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  1. Both genetic and environmental factors contribute to rheumatoid arthritis (RA), a common and complex autoimmune disease. As well as the major susceptibility gene HLA-DRB1, recent genome-wide and candidate-gene st...

    Authors: Klaus Stark, Jozef Rovenský, Stanislava Blažičková, Hans Grosse-Wilde, Stanislav Ferencik, Christian Hengstenberg and Rainer H Straub
    Citation: Arthritis Research & Therapy 2009 11:R70
    Content type: Research article Published on:

  2. We aimed to replicate association of newly identified systemic lupus erythematosus (SLE) loci.

    Authors: Marian Suarez-Gestal, Manuel Calaza, Emöke Endreffy, Rudolf Pullmann, Josep Ordi-Ros, Gian Domenico Sebastiani, Sarka Ruzickova, Maria Jose Santos, Chryssa Papasteriades, Maurizio Marchini, Fotini N Skopouli, Ana Suarez, Francisco J Blanco, Sandra D'Alfonso, Marc Bijl, Patricia Carreira…
    Citation: Arthritis Research & Therapy 2009 11:R69
    Content type: Research article Published on:

  3. Similar to matrix metalloproteinases, glycosidases also play a major role in cartilage degradation. Carbohydrate cleavage products, generated by these latter enzymes, are released from degrading cartilage duri...

    Authors: Mária Pásztói, György Nagy, Pál Géher, Tamás Lakatos, Kálmán Tóth, Károly Wellinger, Péter Pócza, Bence György, Marianna C Holub, Ágnes Kittel, Krisztina Pálóczy, Mercédesz Mazán, Péter Nyirkos, András Falus and Edit I Buzas
    Citation: Arthritis Research & Therapy 2009 11:R68
    Content type: Research article Published on:

  4. Functioning is recognized as an important study outcome in chronic widespread pain (CWP). The Comprehensive ICF Core Set for CWP is an application of the International Classification of Functioning, Disability an...

    Authors: Robin Hieblinger, Michaela Coenen, Gerold Stucki, Andreas Winkelmann and Alarcos Cieza
    Citation: Arthritis Research & Therapy 2009 11:R67
    Content type: Research article Published on:

  5. Behçet's disease is a chronic systemic inflammatory disease that remains incompletely understood. Herein, we perform the first genome-wide association study in Behçet's disease.

    Authors: Yiping Fei, Ryan Webb, Beth L Cobb, Haner Direskeneli, Güher Saruhan-Direskeneli and Amr H Sawalha
    Citation: Arthritis Research & Therapy 2009 11:R66
    Content type: Research article Published on:

  6. The aim of this study was to compare the effects of tumour necrosis factor-alpha (TNF-α) and interleukin-1-beta (IL-1β) on protease and catabolic cytokine and receptor gene expression in normal and degenerate ...

    Authors: S Jane Millward-Sadler, Patrick W Costello, Anthony J Freemont and Judith A Hoyland
    Citation: Arthritis Research & Therapy 2009 11:R65
    Content type: Research article Published on:

  7. Rheumatoid arthritis (RA) is characterised by invasion of cartilage, bone and tendon by inflamed synovium. Previous studies in our laboratory have shown that hypoxia is a feature of RA synovitis. In the presen...

    Authors: Mohammed A Akhavani, Leigh Madden, Ian Buysschaert, Branavan Sivakumar, Norbert Kang and Ewa M Paleolog
    Citation: Arthritis Research & Therapy 2009 11:R64
    Content type: Research article Published on:

  8. Fatty acids have been implicated in osteoarthritis (OA), yet the mechanism by which fatty acids affect knee structure and consequently the risk of knee OA has not been fully elucidated. Higher intakes of fatty...

    Authors: Yuanyuan Wang, Miranda L Davies-Tuck, Anita E Wluka, Andrew Forbes, Dallas R English, Graham G Giles, Richard O'Sullivan and Flavia M Cicuttini
    Citation: Arthritis Research & Therapy 2009 11:R63
    Content type: Research article Published on:

  11. Reconstitution of peripheral blood (PB) B cells after therapeutic depletion with the chimeric anti-CD20 antibody rituximab (RTX) mimics lymphatic ontogeny. In this situation, the repletion kinetics and migrato...

    Authors: Burkhard Möller, Daniel Aeberli, Stefan Eggli, Martin Fuhrer, Istvan Vajtai, Esther Vögelin, Hans-Rudolf Ziswiler, Clemens A Dahinden and Peter M Villiger
    Citation: Arthritis Research & Therapy 2009 11:R62
    Content type: Research article Published on:

  12. Maladaptive physiological responses to stress appear to play a role in chronic inflammatory diseases such as rheumatoid arthritis (RA). However, relatively little stress research in RA patients has involved th...

