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  1. TNF blockade therapy has substantially advanced the treatment of peripheral spondyloarthritides but revolutionised the treatment of severe ankylosing spondylitis. The capacity of biologic treatment to improve ...

    Authors: Andrew Barr and Andrew Keat
    Citation: Arthritis Research & Therapy 2010 12:221
    Content type: Review Published on:

  3. Investigation of the genetic basis of hyperuricaemia is a subject of intense interest. However, clinical studies commonly include hyperuricaemic patients without distinguishing between 'over-producers' or 'und...

    Authors: Praveen L Indraratna, Sophie L Stocker, Kenneth M Williams, Garry G Graham, Graham Jones and Richard O Day
    Citation: Arthritis Research & Therapy 2010 12:149
    Content type: Commentary Published on:

  4. This study tested the hypothesis that baseline ratings of fatigue/tiredness would be negatively associated with the efficacy of duloxetine on measures of pain and functional ability in patients with fibromyalgia.

    Authors: Laurence A Bradley, Robert Bennett, Irwin J Russell, Madelaine M Wohlreich, Amy S Chappell, Fujun Wang, Deborah N D'Souza and Harvey Moldofsky
    Citation: Arthritis Research & Therapy 2010 12:R141
    Content type: Research article Published on:

  5. Based on increasing knowledge on the pathogenesis of rheumatoid arthritis (RA), more and more potential therapeutics have been developed. To evaluate their therapeutic efficacy, safety and toxicity, appropriat...

    Authors: Frank Petersen and Xinhua Yu
    Citation: Arthritis Research & Therapy 2010 12:148
    Content type: Editorial Published on:

  6. The aim of this study was to estimate the prevalence and determinants of vitamin D deficiency in patients with rheumatoid arthritis (RA) as compared to healthy controls and to analyze the association between 2...

    Authors: Maurizio Rossini, Susanna Maddali Bongi, Giovanni La Montagna, Giovanni Minisola, Nazzarena Malavolta, Luigi Bernini, Enrico Cacace, Luigi Sinigaglia, Ombretta Di Munno and Silvano Adami
    Citation: Arthritis Research & Therapy 2010 12:R216
    Content type: Research article Published on:

  7. Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by production of autoantibodies and immune complex deposition in various organs. Aberrations in the T lymphocyte compartment and dysre...

    Authors: Hathaipat Puwipirom, Nattiya Hirankarn, Pimpayao Sodsai, Yingyos Avihingsanon, Jongkonnee Wongpiyabovorn and Tanapat Palaga
    Citation: Arthritis Research & Therapy 2010 12:R215
    Content type: Research article Published on:

  8. The risk of cardiovascular disease (CVD) and atherosclerosis is reported to be increased in systemic lupus erythematosus (SLE). We recently reported a negative association between natural IgM-antibodies agains...

    Authors: Cristina Anania, Thomas Gustafsson, Xiang Hua, Jun Su, Max Vikström, Ulf de Faire, Mikael Heimbürger, Tomas Jogestrand and Johan Frostegård
    Citation: Arthritis Research & Therapy 2010 12:R214
    Content type: Research article Published on:

  9. A deletion polymorphism in glutathione S-transferase Mu-1 (GSTM1-null) has previously been implicated to play a role in rheumatoid arthritis (RA) risk and progression, although no prior investigations have examin...

    Authors: Ted R Mikuls, Karen A Gould, Kimberly K Bynoté, Fang Yu, Tricia D LeVan, Geoffrey M Thiele, Kaleb D Michaud, James R O'Dell, Andreas M Reimold, Roderick Hooker, Liron Caplan, Dannette S Johnson, Gail Kerr, J Steuart Richards, Grant W Cannon, Lindsey A Criswell…
    Citation: Arthritis Research & Therapy 2010 12:R213
    Content type: Research article Published on:

  10. The transcription factor Fli1 is implicated in the pathogenesis of systemic lupus erythematosus (SLE). Recently, a GAn polymorphic microsatellite was characterized in the mouse Fli1 promoter that modulates promot...

