Goldring MB, Goldring SR: Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis. Ann N Y Acad Sci. 2010, 1192: 230-237. 10.1111/j.1749-6632.2009.05240.x.
Article
CAS
PubMed
Google Scholar
Loeser RF: Molecular mechanisms of cartilage destruction: mechanics, inflammatory mediators, and aging collide. Arthritis Rheum. 2006, 54: 1357-1360. 10.1002/art.21813.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP, Fahmi H: Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol. 2011, 7: 33-42. 10.1038/nrrheum.2010.196.
Article
CAS
PubMed
Google Scholar
Daheshia M, Yao JQ: The interleukin 1beta pathway in the pathogenesis of osteoarthritis. J Rheumatol. 2008, 35: 2306-2312. 10.3899/jrheum.080346.
Article
CAS
PubMed
Google Scholar
Clements KM, Price JS, Chambers MG, Visco DM, Poole AR, Mason RM: Gene deletion of either interleukin-1beta, interleukin-1beta-converting enzyme, inducible nitric oxide synthase, or stromelysin 1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament and partial medial meniscectomy. Arthritis Rheum. 2003, 48: 3452-3463. 10.1002/art.11355.
Article
CAS
PubMed
Google Scholar
Blom AB, Van Lent PL, van der Kraan PM, Joosten LA, van den Berg WB: Differential role for interleukin-1 in induced instability osteoarthritis and spontaneously occurring osteoarthritis in mice [abstract]. Osteoarthritis Cartilage. 2004, 12: S90-
Article
Google Scholar
de Hooge AS, van de Loo FA, Bennink MB, Arntz OJ, de Hooge P, van den Berg WB: Male IL-6 gene knock out mice developed more advanced osteoarthritis upon aging. Osteoarthritis Cartilage. 2005, 13: 66-73. 10.1016/j.joca.2004.09.011.
Article
PubMed
Google Scholar
Davey GM, Heath WR, Starr R: SOCS1: a potent and multifaceted regulator of cytokines and cell-mediated inflammation. Tissue Antigens. 2006, 67: 1-9.
Article
CAS
PubMed
Google Scholar
Yoshimura A, Naka T, Kubo M: SOCS proteins, cytokine signalling and immune regulation. Nat Rev Immunol. 2007, 7: 454-465. 10.1038/nri2093.
Article
CAS
PubMed
Google Scholar
Diao Y, Wang X, Wu Z: SOCS1, SOCS3, and PIAS1 promote myogenic differentiation by inhibiting the leukemia inhibitory factor-induced JAK1/STAT1/STAT3 pathway. Mol Cell Biol. 2009, 29: 5084-5093. 10.1128/MCB.00267-09.
Article
PubMed Central
CAS
PubMed
Google Scholar
Song MM, Shuai K: The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities. J Biol Chem. 1998, 273: 35056-35062. 10.1074/jbc.273.52.35056.
Article
CAS
PubMed
Google Scholar
Wong PK, Egan PJ, Croker BA, O'Donnell K, Sims NA, Drake S, Kiu H, McManus EJ, Alexander WS, Roberts AW, Wicks IP: SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis. J Clin Invest. 2006, 116: 1571-1581. 10.1172/JCI25660.
Article
PubMed Central
CAS
PubMed
Google Scholar
Deon D, Ahmed S, Tai K, Scaletta N, Herrero C, Lee IH, Krause A, Ivashkiv LB: Cross-talk between IL-1 and IL-6 signaling pathways in rheumatoid arthritis synovial fibroblasts. J Immunol. 2001, 167: 5395-5403.
Article
CAS
PubMed
Google Scholar
Smeets RL, Veenbergen S, Arntz OJ, Bennink MB, Joosten LA, van den Berg WB, van de Loo FA: A novel role for suppressor of cytokine signaling 3 in cartilage destruction via induction of chondrocyte desensitization toward insulin-like growth factor. Arthritis Rheum. 2006, 54: 1518-1528. 10.1002/art.21752.
Article
CAS
PubMed
Google Scholar
Chong MM, Metcalf D, Jamieson E, Alexander WS, Kay TW: Suppressor of cytokine signaling-1 in T cells and macrophages is critical for preventing lethal inflammation. Blood. 2005, 106: 1668-1675. 10.1182/blood-2004-08-3049.
