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  1. IL-10 is a very important anti-inflammatory cytokine. However, the role of this cytokine in T cells in the pathogenesis of collagen-induced arthritis is unclear. The purpose of this study was to define the rol...

    Authors: Jian Tao, Masahito Kamanaka, Jianlei Hao, Zhifang Hao, Xi Jiang, Joe E Craft, Richard A Flavell, Zhenzhou Wu, Zhangyong Hong, Liqing Zhao and Zhinan Yin
    Citation: Arthritis Research & Therapy 2011 13:R212
    Content type: Research article Published on:

  2. The prevalence of antibodies to RNA polymerase III (anti-RNAP) differs among systemic sclerosis (SSc) cohorts worldwide. Previously reported associations of anti-RNAP include diffuse cutaneous disease, tendon ...

    Authors: Mandana Nikpour, Pravin Hissaria, Jillian Byron, Joanne Sahhar, Maree Micallef, William Paspaliaris, Janet Roddy, Peter Nash, Alan Sturgess, Susanna Proudman and Wendy Stevens
    Citation: Arthritis Research & Therapy 2011 13:R211
    Content type: Research article Published on:

  3. Systemic lupus erythematosus is a prototypic autoimmune disease characterized by autoantibody production and immune complex formation/deposition in target organs such as the kidney. Resultant local inflammatio...

    Authors: Tamara K Nowling and Gary S Gilkeson
    Citation: Arthritis Research & Therapy 2011 13:250
    Content type: Review Published on:

  4. Osteoarthritis (OA) is a complex, multifactorial joint disease affecting both the cartilage and the subchondral bone. Animal models of OA aid in the understanding of the pathogenesis of OA and testing suitable...

    Authors: Geetha Mohan, Egon Perilli, Julia S Kuliwaba, Julia M Humphries, Ian H Parkinson and Nicola L Fazzalari
    Citation: Arthritis Research & Therapy 2011 13:R210
    Content type: Research article Published on:

  6. Treatment of Sjögren's syndrome is almost entirely symptomatic. A lack of true understanding of the underlying immunological pathology of the disease prevents directed therapy. Interleukin-21 (IL-21) is elevat...

    Authors: R Hal Scofield
    Citation: Arthritis Research & Therapy 2011 13:137
    Content type: Editorial Published on:

  7. As a group, rheumatoid arthritis (RA) patients exhibit increased risk of infection, and those treated with anti-tumor necrosis factor (TNF) therapy are at further risk. This increased susceptibility may result...

    Authors: James J Kobie, Bo Zheng, Peter Bryk, Michael Barnes, Christopher T Ritchlin, Darren A Tabechian, Allen P Anandarajah, R John Looney, Ralf G Thiele, Jennifer H Anolik, Andreea Coca, Chungwen Wei, Alexander F Rosenberg, Changyong Feng, John J Treanor, F Eun-Hyung Lee…
    Citation: Arthritis Research & Therapy 2011 13:R209
    Content type: Research article Published on:

  8. Rheumatoid arthritis (RA) is considered a T cell driven autoimmune disease, therefore, the ability of B cell depleting biologics, e.g., anti-CD20 antibodies, to alleviate RA is unclear. This study examined the...

    Authors: Paul Eggleton, Edwin Bremer, Joanna M Tarr, Marco de Bruyn, Wijnand Helfrich, Alexandra Kendall, Richard C Haigh, Nick J Viner and Paul G Winyard
    Citation: Arthritis Research & Therapy 2011 13:R208
    Content type: Research article Published on:

  9. Chronic inflammation is a profound systemic modification of the cellular microenvironment which could affect survival, repair and maintenance of muscle stem cells. The aim of this study was to define the role ...

    Authors: Bouke J Duijnisveld, Anne Bigot, Karel GM Beenakker, Débora M Portilho, Vered Raz, Huub JL van der Heide, Cornelis PJ Visser, Soraya Chaouch, Kamel Mamchaoui, Rudi GJ Westendorp, Vincent Mouly, Gillian S Butler-Browne, Rob GHH Nelissen and Andrea B Maier
    Citation: Arthritis Research & Therapy 2011 13:R207
    Content type: Research article Published on:

    The Letter to this article has been published in Arthritis Research & Therapy 2018 20:51

  10. Inherited deficiencies of several complement components strongly predispose to systemic lupus erythematosus (SLE) while deficiencies of complement inhibitors are found in kidney diseases such as atypical hemol...

