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  1. The aim of this study was to characterize interleukin 17 (IL-17) and interleukin 22 (IL-22) producing cells in peripheral blood (PB), skin, synovial fluid (SF) and synovial tissue (ST) in patients with psorias...

    Authors: Helen Benham, Paul Norris, Jane Goodall, Mihir D Wechalekar, Oliver FitzGerald, Agnes Szentpetery, Malcolm Smith, Ranjeny Thomas and Hill Gaston
    Citation: Arthritis Research & Therapy 2013 15:R136
    Content type: Research article Published on:

  2. Evidences of biologics-free disease control after discontinuing adalimumab (ADA) in rheumatoid arthritis (RA) patients in clinical practice have not been sufficiently investigated. Purpose of this study is to ...

    Authors: Shintaro Hirata, Kazuyoshi Saito, Satoshi Kubo, Shunsuke Fukuyo, Yasushi Mizuno, Shigeru Iwata, Masao Nawata, Norifumi Sawamukai, Kazuhisa Nakano, Kunihiro Yamaoka and Yoshiya Tanaka
    Citation: Arthritis Research & Therapy 2013 15:R135
    Content type: Research article Published on:

  3. In cross-sectional studies, patients with rheumatoid arthritis (RA) have higher coronary artery calcium (CAC) than controls. However, their rate of progression of CAC and the predictors of CAC progression have...

    Authors: Cecilia P Chung, Jon T Giles, Richard A Kronmal, Wendy S Post, Allan C Gelber, Michelle Petri, Moyses Szklo, Robert Detrano, Matthew J Budoff, Roger S Blumenthal, Pamela Ouyang, David Bush and Joan M Bathon
    Citation: Arthritis Research & Therapy 2013 15:R134
    Content type: Research article Published on:

  4. Most research in gout has concentrated on the proinflammatory mechanisms toexplain the inflammation that is generated when leucocytes are in contact withmonosodium urate crystals. However, the episodic nature ...

    Authors: Alexander So
    Citation: Arthritis Research & Therapy 2013 15:118
    Content type: Editorial Published on:

  5. Eosinophilic granulomatosis with polyangiitis (EGPA) is part of antineutrophil cytoplasmic antibodies (ANCAs)-associated vasculitides. In EGPA small-vessel vasculitis is associated with eosinophilia and asthma...

    Authors: Jens Thiel, Fabian Hässler, Ulrich Salzer, Reinhard E Voll and Nils Venhoff
    Citation: Arthritis Research & Therapy 2013 15:R133
    Content type: Research article Published on:

  6. Oncostatin M (OSM) has been implicated in the pathophysiology of rheumatoid arthritis (RA) through its effect on inflammation and joint damage. GSK315234 is a humanised anti-OSM Immunoglobulin G1 (IgG1) monocl...

    Authors: Ernest H Choy, Marina Bendit, Dana McAleer, Feng Liu, Maria Feeney, Sara Brett, Stefano Zamuner, Andrea Campanile and John Toso
    Citation: Arthritis Research & Therapy 2013 15:R132
    Content type: Research article Published on:

  7. The aetiopathogenesis of juvenile dermatomyositis (JDM) remains poorly understood. In particular the contribution of monocytes or macrophages, which are frequently observed to be an infiltrate within muscle ti...

    Authors: Kiran Nistala, Hemlata Varsani, Helmut Wittkowski, Thomas Vogl, Petra Krol, Vanita Shah, Kamel Mamchaoui, Paul A Brogan, Johannes Roth and Lucy R Wedderburn
    Citation: Arthritis Research & Therapy 2013 15:R131
    Content type: Research article Published on:

  8. The aim of this study was to investigate vulnerability and long-term influence of traumatic stress caused by the Great East Japan Disaster which occurred on March 11, 2011, in patients with fibromyalgia, which...

