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  2. The aim of this study was to determine the prevalence of gastrointestinal and behavioural symptoms occurring before (anticipatory/associative) and after methotrexate (MTX) administration, termed MTX intoleranc...

    Authors: Maja Bulatović Ćalasan, Oscar FC van den Bosch, Marjonne CW Creemers, Martijn Custers, Antonius HM Heurkens, Jan Maarten van Woerkom and Nico M Wulffraat
    Citation: Arthritis Research & Therapy 2013 15:R217
    Content type: Research article Published on:

  3. In a subset of patients with limited cutaneous (lc) systemic sclerosis (SSc), anti-CENP-A antibodies (Ab) cross-react with a peptide (FOXE3p53-62) that presents striking homology with one of the two immunodomi...

    Authors: Federico Perosa, Elvira Favoino, Giovanna Cuomo, Liboria Digiglio, Franco Dammacco, Marcella Prete, Gabriele Valentini and Vito Racanelli
    Citation: Arthritis Research & Therapy 2013 15:R72
    Content type: Research article Published on:

  5. Studies have shown that fat lesions follow resolution of inflammation in the spine of patients with axial spondyloarthritis (SpA). Fat lesions at vertebral corners have also been shown to predict development o...

    Authors: Susanne Juhl Pedersen, Zheng Zhao, Robert GW Lambert, Stephanie Wichuk, Mikkel Østergaard, Ulrich Weber and Walter P Maksymowych
    Citation: Arthritis Research & Therapy 2013 15:R216
    Content type: Research article Published on:

  6. Complexes between cartilage oligomeric matrix protein (COMP) and the complement activation product C3b have been found in the circulation of patients with rheumatoid arthritis and systemic lupus erythematosus....

    Authors: Kaisa E Otteby, Emelie Holmquist, Tore Saxne, Dick Heinegård, Roger Hesselstrand and Anna M Blom
    Citation: Arthritis Research & Therapy 2013 15:R215
    Content type: Research article Published on:

  7. Costochondral cells may be isolated with minimal donor site morbidity and are unaffected by pathologies of the diarthrodial joints. Identification of optimal exogenous stimuli will allow abundant and robust hy...

    Authors: Meghan K Murphy, Grayson D DuRaine, A Hari Reddi, Jerry C Hu and Kyriacos A Athanasiou
    Citation: Arthritis Research & Therapy 2013 15:R214
    Content type: Research article Published on:

  8. The aims of these studies were to identify the cytokine and chemokine expression profile of nucleus pulposus (NP) cells and to determine the relationships between NP cell cytokine and chemokine production and ...

    Authors: Kate L E Phillips, Neil Chiverton, Anthony LR Michael, Ashley A Cole, Lee M Breakwell, Gail Haddock, Rowena AD Bunning, Alison K Cross and Christine L Le Maitre
    Citation: Arthritis Research & Therapy 2013 15:R213
    Content type: Research article Published on:

  9. Systemic lupus erythematosus (SLE) is characterized by impaired efferocytosis and aberrant activation of innate immunity. We asked if shedding of MER receptor tyrosine kinase (MerTK) and AXL into soluble (s) e...

    Authors: Gaetano Zizzo, Justus Guerrieri, Lindsay M Dittman, Joan T Merrill and Philip L Cohen
    Citation: Arthritis Research & Therapy 2013 15:R212
    Content type: Research article Published on:

  10. Psoriatic arthritis (PsA) is a distinctive inflammatory arthritis which may typically develop in a subgroup of individuals suffering from psoriasis. We recently described progranulin autoantibodies (PGRN-Abs) ...

    Authors: Lorenz Thurner, Marina Zaks, Klaus-Dieter Preuss, Natalie Fadle, Evi Regitz, Mei Fang Ong, Michael Pfreundschuh and Gunter Assmann
    Citation: Arthritis Research & Therapy 2013 15:R211
    Content type: Research article Published on:

  11. Osteoarthritis (OA) is a major cause of disability in the adult population. As a progressive degenerative joint disorder, OA is characterized by cartilage damage, changes in the subchondral bone, osteophyte fo...

    Authors: Guangyi Li, Jimin Yin, Junjie Gao, Tak S Cheng, Nathan J Pavlos, Changqing Zhang and Ming H Zheng
    Citation: Arthritis Research & Therapy 2013 15:223
    Content type: Review Published on:

  12. Adipokines such as adiponectin, leptin, and visfatin/nicotinamide phosphoribosyltransferase (NAMPT) have recently emerged as pro-inflammatory mediators involved in the pathophysiology of rheumatoid arthritis (...