Article
CAS
PubMed
Google Scholar
Strebovsky J, Walker P, Lang R, Dalpke AH: Suppressor of cytokine signaling 1 (SOCS1) limits NFkappaB signaling by decreasing p65 stability within the cell nucleus. FASEB J. 2011, 25: 863-874. 10.1096/fj.10-170597.
Article
CAS
PubMed
Google Scholar
Mitchell T, Sugden B: Stimulation of NF-kappa B-mediated transcription by mutant derivatives of the latent membrane protein of Epstein-Barr virus. J Virol. 1995, 69: 2968-2976.
PubMed Central
CAS
PubMed
Google Scholar
Kang EH, Lee YJ, Kim TK, Chang CB, Chung JH, Shin K, Lee EY, Lee EB, Song YW: Adiponectin is a potential catabolic mediator in osteoarthritis cartilage. Arthritis Res Ther. 2010, 12: R231-10.1186/ar3218.
Article
PubMed Central
CAS
PubMed
Google Scholar
Pritzker KP, Gay S, Jimenez SA, Ostergaard K, Pelletier JP, Revell PA, Salter D, van den Berg WB: Osteoarthritis cartilage histopathology: grading and staging. Osteoarthritis Cartilage. 2006, 14: 13-29. 10.1016/j.joca.2005.07.014.
Article
CAS
PubMed
Google Scholar
Koelsche C, Strebovsky J, Baetz A, Dalpke AH: Structural and functional analysis of a nuclear localization signal in SOCS1. Mol Immunol. 2009, 46: 2474-2480. 10.1016/j.molimm.2009.05.020.
Article
CAS
PubMed
Google Scholar
Gebauer M, Saas J, Sohler F, Haag J, Söder S, Pieper M, Bartnik E, Beninga J, Zimmer R, Aigner T: Comparison of the chondrosarcoma cell line SW1353 with primary human adult articular chondrocytes with regard to their gene expression profile and reactivity to IL-1beta. Osteoarthritis Cartilage. 2005, 13: 697-708. 10.1016/j.joca.2005.04.004.
Article
CAS
PubMed
Google Scholar
http://rsbweb.nih.gov/ij/,
Hoffmann A, Levchenko A, Scott ML, Baltimore D: The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science. 2002, 298: 1241-1245. 10.1126/science.1071914.
Article
CAS
PubMed
Google Scholar
Frobøse H, Rønn SG, Heding PE, Mendoza H, Cohen P, Mandrup-Poulsen T, Billestrup N: Suppressor of cytokine signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6/TAK1 complex. Mol Endocrinol. 2006, 20: 1587-1596.
Article
PubMed
Google Scholar
Chevalier X, Goupille P, Beaulieu AD, Burch FX, Bensen WG, Conrozier T, Loeuille D, Kivitz AJ, Silver D, Appleton BE: Intraarticular injection of anakinra in osteoarthritis of the knee: a multicenter, randomized, double-blind, placebo-controlled study. Arthritis Rheum. 2009, 61: 344-352. 10.1002/art.24096.
Article
CAS
PubMed
Google Scholar
Cohen SB, Proudman S, Kivitz AJ, Burch FX, Donohue JP, Burstein D, Sun YN, Banfield C, Vincent MS, Ni L, Zack DJ: A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL-1R1) in patients with osteoarthritis of the knee. Arthritis Res Ther. 2011, 13: R125-10.1186/ar3430.
Article
PubMed Central
CAS
PubMed
Google Scholar
Steyn FJ, Anderson GM, Grattan DR: Hormonal regulation of suppressors of cytokine signaling (SOCS) messenger ribonucleic acid in the arcuate nucleus during late pregnancy. Endocrinology. 2008, 149: 3206-3214. 10.1210/en.2007-1623.
Article
CAS
PubMed
Google Scholar
Su L, Sun Y, Ma F, Lü P, Huang H, Zhou J: Progesterone inhibits Toll-like receptor 4-mediated innate immune response in macrophages by suppressing NF-kappaB activation and enhancing SOCS1 expression. Immunol Lett. 2009, 125: 151-155. 10.1016/j.imlet.2009.07.003.
Article
CAS
PubMed
Google Scholar
Fan Z, Bau B, Yang H, Aigner T: IL-1beta induction of IL-6 and LIF in normal articular human chondrocytes involves the ERK, p38 and NFkappaB signaling pathways. Cytokine. 2004, 28: 17-24. 10.1016/j.cyto.2004.06.003.