    Authors: Robert R Edwards, Ajay D Wasan, Clifton O Bingham III, Joan Bathon, Jennifer A Haythornthwaite, Michael T Smith and Gayle G Page
    Citation: Arthritis Research & Therapy 2009 11:R61
    Content type: Research article Published on:

  13. The gene MICA encodes the protein major histocompatibility complex class I polypeptide-related sequence A. It is expressed in synovium of patients with rheumatoid arthritis (RA) and its implication in autoimmunit...

    Authors: Holger Kirsten, Elisabeth Petit-Teixeira, Markus Scholz, Dirk Hasenclever, Helene Hantmann, Dirk Heider, Ulf Wagner, Ulrich Sack, Vitor Hugo Teixeira, Bernard Prum, Jana Burkhardt, Céline Pierlot, Frank Emmrich, François Cornelis and Peter Ahnert
    Citation: Arthritis Research & Therapy 2009 11:R60
    Content type: Research article Published on:

  14. Authors: Carlotta Nannini, Colin P West, Patricia J Erwin and Eric L Matteson
    Citation: Arthritis Research & Therapy 2009 11:408
    Content type: Erratum Published on:

    The original article was published in Arthritis Research & Therapy 2008 10:R124

  16. Behçet's disease is a complex vasculitis of unknown etiology. Abundant neutrophils suggest the involvement of innate immunity. Cytokines are skewed to the T-helper-1 pattern. Few sterile organs are easily acce...

    Authors: Jan AM van Laar, Jasper H Kappen, Paul LA van Daele and P Martin van Hagen
    Citation: Arthritis Research & Therapy 2009 11:109
    Content type: Editorial Published on:

  17. Lupus patients need alternatives to steroids and cytotoxic drugs. We recently found that apigenin, a non-mutagenic dietary flavonoid, can sensitize recurrently activated, normal human T cells to apoptosis by i...

    Authors: Hee-Kap Kang, Diane Ecklund, Michael Liu and Syamal K Datta
    Citation: Arthritis Research & Therapy 2009 11:R59
    Content type: Research article Published on:

  18. Bisphosphonates are the most widely used class of drug for inhibiting osteoclast-mediated bone loss, but their effectiveness at preventing joint destruction in rheumatoid arthritis has generally been disappoin...

    Authors: Karen A Sutherland, Helena L Rogers, Denise Tosh and Michael J Rogers
    Citation: Arthritis Research & Therapy 2009 11:R58
    Content type: Research article Published on:

  23. To identify markers and mechanisms of resistance to adalimumab therapy, we studied global gene expression profiles in synovial tissue specimens obtained from severe rheumatoid arthritis (RA) patients before an...

    Authors: Valérie Badot, Christine Galant, Adrien Nzeusseu Toukap, Ivan Theate, Anne-Lise Maudoux, Benoît J Van den Eynde, Patrick Durez, Frédéric A Houssiau and Bernard R Lauwerys
    Citation: Arthritis Research & Therapy 2009 11:R57
    Content type: Research article Published on:

  24. Autoimmunity, microangiopathy and tissue fibrosis are hallmarks of systemic sclerosis (SSc). Vascular alterations and reduced capillary density decrease blood flow and impair tissue oxygenation in SSc. Oxygen ...

    Authors: Christian Beyer, Georg Schett, Steffen Gay, Oliver Distler and Jörg HW Distler
    Citation: Arthritis Research & Therapy 2009 11:220
    Content type: Review Published on:

  25. With little in the way of effective therapeutic strategies to target the innate immune response, a better understanding of the critical pathways regulating neutrophil and macrophage responses in inflammation i...

    Authors: Sarah R Walmsley, Edwin R Chilvers and Moira KB Whyte
    Citation: Arthritis Research & Therapy 2009 11:219
    Content type: Review Published on:

  26. Recently, we reported the development of the C57BL/6.NOD-Aec1Aec2 mouse that carries two genetic intervals derived from the non-obese diabetic (NOD) mouse capable of conferring Sjögren's syndrome (SjS)-like disea...

    Authors: Cuong Q Nguyen, Ashok Sharma, Byung Ha Lee, Jin-Xiong She, Richard A McIndoe and Ammon B Peck
    Citation: Arthritis Research & Therapy 2009 11:R56
    Content type: Research article Published on:

  27. Aging proteins undergo non-enzymatic post-translational modification, including isomerization and racemization. We hypothesized that cartilage with many long-lived components could accumulate non-enzymatically...

