Peterson CK, Bolton JE, Wood AR: A cross-sectional study correlating lumbar spine degeneration with disability and pain. Spine (Phila Pa 1976). 2000, 25: 218-223. 10.1097/00007632-200001150-00013.
Article
CAS
Google Scholar
Luoma K, Riihimäki H, Luukkonen R, Raininko R, Viikari-Juntura E, Lamminen A: Low back pain in relation to lumbar disc degeneration. Spine (Phila Pa 1976). 2000, 25: 487-492. 10.1097/00007632-200002150-00016.
Article
CAS
Google Scholar
Burke JG, Watson RW, McCormack D, Dowling FE, Walsh MG, Fitzpatrick JM: Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators. J Bone Joint Surg Br. 2002, 84: 196-201. 10.1302/0301-620X.84B2.12511.
Article
CAS
PubMed
Google Scholar
Cunha FQ, Lorenzetti BB, Poole S, Ferreira SH: Interleukin-8 as a mediator of sympathetic pain. Br J Pharmacol. 1991, 104: 765-767. 10.1111/j.1476-5381.1991.tb12502.x.
Article
PubMed Central
CAS
PubMed
Google Scholar
De Jongh RF, Vissers KC, Meert TF, Booij LH, De Deyne CS, Heylen RJ: The role of interleukin-6 in nociception and pain. Anesth Analg. 2003, 96: 1096-1103.
Article
CAS
PubMed
Google Scholar
Kochukov MY, McNearney TA, Yin H, Zhang L, Ma F, Ponomareva L, Abshire S, Westlund KN: Tumor necrosis factor-alpha (TNF-alpha) enhances functional thermal and chemical responses of TRP cation channels in human synoviocytes. Mol Pain. 2009, 5: 49-10.1186/1744-8069-5-49.
Article
PubMed Central
PubMed
Google Scholar
Goupille P, Jayson MI, Valat JP, Freemont AJ: Matrix metalloproteinases: the clue to intervertebral disc degeneration?. Spine (Phila Pa 1976). 1998, 23: 1612-1626. 10.1097/00007632-199807150-00021.
Article
CAS
Google Scholar
Le Maitre CL, Freemont AJ, Hoyland JA: Localization of degradative enzymes and their inhibitors in the degenerate human intervertebral disc. J Pathol. 2004, 204: 47-54. 10.1002/path.1608.
Article
CAS
PubMed
Google Scholar
Patel KP, Sandy JD, Akeda K, Miyamoto K, Chujo T, An HS, Masuda K: Aggrecanases and aggrecanase-generated fragments in the human intervertebral disc at early and advanced stages of disc degeneration. Spine (Phila Pa 1976). 2007, 32: 2596-2603. 10.1097/BRS.0b013e318158cb85.
Article
Google Scholar
Bachmeier BE, Nerlich A, Mittermaier N, Weiler C, Lumenta C, Wuertz K, Boos N: Matrix metalloproteinase expression levels suggest distinct enzyme roles during lumbar disc herniation and degeneration. Eur Spine J. 2009, 18: 1573-1586. 10.1007/s00586-009-1031-8.
Article
PubMed Central
PubMed
Google Scholar
Tiaden AN, Klawitter M, Lux V, Mirsaidi A, Bahrenberg G, Glanz S, Quero L, Liebscher T, Wuertz K, Ehrmann M, Richards PJ: Detrimental role for human high temperature requirement serine protease A1 (HTRA1) in the pathogenesis of intervertebral disc (IVD) degeneration. J Biol Chem. 2012, 287: 21335-21345. 10.1074/jbc.M112.341032.
Article
PubMed Central
CAS
PubMed
Google Scholar
Anderson DG, Li X, Balian G: A fibronectin fragment alters the metabolism by rabbit intervertebral disc cells in vitro. Spine (Phila Pa 1976). 2005, 30: 1242-1246. 10.1097/01.brs.0000164097.47091.4c.
Article
Google Scholar
Xia M, Zhu Y: Fibronectin fragment activation of ERK increasing integrin α5 and β1 subunit expression to degenerate nucleus pulposus cells. J Orthop Res. 2011, 29: 556-561. 10.1002/jor.21273.
Article
CAS
PubMed
Google Scholar
Mwale F, Wang HT, Zukor DJ, Huk OL, Petit A, Antoniou J: Effect of a Type II collagen fragment on the expression of genes of the extracellular matrix in cells of the intervertebral disc. Open Orthop J. 2008, 2: 1-9. 10.2174/1874325000802010001.