    Authors: Magali Meyer, Jérémie Sellam, Soraya Fellahi, Salma Kotti, Jean-Philippe Bastard, Olivier Meyer, Frédéric Lioté, Tabassome Simon, Jacqueline Capeau and Francis Berenbaum
    Citation: Arthritis Research & Therapy 2013 15:R210
    Content type: Research article Published on:

  13. The FMS-related tyrosine kinase 3 ligand (Flt3L)/CD135 axis plays a fundamental role in proliferation and differentiation of dendritic cells (DCs). As DCs play an important role in rheumatoid arthritis (RA) im...

    Authors: Maria I Ramos, Samuel Garcia Perez, Saida Aarrass, Boy Helder, Pleun Broekstra, Daan M Gerlag, Kris A Reedquist, Paul Peter Tak and Maria C Lebre
    Citation: Arthritis Research & Therapy 2013 15:R209
    Content type: Research article Published on:

  14. Animal models of disease states are valuable tools for developing new treatments and investigating underlying mechanisms. They should mimic the symptoms and pathology of the disease and importantly be predicti...

    Authors: Josimari M DeSantana, Kamilla ML da Cruz and Kathleen A Sluka
    Citation: Arthritis Research & Therapy 2013 15:222
    Content type: Review Published on:

  15. Cyclophilin A (CypA) is implicated in rheumatoid arthritis (RA) pathogenesis. We studied whether a novel anti-CypA single domain antibody (sdAb) treatment would modulate the severity of the disease in two diff...

    Authors: Li Wang, Junfeng Jia, Conghua Wang, Xiaokui Ma, Chenggong Liao, Zhiguang Fu, Bin Wang, Xiangmin Yang, Ping Zhu, Yu Li and Zhinan Chen
    Citation: Arthritis Research & Therapy 2013 15:R208
    Content type: Research article Published on:

  16. Targeting the CD20 antigen has been a successful therapeutic intervention in the treatment of rheumatoid arthritis (RA). However, in some patients with an inadequate response to anti-CD20 therapy, a persistenc...

    Authors: Jacky Woo, Michel PM Vierboom, Hakju Kwon, Debra Chao, Shiming Ye, Jianmin Li, Karen Lin, Irene Tang, Nicole A Belmar, Taymar Hartman, Elia Breedveld, Vladimir Vexler, Bert A ‘t Hart, Debbie A Law and Gary C Starling
    Citation: Arthritis Research & Therapy 2013 15:R207
    Content type: Research article Published on:

  17. Patients with systemic lupus erythematosus (SLE) have persistent platelet activation and an increased risk of thrombotic events, which cannot be accounted for by traditional cardiovascular risk factors. Factor...

    Authors: Jennie Bäck, Christian Lood, Anders A Bengtsson, Kristina Nilsson Ekdahl and Bo Nilsson
    Citation: Arthritis Research & Therapy 2013 15:R206
    Content type: Research article Published on:

  18. We aimed to investigate the expression and therapeutic modulation of the receptor activator of the NF-κB ligand (RANKL) system in early-untreated rheumatoid arthritis (RA).

    Authors: Shankar Revu, Petra Neregård, Erik af Klint, Marina Korotkova and Anca Irinel Catrina
    Citation: Arthritis Research & Therapy 2013 15:R205
    Content type: Research article Published on:

  19. Our objective was to determine the interrelationships of interleukin (IL)-6 receptor inhibition with haemoglobin, acute-phase reactants and iron metabolism markers (including hepcidin) in patients with rheumat...

    Authors: John D Isaacs, Olivier Harari, Uwe Kobold, Janet S Lee and Corrado Bernasconi
    Citation: Arthritis Research & Therapy 2013 15:R204
    Content type: Research article Published on:

  20. Patients with rheumatoid arthritis (RA) are at an increased risk for cardiovascular disease (CVD). An early manifestation of CVD is endothelial dysfunction which can lead to functional and morphological vascul...

    Authors: Aamer Sandoo, Neil Chanchlani, James Hodson, Jacqueline P Smith, Karen M Douglas and George D Kitas
    Citation: Arthritis Research & Therapy 2013 15:R203
    Content type: Research article Published on:

  21. Fatigue is a disabling, multifaceted symptom that is highly prevalent and stubbornly persistent. Although fatigue is a frequent complaint among patients with fibromyalgia, it has not received the same attentio...