    Authors: Jonathan B Catterall, Daniel Barr, Michael Bolognesi, Robert D Zura and Virginia B Kraus
    Citation: Arthritis Research & Therapy 2009 11:R55
    Content type: Research article Published on:

  28. The objective of this study was to analyze health care and non-health care resource utilization under routine medical practice in a primary care setting claims database and to estimate the incremental average ...

    Authors: Antoni Sicras-Mainar, Javier Rejas, Ruth Navarro, Milagrosa Blanca, Ángela Morcillo, Raquel Larios, Soledad Velasco and Carme Villarroya
    Citation: Arthritis Research & Therapy 2009 11:R54
    Content type: Research article Published on:

  29. The role of apoptotic secretory epithelium as a pro-inflammatory triggering factor of exocrine dysfunction is currently explored in Sjogren's syndrome patients and in the nonobese diabetic (NOD) mouse model. V...

    Authors: Mario Calafat, Luciana Larocca, Valeria Roca, Vanesa Hauk, Nicolás Pregi, Alcira Nesse and Claudia Pérez Leirós
    Citation: Arthritis Research & Therapy 2009 11:R53
    Content type: Research article Published on:

  30. Anti-TNF therapies represent a breakthrough in the treatment of severe psoriatic arthritis. However, little is known about long-term drug persistence with these treatments in patients with psoriatic arthritis ...

    Authors: Amr A Saad, Darren M Ashcroft, Kath D Watson, Kimme L Hyrich, Peter R Noyce and Deborah PM Symmons
    Citation: Arthritis Research & Therapy 2009 11:R52
    Content type: Research article Published on:

  32. Patients with recent-onset rheumatoid arthritis (RA) have impaired brachial artery endothelial function compared with controls matched for age, sex and cardiovascular risk factors. The present study examined e...

    Authors: Suad Hannawi, Thomas H Marwick and Ranjeny Thomas
    Citation: Arthritis Research & Therapy 2009 11:R51
    Content type: Research article Published on:

  33. Conventional disease-modifying antirheumatic drugs such as methotrexate are the mainstay of treatment for rheumatoid arthritis. More recently, biologic agents such as etanercept, infliximab and adalimumab, whi...

    Authors: Andrea Rubbert-Roth and Axel Finckh
    Citation: Arthritis Research & Therapy 2009 11(Suppl 1):S1
    Content type: Review Published on:

    This article is part of a Supplement: Volume 11 Supplement 1

  34. The increased burden of cardiovascular disease in patients with rheumatoid arthritis and systemic lupus erythematosus has recently become the focus of intense investigation. Proatherogenic risk factors and dys...

    Authors: Louise E Full, Cristina Ruisanchez and Claudia Monaco
    Citation: Arthritis Research & Therapy 2009 11:217
    Content type: Review Published on:

  35. The present study was conducted to determine whether patients with polymyalgia rheumatica (PMR) are at an increased risk of peripheral arterial disease (PAD).

    Authors: Kenneth J Warrington, Elena P Jarpa, Cynthia S Crowson, Leslie T Cooper, Gene G Hunder, Eric L Matteson and Sherine E Gabriel
    Citation: Arthritis Research & Therapy 2009 11:R50
    Content type: Research article Published on:

  36. The objective of this study was to determine the anti-inflammatory, nociceptive, and antiarthritic effects of piperine, the active phenolic component in black pepper extract.

    Authors: Jun Soo Bang, Da Hee Oh, Hyun Mi Choi, Bong-Jun Sur, Sung-Jig Lim, Jung Yeon Kim, Hyung-In Yang, Myung Chul Yoo, Dae-Hyun Hahm and Kyoung Soo Kim
    Citation: Arthritis Research & Therapy 2009 11:R49
    Content type: Research article Published on:

  37. Synovial cells are potential sources of inflammatory mediators in bacterial-induced arthritis but their involvement in the inflammatory response to Candida albicans-induced septic arthritis is largely unknown.

    Authors: Herng-Sheng Lee, Chung-Shinn Lee, Chi-Jung Yang, Sui-Long Su and Donald M Salter
    Citation: Arthritis Research & Therapy 2009 11:R48
    Content type: Research article Published on:

  38. Asporin, also known as periodontal ligament-associated protein 1 (PLAP1), is a member of the family of small leucine-rich proteoglycan (SLRP) family. It is present within the cartilage extracellular matrix (EC...

    Authors: Helen E Gruber, Jane A Ingram, Gretchen L Hoelscher, Natalia Zinchenko, Edward N Hanley Jr and Yubo Sun
    Citation: Arthritis Research & Therapy 2009 11:R47
    Content type: Research article Published on:

  39. Adherence to urate-lowering drugs (ULDs) has not been well evaluated among those with gout. Our aim was to assess the level and determinants of non-adherence with ULDs prescribed for gout.