    Authors: Chie Usui, Kotaro Hatta, Satoko Aratani, Naoko Yagishita, Kenya Nishioka, Satoko Okamura, Kenji Itoh, Yoshihisa Yamano, Hiroyuki Nakamura, Nozomu Asukai, Toshihiro Nakajima and Kusuki Nishioka
    Citation: Arthritis Research & Therapy 2013 15:R130
    Content type: Research article Published on:

  9. Treatment of chondral injuries remains a major issue despite the many advances made in cartilage repair techniques. Although it has been postulated that the use of marrow stimulation in combination with cell-b...

    Authors: Hui Yin Nam, Puvanan Karunanithi, Wagner Cheng Poh Loo, Sangeetha Vasudevaraj Naveen, Hui Cheng Chen, Paisal Hussin, Lucy Chan and Tunku Kamarul
    Citation: Arthritis Research & Therapy 2013 15:R129
    Content type: Research article Published on:

  10. Whether adiponectin levels associate with atherogenesis in RA is uncertain. We examined the independent relationships of total and high molecular weight (HMW) adiponectin concentrations with cardiometabolic ri...

    Authors: Patrick H Dessein, Angela J Woodiwiss, Gavin R Norton, Linda Tsang and Ahmed Solomon
    Citation: Arthritis Research & Therapy 2013 15:R128
    Content type: Research article Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2014 16:503

  11. Articular chondrocytes undergo an obvious phenotypic change when cultured in monolayers. During this change, or dedifferentiation, the expression of type I and type III procollagen is induced where normal chon...

    Authors: Nobuho Tanaka, Yasuko Ikeda, Tetsuo Yamaguchi, Hiroshi Furukawa, Hiroyuki Mitomi, Takumi Nakagawa, Shigeto Tohma and Naoshi Fukui
    Citation: Arthritis Research & Therapy 2013 15:R127
    Content type: Research article Published on:

  12. Osteoarthritis is, at least in a subset of patients, associated with hypertrophic differentiation of articular chondrocytes. Recently, we identified the bone morphogenetic protein (BMP) and wingless-type MMTV ...

    Authors: Jeroen CH Leijten, Steffan D Bos, Ellie BM Landman, Nicole Georgi, Holger Jahr, Ingrid Meulenbelt, Janine N Post, Clemens A van Blitterswijk and Marcel Karperien
    Citation: Arthritis Research & Therapy 2013 15:R126
    Content type: Research article Published on:

  13. Patients with chronic inflammatory diseases have increased bone loss and bone fragility and are at increased risk of fracture. Although anti-resorptive drugs are effective in blocking inflammation-induced bone...

    Authors: Massimo Marenzana, Alex Vugler, Adrian Moore and Martyn Robinson
    Citation: Arthritis Research & Therapy 2013 15:R125
    Content type: Research article Published on:

  14. To prospectively evaluate quantitative assessment of fluorescence optical imaging (FOI) for differentiation of synovitic from non-synovitic joints in patients suffering from rheumatoid arthritis (RA).

    Authors: Valentin S Schäfer, Wolfgang Hartung, Patrick Hoffstetter, Jörn Berger, Christian Stroszczynski, Martina Müller, Martin Fleck and Boris Ehrenstein
    Citation: Arthritis Research & Therapy 2013 15:R124
    Content type: Research article Published on:

  15. Gout is a common arthritis that occurs particularly in patients who frequently have associated comorbidities that limit the use of conventional therapies. The main mechanism of crystal-induced inflammation is ...

    Authors: Sébastien Ottaviani, Anna Moltó, Hang-Korng Ea, Séverine Neveu, Ghislaine Gill, Lauren Brunier, Elisabeth Palazzo, Olivier Meyer, Pascal Richette, Thomas Bardin, Yannick Allanore, Frédéric Lioté, Maxime Dougados and Philippe Dieudé
    Citation: Arthritis Research & Therapy 2013 15:R123
    Content type: Research article Published on:

  16. Notochordal cells (NCs) pattern aneural and avascular intervertebral discs (IVDs), and their disappearance, is associated with onset of IVD degeneration. This study induced and characterized the maturation of ...

