdominal fat distribution are associated with hand OA.

    Authors: A Willemien Visser, Andreea Ioan-Facsinay, Renée de Mutsert, Ralph L Widya, Marieke Loef, Albert de Roos, Saskia le Cessie, Martin den Heijer, Frits R Rosendaal and Margreet Kloppenburg
    Citation: Arthritis Research & Therapy 2014 16:R19
    Content type: Research article Published on:

  19. Unraveling the mechanisms underlying the inflammatory response in rheumatoid arthritis is crucial in order to better understand the disease and to develop novel therapeutic approaches. Although the effect of t...

    Authors: Rik A de Groen, Bi-Sheng Liu and André Boonstra
    Citation: Arthritis Research & Therapy 2014 16:102
    Content type: Editorial Published on:

  20. While many of the commonly used conservative treatments for knee osteoarthritis (OA) have been recognized to be effective, there is still insufficient evidence available. Among the pharmacological treatments f...

    Authors: Muneaki Ishijima, Toshitaka Nakamura, Katsuji Shimizu, Kunihiko Hayashi, Hiraku Kikuchi, Satoshi Soen, Go Omori, Toshihiko Yamashita, Yuji Uchio, Junji Chiba, Yuki Ideno, Mitsuaki Kubota, Hisashi Kurosawa and Kazuo Kaneko
    Citation: Arthritis Research & Therapy 2014 16:R18
    Content type: Research article Published on:

  22. Nerve growth factor (NGF) level is increased in osteoarthritis (OA) joints and is involved in pain associated with OA. Stimuli responsible for NGF stimulation in chondrocytes are unknown. We investigated wheth...

    Authors: Emilie Pecchi, Sabrina Priam, Marjolaine Gosset, Audrey Pigenet, Laure Sudre, Marie-Charlotte Laiguillon, Francis Berenbaum and Xavier Houard
    Citation: Arthritis Research & Therapy 2014 16:R16
    Content type: Research article Published on:

  23. This review addresses the current status of drug therapy for the management of fibromyalgia syndrome (FMS) and is based on interdisciplinary FMS management guidelines, meta-analyses of drug trial data, and obs...

    Authors: Winfried Häuser, Brian Walitt, Mary-Ann Fitzcharles and Claudia Sommer
    Citation: Arthritis Research & Therapy 2014 16:201
    Content type: Review Published on:

  24. The aims of this study were to evaluate the diagnostic accuracy of blood B-cell subset profiling and immune-system activation marker assays in primary Sjögren’s syndrome (pSS) and to assess whether adding thes...

    Authors: Divi Cornec, Alain Saraux, Jacques-Olivier Pers, Sandrine Jousse-Joulin, Thierry Marhadour, Anne-Marie Roguedas-Contios, Steeve Genestet, Yves Renaudineau and Valérie Devauchelle-Pensec
    Citation: Arthritis Research & Therapy 2014 16:R15
    Content type: Research article Published on:

  25. A C-to-T single nucleotide polymorphism (SNP) located at position 1858 of human protein tyrosine phosphatase, non-receptor type 22 (PTPN22) complementary DNA (cDNA) is associated with an increased risk of syst...

    Authors: Hui-Hsin Chang, William Tseng, Jing Cui, Karen Costenbader and I-Cheng Ho
    Citation: Arthritis Research & Therapy 2014 16:R14
    Content type: Research article Published on:

  26. UK guidelines recommend that all early active rheumatoid arthritis (RA) patients are offered combination disease-modifying antirheumatic drugs (DMARDs) and short-term corticosteroids. Anti-citrullinated protei...

    Authors: Seth D Seegobin, Margaret HY Ma, Chanaka Dahanayake, Andrew P Cope, David L Scott, Cathryn M Lewis and Ian C Scott
    Citation: Arthritis Research & Therapy 2014 16:R13
    Content type: Research article Published on:

  27. High levels of the oncoprotein survivin may be detected in the majority of patients with early rheumatoid arthritis (RA). Survivin is a sensitive predictor of joint damage and persistent disease activity. Surv...

    Authors: Björn Svensson, Ingiäld Hafström, Malin C Erlandsson, Kristina Forslind and Maria I Bokarewa
    Citation: Arthritis Research & Therapy 2014 16:R12
    Content type: Research article Published on:

  28. Previous observations implicate Indian hedgehog (Ihh) signaling in osteoarthritis (OA) development because it regulates chondrocyte hypertrophy and matrix metallopeptidase 13 (MMP-13) expression. However, ther...