    Authors: Andreas Jönsen, Sara C Nilsson, Emma Ahlqvist, Elisabet Svenungsson, Iva Gunnarsson, Karin G Eriksson, Anders Bengtsson, Agneta Zickert, Maija-Leena Eloranta, Lennart Truedsson, Lars Rönnblom, Gunnel Nordmark, Gunnar Sturfelt and Anna M Blom
    Citation: Arthritis Research & Therapy 2011 13:R206
    Content type: Research article Published on:

  11. Advanced glycation end products (AGEs) are produced and can accumulate during chronic inflammation, as might be present in patients with rheumatoid arthritis (RA). AGEs are involved in the development of cardi...

    Authors: Lodewijk de Groot, Helmy Hinkema, Johanna Westra, Andries J Smit, Cees GM Kallenberg, Marc Bijl and Marcel D Posthumus
    Citation: Arthritis Research & Therapy 2011 13:R205
    Content type: Research article Published on:

  12. Hand osteoarthritis (OA) is very frequent in middle-aged and older women and men in the general population. Currently, owing to high feasibility and low costs, conventional radiography (CR) is the method of ch...

    Authors: Ida K Haugen and Pernille Bøyesen
    Citation: Arthritis Research & Therapy 2011 13:248
    Content type: Review Published on:

  13. The goal of this study was to compare the efficacy in terms of Health Assessment Questionnaire change from baseline (HAQ CFB), 50% improvement in American College of Rheumatology criterion (ACR-50) and Disease...

    Authors: Patricia Guyot, Peter Taylor, Robin Christensen, Louisa Pericleous, Coralie Poncet, Maximilian Lebmeier, Pieter Drost and Gert Bergman
    Citation: Arthritis Research & Therapy 2011 13:R204
    Content type: Research article Published on:

  14. Articular cartilage functions in withstanding mechanical loads and provides a lubricating surface for frictionless movement of joints. Osteoarthritis, characterised by cartilage degeneration, develops due to t...

    Authors: Rhian S Thomas, Alan R Clarke, Victor C Duance and Emma J Blain
    Citation: Arthritis Research & Therapy 2011 13:R203
    Content type: Research article Published on:

  15. To assess the effect of canakinumab, a fully human anti-interleukin-1β antibody, on symptoms and health-related quality of life (HRQoL) in patients with cryopyrin-associated periodic syndrome (CAPS).

    Authors: Isabelle Koné-Paut, Helen J Lachmann, Jasmin B Kuemmerle-Deschner, Eric Hachulla, Kieron S Leslie, Richard Mouy, Alberto Ferreira, Karine Lheritier, Neha Patel, Ralph Preiss and Philip N Hawkins
    Citation: Arthritis Research & Therapy 2011 13:R202
    Content type: Research article Published on:

  16. In anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAV), persistent inflammation within the vessel wall suggests perturbed neutrophil trafficking leading to accumulation of activated n...

    Authors: Nan Hu, Johanna Westra, Abraham Rutgers, Berber Doornbos-Van der Meer, Minke G Huitema, Coen A Stegeman, Wayel H Abdulahad, Simon C Satchell, Peter W Mathieson, Peter Heeringa and Cees G M Kallenberg
    Citation: Arthritis Research & Therapy 2011 13:R201
    Content type: Research article Published on:

  17. Intervertebral disc tissue homeostasis is modulated by a variety of molecules. Silent mating type information regulator 2 homolog 1 (SIRT1) plays a key role in various physiological processes. The aim of the p...

    Authors: Zhongying Zhang, Kenichiro Kakutani, Koichiro Maeno, Toru Takada, Takashi Yurube, Minoru Doita, Masahiro Kurosaka and Kotaro Nishida
    Citation: Arthritis Research & Therapy 2011 13:R200
    Content type: Research article Published on:

  18. Systemic lupus erythematosus (SLE or lupus) is a chronic autoimmune disease, and kidney involvement with SLE, a.k.a. lupus nephritis (LN), is a frequent and severe complication of SLE that increases patient mo...