    Authors: Ann Vincent, Roberto P Benzo, Mary O Whipple, Samantha J McAllister, Patricia J Erwin and Leorey N Saligan
    Citation: Arthritis Research & Therapy 2013 15:221
    Content type: Review Published on:

  23. Inflammatory cytokines play a key role in the pathogenesis of joint diseases such as rheumatoid arthritis (RA). Current therapies target mainly tumor necrosis factor α (TNF-α) as this has proven benefits. Howe...

    Authors: Constanze Buhrmann, Parviz Shayan, Bharat B Aggarwal and Mehdi Shakibaei
    Citation: Arthritis Research & Therapy 2013 15:R202
    Content type: Research article Published on:

  24. In fibrosis fibroblasts are activated and overproduce collagen in a process with unknown drivers and equally unknown brakes that recently implicated a novel and surprising player, the B cell. B cells may be cr...

    Authors: Dimitrios Daoussis and Stamatis-Nick C Liossis
    Citation: Arthritis Research & Therapy 2013 15:125
    Content type: Editorial Published on:

  25. Irritable bowel syndrome (IBS) and fibromyalgia syndrome (FMS) are two common central sensitization disorders frequently associated in the same patient, and some of these patients with IBS plus FMS (IBS/FMS) c...

    Authors: Luis Rodrigo, Ignacio Blanco, Julio Bobes and Frederick J de Serres
    Citation: Arthritis Research & Therapy 2013 15:R201
    Content type: Research article Published on:

  26. Psychological stress may alter immune function by activating physiological stress pathways. Building on our previous study, in which we report that stress management training led to an altered self-reported an...

    Authors: Sabine JM de Brouwer, Henriët van Middendorp, Floris W Kraaimaat, Timothy RDJ Radstake, Irma Joosten, A Rogier T Donders, Agnes Eijsbouts, Saskia Spillekom-van Koulil, Piet LCM van Riel and Andrea WM Evers
    Citation: Arthritis Research & Therapy 2013 15:R200
    Content type: Research article Published on:

  27. It remains challenging to predict the outcomes of therapy in patients with rheumatoid arthritis (RA). The objective of this study was to identify immune response signatures that correlate with clinical treatme...

    Authors: John M Davis III, Keith L Knutson, Michael A Strausbauch, Abigail B Green, Cynthia S Crowson, Terry M Therneau, Eric L Matteson and Sherine E Gabriel
    Citation: Arthritis Research & Therapy 2013 15:R199
    Content type: Research article Published on:

  28. Increased activity of osteoclasts is responsible for bone loss and joint destruction in rheumatoid arthritis. For osteoclast development and bone resorption activity, cytoskeletal organization must be properly...

    Authors: Fumitaka Mizoguchi, Yousuke Murakami, Tetsuya Saito, Nobuyuki Miyasaka and Hitoshi Kohsaka
    Citation: Arthritis Research & Therapy 2013 15:R102
    Content type: Research article Published on:

  29. The aim of this study was to assess cancer incidence in childhood-onset systemic lupus erythematosus (SLE).

    Authors: Sasha Bernatsky, Ann E Clarke, Jeremy Labrecque, Emily von Scheven, Laura E Schanberg, Earl D Silverman, Hermine I Brunner, Kathleen A Haines, Randy Q Cron, Kathleen M O’Neil, Kiem Oen, Alan M Rosenberg, Ciarán M Duffy, Lawrence Joseph, Jennifer L Lee, Mruganka Kale…
    Citation: Arthritis Research & Therapy 2013 15:R198
    Content type: Research article Published on:

  30. MicroRNAs (miRNAs) down-regulate their target genes. The intronic miR-140, present in the WW domain containing E3 ubiquitin protein ligase 2 (WWP2) gene, decreases the expression of genes that play detrimental ro...

    Authors: Ginette Tardif, Jean-Pierre Pelletier, Hassan Fahmi, David Hum, Yue Zhang, Mohit Kapoor and Johanne Martel-Pelletier
    Citation: Arthritis Research & Therapy 2013 15:R197
    Content type: Research article Published on:

  31. Increasing evidence has suggested that linear epitopes of antineutrophil cytoplasmic antibody (ANCA) directed to myeloperoxidase (MPO) might provide clues to the pathogenesis of propylthiouracil (PTU)-induced ...

    Authors: Chen Wang, Shen-ju Gou, Peng-cheng Xu, Ming-hui Zhao and Min Chen
    Citation: Arthritis Research & Therapy 2013 15:R196
    Content type: Research article Published on:

  32. Serious infection, cardiovascular disease, and mortality are increased in rheumatoid arthritis (RA). Whether RA affects the risk for these complications after total joint arthroplasty (TJA) is unknown, we hypo...