Article
PubMed Central
CAS
PubMed
Google Scholar
Feng H, Danfelter M, Strömqvist B, Heinegård D: Extracellular matrix in disc degeneration. J Bone Joint Surg Am. 2006, 88 (Suppl 2): 25-29.
Article
PubMed
Google Scholar
Noble PW: Hyaluronan and its catabolic products in tissue injury and repair. Matrix Biol. 2002, 21: 25-29. 10.1016/S0945-053X(01)00184-6.
Article
CAS
PubMed
Google Scholar
Lepperdinger G, Müllegger J, Kreil G: Hyal2--less active, but more versatile?. Matrix Biol. 2001, 20: 509-514. 10.1016/S0945-053X(01)00170-6.
Article
CAS
PubMed
Google Scholar
Eldridge L, Moldobaeva A, Wagner EM: Increased hyaluronan fragmentation during pulmonary ischemia. Am J Physiol Lung Cell Mol Physiol. 2011, 301: L782-788. 10.1152/ajplung.00079.2011.
Article
PubMed Central
CAS
PubMed
Google Scholar
Sztrolovics R, Recklies AD, Roughley PJ, Mort JS: Hyaluronate degradation as an alternative mechanism for proteoglycan release from cartilage during interleukin-1beta-stimulated catabolism. Biochem J. 2002, 362: 473-479. 10.1042/0264-6021:3620473.
Article
PubMed Central
CAS
PubMed
Google Scholar
Lyons G, Eisenstein SM, Sweet MB: Biochemical changes in intervertebral disc degeneration. Biochim Biophys Acta. 1981, 673: 443-453.
Article
CAS
PubMed
Google Scholar
Le Maitre CL, Freemont AJ, Hoyland JA: The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration. Arthritis Res Ther. 2005, 7: R732-745. 10.1186/ar1732.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ohno S, Im HJ, Knudson CB, Knudson W: Hyaluronan oligosaccharides induce matrix metalloproteinase 13 via transcriptional activation of NFkappaB and p38 MAP kinase in articular chondrocytes. J Biol Chem. 2006, 281: 17952-17960. 10.1074/jbc.M602750200.
Article
PubMed Central
CAS
PubMed
Google Scholar
Campo GM, Avenoso A, Campo S, D'Ascola A, Traina P, Calatroni A: Differential effect of molecular size HA in mouse chondrocytes stimulated with PMA. Biochim Biophys Acta. 2009, 1790: 1353-1367. 10.1016/j.bbagen.2009.07.003.
Article
CAS
PubMed
Google Scholar
Campo GM, Avenoso A, Campo S, D'Ascola A, Nastasi G, Calatroni A: Small hyaluronan oligosaccharides induce inflammation by engaging both toll-like-4 and CD44 receptors in human chondrocytes. Biochem Pharmacol. 2010, 80: 480-490. 10.1016/j.bcp.2010.04.024.
Article
CAS
PubMed
Google Scholar
Campo GM, Avenoso A, D'Ascola A, Prestipino V, Scuruchi M, Nastasi G, Calatroni A, Campo S: Hyaluronan differently modulates TLR-4 and the inflammatory response in mouse chondrocytes. Biofactors. 2012, 38: 69-76. 10.1002/biof.202.
Article
CAS
PubMed
Google Scholar
Slevin M, Krupinski J, Gaffney J, Matou S, West D, Delisser H, Savani RC, Kumar S: Hyaluronan-mediated angiogenesis in vascular disease: uncovering RHAMM and CD44 receptor signaling pathways. Matrix Biol. 2007, 26: 58-68. 10.1016/j.matbio.2006.08.261.
Article
CAS
PubMed
Google Scholar
Fieber C, Baumann P, Vallon R, Termeer C, Simon JC, Hofmann M, Angel P, Herrlich P, Sleeman JP: Hyaluronan-oligosaccharide-induced transcription of metalloproteases. J Cell Sci. 2004, 117: 359-367. 10.1242/jcs.00831.
Article
CAS
PubMed
Google Scholar
Iacob S, Knudson CB: Hyaluronan fragments activate nitric oxide synthase and the production of nitric oxide by articular chondrocytes. Int J Biochem Cell Biol. 2006, 38: 123-133. 10.1016/j.biocel.2005.08.011.