    Authors: Lindsey E Romick-Rosendale, Hermine I Brunner, Michael R Bennett, Rina Mina, Shannen Nelson, Michelle Petri, Adnan Kiani, Prasad Devarajan and Michael A Kennedy
    Citation: Arthritis Research & Therapy 2011 13:R199
    Content type: Research article Published on:

  19. Increasing obesity and type 2 diabetes, in part due to the high-fat (HF) Western diet, parallels an increased incidence of osteoarthritis (OA). This study was undertaken to establish a causal relation between ...

    Authors: Robert A Mooney, Erik R Sampson, Jaclyn Lerea, Randy N Rosier and Michael J Zuscik
    Citation: Arthritis Research & Therapy 2011 13:R198
    Content type: Research article Published on:

  20. The reduction of the inflammatory status represents one of the most important targets in rheumatoid arthritis (RA). A central role of A2A and A3 adenosine receptors (ARs) in mechanisms of inflammation has been re...

    Authors: Katia Varani, Melissa Padovan, Fabrizio Vincenzi, Martina Targa, Francesco Trotta, Marcello Govoni and Pier Andrea Borea
    Citation: Arthritis Research & Therapy 2011 13:R197
    Content type: Research article Published on:

  21. Muckle-Wells syndrome (MWS) is an inherited autoinflammatory disease characterized by fever, rash, arthralgia, conjunctivitis, sensorineural deafness and potentially life-threatening amyloidosis. The NLRP3/CIAS1 ...

    Authors: Jasmin B Kuemmerle-Deschner, Peter Lohse, Ina Koetter, Guenther E Dannecker, Fabian Reess, Katharina Ummenhofer, Silvia Koch, Nikolay Tzaribachev, Anja Bialkowski and Susanne M Benseler
    Citation: Arthritis Research & Therapy 2011 13:R196
    Content type: Research article Published on:

  22. The deposition of monosodium urate (MSU) crystals in synovial fluid and tissue leads to gouty arthritis frequently associated with synovial inflammation and bone erosions. The cellular mechanism that links MSU...

    Authors: Ulrike Harre, Anja Derer, Christine Schorn, Georg Schett and Martin Herrmann
    Citation: Arthritis Research & Therapy 2011 13:135
    Content type: Editorial Published on:

  24. The antigen recognition pattern of immunoglobulin M (IgM) could, when directed against protein antigens, provide an indication of the antigenic moieties triggering new B cells. The half-life of IgM is short an...

    Authors: Parawee Suwannalai, Annemiek Willemze, Linda van Toorn, Gerrie Stoeken-Rijsbergen, Nivine Levarht, Jan Wouter Drijfhout, Tom W J Huizinga, Rene E M Toes and Leendert A Trouw
    Citation: Arthritis Research & Therapy 2011 13:R195
    Content type: Research article Published on:

  25. A growing interest has arisen in salivary proteomics as a tool for the identification of biomarkers for primary Sjögren's syndrome (pSS). Nonetheless, only a limited number of preclinical validation studies ha...

    Authors: Chiara Baldini, Laura Giusti, Federica Ciregia, Ylenia Da Valle, Camillo Giacomelli, Elena Donadio, Francesca Sernissi, Laura Bazzichi, Gino Giannaccini, Stefano Bombardieri and Antonio Lucacchini
    Citation: Arthritis Research & Therapy 2011 13:R194
    Content type: Research article Published on:

  26. Follistatin-like protein 1 (FSTL1) is a secreted glycoprotein that has been implicated in arthritis pathogenesis in a mouse model. The aim of this study is to detect FSTL1 expression and to further assess its ...

    Authors: Yuji Wang, Dawei Li, Nanwei Xu, Weijian Tao, Ruixia Zhu, Rongbin Sun, Weiwei Fan, Ping Zhang, Tianhua Dong and Long Yu
    Citation: Arthritis Research & Therapy 2011 13:R193
    Content type: Research article Published on:

  28. Imaging of cartilage has traditionally been achieved indirectly with conventional radiography. Loss of joint space width, or 'joint space narrowing', is considered a surrogate marker for cartilage thinning. Ho...