    Authors: Devina Purmessur, Clare C Guterl, Samuel K Cho, Marisa C Cornejo, Ying W Lam, Bryan A Ballif, Damien M Laudier and James C Iatridis
    Citation: Arthritis Research & Therapy 2013 15:R122
    Content type: Research article Published on:

  17. Despite many advances in our understanding of the molecular basis of disc degeneration, there remains a paucity of preclinical models which can be used to study the biochemical and molecular events that drive ...

    Authors: Dessislava Z Markova, Christopher K Kepler, Sankar Addya, Hallie B Murray, Alexander R Vaccaro, Irving M Shapiro, D Greg Anderson, Todd J Albert and Makarand V Risbud
    Citation: Arthritis Research & Therapy 2013 15:R121
    Content type: Research article Published on:

  18. Recent advances suggest that the cellular redox state may play a significantrole in the progression of fibrosis in systemic sclerosis (SSc). Another,and as yet poorly accounted for, feature of SSc is its overl...

    Authors: Gianluca Bagnato, Alessandra Bitto, Natasha Irrera, Gabriele Pizzino, Donatella Sangari, Maurizio Cinquegrani, William Neal Roberts, Marco Atteritano, Domenica Altavilla, Francesco Squadrito, Gianfilippo Bagnato and Antonino Saitta
    Citation: Arthritis Research & Therapy 2013 15:R120
    Content type: Research article Published on:

    The Erratum to this article has been published in Arthritis Research & Therapy 2014 16:406

  19. The repair capability of traumatized articular cartilage is highly limited so that joint injuries often lead to osteoarthritis. Migratory chondrogenic progenitor cells (CPC) might represent a target cell popul...

    Authors: Helga Joos, Anja Wildner, Cathrin Hogrefe, Heiko Reichel and Rolf E Brenner
    Citation: Arthritis Research & Therapy 2013 15:R119
    Content type: Research article Published on:

  20. Analyses of large clinical datasets from early arthritis cohorts permit the development of algorithms that may be used for outcome prediction in individual patients. The value added by routine use of musculosk...

    Authors: Arthur G Pratt, Alice R Lorenzi, Gill Wilson, Philip N Platt and John D Isaacs
    Citation: Arthritis Research & Therapy 2013 15:R118
    Content type: Research article Published on:

  21. Low testosterone levels in men are associated with fatigue, limited physical performance and reduced health-related quality of life (HRQOL); however, this relationship has never been assessed in patients with ...

    Authors: Janneke Tuin, Jan-Stephan F Sanders, Birgit M Buhl, André P van Beek and Coen A Stegeman
    Citation: Arthritis Research & Therapy 2013 15:R117
    Content type: Research article Published on:

  22. Inflammation of the synovial membrane plays an important role in the pathophysiology of osteoarthritis (OA). The synovial tissue of patients with initial OA is characterized by infiltration of mononuclear cell...

    Authors: Ana Carolina Araruna Alves, Rodolfo de Paula Vieira, Ernesto Cesar Pinto Leal-Junior, Solange Almeida dos Santos, Ana Paula Ligeiro, Regiane Albertini, Jose Antonio Silva Junior and Paulo de Tarso Camillo de Carvalho
    Citation: Arthritis Research & Therapy 2013 15:R116
    Content type: Research article Published on:

  23. The pathogenesis of osteoarthritis (OA) is characterized by the production of high amounts of nitric oxide (NO), as a consequence of up-regulation of chondrocyte-inducible nitric oxide synthase (iNOS) induced by ...

    Authors: María C de Andrés, Emilia Maneiro, Miguel A Martín, Joaquín Arenas and Francisco J Blanco
    Citation: Arthritis Research & Therapy 2013 15:R115
    Content type: Research article Published on:

  24. TNF Receptor-Associated Factor 5 (TRAF5) has been shown to be associated with autoimmune disease. The current study sought to investigate the potential association of TRAF5 with acute anterior uveitis (AAU) and p...

