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  1. There is limited information regarding disease-modifying antirheumatic drug (DMARD)-dependent risks of overall, incident, and recurrent herpes zoster (HZ) during first-line biologic DMARD (bDMARD) or targeted ...

    Authors: Seogsong Jeong, Seulggie Choi, Sang Min Park, Jinseok Kim, Byeongzu Ghang and Eun Young Lee
    Citation: Arthritis Research & Therapy 2022 24:180
  2. Infection is a major cause of mortality in patients with systemic lupus erythematosus (SLE). Therefore, minimizing the risk of infection is an important clinical goal to improve the long-term prognosis of SLE ...

    Authors: Kazuya Abe, Yuichi Ishikawa, Yasuhiko Kita, Nobuyuki Yajima, Eisuke Inoue, Ken-ei Sada, Yoshia Miyawaki, Ryusuke Yoshimi, Yasuhiro Shimojima, Shigeru Ohno, Hiroshi Kajiyama, Kunihiro Ichinose, Shuzo Sato and Michio Fujiwara
    Citation: Arthritis Research & Therapy 2022 24:179
  3. Studies on the association between coffee, a modifiable lifestyle factor, and rheumatoid arthritis (RA), a chronic autoimmune disease primarily affecting the joints, have been conflicting. The aim of the prese...

    Authors: Helga Westerlind, Justine Dukuzimana, Xiaomin Lu, Lars Alfredsson, Lars Klareskog and Daniela Di Giuseppe
    Citation: Arthritis Research & Therapy 2022 24:178
  4. Authors: Elisa Gremese, Barbara Tolusso, Luca Petricca, Clara Di Mario, Maria Rita Gigante, Gianfranco Ferraccioli and Stefano Alivernini
    Citation: Arthritis Research & Therapy 2022 24:177

    The original article was published in Arthritis Research & Therapy 2022 24:143

  5. Spondyloarthritis (SpA) is an autoimmune and autoinflammatory musculoskeletal disease characterised by systemic enthesitis. Recent research has focused on subclinical inflammatory bowel disease (IBD) in SpA pa...

    Authors: Yuya Tabuchi, Masao Katsushima, Yuri Nishida, Mirei Shirakashi, Hideaki Tsuji, Hideo Onizawa, Koji Kitagori, Shuji Akizuki, Ran Nakashima, Kosaku Murakami, Koichi Murata, Hajime Yoshifuji, Masao Tanaka, Akio Morinobu and Motomu Hashimoto
    Citation: Arthritis Research & Therapy 2022 24:176
  6. Linked metabolic and cardiovascular comorbidities are prevalent in hyperuricemia and gout. For mechanistic insight into impact on inflammatory processes and cardiometabolic risk factors of xanthine oxidase inh...

    Authors: Monica Guma, Benyamin Dadpey, Roxana Coras, Ted R. Mikuls, Bartlett Hamilton, Oswald Quehenberger, Hilda Thorisdottir, David Bittleman, Kimberly Lauro, Shannon M. Reilly, Ru Liu-Bryan and Robert Terkeltaub
    Citation: Arthritis Research & Therapy 2022 24:175
  7. Osteoarthritis (OA) is an age-related cartilage degenerative disease, and chondrocyte senescence has been extensively studied in recent years. Increased numbers of senescent chondrocytes are found in OA cartil...

    Authors: Yikai Liu, Zian Zhang, Tao Li, Hao Xu and Haining Zhang
    Citation: Arthritis Research & Therapy 2022 24:174
  8. The objective of this study was to investigate the prognostic impact of right ventricular (RV) function at rest and during exercise in patients with systemic sclerosis (SSc) presenting for a screening for pulm...

    Authors: Panagiota Xanthouli, Julia Miazgowski, Nicola Benjamin, Ojan Gordjani, Benjamin Egenlauf, Satenik Harutyunova, Rebekka Seeger, Alberto M. Marra, Norbert Blank, Hanns-Martin Lorenz, Ekkehard Grünig and Christina A. Eichstaedt
    Citation: Arthritis Research & Therapy 2022 24:173
  9. Insulin-like growth factor-1 (IGF-1) has the potential to be used for osteoarthritis (OA) treatment but has not been evaluated in clinics yet owing to toxicity concerns. It suffers from short intra-joint resid...