Article
PubMed Central
CAS
PubMed
Google Scholar
Takeuchi O, Akira S: Pattern recognition receptors and inflammation. Cell. 2010, 140: 805-820. 10.1016/j.cell.2010.01.022.
Article
CAS
PubMed
Google Scholar
Le Maitre CL, Hoyland JA, Freemont AJ: Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1beta and TNFalpha expression profile. Arthritis Res Ther. 2007, 9: R77-10.1186/ar2275.
Article
PubMed Central
PubMed
Google Scholar
Homandberg GA, Meyers R, Williams JM: Intraarticular injection of fibronectin fragments causes severe depletion of cartilage proteoglycans in vivo. J Rheumatol. 1993, 20: 1378-1382.
CAS
PubMed
Google Scholar
Jennings L, Wu L, King KB, Hammerle H, Cs-Szabo G, Mollenhauer J: The effects of collagen fragments on the extracellular matrix metabolism of bovine and human chondrocytes. Connect Tissue Res. 2001, 42: 71-86. 10.3109/03008200109014250.
Article
CAS
PubMed
Google Scholar
Pulai JI, Chen H, Im HJ, Kumar S, Hanning C, Hegde PS, Loeser RF: NF-kappa B mediates the stimulation of cytokine and chemokine expression by human articular chondrocytes in response to fibronectin fragments. J Immunol. 2005, 174: 5781-5788.
Article
PubMed Central
CAS
PubMed
Google Scholar
Termeer C, Benedix F, Sleeman J, Fieber C, Voith U, Ahrens T, Miyake K, Freudenberg M, Galanos C, Simon JC: Oligosaccharides of hyaluronan activate dendritic cells via toll-like receptor 4. J Exp Med. 2002, 195: 99-111. 10.1084/jem.20001858.
Article
PubMed Central
CAS
PubMed
Google Scholar
McKee CM, Penno MB, Cowman M, Burdick MD, Strieter RM, Bao C, Noble PW: Hyaluronan (HA) fragments induce chemokine gene expression in alveolar macrophages. The role of HA size and CD44. J Clin Invest. 1996, 98: 2403-2413. 10.1172/JCI119054.
Article
PubMed Central
CAS
PubMed
Google Scholar
Schmitz I, Ariyoshi W, Takahashi N, Knudson CB, Knudson W: Hyaluronan oligosaccharide treatment of chondrocytes stimulates expression of both HAS-2 and MMP-3, but by different signaling pathways. Osteoarthritis Cartilage. 2010, 18: 447-54. 10.1016/j.joca.2009.10.007.
Article
PubMed Central
CAS
PubMed
Google Scholar
Cuellar JM, Montesano PX, Carstens E: Role of TNF-alpha in sensitization of nociceptive dorsal horn neurons induced by application of nucleus pulposus to L5 dorsal root ganglion in rats. Pain. 2004, 110: 578-587. 10.1016/j.pain.2004.03.029.
Article
CAS
PubMed
Google Scholar
Scheibner KA, Lutz MA, Boodoo S, Fenton MJ, Powell JD, Horton MR: Hyaluronan fragments act as an endogenous danger signal by engaging TLR2. J Immunol. 2006, 177: 1272-1281.
Article
CAS
PubMed
Google Scholar
Séguin CA, Bojarski M, Pilliar RM, Roughley PJ, Kandel RA: Differential regulation of matrix degrading enzymes in a TNFalpha-induced model of nucleus pulposus tissue degeneration. Matrix Biol. 2006, 25: 409-418. 10.1016/j.matbio.2006.07.002.
Article
PubMed
Google Scholar
Klawitter M, Quero L, Klasen J, Gloess AN, Klopprogge B, Hausmann O, Boos N, Wuertz K: Curcuma DMSO extracts and curcumin exhibit an anti-inflammatory and anti-catabolic effect on human intervertebral disc cells, possibly by influencing TLR2 expression and JNK activity. J Inflamm (Lond). 2012, 9: 29-10.1186/1476-9255-9-29.
Article
CAS
Google Scholar
Studer RK, Gilbertson LG, Georgescu H, Sowa G, Vo N, Kang JD: p38 MAPK inhibition modulates rabbit nucleus pulposus cell response to IL-1. J Orthop Res. 2008, 26: 991-998. 10.1002/jor.20604.
Article
CAS
PubMed
Google Scholar