Article
CAS
PubMed
Google Scholar
Fan Z, Bau B, Yang H, Soeder S, Aigner T: Freshly isolated osteoarthritic chondrocytes are catabolically more active than normal chondrocytes, but less responsive to catabolic stimulation with interleukin-1beta. Arthritis Rheum. 2005, 52: 136-143. 10.1002/art.20725.
Article
CAS
PubMed
Google Scholar
de Andrés MC, Imagawa K, Hashimoto K, Gonzalez A, Goldring MB, Roach HI, Oreffo RO: Suppressors of cytokine signalling (SOCS) are reduced in osteoarthritis. Biochem Biophys Res Commun. 2011, 407: 54-59. 10.1016/j.bbrc.2011.02.101.
Article
PubMed Central
PubMed
Google Scholar
van de Loo FA, Veenbergen S, van den Brand B, Bennink MB, Blaney-Davidson E, Arntz OJ, van Beuningen HM, van der Kraan PM, van den Berg WB: Enhanced suppressor of cytokine signaling (SOCS)-3 in arthritic cartilage dysregulates human chondrocyte function. Arthritis Rheum. 2012, 64: 3313-3323. 10.1002/art.34529.
Article
CAS
PubMed
Google Scholar
van Buul GM, Villafuertes E, Bos PK, Waarsing JH, Kops N, Narcisi R, Weinans H, Verhaar JA, Bernsen MR, van Osch GJ: Mesenchymal stem cells secrete factors that inhibit inflammatory processes in short-term osteoarthritic synovium and cartilage explant culture. Osteoarthritis Cartilage. 2012, 20: 1186-1196. 10.1016/j.joca.2012.06.003.
Article
CAS
PubMed
Google Scholar
Fujimoto A, Akifusa S, Hirofuji T, Yamashita Y: Involvement of suppressor of cytokine signaling-1 in globular adiponectin-induced granulocyte colony-stimulating factor in RAW 264 cell. Mol Immunol. 2011, 48: 2052-2058. 10.1016/j.molimm.2011.06.440.
Article
CAS
PubMed
Google Scholar
Kinjyo I, Hanada T, Inagaki-Ohara K, Mori H, Aki D, Ohishi M, Yoshida H, Kubo M, Yoshimura A: SOCS1/JAB is a negative regulator of LPS-induced macrophage activation. Immunity. 2002, 17: 583-591. 10.1016/S1074-7613(02)00446-6.
Article
CAS
PubMed
Google Scholar
Ryo A, Suizu F, Yoshida Y, Perrem K, Liou YC, Wulf G, Rottapel R, Yamaoka S, Lu KP: Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA. Mol Cell. 2003, 12: 1413-1426. 10.1016/S1097-2765(03)00490-8.
Article
CAS
PubMed
Google Scholar
Mansell A, Smith R, Doyle SL, Gray P, Fenner JE, Crack PJ, Nicholson SE, Hilton DJ, O'Neill LA, Hertzog PJ: Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation. Nat Immunol. 2006, 7: 148-155.
Article
CAS
PubMed
Google Scholar
Baetz A, Koelsche C, Strebovsky J, Heeg K, Dalpke AH: Identification of a nuclear localization signal in suppressor of cytokine signaling 1. FASEB J. 2008, 22: 4296-4305. 10.1096/fj.08-116079.
Article
CAS
PubMed
Google Scholar
Klatt AR, Klinger G, Neumüller O, Eidenmüller B, Wagner I, Achenbach T, Aigner T, Bartnik E: TAK1 downregulation reduces IL-1beta induced expression of MMP13, MMP1 and TNF-alpha. Biomed Pharmacother. 2006, 60: 55-61. 10.1016/j.biopha.2005.08.007.
Article
CAS
PubMed
Google Scholar
Goldring MB: The role of the chondrocyte in osteoarthritis. Arthritis Rheum. 2000, 43: 1916-1926. 10.1002/1529-0131(200009)43:9<1916::AID-ANR2>3.0.CO;2-I.
Article
CAS
PubMed
Google Scholar
Marine JC, Topham DJ, McKay C, Wang D, Parganas E, Stravopodis D, Yoshimura A, Ihle JN: SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality. Cell. 1999, 98: 609-616. 10.1016/S0092-8674(00)80048-3.
Article
CAS
PubMed
Google Scholar