    Authors: Armin Vedadghavami, Bill Hakim, Tengfei He and Ambika G. Bajpayee
    Citation: Arthritis Research & Therapy 2022 24:172
  10. Rheumatoid arthritis (RA) is an autoimmune disease, characterized by chronic and systemic inflammation. Besides, it is known that RA patients may present several comorbidities, such as sarcopenia, a condition ...

    Authors: Thales R. Hein, Leonardo Peterson, Barbara J. Bartikoski, Juliana Portes, Rafaela C. Espírito Santo and Ricardo M. Xavier
    Citation: Arthritis Research & Therapy 2022 24:171

    The Comment to this article has been published in Arthritis Research & Therapy 2022 24:245

  11. Neutrophils and aberrant NETosis have been implicated in the pathogenesis of diverse autoimmune diseases; however, their roles in primary Sjögren’s syndrome (pSS) remain unclear. We aimed to reveal the potenti...

    Authors: Yu Peng, Xunyao Wu, Shulan Zhang, Chuiwen Deng, Lidan Zhao, Mu Wang, Qingjun Wu, Huaxia Yang, Jiaxin Zhou, Linyi Peng, Xuan Luo, Yingying Chen, Anqi Wang, Qiufeng Xiao, Wen Zhang, Yan Zhao…
    Citation: Arthritis Research & Therapy 2022 24:170
  12. Extracellular vesicles are involved in the intercellular communication of the immune system. In rheumatoid arthritis (RA), these structures are considered a source of autoantigens that drive proinflammatory re...

    Authors: Héctor Rincón-Arévalo, Catalina Burbano, Laura Atehortúa, Mauricio Rojas, Adriana Vanegas-García, Gloria Vásquez and Diana Castaño
    Citation: Arthritis Research & Therapy 2022 24:169
  13. Peripheral and central nociceptive sensitization is a critical pathogenetic component in osteoarthritis (OA) chronic pain. T-type calcium channel 3.2 (CaV3.2) regulates neuronal excitability and plays important r...

    Authors: Brandon Itson-Zoske, Seung Min Shin, Hao Xu, Chensheng Qiu, Fan Fan, Quinn H. Hogan and Hongwei Yu
    Citation: Arthritis Research & Therapy 2022 24:168
  14. The clinical value of cryoglobulinemia (CG) in systemic lupus erythematosus (SLE) is largely unknown. The aim of this retrospective study was to describe the characteristics of CG in SLE, its impact on SLE phe...

    Authors: Yoann Roubertou, Sabine Mainbourg, Arnaud Hot, Denis Fouque, Cyrille Confavreux, Roland Chapurlat, Sébastien Debarbieux, Denis Jullien, Pascal Sève, Laurent Juillard, Marie-Nathalie Kolopp-Sarda and Jean-Christophe Lega
    Citation: Arthritis Research & Therapy 2022 24:167
  15. To determine whether gene-gene interaction network analysis of RNA sequencing (RNA-Seq) of synovial biopsies in early rheumatoid arthritis (RA) can inform our understanding of RA pathogenesis and yield improve...

    Authors: Elisabetta Sciacca, Anna E. A. Surace, Salvatore Alaimo, Alfredo Pulvirenti, Felice Rivellese, Katriona Goldmann, Alfredo Ferro, Vito Latora, Costantino Pitzalis and Myles J. Lewis
    Citation: Arthritis Research & Therapy 2022 24:166
  16. Dietary magnesium deficiency, which is common in modern diet, has been associated with osteoarthritis (OA) susceptibility. Despite this clinical association, no study has addressed if dietary magnesium deficie...

    Authors: Ruijun Bai, Michael Z. Miao, Hui Li, Yiqing Wang, Ruixue Hou, Ke He, Xuan Wu, Hongyu Jin, Chao Zeng, Yang Cui and Guanghua Lei
    Citation: Arthritis Research & Therapy 2022 24:165
  17. Male HLA-B27-positive radiographic-axial spondyloarthritis (r-axSpA) patients are prone to have severe spinal radiographic progression, but the underlying mechanisms are unclear. We recently showed that persis...