    Authors: Erin E Morris, May Y Amria, Emily Kistner-Griffin, John L Svenson, Diane L Kamen, Gary S Gilkeson and Tamara K Nowling
    Citation: Arthritis Research & Therapy 2010 12:R212
    Content type: Research article Published on:

  11. The goal of this study was to identify serum markers that are modulated by treatment with golimumab with or without methotrexate (MTX) and are associated with clinical response.

    Authors: Sudha Visvanathan, Mahboob U Rahman, Edward Keystone, Mark Genovese, Lars Klareskog, Elizabeth Hsia, Michael Mack, Jacqui Buchanan, Michael Elashoff and Carrie Wagner
    Citation: Arthritis Research & Therapy 2010 12:R211
    Content type: Research article Published on:

  12. Rheumatoid arthritis (RA) is a T-cell-mediated systemic autoimmune disease, characterized by synovium inflammation and articular destruction. Bone marrow mesenchymal stem cells (MSCs) could be effective in the...

    Authors: Yanying Liu, Rong Mu, Shiyao Wang, Li Long, Xia Liu, Ru Li, Jian Sun, Jianping Guo, Xiaoping Zhang, Jing Guo, Ping Yu, Chunlei Li, Xiangyuan Liu, Zhenyu Huang, Dapeng Wang, Hu Li…
    Citation: Arthritis Research & Therapy 2010 12:R210
    Content type: Research article Published on:

  13. After publication of our recent article [1], we noticed that Virginia Kraus had been inadvertently omitted as coauthor. The author list is now complete and the competing interests section modified accordingly.

    Authors: Martin K Lotz and Virginia B Kraus
    Citation: Arthritis Research & Therapy 2010 12:408
    Content type: Erratum Published on:

    The original article was published in Arthritis Research & Therapy 2010 12:211

  14. We sought to assess vascularity in wrist tenosynovitis by using power Doppler ultrasound (PDUS) and to compare detection of intra- and peritendinous vascularity with that of contrast-enhanced grey-scale ultras...

    Authors: Andrea S Klauser, Magdalena Franz, Rohit Arora, Gudrun M Feuchtner, Johann Gruber, Michael Schirmer, Werner R Jaschke and Markus F Gabl
    Citation: Arthritis Research & Therapy 2010 12:R209
    Content type: Research article Published on:

  15. While the role of mycophenolate mofetil (MMF) in the management of lupus nephritis has been increasingly recognized, limited information is available regarding its efficacy and safety as a long-term maintenanc...

    Authors: Katerina Laskari, Clio P Mavragani, Athanasios G Tzioufas and Haralampos M Moutsopoulos
    Citation: Arthritis Research & Therapy 2010 12:R208
    Content type: Research article Published on:

  16. Although autoimmune diseases exhibit contrasting epidemiological features, pathology, and clinical manifestations, three lines of evidence demonstrate that these diseases share similar immunogenetic mechanisms...

    Authors: Juan-Manuel Anaya
    Citation: Arthritis Research & Therapy 2010 12:147
    Content type: Editorial Published on:

  17. In inflammatory joint disease, such as osteoarthritis (OA), there is an increased level of proinflammatory cytokines, such as interleukin (IL)-1β. These cytokines stimulate the production of matrix metalloprot...

    Authors: Angus KT Wann, Jiten Mistry, Emma J Blain, Adina T Michael-Titus and Martin M Knight
    Citation: Arthritis Research & Therapy 2010 12:R207
    Content type: Research article Published on:

  18. Synovial mesenchymal stem cells (MSCs) have high proliferative and chondrogenic potentials, and MSCs transplanted into the articular cartilage defect produce abundant extracellular matrix. Because of similarit...

    Authors: Takashi Miyamoto, Takeshi Muneta, Takashi Tabuchi, Kenji Matsumoto, Hirohisa Saito, Kunikazu Tsuji and Ichiro Sekiya
    Citation: Arthritis Research & Therapy 2010 12:R206
    Content type: Research article Published on:

  19. Most authorities recommend starting biological agents upon failure of at least one disease-modifying agent in patients with rheumatoid arthritis. However, owing to the absence of head-to-head studies, there is...