    Authors: Kaleb Michaud, Edward V Fehringer, Kevin Garvin, James R O’Dell and Ted R Mikuls
    Citation: Arthritis Research & Therapy 2013 15:R195
    Content type: Research article Published on:

  33. Cardiovascular (CV) morbidity and mortality are increased in patients with rheumatoid arthritis (RA). Inflammation is thought to be an important factor in accelerated atherosclerosis in RA, whereas insulin res...

    Authors: Yoon Kang, Hee-Jin Park, Mi-I Kang, Hyang-Sun Lee, Sang-Won Lee, Soo-Kon Lee and Yong-Beom Park
    Citation: Arthritis Research & Therapy 2013 15:R194
    Content type: Research article Published on:

  34. Pulmonary arterial hypertension (PAH) is a major cause of mortality in systemic sclerosis (SSc). Screening guidelines for PAH recommend multiple investigations, including annual echocardiography, which togethe...

    Authors: Vivek Thakkar, Wendy Stevens, David Prior, Peter Youssef, Danny Liew, Eli Gabbay, Janet Roddy, Jennifer G Walker, Jane Zochling, Joanne Sahhar, Peter Nash, Susan Lester, Maureen Rischmueller, Susanna M Proudman and Mandana Nikpour
    Citation: Arthritis Research & Therapy 2013 15:R193
    Content type: Research article Published on:

  35. N-palmitoylethanolamine (PEA) is an endogenous fatty acid amide belonging to the family of the N-acylethanolamines (NAEs). Recently, several studies demonstrated that PEA is an importa...

    Authors: Daniela Impellizzeri, Emanuela Esposito, Rosanna Di Paola, Akbar Ahmad, Michela Campolo, Angelo Peli, Valeria Maria Morittu, Domenico Britti and Salvatore Cuzzocrea
    Citation: Arthritis Research & Therapy 2013 15:4055
    Content type: Research article Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2016 18:101

  36. Although IL-1β is believed to be crucial in the pathogenesis of osteoarthritis (OA), the IL-1β blockade brings no therapeutic benefit in human OA and results in OA aggravation in several animal models. We expl...

    Authors: Yong Seok Choi, Jin Kyun Park, Eun Ha Kang, Young-Kyun Lee, Tae Kyun Kim, Jin-Haeng Chung, Jason M Zimmerer, William E Carson III, Yeong Wook Song and Yun Jong Lee
    Citation: Arthritis Research & Therapy 2013 15:R191
    Content type: Research article Published on:

  37. The aim of this study was to evaluate, for the first time, the differences in gene expression profiles of normal and osteoarthritic (OA) subchondral bone in human subjects.

    Authors: Ching-Heng Chou, Chia-Chun Wu, I-Wen Song, Hui-Ping Chuang, Liang-Suei Lu, Jen-Huei Chang, San-Yuan Kuo, Chian-Her Lee, Jer-Yuarn Wu, Yuan-Tsong Chen, Virginia Byers Kraus and Ming Ta Michael Lee
    Citation: Arthritis Research & Therapy 2013 15:R190
    Content type: Research article Published on:

  38. Increased expression of the proinflammatory cytokine TNF-α in intervertebral discs (IVDs) leads to inflammation, which results in progressive IVD degeneration. We have previously reported that activation of Wn...

    Authors: Akihiko Hiyama, Katsuya Yokoyama, Tadashi Nukaga, Daisuke Sakai and Joji Mochida
    Citation: Arthritis Research & Therapy 2013 15:R189
    Content type: Research article Published on:

  39. The purpose of this study was to evaluate the presence and levels of interferon-gamma inducible protein-10 (IP-10) in the plasma and skin of pediatric localized scleroderma (LS) patients compared to those of h...

    Authors: Kelsey E Magee, Christina E Kelsey, Katherine L Kurzinski, Jonhan Ho, Logan R Mlakar, Carol A Feghali-Bostwick and Kathryn S Torok
    Citation: Arthritis Research & Therapy 2013 15:R188
    Content type: Research article Published on:

  40. It is well known that neutrophils play very important roles in the development of rheumatoid arthritis (RA) and interleukin (IL)-8 is a critical chemokine in promoting neutrophil migration. We previously showe...