    Authors: Florence W. L. Tsui, Aifeng Lin, Ismail Sari, Zhenbo Zhang, Kenneth P. H. Pritzker, Hing Wo Tsui and Robert D. Inman
    Citation: Arthritis Research & Therapy 2022 24:164
  18. Multiple studies have confirmed dysbiosis in ankylosing spondylitis (AS) and inflammatory bowel disease (IBD); however, due to methodological differences across studies, it has not been possible to determine i...

    Authors: P. R. Sternes, L. Brett, J. Phipps, F. Ciccia, T. Kenna, E. de Guzman, K. Zimmermann, M. Morrison, G. Holtmann, E. Klingberg, D. Mauro, C. McIvor, H. Forsblad-d’Elia and M. A. Brown
    Citation: Arthritis Research & Therapy 2022 24:163
  19. Methotrexate is the preferred initial disease-modifying antirheumatic drug (DMARD) for rheumatoid arthritis (RA). However, clinically useful tools for individualized prediction of response to methotrexate trea...

    Authors: Stephanie Q. Duong, Cynthia S. Crowson, Arjun Athreya, Elizabeth J. Atkinson, John M. Davis III, Kenneth J. Warrington, Eric L. Matteson, Richard Weinshilboum, Liewei Wang and Elena Myasoedova
    Citation: Arthritis Research & Therapy 2022 24:162
  20. Osteoporosis is a global health concern with an increasing prevalence worldwide. Denosumab is an antiresoptive agent that has been demonstrated to be effective and safe in osteoporotic patients. This study aim...

    Authors: Ahmadreza Jamshidi, Mahdi Vojdanian, Mohsen Soroush, Mahmoud Akbarian, Mehrdad Aghaei, Asghar Hajiabbasi, Zahra Mirfeizi, Alireza Khabbazi, Gholamhosein Alishiri, Anousheh Haghighi, Ahmad Salimzadeh, Hadi Karimzadeh, Fatemeh Shirani, Mohammad Reza Hatef Fard, MohammadAli Nazarinia, Soosan Soroosh…
    Citation: Arthritis Research & Therapy 2022 24:161
  21. To assess markers of neutrophil activation such as calprotectin and N-formyl methionine (fMET) in anti-neutrophil cytoplasmic autoantibody-associated vasculitis (AAV) and large-vessel vasculitis (LVV).

    Authors: Despina Michailidou, Bhargavi Duvvuri, Runa Kuley, David Cuthbertson, Peter C. Grayson, Nader A. Khalidi, Curry L. Koening, Carol A. Langford, Carol A. McAlear, Larry W. Moreland, Christian Pagnoux, Philip Seo, Ulrich Specks, Antoine G. Sreih, Kenneth J. Warrington, Tomas Mustelin…
    Citation: Arthritis Research & Therapy 2022 24:160
  22. To investigate the safety and effectiveness of mepolizumab (MPZ), an anti-interleukin-5 antibody, as remission induction therapy for severe eosinophilic granulomatosis with polyangiitis (EGPA).

    Authors: Masanobu Ueno, Ippei Miyagawa, Takafumi Aritomi, Koichi Kimura, Shigeru Iwata, Kentaro Hanami, Syunsuke Fukuyo, Satoshi Kubo, Yusuke Miyazaki, Shingo Nakayamada and Yoshiya Tanaka
    Citation: Arthritis Research & Therapy 2022 24:159
  23. Light alteration affects the internal environment and metabolic homeostasis of the body through circadian rhythm disorders (CRD). CRD is one of the factors that induce and accelerate osteoarthritis (OA). There...

    Authors: Xiaopeng Song, Mingchao Zhao, Jilang Tang, Tianwen Ma, Hui Bai, Xinyu Wang, Lin Liu, Ting Li, Xinyu Xu, Xuanbo Sheng, Binger Zhao, Yingying Wang, Tiantian Wang, Yingchao Guo, Xinmin Zhang and Li Gao
    Citation: Arthritis Research & Therapy 2022 24:158
  24. Tumor necrosis factor (TNF) inhibitors increase the risk of tuberculosis (TB) in patients with rheumatoid arthritis (RA). This study compared the incidence of TB after treatment with TNF inhibitors and tociliz...

