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  1. The Kitasato Symposium 2009: New Prospects for Cytokine Inhibition was held in Berlin, Germany from 7 to 9 May 2009. The key aims of this meeting were to bring together a group of front-line researchers and rh...

    Authors: Gerd R Burmester, Peter E Lipsky and Thomas Dörner
    Citation: Arthritis Research & Therapy 2009 11:301
    Content type: Meeting report Published on:

  2. Passive blockade of tumor necrosis factor-alpha (TNF-α) has demonstrated high therapeutic efficiency in chronic inflammatory diseases, such as rheumatoid arthritis, although some concerns remain such as occurr...

    Authors: Laure Delavallée, Luca Semerano, Eric Assier, Géraldine Vogel, Grégoire Vuagniaux, Marion Laborie, Daniel Zagury, Natacha Bessis and Marie-Christophe Boissier
    Citation: Arthritis Research & Therapy 2009 11:R195
    Content type: Research article Published on:

  4. Borrelia burgdorferi sensu lato is the causative agent of Lyme borreliosis in humans. This inflammatory disease can affect the skin, the peripheral and central nervous system, the musculoskeletal and cardiovascul...

    Authors: Hermann J Girschick, Henner Morbach and Dennis Tappe
    Citation: Arthritis Research & Therapy 2009 11:258
    Content type: Review Published on:

  5. Interleukin (IL)-23 is essential for the development of various experimental autoimmune models. However, the role of IL-23 in non-autoimmune experimental arthritis remains unclear. Here, we examined the role o...

    Authors: Ferry Cornelissen, Adriana MC Mus, Patrick S Asmawidjaja, Jan Piet van Hamburg, Joel Tocker and Erik Lubberts
    Citation: Arthritis Research & Therapy 2009 11:R194
    Content type: Research article Published on:

  6. Improvement of rheumatoid arthritis (RA) during pregnancy has been causatively associated with increased galactosylation of immunoglobulin G (IgG) N-glycans. Since previous studies were small, did not include ...

    Authors: Fleur E van de Geijn, Manfred Wuhrer, Maurice HJ Selman, Sten P Willemsen, Yaël A de Man, André M Deelder, Johanna MW Hazes and Radboud JEM Dolhain
    Citation: Arthritis Research & Therapy 2009 11:R193
    Content type: Research article Published on:

  7. The medicinal treatment of osteoarthritis (OA) is mostly symptomatic to relieve pain and incapacity with analgesics and non-steroidal anti-inflammatory drugs (NSAIDs), drugs with well-known risks. Complementar...

    Authors: Alain Jacquet, Pierre-Olivier Girodet, Antoine Pariente, Karelle Forest, Laurent Mallet and Nicholas Moore
    Citation: Arthritis Research & Therapy 2009 11:R192
    Content type: Research article Published on:

  8. Physical function is a key component of patient-reported outcome (PRO) assessment in rheumatology. Modern psychometric methods, such as Item Response Theory (IRT) and Computerized Adaptive Testing, can materia...

    Authors: Bonnie Bruce, James F Fries, Debbie Ambrosini, Bharathi Lingala, Barbara Gandek, Matthias Rose and John E Ware Jr
    Citation: Arthritis Research & Therapy 2009 11:R191
    Content type: Research article Published on:

  9. Glucocorticoids have extensively been used in the treatment of rheumatoid arthritis and other inflammatory diseases. However, their side-effects remain the major limitation in clinical use and an improved ther...

    Authors: Una Rauchhaus, Franz Werner Schwaiger and Steffen Panzner
    Citation: Arthritis Research & Therapy 2009 11:R190
    Content type: Research article Published on:

  10. Tumor necrosis factor is a pleiotropic cytokine with potent immune regulatory functions. Although tumor necrosis factor inhibitors have demonstrated great utility in treating other autoimmune diseases, such as...

    Authors: Jelle L Vosters, Hongen Yin, Nienke Roescher, Marc R Kok, Paul P Tak and John A Chiorini
    Citation: Arthritis Research & Therapy 2009 11:R189
    Content type: Research article Published on:

  11. Serum levels of C-reactive protein (CRP) seldom reflect disease activity in systemic lupus erythematosus (SLE). We have previously shown that autoantibodies against neo-epitopes of CRP often occur in SLE, but ...