    Authors: Leslie R Harrold, Susan E Andrade, Becky A Briesacher, Marsha A Raebel, Hassan Fouayzi, Robert A Yood and Ira S Ockene
    Citation: Arthritis Research & Therapy 2009 11:R46
    Content type: Research article Published on:

  43. A candidate gene approach, in a large case–control association study in the Dutch population, has shown that a 480 kb block on chromosome 4q27 encompassing KIAA1109/Tenr/IL2/IL21 genes is associated with rheumato...

    Authors: Vitor Hugo Teixeira, Celine Pierlot, Paola Migliorini, Alejandro Balsa, René Westhovens, Pilar Barrera, Helena Alves, Carlos Vaz, Manuela Fernandes, Dora Pascual-Salcedo, Stefano Bombardieri, Jan Dequeker, Timothy R Radstake, Piet Van Riel, Leo van de Putte, Antonio Lopes-Vaz…
    Citation: Arthritis Research & Therapy 2009 11:R45
    Content type: Research article Published on:

  44. 15-Lipoxygenases and their metabolites have been shown to exhibit anti-inflammatory and immunomodulatory properties, but little is known regarding their expression and function in chondrocytes. The objective o...

    Authors: Nadir Chabane, Nadia Zayed, Mohamed Benderdour, Johanne Martel-Pelletier, Jean-Pierre Pelletier, Nicolas Duval and Hassan Fahmi
    Citation: Arthritis Research & Therapy 2009 11:R44
    Content type: Research article Published on:

  45. Phosphatidylcholine and phosphatidylcholine-derived metabolites exhibit anti-inflammatory properties in various stress conditions. We hypothesized that dietary phosphatidylcholine may potentially function as a...

    Authors: Gabor Erős, Saleh Ibrahim, Nikolai Siebert, Mihály Boros and Brigitte Vollmar
    Citation: Arthritis Research & Therapy 2009 11:R43
    Content type: Research article Published on:

  46. Genome-wide association studies of rheumatoid arthritis (RA) have identified an association of the disease with a 6q23 region devoid of genes. TNFAIP3, an RA candidate gene, flanks this region, and polymorphisms ...

    Authors: Rebeca Dieguez-Gonzalez, Manuel Calaza, Eva Perez-Pampin, Alejandro Balsa, Francisco J Blanco, Juan D Cañete, Rafael Caliz, Luis Carreño, Arturo R de la Serna, Benjamin Fernandez-Gutierrez, Ana Maria Ortiz, Gabriel Herrero-Beaumont, Jose L Pablos, Javier Narvaez, Federico Navarro, Jose L Marenco…
    Citation: Arthritis Research & Therapy 2009 11:R42
    Content type: Research article Published on:

  47. The aims of this study were, first, to investigate the in vivo effects of treatment with avocado/soybean unsaponifiables on the development of osteoarthritic structural changes in the anterior cruciate ligament d...

    Authors: Christelle Boileau, Johanne Martel-Pelletier, Judith Caron, Philippe Msika, Georges B Guillou, Caroline Baudouin and Jean-Pierre Pelletier
    Citation: Arthritis Research & Therapy 2009 11:R41
    Content type: Research article Published on:

  48. In the present study, we investigated the ability of microparticles isolated from synovial fluids from patients with rheumatoid arthritis or osteoarthritis to induce the synthesis and release of key cytokines ...

    Authors: Laurent Messer, Ghada Alsaleh, Jean-Marie Freyssinet, Fatiha Zobairi, Isabelle Leray, Jacques-Eric Gottenberg, Jean Sibilia, Florence Toti-Orfanoudakis and Dominique Wachsmann
    Citation: Arthritis Research & Therapy 2009 11:R40
    Content type: Research article Published on:

  49. The receptor for advanced glycation end products (RAGE) is a member of the immunoglobulin superfamily of cell surface receptor molecules. High concentrations of three of its putative proinflammatory ligands, S...

    Authors: Yueh-Sheng Chen, Weixing Yan, Carolyn L Geczy, Matthew A Brown and Ranjeny Thomas
    Citation: Arthritis Research & Therapy 2009 11:R39
    Content type: Research article Published on:

  50. Although cardiovascular morbidity and mortality are increased in rheumatoid arthritis, little is known about the burden of subclinical coronary atherosclerosis in these patients.

    Authors: Jon T Giles, Moyses Szklo, Wendy Post, Michelle Petri, Roger S Blumenthal, Gordon Lam, Allan C Gelber, Robert Detrano, William W Scott Jr, Richard A Kronmal and Joan M Bathon
    Citation: Arthritis Research & Therapy 2009 11:R36
    Content type: Research article Published on:
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Arthritis Research & Therapy

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