    Authors: Jingming Zhou, Qian Chen, Beate Lanske, Braden C Fleming, Richard Terek, Xiaochun Wei, Ge Zhang, Shaowei Wang, Kai Li and Lei Wei
    Citation: Arthritis Research & Therapy 2014 16:R11
    Content type: Research article Published on:

  29. Animal models currently used in osteoarthritis-associated pain research inadequately reproduce the initiating events and structural pathology of human osteoarthritis. Conversely, intra-articular injection of c...

    Authors: Sara Adães, Marcelo Mendonça, Telmo N Santos, José M Castro-Lopes, Joana Ferreira-Gomes and Fani L Neto
    Citation: Arthritis Research & Therapy 2014 16:R10
    Content type: Research article Published on:

  30. Abnormal toll-like receptor (TLR)3 signaling plays an indispensable role in pathogenesis of both experimental and human rheumatoid arthritis, and microRNAs (miRNAs) might orchestrate this signaling pathway. Th...

    Authors: Congshan Jiang, Wenhua Zhu, Jing Xu, Bo Wang, Weikun Hou, Rui Zhang, Nannan Zhong, Qilan Ning, Yan Han, Hongchuan Yu, Jian Sun, Liesu Meng and Shemin Lu
    Citation: Arthritis Research & Therapy 2014 16:R9
    Content type: Research article Published on:

  31. Juvenile idiopathic arthritis (JIA) is the most common rheumatological disease of childhood with a prevalence of around 1 in 1,000. Without appropriate treatment it can have devastating consequences including ...

    Authors: Sorcha Finnegan, Joanne Robson, Caitriona Scaife, Catherine McAllister, Stephen R Pennington, David S Gibson and Madeleine E Rooney
    Citation: Arthritis Research & Therapy 2014 16:R8
    Content type: Research article Published on:

  32. T cells orchestrate joint inflammation in rheumatoid arthritis (RA), yet they are difficult to study due to the small numbers of antigen-specific cells. The goal of this study was to characterize a new humaniz...

    Authors: Bo Tang, Seunghyun Kim, Sarah Hammond, David L Cullins, David D Brand, Edward F Rosloniec, John M Stuart, Arnold E Postlethwaite, Andrew H Kang and Linda K Myers
    Citation: Arthritis Research & Therapy 2014 16:R7
    Content type: Research article Published on:

  33. A recent genome-wide association study (GWAS) comprising a French cohort of systemic sclerosis (SSc) reported several non-HLA single-nucleotide polymorphisms (SNPs) showing a nominal association in the discove...

    Authors: Elena López-Isac, Lara Bossini-Castillo, Carmen P Simeon, María Victoria Egurbide, Juan José Alegre-Sancho, Jose Luis Callejas, José Andrés Roman-Ivorra, Mayka Freire, Lorenzo Beretta, Alessandro Santaniello, Paolo Airó, Claudio Lunardi, Nicolas Hunzelmann, Gabriela Riemekasten, Torsten Witte, Alexander Kreuter…
    Citation: Arthritis Research & Therapy 2014 16:R6
    Content type: Research article Published on:

  34. The aim of this study was to identify and characterize subclinical synovitis in patients with rheumatoid arthritis (RA) in clinical remission using power Doppler ultrasound (PDUS) and serum levels of biomarker...

    Authors: Julio Ramírez, Virginia Ruíz-Esquide, Isaac Pomés, Raquel Celis, Andrea Cuervo, Mª Victoria Hernández, Jaume Pomés, José L Pablos, Raimon Sanmartí and Juan D Cañete
    Citation: Arthritis Research & Therapy 2014 16:R5
    Content type: Research article Published on:

  35. Although immune dysfunction plays a role in the pathogenesis of systemic sclerosis (SSc), involvement of T helper 17 (Th17) and T regulatory (Treg) cells remains unclear. We aimed to investigate the presence o...

    Authors: Xiaoqin Yang, Ji Yang, Xiaojing Xing, Linlin Wan and Ming Li
    Citation: Arthritis Research & Therapy 2014 16:R4
    Content type: Research article Published on:

  36. Infection with Epstein-Barr virus (EBV) has been suggested to contribute to the pathogenesis of systemic lupus erythematosus (SLE). We sought to determine whether prior infection with the virus occurs more fre...

