Skip to main content

Articles

Page 96 of 155

  1. Despite recent advances in anti-inflammatory therapy, rheumatoid arthritis (RA) patients continue to rate pain as a priority. The etiology of RA pain is likely multifactorial, including both inflammatory and n...

    Authors: Yvonne C Lee, Lori B Chibnik, Bing Lu, Ajay D Wasan, Robert R Edwards, Anne H Fossel, Simon M Helfgott, Daniel H Solomon, Daniel J Clauw and Elizabeth W Karlson
    Citation: Arthritis Research & Therapy 2009 11:R160
    Content type: Research article Published on:

  4. The majority of autoimmune diseases predominate in females. In searching for an explanation for this female excess, most attention has focused on hormonal changes - both exogenous changes (for example, oral co...

    Authors: Jacqueline E Oliver and Alan J Silman
    Citation: Arthritis Research & Therapy 2009 11:252
    Content type: Review Published on:

  5. Calcified deposits (CDs) in skin and muscles are common in juvenile dermatomyositis (DM), and less frequent in adult DM. Limited information exists about the microstructure and composition of these deposits, a...

    Authors: Naomi Eidelman, Alan Boyde, Andrew J Bushby, Peter GT Howell, Jirun Sun, Dale E Newbury, Frederick W Miller, Pamela G Robey and Lisa G Rider
    Citation: Arthritis Research & Therapy 2009 11:R159
    Content type: Research article Published on:

  6. Interleukin (IL)-17 plays an important role in the pathogenesis of rheumatoid arthritis and the mouse model collagen-induced arthritis (CIA). Interferon(IFN)-γ and IL-4 have been shown to suppress Th17 develop...

    Authors: Sujata Sarkar, Laura A Cooney, Peter White, Deborah B Dunlop, Judith Endres, Julie M Jorns, Matthew J Wasco and David A Fox
    Citation: Arthritis Research & Therapy 2009 11:R158
    Content type: Research article Published on:

  7. The aim of this study was to determine a low disease activity threshold - a 28-joint disease activity score (DAS28) value - for the decision to maintain unchanged disease-modifying antirheumatic drug (DMARD) t...

    Authors: Michel de Bandt, Bruno Fautrel, Jean Francis Maillefert, Jean Marie Berthelot, Bernard Combe, René-Marc Flipo, Frédéric Lioté, Olivier Meyer, Alain Saraux, Daniel Wendling, Xavier Le Loët and Francis Guillemin
    Citation: Arthritis Research & Therapy 2009 11:R157
    Content type: Research article Published on:

  9. Cell stimulation leads to the shedding of phosphatidylserine (PS)-rich microparticles (MPs). Because autoimmune diseases (AIDs) are characterized by cell activation, we investigated level of circulating MPs as...

    Authors: Jérémie Sellam, Valérie Proulle, Astrid Jüngel, Marc Ittah, Corinne Miceli Richard, Jacques-Eric Gottenberg, Florence Toti, Joelle Benessiano, Steffen Gay, Jean-Marie Freyssinet and Xavier Mariette
    Citation: Arthritis Research & Therapy 2009 11:R156
    Content type: Research article Published on:

  10. Undifferentiated arthritis (UA) has a variable disease course; 40 to 50% of UA patients remit spontaneously, while 30% develop rheumatoid arthritis (RA). Identifying the UA patients who will develop RA is esse...

    Authors: Mohamed M Thabet, Thomas WJ Huizinga, Désirée M van der Heijde and Annette HM van der Helm-van Mil
    Citation: Arthritis Research & Therapy 2009 11:R155
    Content type: Research article Published on:

  14. Many of the chronic inflammatory and degenerative disorders that present to clinical rheumatologists have a complex genetic aetiology. Over the past decade a dramatic improvement in technology and methodology ...

    Authors: Alex Clarke and Timothy J Vyse
    Citation: Arthritis Research & Therapy 2009 11:248
    Content type: Review Published on:

  15. B-cell development is tightly regulated, including the induction of B-cell memory and antibody-secreting plasmablasts and plasma cells. In the last decade, we have expanded our understanding of effector functi...

    Authors: Thomas Dörner, Annett M Jacobi and Peter E Lipsky
    Citation: Arthritis Research & Therapy 2009 11:247
    Content type: Review Published on:

  17. Advances in genetics and new understanding of the molecular pathways that mediate innate and adaptive immune system activation, along with renewed focus on the role of the complement system as a mediator of in...