    Authors: Christopher Sjöwall, Agneta Zickert, Thomas Skogh, Jonas Wetterö and Iva Gunnarsson
    Citation: Arthritis Research & Therapy 2009 11:R188
    Content type: Research article Published on:

  12. Rat adjuvant-induced arthritis (AIA) and collagen-induced arthritis (CIA) feature bone loss and systemic increases in TNFα, IL-1β, and receptor activator of NF-κB ligand (RANKL). Anti-IL-1 or anti-TNFα therapi...

    Authors: Marina Stolina, Georg Schett, Denise Dwyer, Steven Vonderfecht, Scot Middleton, Diane Duryea, Efrain Pacheco, Gwyneth Van, Brad Bolon, Ulrich Feige, Debra Zack and Paul Kostenuik
    Citation: Arthritis Research & Therapy 2009 11:R187
    Content type: Research article Published on:

  15. Cardiovascular disease (CVD) is a major cause of premature mortality among Systemic lupus erythematosus (SLE) patients. Many studies have measured and evaluated risk factors for premature subclinical atheroscl...

    Authors: Johanna Gustafsson, Iva Gunnarsson, Ola Börjesson, Susanne Pettersson, Sonia Möller, Guo-Zhong Fei, Kerstin Elvin, Julia F Simard, Lars-Olof Hansson, Ingrid E Lundberg, Anders Larsson and Elisabet Svenungsson
    Citation: Arthritis Research & Therapy 2009 11:R186
    Content type: Research article Published on:

  16. Osteoclasts play a key role in the pathogenesis of bone erosion and systemic bone mass loss during rheumatoid arthritis (RA). In this study, we aimed to determine the effect of methotrexate (MTX) and zoledroni...

    Authors: Benoit Le Goff, Elise Soltner, Céline Charrier, Yves Maugars, Françoise Rédini, Dominique Heymann and Jean-Marie Berthelot
    Citation: Arthritis Research & Therapy 2009 11:R185
    Content type: Research article Published on:

  17. For many years the heterogeneity of CD4+ T-helper (Th) cells has been limited to Th1 and Th2 cells, which have been considered not only to be responsible for different types of protective responses, but also for ...

    Authors: Francesco Annunziato and Sergio Romagnani
    Citation: Arthritis Research & Therapy 2009 11:257
    Content type: Review Published on:

  18. The regulation and elevation in expression of the catabolic matrix metalloproteinases (MMPs) is of high importance in the human intervertebral disc since upregulation of these matrix-degrading enzymes results ...

    Authors: Helen E Gruber, Jane A Ingram, Gretchen L Hoelscher, Natalia Zinchenko, H James Norton and Edward N Hanley Jr
    Citation: Arthritis Research & Therapy 2009 11:R184
    Content type: Research article Published on:

  19. Comparison of intra-articular bacterial-derived hyaluronic acid (Hyalubrix®) (HA) with local analgesia (mepivacaine) for osteoarthritis (OA) of the hip.

    Authors: Alberto Migliore, Umberto Massafra, Emanuele Bizzi, Francesca Vacca, Severino Martin-Martin, Mauro Granata, Andrea Alimonti and Sandro Tormenta
    Citation: Arthritis Research & Therapy 2009 11:R183
    Content type: Research article Published on:

  20. Functional status is an integral component of health-related quality of life in patients with ankylosing spondylitis (AS). The purpose of this study was to investigate the role of psychological variables in se...

    Authors: Tamar F Brionez, Shervin Assassi, John D Reveille, Thomas J Learch, Laura Diekman, Michael M Ward, John C Davis Jr, Michael H Weisman and Perry Nicassio
    Citation: Arthritis Research & Therapy 2009 11:R182
    Content type: Research article Published on:

  21. Given the emerging evidence that osteoarthritis (OA) may have a vascular basis, the aim of this study was to determine whether serum lipids were associated with change in knee cartilage, presence of bone marro...