    Authors: Qin Xiang, Lu Chen, Jing Fang, Shengping Hou, Lin Wei, Lin Bai, Yunjia Liu, Yan Zhou, Aize Kijlstra and Peizeng Yang
    Citation: Arthritis Research & Therapy 2013 15:R113
    Content type: Research article Published on:

  25. Bone marrow lesion (BML) size may be an important imaging biomarker for osteoarthritis-related clinical trials and reducing BML size may be an important therapeutic goal. However, data on the interrelationship...

    Authors: Jeffrey B Driban, Lori Lyn Price, Grace H Lo, Jincheng Pang, David J Hunter, Eric Miller, Robert J Ward, Charles B Eaton, John A Lynch and Timothy E McAlindon
    Citation: Arthritis Research & Therapy 2013 15:R112
    Content type: Research article Published on:

  26. We have previously reported that bacterial toxins, especially endotoxins such as lipopolysaccharides (LPS), might be important causative agents in the pathogenesis of rheumatoid arthritis (RA) in an in vitro mode...

    Authors: Wolfgang Lorenz, Constanze Buhrmann, Ali Mobasheri, Cora Lueders and Mehdi Shakibaei
    Citation: Arthritis Research & Therapy 2013 15:R111
    Content type: Research article Published on:

  27. Rheumatoid arthritis (RA), a chronic inflammatory disease, is associated with insulin resistance. Experimental evidence indicates that the relationship between insulin resistance and inflammation is bidirectio...

    Authors: Michelle J Ormseth, Annette M Oeser, Andrew Cunningham, Aihua Bian, Ayumi Shintani, Joseph Solus, S Bobo Tanner and C Michael Stein
    Citation: Arthritis Research & Therapy 2013 15:R110
    Content type: Research article Published on:

  28. Therapeutic vaccination with antigen-specific tolerogenic dendritic cells (tolDC) might become a future option of individualized therapy for patients with autoimmune diseases. In this study, we tested the poss...

    Authors: Roman Volchenkov, Johan G Brun, Roland Jonsson and Silke Appel
    Citation: Arthritis Research & Therapy 2013 15:R114
    Content type: Research article Published on:

  29. Prior studies have demonstrated an increased frequency of antibodies to Porphyromonas gingivalis (Pg), a leading agent of periodontal disease, in rheumatoid arthritis (RA) patients. However, these patients genera...

    Authors: Sheila L Arvikar, Deborah S Collier, Mark C Fisher, Sebastian Unizony, George L Cohen, Gail McHugh, Toshihisa Kawai, Klemen Strle and Allen C Steere
    Citation: Arthritis Research & Therapy 2013 15:R109
    Content type: Research article Published on:

  30. Monocytic cells play a central role in the aetiology of rheumatoid arthritis, and manipulation of the activation of these cells is an approach currently under investigation to discover new therapies for this a...

    Authors: Richa K Dave, Amy J Naylor, Stephen P Young, Rachel Bayley, Debbie L Hardie, Oliver Haworth, David A Rider, Andrew D Cook, Christopher D Buckley and Stuart Kellie
    Citation: Arthritis Research & Therapy 2013 15:R108
    Content type: Research article Published on:

  31. Patients with rheumatoid arthritis (RA) are at an increased risk for cardiovascular disease (CVD). One of the earliest manifestations of CVD is endothelial dysfunction (ED), which can lead to functional and mo...

    Authors: Aamer Sandoo, James Hodson, Karen M Douglas, Jacqueline P Smith and George D Kitas
    Citation: Arthritis Research & Therapy 2013 15:R107
    Content type: Research article Published on:

  32. The aim of this analysis was to describe comprehensively the cross-sectional and longitudinal patterns of analgesic and nutraceutical medication use for knee osteoarthritis (OA) in a contemporary US cohort and...