    Authors: Mary K Crow
    Citation: Arthritis Research & Therapy 2009 11:245
    Content type: Review Published on:

  18. Inflammatory rheumatic diseases are generally multifaceted disorders and, therefore, measurement of multiple outcomes is relevant to most of these diseases. Developments in outcome measures in the rheumatic di...

    Authors: Jaap Fransen and Piet LCM van Riel
    Citation: Arthritis Research & Therapy 2009 11:244
    Content type: Review Published on:

  19. The past 10 years have seen the description of families of receptors that drive proinflammatory cytokine production in infection and tissue injury. Two major classes have been examined in the context of inflam...

    Authors: William J McCormack, Andrew E Parker and Luke A O'Neill
    Citation: Arthritis Research & Therapy 2009 11:243
    Content type: Review Published on:

  21. Glomerulonephritis is a major cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE). Deposition of autoantibodies in the glomeruli plays a key role in the development of lupus ne...

    Authors: Jessica J Manson, Alexander Ma, Pauline Rogers, Lesley J Mason, Jo H Berden, Johan van der Vlag, David P D'Cruz, David A Isenberg and Anisur Rahman
    Citation: Arthritis Research & Therapy 2009 11:R154
    Content type: Research article Published on:

  22. Our previous study has reported that, in patients with untreated new-onset lupus (UNOL), there was an abnormal increase in the number of CD4+CD25-Foxp3+ T cells that correlated with disease activity and significa...

    Authors: Hua-xia Yang, Wen Zhang, Li-dan Zhao, Yang Li, Feng-chun Zhang, Fu-lin Tang, Wei He and Xuan Zhang
    Citation: Arthritis Research & Therapy 2009 11:R153
    Content type: Research article Published on:

  23. Angiogenesis is an important process in the development of destructive synovial pannus in rheumatoid arthritis (RA). The ITGAV +gene encodes a cell cycle-associated antigen, integrin ανβ 3, which plays a role in ...

    Authors: Jade E Hollis-Moffatt, Kerry A Rowley, Amanda J Phipps-Green, Marilyn E Merriman, Nicola Dalbeth, Peter Gow, Andrew A Harrison, John Highton, Peter BB Jones, Lisa K Stamp, Pille Harrison, B Paul Wordsworth and Tony R Merriman
    Citation: Arthritis Research & Therapy 2009 11:R152
    Content type: Research article Published on:

  24. The melanocortin peptides have marked anti-inflammatory potential, primarily through inhibition of proinflammatory cytokine production and action on phagocytic cell functions. Gout is an acute form of arthriti...

    Authors: Franco Capsoni, Anna Maria Ongari, Eva Reali and Anna Catania
    Citation: Arthritis Research & Therapy 2009 11:R151
    Content type: Research article Published on:

  26. In chronic inflammatory disorders, B cells can contribute to tissue damage by autoantibody production and antigen presentation to T cells. Here, we have characterized synovial fluid and tissue B-cell subsets i...

    Authors: Anna Corcione, Francesca Ferlito, Marco Gattorno, Andrea Gregorio, Angela Pistorio, Roberto Gastaldi, Claudio Gambini, Alberto Martini, Elisabetta Traggiai and Vito Pistoia
    Citation: Arthritis Research & Therapy 2009 11:R150
    Content type: Research article Published on:

  27. Accumulation of B cells in the rheumatoid arthritis (RA) synovium has been reported, and it has been thought that these cells might contribute to the pathogenesis of RA by antigen presentation, autoantibody pr...

    Authors: Toshihiro Nanki, Kazuki Takada, Yukiko Komano, Tomohiro Morio, Hirokazu Kanegane, Atsuo Nakajima, Peter E Lipsky and Nobuyuki Miyasaka
    Citation: Arthritis Research & Therapy 2009 11:R149
    Content type: Research article Published on:

  28. The present study compares bone morphogenetic protein (BMP)-4 and BMP-2 gene transfer as agents of chondrogenesis and hypertrophy in human primary mesenchymal stem cells (MSCs) maintained as pellet cultures.