    Authors: Miranda L Davies-Tuck, Fahad Hanna, Susan R Davis, Robin J Bell, Sonia L Davison, Anita E Wluka, Jenny Adams and Flavia M Cicuttini
    Citation: Arthritis Research & Therapy 2009 11:R181
    Content type: Research article Published on:

  22. Chicken type II collagen (CCII) is a protein extracted from the cartilage of chicken breast and exhibits intriguing possibilities for the treatment of autoimmune diseases by inducing oral tolerance. A 24-week,...

    Authors: Wei Wei, Ling-Ling Zhang, Jian-Hua Xu, Feng Xiao, Chun-De Bao, Li-Qing Ni, Xing-Fu Li, Yu-Qing Wu, Ling-Yun Sun, Rong-Hua Zhang, Bao-Liang Sun, Sheng-Qian Xu, Shang Liu, Wei Zhang, Jie Shen, Hua-Xiang Liu…
    Citation: Arthritis Research & Therapy 2009 11:R180
    Content type: Research article Published on:

  24. Reactivation of hepatitis B virus (HBV) infection in patients with past infection has been described in 5% to 10% of individuals undergoing immunosuppressive therapies. No data are available to date on the out...

    Authors: Caroline Charpin, Sandrine Guis, Philippe Colson, Patrick Borentain, Jean-Pierre Mattéi, Patrice Alcaraz, Nathalie Balandraud, Benoit Thomachot, Jean Roudier and René Gérolami
    Citation: Arthritis Research & Therapy 2009 11:R179
    Content type: Research article Published on:

  25. Adjustment of infliximab dosage for individuals may be useful in improving therapeutic response in rheumatoid arthritis (RA). Herein, we aimed to determine whether measurement of infliximab serum concentration...

    Authors: Denis Mulleman, Jean-Camille Méric, Gilles Paintaud, Emilie Ducourau, Charlotte Magdelaine-Beuzelin, Jean-Pierre Valat and Philippe Goupille
    Citation: Arthritis Research & Therapy 2009 11:R178
    Content type: Research article Published on:

  26. Treatment with the chimerical monoclonal antibody rituximab results in CD20-directed B cell depletion. Although this depletion is almost complete in the peripheral blood of nearly all patients with rheumatoid ...

    Authors: Maria JH Boumans and Paul P Tak
    Citation: Arthritis Research & Therapy 2009 11:134
    Content type: Editorial Published on:

  27. Synovial biopsies, gained either by blind needle biopsy or minimally invasive arthroscopy, offer additional information in certain clinical situations where routine assessment has not permitted a certain diagn...

    Authors: Stefan Vordenbäumen, Leo AB Joosten, Johannes Friemann, Matthias Schneider and Benedikt Ostendorf
    Citation: Arthritis Research & Therapy 2009 11:256
    Content type: Review Published on:

  28. Ankylosing spondylitis (AS) and inflammatory bowel disease (IBD) share similarities and are classified as spondyloarthropathies. In IBD, anti-Saccharomyces cerevisiae antibody (ASCA), anti-I2 (associated with ant...

    Authors: Matthew L Mundwiler, Ling Mei, Carol J Landers, John D Reveille, Stephan Targan and Michael H Weisman
    Citation: Arthritis Research & Therapy 2009 11:R177
    Content type: Research article Published on:

  29. Co-stimulatory signal B7(CD80/CD86):CD28 is needed in order to activate T cells in immune response. Cytotoxic T lymphocyte-associated antigen-4-immunoglobulin (CTLA4-Ig) binding to the B7 molecules on antigen-...

    Authors: Maurizio Cutolo, Stefano Soldano, Paola Montagna, Alberto Sulli, Bruno Seriolo, Barbara Villaggio, Pierfranco Triolo, Paolo Clerico, Lamberto Felli and Renata Brizzolara
    Citation: Arthritis Research & Therapy 2009 11:R176
    Content type: Research article Published on:

  30. Polymerase chain reaction (PCR) and ligase chain reaction (LCR) are used in research for detection of Chlamydia trachomatis (C. tr.) in synovial fluid (SF). However there is no standardized system for diagnost...