    Authors: Sarah R Kingsbury, Elizabeth MA Hensor, Ceara AE Walsh, Marc C Hochberg and Philip G Conaghan
    Citation: Arthritis Research & Therapy 2013 15:R106
    Content type: Research article Published on:

  33. We studied the effect of rosuvastatin on endothelial and macrovascular function, cardiovascular risk factors and the complement pathway in patients with systemic sclerosis (SSc).

    Authors: Orsolya Timár, Zoltán Szekanecz, György Kerekes, Judit Végh, Anna V Oláh, Gábor Nagy, Zoltán Csiki, Katalin Dankó, Szilvia Szamosi, Ágnes Németh, Pál Soltész and Gabriella Szücs
    Citation: Arthritis Research & Therapy 2013 15:R105
    Content type: Research article Published on:

  34. Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are systemic inflammatory disorders that include granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), Churg-Strauss s...

    Authors: Alexandre Wagner Silva de Souza, Johanna Westra, Johan Bijzet, Pieter C Limburg, Coen A Stegeman, Marc Bijl and Cees GM Kallenberg
    Citation: Arthritis Research & Therapy 2013 15:R104
    Content type: Research article Published on:

  35. Calcium-containing (CaC) crystals, including basic calcium phosphate (BCP) and calcium pyrophosphate dihydrate (CPP), are associated with destructive forms of osteoarthritis (OA). We assessed their distributio...

    Authors: Christelle Nguyen, Dominique Bazin, Michel Daudon, Aurore Chatron-Colliet, Didier Hannouche, Arnaud Bianchi, Dominique Côme, Alexander So, Nathalie Busso, Frédéric Lioté and Hang-Korng Ea
    Citation: Arthritis Research & Therapy 2013 15:R103
    Content type: Research article Published on:

  36. Gout is the most prevalent arthritis and significantly impacts on function and quality of life. Given that gout associates with disabling comorbid conditions, it is not clear whether such a complex of diseases...

    Authors: Carlo Alberto Scirè, Maria Manara, Marco Amedeo Cimmino, Marcello Govoni, Fausto Salaffi, Leonardo Punzi, Maria Cristina Monti, Greta Carrara, Carlomaurizio Montecucco, Marco Matucci-Cerinic and Giovanni Minisola
    Citation: Arthritis Research & Therapy 2013 15:R101
    Content type: Research article Published on:

  37. The attainment of remission has become an important end point for clinical trials in juvenile idiopathic arthritis (JIA), although we do not yet have a full understanding of what remission is at the cell and m...

    Authors: Kaiyu Jiang, Mark Barton Frank, Yanmin Chen, Jeanette Osban and James N Jarvis
    Citation: Arthritis Research & Therapy 2013 15:R100
    Content type: Research article Published on:

  38. The aim of this study was to investigate the construct validity and test-retest reliability of the International Physical Activity Questionnaire (IPAQ; long form) and the Short QUestionnaire to Assess Health-e...

    Authors: Suzanne Arends, Marianne Hofman, Yvo PT Kamsma, Eveline van der Veer, Pieternella M Houtman, Cees GM Kallenberg, Anneke Spoorenberg and Elisabeth Brouwer
    Citation: Arthritis Research & Therapy 2013 15:R99
    Content type: Research article Published on:

  39. Age is an important factor in the development of osteoarthritis. Microarray studies provide insight into cartilage aging but do not reveal the full transcriptomic phenotype of chondrocytes such as small noncod...

    Authors: Mandy Jayne Peffers, Xuan Liu and Peter David Clegg
    Citation: Arthritis Research & Therapy 2013 15:R98
    Content type: Research article Published on:

  40. Serum interleukin (IL)-17 concentrations have been reported to be increased in systemic lupus erythematosus (SLE), but associations with clinical characteristics are not well understood. We characterized clini...

    Authors: Fabien B Vincent, Melissa Northcott, Alberta Hoi, Fabienne Mackay and Eric F Morand
    Citation: Arthritis Research & Therapy 2013 15:R97
    Content type: Research article Published on:

  42. Rheumatoid arthritis (RA) is characterized by inflamed joint-derived cytokine-mediated high-grade systemic inflammation that enhances cardiovascular metabolic risk and disease in developed populations. We inve...