    Authors: Andre F Steinert, Benedikt Proffen, Manuela Kunz, Christian Hendrich, Steven C Ghivizzani, Ulrich Nöth, Axel Rethwilm, Jochen Eulert and Christopher H Evans
    Citation: Arthritis Research & Therapy 2009 11:R148
    Content type: Research article Published on:

  29. Systemic sclerosis (SSc) (scleroderma) is a complex autoimmune disease that clinically manifests as progressive fibrosis of the skin and internal organs. Anti-centromere antibodies (ACAs), anti-topoisomerase a...

    Authors: Pravitt Gourh, Frank C Arnett, Shervin Assassi, Filemon K Tan, Mei Huang, Laura Diekman, Maureen D Mayes, John D Reveille and Sandeep K Agarwal
    Citation: Arthritis Research & Therapy 2009 11:R147
    Content type: Research article Published on:

  30. The current 1987 American College of Rheumatology (ACR) classification criteria for rheumatoid arthritis (RA) have proven less useful in early arthritis. The objective of this study was to identify and compare...

    Authors: Maria D Mjaavatten, Till Uhlig, Anne J Haugen, Halvor Nygaard, Göran Sidenvall, Knut Helgetveit and Tore K Kvien
    Citation: Arthritis Research & Therapy 2009 11:R146
    Content type: Research article Published on:

  32. Sulfur compounds isolated from garlic exert anti-inflammatory properties. We recently isolated thiacremonone, a novel sulfur compound from garlic. Here, we investigated the anti-inflammatory and arthritis prop...

    Authors: Jung Ok Ban, Ju Hoon Oh, Tae Myoung Kim, Dae Joong Kim, Heon-Sang Jeong, Sang Bae Han and Jin Tae Hong
    Citation: Arthritis Research & Therapy 2009 11:R145
    Content type: Research article Published on:

  33. A proliferation-inducing ligand (APRIL) from the TNF family, owing to its role in the generation and survival of plasma cells (PCs), is currently targeted for rheumatoid arthritis (RA) treatment. However, litt...

    Authors: Cem Gabay, Veit Krenn, Carine Bosshard, Christian Alexander Seemayer, Carlo Chizzolini and Bertrand Huard
    Citation: Arthritis Research & Therapy 2009 11:R144
    Content type: Research article Published on:

  34. TNF-like weak inducer of apoptosis (TWEAK) has been implicated as a mediator of chronic inflammatory processes via prolonged activation of the NF-κB pathway in several tissues, including the kidney. Evidence f...

    Authors: Noa Schwartz, Tamar Rubinstein, Linda C Burkly, Christopher E Collins, Irene Blanco, Lihe Su, Bernard Hojaili, Meggan Mackay, Cynthia Aranow, William Stohl, Brad H Rovin, Jennifer S Michaelson and Chaim Putterman
    Citation: Arthritis Research & Therapy 2009 11:R143
    Content type: Research article Published on:

  35. In this article, we present a comparative immunohistochemical evaluation of four clinical-stage antibodies (L19, F16, G11 and F8) directed against splice isoforms of fibronectin and of tenascin-C for their abi...

    Authors: Kathrin Schwager, Manuela Kaspar, Frank Bootz, Roberto Marcolongo, Erberto Paresce, Dario Neri and Eveline Trachsel
    Citation: Arthritis Research & Therapy 2009 11:R142
    Content type: Research article Published on:

  36. Little is known about factors that induce meniscus damage. Since joint inflammation appears to be a causative factor for meniscal destruction, we investigated the influence of tumor necrosis factor (TNFα) on g...

    Authors: Henning Voigt, Angelika K Lemke, Rolf Mentlein, Michael Schünke and Bodo Kurz
    Citation: Arthritis Research & Therapy 2009 11:R141
    Content type: Research article Published on:

  37. Neither hormone receptor genes nor plasma androgens seem significantly altered in female subjects before they became affected by rheumatoid arthritis (RA) and, therefore, do not seem to play a role as risk fac...

    Authors: Maurizio Cutolo
    Citation: Arthritis Research & Therapy 2009 11:126
    Content type: Editorial Published on:

  40. Osteoarthritis (OA) affects all articular tissues and finally leads to joint failure. Although articular tissues have long been considered unresponsive to estrogens or their deficiency, there is now increasing...