    Authors: Julia Freise, Iris Bernau, Sabine Meier, Henning Zeidler and Jens G Kuipers
    Citation: Arthritis Research & Therapy 2009 11:R175
    Content type: Research article Published on:

  31. One of the major challenges in rheumatology is to overcome the classification criteria that previously defined systemic lupus erythematosis, since the heterogeneity of the disease(s) appears to represent a com...

    Authors: Michael F Smith Jr, Falk Hiepe, Thomas Dörner and Gerd Burmester
    Citation: Arthritis Research & Therapy 2009 11:255
    Content type: Review Published on:

  32. A protein analysis using a mass spectrometry indicated that there are serum proteins showing significant quantitative changes after the administration of infliximab. Among them, connective tissue growth factor...

    Authors: Kazuhisa Nozawa, Maki Fujishiro, Mikiko Kawasaki, Hiroshi Kaneko, Kazuhisa Iwabuchi, Mitsuaki Yanagida, Fujihiko Suzuki, Keiji Miyazawa, Yoshinari Takasaki, Hideoki Ogawa, Kenji Takamori and Iwao Sekigawa
    Citation: Arthritis Research & Therapy 2009 11:R174
    Content type: Research article Published on:

  33. Little is known about endogenous or cytokine-stimulated aggrecan catabolism in the meniscal fibrocartilage of the knee. The objectives of this study were to characterize the structure, distribution, and proces...

    Authors: Christopher G Wilson, Eric J Vanderploeg, Fengrong Zuo, John D Sandy and Marc E Levenston
    Citation: Arthritis Research & Therapy 2009 11:R173
    Content type: Research article Published on:

  34. Renal involvement is common in systemic lupus erythematosus. Early diagnosis of lupus nephritis (LN), allowing the instigation of appropriate therapy, remains an important clinical challenge. Current biomarker...

    Authors: Neeraj Dhaun and David C Kluth
    Citation: Arthritis Research & Therapy 2009 11:133
    Content type: Editorial Published on:

  35. Earlier work indicates that the cholesterol-lowering drug, simvastatin, is anabolic to chondrogenic expression of rat intervertebral disc (IVD) cells, which suggests a potential role for simvastatin in IVD reg...

    Authors: Huina Zhang, Lin Wang, Jun Beom Park, Paul Park, Victor C Yang, Scott J Hollister, Frank La Marca and Chia-Ying Lin
    Citation: Arthritis Research & Therapy 2009 11:R172
    Content type: Research article Published on:

  36. Ankylosing spondylitis (AS) is a severe, chronic inflammatory disease strongly associated with HLA-B27. The presence of additional HLA risk factors has been suggested by several studies. The aim of the current...

    Authors: Fabiana Paladini, Francesca Belfiore, Elisa Cocco, Carlo Carcassi, Alberto Cauli, Alessandra Vacca, Maria Teresa Fiorillo, Alessandro Mathieu, Isabella Cascino and Rosa Sorrentino
    Citation: Arthritis Research & Therapy 2009 11:R171
    Content type: Research article Published on:

  37. The objective of this study was to assess the impact of certolizumab pegol (CZP) treatment on health-related quality of life (HRQoL), fatigue and other patient-reported outcomes (PROs) in patients with rheumat...

    Authors: Vibeke Strand, Philip Mease, Gerd R Burmester, Enkeleida Nikaï, Geoffroy Coteur, Ronald van Vollenhoven, Bernard Combe, Edward C Keystone and Arthur Kavanaugh
    Citation: Arthritis Research & Therapy 2009 11:R170
    Content type: Research article Published on:

  38. Spontaneous resorption of disc herniation (DH) after sciatica is well documented. The matrix metalloproteinases (MMP)-1 and MMP-3 are enzymes potentially involved in this process. Glucocorticoid injections are...

    Authors: Stéphane Genevay, Axel Finckh, Françoise Mezin, Enrico Tessitore and Pierre-André Guerne
    Citation: Arthritis Research & Therapy 2009 11:R169
    Content type: Research article Published on:

  39. Axial spondyloarthropathy (SpA) is a group of inflammatory diseases, with ankylosing spondylitis as the prototype. SpA affects the axial skeleton, entheses, joints and, at times, the eyes. This study tested th...