    Authors: Patrick H Dessein, Angela J Woodiwiss, Gavin R Norton and Ahmed Solomon
    Citation: Arthritis Research & Therapy 2013 15:R96
    Content type: Research article Published on:

  43. Rheumatoid arthritis is an autoimmune disease with poorly understood pathophysiology. Genetic components of disease etiology, especially human leukocyte antigen (HLA) associations, are well known. Ethnic diffe...

    Authors: Ambreen Gul Muazzam, Atika Mansoor, Lubna Ali, Saima Siddiqi, Abdul Hameed, Muhammad Ajmal and Kehkashan Mazhar
    Citation: Arthritis Research & Therapy 2013 15:R95
    Content type: Research article Published on:

  44. Intervertebral disc (IVD) degeneration is characterized by extracellular matrix breakdown and is considered to be a primary cause of discogenic back pain. Although increases in pro-inflammatory cytokine levels...

    Authors: Lilian Quero, Marina Klawitter, Anja Schmaus, Melanie Rothley, Jonathan Sleeman, André N Tiaden, Juergen Klasen, Norbert Boos, Michael O Hottiger, Karin Wuertz and Peter J Richards
    Citation: Arthritis Research & Therapy 2013 15:R94
    Content type: Research article Published on:

  46. In this study, we tested the ability of small molecule inhibitors of WNT/β-catenin signaling to block interleukin 1β (IL-1β)- and tumor necrosis factor α (TNFα)-induced cartilage degradation. Proinflammatory c...

    Authors: Ellie BM Landman, Razvan L Miclea, Clemens A van Blitterswijk and Marcel Karperien
    Citation: Arthritis Research & Therapy 2013 15:R93
    Content type: Research article Published on:

  47. Hypoxia is considered to be a positive influence on the healthy chondrocyte phenotype and cartilage matrix formation. However, hypoxia-inducible factors (HIFs) have been implicated in the pathogenesis of osteo...

    Authors: Brandon D Markway, Holly Cho and Brian Johnstone
    Citation: Arthritis Research & Therapy 2013 15:R92
    Content type: Research article Published on:

  48. Our objective was to determine which one of the two function charts available in Spain to calculate cardiovascular (CV) risk, Systematic COronary Risk Evaluation (SCORE) or Framingham-REgistre GIroní del COR (...

    Authors: Carmen Gómez-Vaquero, Alfonso Corrales, Andrea Zacarías, Javier Rueda-Gotor, Ricardo Blanco, Carlos González-Juanatey, Javier Llorca and Miguel A González-Gay
    Citation: Arthritis Research & Therapy 2013 15:R91
    Content type: Research article Published on:

  49. Systemic sclerosis (SSc) is a connective tissue disorder characterized by endothelial cell injury, autoimmunity and fibrosis. The following three fibrillin-1 alterations have been reported in SSc. (1) Fibrilli...

    Authors: Marilisa Villano, Annalisa Borghini, Mirko Manetti, Erica Gabbrielli, Antonella Rossi, Piersante Sestini, Anna Franca Milia, Francesca Nacci, Serena Guiducci, Marco Matucci-Cerinic, Lidia Ibba-Manneschi and Elisabetta Weber
    Citation: Arthritis Research & Therapy 2013 15:R90
    Content type: Research article Published on:

  50. Little is known about rheumatoid arthritis in the black, particularly in Congolese, populations. Our objective was to describe the phenotype and genotype of rheumatoid arthritis (RA) in Congolese.

    Authors: JJ Malemba, JM Mbuyi-Muamba, J Mukaya, X Bossuyt, MP Emonds, K Deiteren, R Westhovens and P Verschueren
    Citation: Arthritis Research & Therapy 2013 15:R89
    Content type: Research article Published on:
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Arthritis Research & Therapy

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