    Authors: Sofia Ramiro, Pedro Machado, Jasvinder A Singh, Robert B Landewé and José António P da Silva
    Citation: Arthritis Research & Therapy 2010 12:220
    Content type: Review Published on:

  20. Microvasculopathy is one of the characteristic features in patients with systemic sclerosis (SSc), but underlying mechanisms still remain uncertain. In this study, we evaluated the potential involvement of mon...

    Authors: Yukie Yamaguchi, Yuka Okazaki, Noriyuki Seta, Takashi Satoh, Kazuo Takahashi, Zenro Ikezawa and Masataka Kuwana
    Citation: Arthritis Research & Therapy 2010 12:R205
    Content type: Research article Published on:

  21. Epratuzumab, a humanized anti-CD22 monoclonal antibody, is under investigation as a therapeutic antibody in non-Hodgkin's lymphoma and systemic lupus erythematosus (SLE), but its mechanism of action on B-cells...

    Authors: Capucine Daridon, Daniela Blassfeld, Karin Reiter, Henrik E Mei, Claudia Giesecke, David M Goldenberg, Arne Hansen, Arwed Hostmann, Daniela Frölich and Thomas Dörner
    Citation: Arthritis Research & Therapy 2010 12:R204
    Content type: Research article Published on:

  22. The purpose of this work was to establish and validate combined small animal positron emission tomography - computed tomography (PET/CT) as a new in vivo imaging method for visualisation and quantification of joi...

    Authors: Ingo M Irmler, Thomas Opfermann, Peter Gebhardt, Mieczyslaw Gajda, Rolf Bräuer, Hans P Saluz and Thomas Kamradt
    Citation: Arthritis Research & Therapy 2010 12:R203
    Content type: Research article Published on:

  26. A cross-regulation between type I IFN and TNFα has been proposed recently, where both cytokines are hypothesized to counteract each other. According to this model, different autoimmune diseases can be viewed a...

    Authors: Tineke Cantaert, Dominique Baeten, Paul P Tak and Lisa GM van Baarsen
    Citation: Arthritis Research & Therapy 2010 12:219
    Content type: Review Published on:

  27. Cartilage thickness from MR images has been identified as a possible biomarker in knee osteoarthritis (OA) research. The ability to acquire MR data at multiple centers by using different vendors' scanners woul...

    Authors: Sharon Balamoody, Tomos G Williams, John C Waterton, Michael Bowes, Richard Hodgson, Chris J Taylor and Charles E Hutchinson
    Citation: Arthritis Research & Therapy 2010 12:R202
    Content type: Research article Published on:

  28. Pain management in conditions of chronic inflammation is a clinical challenge, and increasing our understanding of the mechanisms driving this type of pain is important. In the previous issue of Arthritis Researc...

    Authors: Camilla I Svensson
    Citation: Arthritis Research & Therapy 2010 12:145
    Content type: Editorial Published on:

  30. Objectives were to investigate whether interactions between human osteoarthritic chondrocytes and 4-hydroxynonenal (HNE)-modified type II collagen (Col II) affect cell phenotype and functions and to determine ...

    Authors: Rana El-Bikai, Mélanie Welman, Yoran Margaron, Jean-François Côté, Luke Macqueen, Michael D Buschmann, Hassan Fahmi, Qin Shi, Karim Maghni, Julio C Fernandes and Mohamed Benderdour
    Citation: Arthritis Research & Therapy 2010 12:R201
    Content type: Research article Published on:

  31. There is an ever-increasing need for animal models to evaluate efficacy and safety of new therapeutics in the field of rheumatoid arthritis (RA). Particularly for the early preclinical evaluation of human-spec...

    Authors: Michel PM Vierboom, Elia Breedveld, Ivanela Kondova and Bert A 't Hart
    Citation: Arthritis Research & Therapy 2010 12:R200
    Content type: Research article Published on:

  32. Urokinase-type plasminogen activator (u-PA) has been implicated in tissue destruction/remodeling. The absence of u-PA results in resistance of mice to systemic immune complex-driven arthritis models; monoartic...