    Authors: Peter Hanlon, Alison Avenell, Lorna Aucott and Mark A Vickers
    Citation: Arthritis Research & Therapy 2014 16:R3
    Content type: Research article Published on:

  38. An adjuvanted pandemic H1N1 influenza (pH1N1) vaccine (Pandemrix®) was reported as highly immunogenic resulting in seroconversion in 77 to 94% of adults after administration of a single dose. The aim of the st...

    Authors: Meliha C Kapetanovic, Lars-Erik Kristensen, Tore Saxne, Teodora Aktas, Andreas Mörner and Pierre Geborek
    Citation: Arthritis Research & Therapy 2014 16:R2
    Content type: Research article Published on:

  39. The aim of this study was to determine the association between individual quadriceps muscle volumes and the quadriceps enthesis structures and cartilage morphology at the patellofemoral joint (PFJ).

    Authors: Hechmi Toumi, Thomas M Best, Marija Mazor, Raphael Coursier, Antonio Pinti and Eric Lespessailles
    Citation: Arthritis Research & Therapy 2014 16:R1
    Content type: Research article Published on:

  41. Arthritic diseases are characterized by the degradation of collagenous and noncollagenous extracellular matrix (ECM) components in articular cartilage. The increased expression and activity of matrix metallopr...

    Authors: Adam Williams, Julia R Smith, David Allaway, Pat Harris, Susan Liddell and Ali Mobasheri
    Citation: Arthritis Research & Therapy 2013 15:R223
    Content type: Research article Published on:

  42. Matrix metalloproteinases (MMPs) are important in tissue remodelling. Here we investigate the role of collagenase-3 (MMP-13) in antibody-induced arthritis.

    Authors: Anjana Singh, Narendiran Rajasekaran, Bettina Hartenstein, Sibylle Szabowski, Mieczyslaw Gajda, Peter Angel, Rolf Bräuer and Harald Illges
    Citation: Arthritis Research & Therapy 2013 15:R222
    Content type: Research article Published on:

  44. Our objectives were to assess the frequency and sustainability of American College of Rheumatology (ACR)/European League against Rheumatism (EULAR) and Disease Activity Score (DAS)28(4v)–C-reactive protein (CR...

    Authors: Emese Balogh, Joao Madruga Dias, Carl Orr, Ronan Mullan, Len Harty, Oliver FitzGerald, Phil Gallagher, Miriam Molloy, Eileen O’Flynn, Alexia Kelly, Patricia Minnock, Madeline O’Neill, Louise Moore, Mairead Murray, Ursula Fearon and Douglas J Veale
    Citation: Arthritis Research & Therapy 2013 15:R221
    Content type: Research article Published on:

  45. There is inconsistent association between urate transporters SLC22A11 (organic anion transporter 4 (OAT4)) and SLC22A12 (urate transporter 1 (URAT1)) and risk of gout. New Zealand (NZ) Māori and Pacific Island pe...

    Authors: Tanya J Flynn, Amanda Phipps-Green, Jade E Hollis-Moffatt, Marilyn E Merriman, Ruth Topless, Grant Montgomery, Brett Chapman, Lisa K Stamp, Nicola Dalbeth and Tony R Merriman
    Citation: Arthritis Research & Therapy 2013 15:R220
    Content type: Research article Published on:

  49. In vitro apoptosis of peripheral monocytes in rheumatoid arthritis (RA) is disturbed and influenced by cytokine production and transmembrane TNF (tmTNF) reverse signaling. The goal of the study was the analysis o...

    Authors: Undine Meusch, Maria Klingner, Christoph Baerwald, Manuela Rossol and Ulf Wagner
    Citation: Arthritis Research & Therapy 2013 15:R219
    Content type: Research article Published on:

  50. Excess C/EBP homologous protein (CHOP) expression is one feature of the unfolded protein response (UPR) to endoplasmic reticulum (ER) stress. Here, we focused on CHOP expression and function in chondrocytes.

    Authors: Matt Husa, Freyr Petursson, Martin Lotz, Robert Terkeltaub and Ru Liu-Bryan
    Citation: Arthritis Research & Therapy 2013 15:R218
    Content type: Research article Published on:
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Arthritis Research & Therapy

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