    Authors: Jorge A Roman-Blas, Santos Castañeda, Raquel Largo and Gabriel Herrero-Beaumont
    Citation: Arthritis Research & Therapy 2009 11:241
    Content type: Review Published on:

  41. The acronym SAPHO was introduced in 1987 to unify the various descriptions of a seronegative arthritis associated with skin manifestations and to show synovitis, acne, pustulosis, hyperostosis, and osteitis wi...

    Authors: Gunter Assmann, Olaf Kueck, Timm Kirchhoff, Herbert Rosenthal, Jan Voswinkel, Michael Pfreundschuh, Henning Zeidler and Annette D Wagner
    Citation: Arthritis Research & Therapy 2009 11:R140
    Content type: Research article Published on:

  42. Patient's expectations are variably reported to influence self-rated outcome and satisfaction after medical treatment; this prospective study examined which of the following was the most important unique deter...

    Authors: Anne F Mannion, Stephane Kämpfen, Urs Munzinger and Ines Kramers-de Quervain
    Citation: Arthritis Research & Therapy 2009 11:R139
    Content type: Research article Published on:

  43. Secretory phospholipase A2 (sPLA2) and matrix metalloproteinase (MMP) inhibitors are potent modulators of inflammation with therapeutic potential, but have limited efficacy in rheumatoid arthritis (RA). The objec...

    Authors: Maung-Maung Thwin, Eleni Douni, Pachiappan Arjunan, George Kollias, Prem V Kumar and Ponnampalam Gopalakrishnakone
    Citation: Arthritis Research & Therapy 2009 11:R138
    Content type: Research article Published on:

  44. Loss of intervertebral disc (IVD) matrix and ultimately disc height as a result of 'degeneration' has been implicated as a major cause of low back pain (LBP). The use of anabolic growth factors as therapies to...

    Authors: Christine L Le Maitre, Anthony J Freemont and Judith A Hoyland
    Citation: Arthritis Research & Therapy 2009 11:R137
    Content type: Research article Published on:

  47. Advanced glycation end products (AGEs) have been introduced to be involved in the pathogenesis of osteoarthritis (OA). The influence of AGEs on osteoarthritic fibroblast-like synovial cells (FLS) has been inco...

    Authors: Sybille Franke, Manfred Sommer, Christiane Rüster, Tzvetanka Bondeva, Julia Marticke, Gunther Hofmann, Gert Hein and Gunter Wolf
    Citation: Arthritis Research & Therapy 2009 11:R136
    Content type: Research article Published on:

  48. Evidence suggests that citrullinated fibrin(ogen) may be a potential in vivo target of anticitrullinated protein/peptide antibodies (ACPA) in rheumatoid arthritis (RA). We compared the diagnostic yield of three e...

    Authors: Raimon Sanmartí, Eduard Graell, Maria L Perez, Guadalupe Ercilla, Odette Viñas, Jose A Gómez-Puerta, Jordi Gratacós, Alejandro Balsa, Maria J Gómara, Marta Larrosa, Juan D Cañete and Isabel Haro
    Citation: Arthritis Research & Therapy 2009 11:R135
    Content type: Research article Published on:

  49. Osteochondral grafts have become popular for treating small, isolated and full-thickness cartilage lesions. It is recommended that a slightly oversized, rather than an exact-sized, osteochondral plug is transp...

    Authors: Koji Hattori, Kota Uematsu, Tomohiro Matsumoto and Hajime Ohgushi
    Citation: Arthritis Research & Therapy 2009 11:R134
    Content type: Research article Published on:

  50. Autologous chondrocyte transplantation (ACT) is a routine technique to regenerate focal cartilage lesions. However, patients with osteoarthritis (OA) are lacking an appropriate long-lasting treatment alternati...

    Authors: Tilo Dehne, Camilla Karlsson, Jochen Ringe, Michael Sittinger and Anders Lindahl
    Citation: Arthritis Research & Therapy 2009 11:R133
    Content type: Research article Published on:
  • Logo
Submit manuscript

Follow

Annual Journal Metrics

  • Citation Impact 2023
    Journal Impact Factor: 4.4
    5-year Journal Impact Factor: 4.9
    Source Normalized Impact per Paper (SNIP): 1.294
    SCImago Journal Rank (SJR): 1.518

    Speed 2023
    Submission to first editorial decision (median days): 9
    Submission to acceptance (median days): 111

    Usage 2023
    Downloads: 3,331,819
    Altmetric mentions: 1,885

Arthritis Research & Therapy

ISSN: 1478-6362

Contact us