    Authors: Christine M De Nardo, Jason C Lenzo, Jarrad Pobjoy, John A Hamilton and Andrew D Cook
    Citation: Arthritis Research & Therapy 2010 12:R199
    Content type: Research article Published on:

  33. Chronic, plaque-associated inflammation of the gingiva and the periodontium are among the most common oral diseases. Periodontitis (PD) is characterized by the inflammatory destruction of the periodontal attac...

    Authors: Jacqueline Detert, Nicole Pischon, Gerd R Burmester and Frank Buttgereit
    Citation: Arthritis Research & Therapy 2010 12:218
    Content type: Review Published on:

  34. The purpose of this research is to assess the effects of oral ibandronate on bone microarchitecture by using high-resolution peripheral quantitative computed tomography (HR-pQCT) in patients with systemic lupu...

    Authors: Edmund K Li, Tracy Y Zhu, Vivian Y Hung, Anthony W Kwok, Vivian W Lee, Kenneth K Lee, James F Griffith, Martin Li, Kong Chiu Wong, Ping Chung Leung, Ling Qin and Lai Shan Tam
    Citation: Arthritis Research & Therapy 2010 12:R198
    Content type: Research article Published on:

  35. Rheumatoid arthritis (RA) is associated with changes in body composition and bone mineral density (BMD). The purpose of the present study was to evaluate whether anti-TNF treatment in early RA has an impact on...

    Authors: Inga-Lill Engvall, Birgitta Tengstrand, Kerstin Brismar and Ingiäld Hafström
    Citation: Arthritis Research & Therapy 2010 12:R197
    Content type: Research article Published on:

  36. Therapeutic monoclonal antibodies have revolutionized the treatment of various inflammatory diseases. Immunogenicity against these antibodies has been shown to be clinically important: it is associated with sh...

    Authors: Charlotte Louise Maria Krieckaert, Geertje Margret Bartelds, Willem Frederik Lems and Gerrit Jan Wolbink
    Citation: Arthritis Research & Therapy 2010 12:217
    Content type: Review Published on:

  37. Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by sustained synovitis. Recently, several studies have proposed neutrophils and Th17 cells as key players in the onset and p...

    Authors: Rita Cascão, Rita A Moura, Inês Perpétuo, Helena Canhão, Elsa Vieira-Sousa, Ana F Mourão, Ana M Rodrigues, Joaquim Polido-Pereira, Mário V Queiroz, Henrique S Rosário, Maria M Souto-Carneiro, Luis Graca and João E Fonseca
    Citation: Arthritis Research & Therapy 2010 12:R196
    Content type: Research article Published on:

  39. Pomegranate has been revered throughout history for its medicinal properties. p38-MAPK is a major signal-transducing pathway in osteoarthritis (OA) and its activation by interleukin-1β (IL-1β) plays a critical...

    Authors: Zafar Rasheed, Nahid Akhtar and Tariq M Haqqi
    Citation: Arthritis Research & Therapy 2010 12:R195
    Content type: Research article Published on:

  40. BRAF (v raf murine sarcoma viral oncogene homologue B1) is a serine-threonine kinase involved in the mitogen-activated protein kinase (MAPK) signalling pathway, known to be implicated in the production of pro-...

    Authors: Caroline Charpin, Marielle Martin, Nathalie Balandraud, Jean Roudier and Isabelle Auger
    Citation: Arthritis Research & Therapy 2010 12:R194
    Content type: Research article Published on:

  41. In the large-scale case-control study EPILIFT, we investigated the dose-response relationship between lifestyle factors (weight, smoking amount, cumulative duration of different sports activities) and lumbar d...

    Authors: Barbara Schumann, Ulrich Bolm-Audorff, Annekatrin Bergmann, Rolf Ellegast, Gine Elsner, Joachim Grifka, Johannes Haerting, Matthias Jäger, Martina Michaelis and Andreas Seidler
    Citation: Arthritis Research & Therapy 2010 12:R193
    Content type: Research article Published on:

  42. Preclinical work has suggested that IL-1 plays a critical role in the pathogenesis of rheumatoid arthritis (RA). The objective of the present study was to determine the effect of a long-acting IL-1 receptor in...