    Authors: Srilakshmi M Sharma, Dongseok Choi, Stephen R Planck, Christina A Harrington, Carrie R Austin, Jinnell A Lewis, Tessa N Diebel, Tammy M Martin, Justine R Smith and James T Rosenbaum
    Citation: Arthritis Research & Therapy 2009 11:R168
    Content type: Research article Published on:

  40. Immunosuppressants, including anti-TNFα antibodies, have remarkable effects in rheumatoid arthritis; however, they increase infectious events. The present study was designed to examine the effects and immunolo...

    Authors: Keiichi Iwanami, Isao Matsumoto, Yohei Yoshiga, Asuka Inoue, Yuya Kondo, Kayo Yamamoto, Yoko Tanaka, Reiko Minami, Taichi Hayashi, Daisuke Goto, Satoshi Ito, Yasuharu Nishimura and Takayuki Sumida
    Citation: Arthritis Research & Therapy 2009 11:R167
    Content type: Research article Published on:

  43. The etiology of degenerative disc disease is unknown. Several investigators have reported the presence of proteolytic enzymes, such as the matrix metalloproteinase (MMP) and ADAMTS (a disintegrin and metallopr...

    Authors: Shoji Seki, Yumiko Asanuma-Abe, Koichi Masuda, Yoshiharu Kawaguchi, Kunihiro Asanuma, Carol Muehleman, Akiko Iwai and Tomoatsu Kimura
    Citation: Arthritis Research & Therapy 2009 11:R166
    Content type: Research article Published on:

  44. Currently available treatments for osteoarthritis (OA) are restricted to nonsteroidal anti-inflammatory drugs, which exhibit numerous side effects and are only temporarily effective. Thus novel, safe and more ...

    Authors: Constanze Csaki, Ali Mobasheri and Mehdi Shakibaei
    Citation: Arthritis Research & Therapy 2009 11:R165
    Content type: Research article Published on:

  45. In 2008, the Food and Drugs Administration required manufacturers of TNFα antagonists to strengthen their warnings about the risk of serious fungal infections in patients with rheumatoid arthritis (RA). Sinus ...

    Authors: Ariane Leboime, Jean-Marie Berthelot, Yannick Allanore, Lama Khalil-Kallouche, Philippe Herman, Philippe Orcel and Frédéric Lioté
    Citation: Arthritis Research & Therapy 2009 11:R164
    Content type: Research article Published on:

  46. The aim of our analysis was to compare the gaining of a major response (disease activity score [DAS] remission or American College of Rheumatology 70% improvement criteria [ACR70]) by switching between all the...

    Authors: Stefano Alivernini, Antonella Laria, Elisa Gremese, Angelo Zoli and Gianfranco Ferraccioli
    Citation: Arthritis Research & Therapy 2009 11:R163
    Content type: Research article Published on:

  47. To determine if structural bone parameters obtained from dual energy X-ray absorptiometry (DXA) contribute to the prediction of progression of hip osteoarthritis (OA) and to test if the difference between the ...

    Authors: Martha C Castaño Betancourt, Jacqueline C Van der Linden, Fernando Rivadeneira, Rianne M Rozendaal, Sita M Bierma Zeinstra, Harrie Weinans and Jan H Waarsing
    Citation: Arthritis Research & Therapy 2009 11:R162
    Content type: Research article Published on:

  48. The role of adiponectin in the pathogenesis of arthritis is still controversial. This study was performed to examine whether adiponectin is involved in joint inflammation and destruction in rheumatoid arthriti...

    Authors: Hyun-Mi Choi, Yeon-Ah Lee, Sang-Hoon Lee, Seung-Jae Hong, Dae-Hyun Hahm, Sang-Yun Choi, Hyung-In Yang, Myung Chul Yoo and Kyoung Soo Kim
    Citation: Arthritis Research & Therapy 2009 11:R161
    Content type: Research article Published on:

  50. The field of biomarkers is a growing one, particularly in osteoarthritis (OA). OA is the most common disabling condition in older persons and a major cause of morbidity. While the debate continues about which ...

    Authors: Frances MK Williams
    Citation: Arthritis Research & Therapy 2009 11:130
    Content type: Editorial Published on:
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Arthritis Research & Therapy

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