    Authors: Ali Guermazi, Frank W Roemer, Deborah Burstein and Daichi Hayashi
    Citation: Arthritis Research & Therapy 2011 13:247
    Content type: Review Published on:

  29. The effect of intra-articular injection of matrix metalloproteinase (MMP)-3 inhibitor was investigated in a rat model to understand the role of MMP-3 in cartilage degradation induced by excessive loading from ...

    Authors: Guo-Xin Ni, Li-Qiong Zhan, Mei-Qin Gao, Lei Lei, Yue-Zhu Zhou and Yan-Xia Pan
    Citation: Arthritis Research & Therapy 2011 13:R192
    Content type: Research article Published on:

  31. Anti-citrullinated protein/peptide antibodies (ACPAs) are highly specific to rheumatoid arthritis (RA) patients and are thought to have a close relationship with the pathogenesis of arthritis. Several proteins...

    Authors: Hirofumi Shoda, Keishi Fujio, Mihoko Shibuya, Tomohisa Okamura, Shuji Sumitomo, Akiko Okamoto, Tetsuji Sawada and Kazuhiko Yamamoto
    Citation: Arthritis Research & Therapy 2011 13:R191
    Content type: Research article Published on:

  32. We aimed to gather knowledge on the cardiac autonomic modulation in patients with fibromyalgia (FM) in response to exercise and to investigate whether this population suffers from chronotropic incompetence (CI).

    Authors: Roberta Potenza da Cunha Ribeiro, Hamilton Roschel, Guilherme Gianini Artioli, Thalita Dassouki, Luiz Augusto Perandini, Ana Luisa Calich, Ana Lúcia de Sá Pinto, Fernanda Rodrigues Lima, Eloísa Bonfá and Bruno Gualano
    Citation: Arthritis Research & Therapy 2011 13:R190
    Content type: Research article Published on:

  33. Many people with rheumatoid arthritis (RA) do not receive care from a rheumatologist. We surveyed primary care physicians (PCPs) to better understand their attitudes, knowledge, and practices regarding the opt...

    Authors: Katie L Garneau, Maura D Iversen, Hsun Tsao and Daniel H Solomon
    Citation: Arthritis Research & Therapy 2011 13:R189
    Content type: Research article Published on:

  34. An increasing number of studies have applied ultrasound to the evaluation of entheses in spondyloarthritis patients. However, no clear agreement exists on the definition of enthesitis, on the number and choice...

    Authors: Frédérique Gandjbakhch, Lene Terslev, Fredrick Joshua, Richard J Wakefield, Esperanza Naredo and Maria Antonietta D'Agostino
    Citation: Arthritis Research & Therapy 2011 13:R188
    Content type: Research article Published on:

  35. Interleukin-1 (IL-1) and tumor necrosis factor-α (TNF-α) are up-regulated in injured and osteoarthritic knee joints. IL-1 and TNF-α inhibit integrative meniscal repair; however, the mechanisms by which this in...

    Authors: Katherine M Riera, Nicole E Rothfusz, Rebecca E Wilusz, JB Weinberg, Farshid Guilak and Amy L McNulty
    Citation: Arthritis Research & Therapy 2011 13:R187
    Content type: Research article Published on:

  36. Recent genome-wide and candidate gene association studies in large numbers of systemic lupus erythematosus (SLE) patients have suggested approximately 30 susceptibility genes. These genes are involved in three...

    Authors: Hua Zhong, Xiao-lan Li, Ming Li, Li-xia Hao, Rong-wei Chen, Kun Xiang, Xue-bin Qi, Runlin Z Ma and Bing Su
    Citation: Arthritis Research & Therapy 2011 13:R186
    Content type: Research article Published on:

  37. At present, there is neither a laboratory test nor an imaging technique able to differentiate people with fibromyalgia (FM) from healthy controls. This lack of an objective biomarker has hampered FM recognitio...

    Authors: Claudia Lerma, Aline Martinez, Natllely Ruiz, Angelica Vargas, Oscar Infante and Manuel Martinez-Lavin
    Citation: Arthritis Research & Therapy 2011 13:R185
    Content type: Research article Published on:

  38. Adiponectin is an adipokine that regulates energy metabolism and insulin sensitivity, but recent studies have pointed also to a role in inflammation and arthritis. The purpose of the present study was to inves...