    Authors: Mario H Cardiel, Paul P Tak, William Bensen, Francis X Burch, Sarka Forejtova, Janusz E Badurski, Tarundeep Kakkar, Terry Bevirt, Liyun Ni, Ellen McCroskery, Angelika Jahreis and Debra J Zack
    Citation: Arthritis Research & Therapy 2010 12:R192
    Content type: Research article Published on:

  43. We compared the odds of vitamin D deficiency in three chronic diseases: systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and type 2 diabetes (T2DM), adjusting for medications, demographics, and l...

    Authors: Anna R Broder, Jonathan N Tobin and Chaim Putterman
    Citation: Arthritis Research & Therapy 2010 12:R191
    Content type: Research article Published on:

  44. Rheumatoid arthritis (RA) is characterized by bone and cartilage invasion by fibroblast-like synoviocytes (FLSs). Adrenomedullin, a peptide with anabolic and antiapoptotic properties, is secreted by rheumatoid...

    Authors: Marie-Dominique Ah Kioon, Carine Asensio, Hang-Korng Ea, Benjamin Uzan, Martine Cohen-Solal and Frédéric Lioté
    Citation: Arthritis Research & Therapy 2010 12:R190
    Content type: Research article Published on:

  45. The objective of this study was to investigate the effects of moderate-to-high intensity Nordic walking (NW) on functional capacity and pain in fibromyalgia (FM).

    Authors: Kaisa Mannerkorpi, Lena Nordeman, Ã…sa Cider and Gunilla Jonsson
    Citation: Arthritis Research & Therapy 2010 12:R189
    Content type: Research article Published on:

  46. Chemokines and their receptors are potential therapeutic targets in rheumatoid arthritis (RA). Among these, several studies suggested the involvement of CXC chemokine 4 (CXCR4) and its ligand CXC ligand 12 (SD...

    Authors: Soo-Hyun Chung, Keisuke Seki, Byung-Il Choi, Keiko B Kimura, Akihiko Ito, Noriyuki Fujikado, Shinobu Saijo and Yoichiro Iwakura
    Citation: Arthritis Research & Therapy 2010 12:R188
    Content type: Research article Published on:

  47. Osteoarthritis (OA) is the most common bone and joint disease influenced by genetic and environmental factors. Recent association studies have uncovered the genetic factors behind OA, its susceptibility genes,...

    Authors: Hiroshi Takahashi, Masahiro Nakajima, Kouichi Ozaki, Toshihiro Tanaka, Naoyuki Kamatani and Shiro Ikegawa
    Citation: Arthritis Research & Therapy 2010 12:R187
    Content type: Research article Published on:

  48. Patients with chronic low back pain (cLBP) have high rates of comorbid psychiatric disorders, mainly depression. Recent evidence suggests that depressive symptoms and pain, as interacting factors, have an effe...

    Authors: Haili Wang, Carsten Ahrens, Winfried Rief, Simone Gantz, Marcus Schiltenwolf and Wiltrud Richter
    Citation: Arthritis Research & Therapy 2010 12:R186
    Content type: Research article Published on:

  49. Our previous work showed higher tumour necrosis factor (TNF)-α levels in patients with chronic low back pain (cLBP) compared to healthy controls. However, patients with depression as a comorbidity did not have...

    Authors: Haili Wang, Carsten Ahrens, Winfried Rief and Marcus Schiltenwolf
    Citation: Arthritis Research & Therapy 2010 12:R185
    Content type: Research article Published on:

  50. Reduced synovial expression of histone deacetylases (HDACs) is proposed to contribute to pathology in rheumatoid arthritis (RA) by enhancing histone-dependent access of transcription factors to promoters of in...

    Authors: Aleksander M Grabiec and Kris A Reedquist
    Citation: Arthritis Research & Therapy 2010 12:142
    Content type: Editorial Published on:
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Arthritis Research & Therapy

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