    Authors: Xianjin Zhu, Lianbo Xiao, Rongfen Huo, Jie Zhang, Jinpiao Lin, Jun Xie, Songtao Sun, Yong He, Yue Sun, Zhou Zhou, Baihua Shen and Ningli Li
    Citation: Arthritis Research & Therapy 2013 15:R187
    Content type: Research article Published on:

  41. Clinical studies suggest a direct influence of periodontal disease (PD) on serum inflammatory markers and disease assessment of patients with established rheumatoid arthritis (RA). However, the influence of PD...

    Authors: Julie Teresa Marchesan, Elizabeth Ann Gerow, Riley Schaff, Andrei Dan Taut, Seung-Yun Shin, James Sugai, David Brand, Aaron Burberry, Julie Jorns, Steven Karl Lundy, Gabriel Nuñez, David A Fox and William V Giannobile
    Citation: Arthritis Research & Therapy 2013 15:R186
    Content type: Research article Published on:

  42. The long-term safety and therapeutic response of sodium oxybate (SXB) in fibromyalgia syndrome (FM) patients were assessed for a combined period of up to 1 year in a prospective, multicenter, open-label, exten...

    Authors: Michael Spaeth, Cayetano Alegre, Serge Perrot, Youyu Grace Wang, Diane R Guinta, Sarah Alvarez-Horine and Irwin Jon Russell
    Citation: Arthritis Research & Therapy 2013 15:R185
    Content type: Research article Published on:

  43. We have previously found an increased mast cell density in tendon biopsies from patients with patellar tendinopathy compared to controls. This study examined the influence of mast cells on basic tenocyte funct...

    Authors: Hayedeh Behzad, Aishwariya Sharma, Rouhollah Mousavizadeh, Alex Lu and Alex Scott
    Citation: Arthritis Research & Therapy 2013 15:R184
    Content type: Research article Published on:

  44. Natural killer (NK) and natural killer T (NKT) cells provide a first line of defense against infection. However, these cells have not yet been examined in patients with Lyme arthritis, a late disease manifesta...

    Authors: Kia Katchar, Elise E Drouin and Allen C Steere
    Citation: Arthritis Research & Therapy 2013 15:R183
    Content type: Research article Published on:

  45. Comparative data on synovial cell infiltrate and cytokine levels in anti citrullinated peptide/protein antibody (ACPA)-positive and ACPA negative rheumatoid arthritis (RA) patients are scarce. Our aim was to a...

    Authors: José A Gómez-Puerta, Raquel Celis, M Victoria Hernández, Virginia Ruiz-Esquide, Julio Ramírez, Isabel Haro, Juan D Cañete and Raimon Sanmartí
    Citation: Arthritis Research & Therapy 2013 15:R182
    Content type: Research article Published on:

  46. Gouty arthritis (gout) is primarily cared for in ambulatory care settings. Although the prevalence of gout in the US is thought to be increasing, there have been few data on this as well as temporal changes in...

    Authors: Eswar Krishnan and Linjun Chen
    Citation: Arthritis Research & Therapy 2013 15:R181
    Content type: Research article Published on:

  47. The development of effective treatments for osteoarthritis (OA) has been hampered by a poor understanding of OA at the cellular and molecular levels. Emerging as a disease of the 'whole joint’, the importance ...

    Authors: John Paul Wanner, Roopashree Subbaiah, Yelenna Skomorovska-Prokvolit, Yousef Shishani, Eric Boilard, Sujatha Mohan, Robert Gillespie, Masaru Miyagi and Reuben Gobezie
    Citation: Arthritis Research & Therapy 2013 15:R180
    Content type: Research article Published on:

  49. Osteoporosis of the axial skeleton is a known complication of ankylosing spondylitis (AS), but bone loss affecting the peripheral skeleton is less studied. This study on volumetric bone mineral density (vBMD) ...

    Authors: Eva Klingberg, Mattias Lorentzon, Jan Göthlin, Dan Mellström, Mats Geijer, Claes Ohlsson, Elizabeth J Atkinson, Sundeep Khosla, Hans Carlsten and Helena Forsblad-d’Elia
    Citation: Arthritis Research & Therapy 2013 15:R179
    Content type: Research article Published on:

  50. Osteoarthritis (OA) is associated with the metabolic syndrome, however the underlying mechanisms remain unclear. We investigated whether low density lipoprotein (LDL) accumulation leads to increased LDL uptake...

    Authors: Wouter de Munter, Arjen B Blom, Monique M Helsen, Birgitte Walgreen, Peter M van der Kraan, Leo AB Joosten, Wim B van den Berg and Peter LEM van Lent
    Citation: Arthritis Research & Therapy 2013 15:R178
    Content type: Research article Published on:
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Arthritis Research & Therapy

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