    Authors: Anna Koskinen, Sami Juslin, Riina Nieminen, Teemu Moilanen, Katriina Vuolteenaho and Eeva Moilanen
    Citation: Arthritis Research & Therapy 2011 13:R184
    Content type: Research article Published on:

  39. There are many exciting new applications for advanced imaging in gout. These modalities employ multiplanar imaging and allow computerized three-dimensional rendering of bone and joints (including tophi) and ha...

    Authors: Fiona M McQueen, Anthony Doyle and Nicola Dalbeth
    Citation: Arthritis Research & Therapy 2011 13:246
    Content type: Review Published on:

  40. Studies have shown that fetal progenitor cells persist in maternal blood or bone marrow for more than 30 years after delivery. Increased trafficking of fetal cells occurs during pregnancy complications, such a...

    Authors: Linda van Wyk, Jacolien van der Marel, Annemie JM Schuerwegh, Anne A Schouffoer, Alexandre E Voskuyl, Tom WJ Huizinga, Diana W Bianchi and Sicco A Scherjon
    Citation: Arthritis Research & Therapy 2011 13:R183
    Content type: Research article Published on:

  41. In Sjögren's syndrome, keratoconjunctivitis sicca (dry eye) is associated with infiltration of lacrimal glands by leukocytes and consequent losses of tear-fluid production and the integrity of the ocular surfa...

    Authors: Roy A Fava, Susan M Kennedy, Sheryl G Wood, Anne I Bolstad, Jadwiga Bienkowska, Adrian Papandile, John A Kelly, Clio P Mavragani, Margaret Gatumu, Kathrine Skarstein and Jeffrey L Browning
    Citation: Arthritis Research & Therapy 2011 13:R182
    Content type: Research article Published on:

  42. Although systemic autoimmune diseases (SAID) share many clinical and laboratory features, whether they also share some common features of pathogenesis remains unclear. We assessed plasma proteomic profiles amo...

    Authors: Terrance P O'Hanlon, Zhuoyan Li, Lu Gan, Mark F Gourley, Lisa G Rider and Frederick W Miller
    Citation: Arthritis Research & Therapy 2011 13:R181
    Content type: Research article Published on:

  45. Integrins play an important role in cell adhesion to the extracellular matrix and other cells. Upon ligand binding, signaling is initiated and several intracellular pathways are activated. This leads to a wide...

    Authors: Torsten Lowin and Rainer H Straub
    Citation: Arthritis Research & Therapy 2011 13:244
    Content type: Review Published on:

  46. Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that is known to be associated with polyclonal B-cell hyperreactivity. The underlying causes of the diffuse B-cell over-reactivity are unclea...

    Authors: Thomas Dörner, Claudia Giesecke and Peter E Lipsky
    Citation: Arthritis Research & Therapy 2011 13:243
    Content type: Review Published on:

  47. Studies investigating genetic risk factors for susceptibility to rheumatoid arthritis (RA) studied anti-citrullinated peptide antibody (CCP)-positive RA more frequently than anti-CCP-negative RA. One of the re...

    Authors: Diederik PC De Rooy, Annemiek Willemze, Bart Mertens, Tom WJ Huizinga and Annette HM Van der Helm-van Mil
    Citation: Arthritis Research & Therapy 2011 13:R180
    Content type: Research article Published on:

  48. Calprotectin (MRP8/MRP14, S100A8/A9) is associated with disease activity in patients with rheumatoid arthritis (RA). Ultrasonography (US) is a reliable method for evaluation of synovitis (B-mode (BM) and power...

    Authors: Hilde Berner Hammer, Magne K Fagerhol, Tale Norbye Wien and Tore K Kvien
    Citation: Arthritis Research & Therapy 2011 13:R178
    Content type: Research article Published on:

  49. The purpose of this study was to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of the humanized anti-CD4 monoclonal antibody MTRX1011A in a randomized, double-blind placebo...

    Authors: Heleen Scheerens, Zheng Su, Bryan Irving, Michael J Townsend, Yanan Zheng, Eric Stefanich, Vishala Chindalore, Clifton O Bingham III and John C Davis Jr
    Citation: Arthritis Research & Therapy 2011 13:R177
    Content type: Research article Published on:
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Arthritis Research & Therapy

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