    Authors: Seung Min Jung, Minkyung Han, Eun Hwa Kim, Inkyung Jung and Yong-Beom Park
    Citation: Arthritis Research & Therapy 2022 24:157
  25. Muscle weakness and decreased fatigue resistance are key manifestations of systemic autoimmune myopathies (SAMs). We here examined whether high-intensity interval training (HIIT) improves fatigue resistance in...

    Authors: Takashi Yamada, Yuki Ashida, Katsuyuki Tamai, Iori Kimura, Nao Yamauchi, Azuma Naito, Nao Tokuda, HÃ¥kan Westerblad, Daniel C. Andersson and Koichi Himori
    Citation: Arthritis Research & Therapy 2022 24:156
  26. In previous clinical trials, patients with active rheumatoid arthritis (RA) treated with upadacitinib (UPA) have improved patient-reported outcomes (PROs). This post hoc analysis of SELECT-CHOICE, a phase 3 cl...

    Authors: Martin Bergman, Namita Tundia, Naomi Martin, Jessica L. Suboticki, Jayeshkumar Patel, Debbie Goldschmidt, Yan Song and Grace C. Wright
    Citation: Arthritis Research & Therapy 2022 24:155

    The Correction to this article has been published in Arthritis Research & Therapy 2022 24:248

  27. MRI-detected inflammation around the extensor tendons of metacarpophalangeal (MCP-) joints is prevalent in RA and poses a markedly increased risk of RA development when present in arthralgia patients. Such inf...

    Authors: Yousra J. Dakkak, Bastiaan T. van Dijk, Friso P. Jansen, Lambertus J. Wisse, Monique Reijnierse, Annette H. M. van der Helm-van Mil and Marco C. DeRuiter
    Citation: Arthritis Research & Therapy 2022 24:154
  28. Very few data are available on predictors of minimal disease activity (MDA) in patients with recent-onset psoriatic arthritis (PsA). Such data are crucial, since the therapeutic measures used to change the adv...

    Authors: Rubén Queiro, Daniel Seoane-Mato, Ana Laiz, Eva Galíndez Agirregoikoa, Carlos Montilla, Hye-Sang Park, Jose A. Pinto-Tasende, Juan J. Bethencourt Baute, Beatriz Joven Ibáñez, Elide Toniolo, Julio Ramírez and Ana Serrano García
    Citation: Arthritis Research & Therapy 2022 24:153
  29. Axial spondyloarthritis (axSpA) is a common chronic inflammatory disease, associated with extracellular matrix (ECM) remodeling of the cartilage, bone, and connective tissues. The primary symptom of axSpA is b...

    Authors: Helena Port, Signe Holm Nielsen, Sofie Falkenløve Madsen, Anne-Christine Bay-Jensen, Morten Karsdal, Sengül Seven, Inge Juul Sørensen, Lone Morsel-Carlsen, Mikkel Østergaard and Susanne Juhl Pedersen
    Citation: Arthritis Research & Therapy 2022 24:152
  30. To estimate associations between fine particulate matter (PM2.5) and ozone and the onset of systemic autoimmune rheumatic diseases (SARDs).

    Authors: Naizhuo Zhao, Audrey Smargiassi, Sonia Jean, Philippe Gamache, Elhadji-Anassour Laouan-Sidi, Hong Chen, Mark S. Goldberg and Sasha Bernatsky
    Citation: Arthritis Research & Therapy 2022 24:151
  31. Healthcare quality for systemic lupus erythematosus (SLE) is a modifiable target for improving patient outcomes. We aimed to assess the quality of care processes in different clinic settings, comparing a subsp...

    Authors: Sidha Sreedharan, Ning Li, Geoff Littlejohn, Russell Buchanan, Mandana Nikpour, Eric Morand, Alberta Hoi and Vera Golder
    Citation: Arthritis Research & Therapy 2022 24:150
  32. Long-term patterns of serum uric acid (SUA) and their association with the risk of myocardial infarction (MI) and mortality are poorly characterized as prior studies measured SUA at a single time point. This s...

    Authors: Xue Tian, Yingting Zuo, Shuohua Chen, Shouling Wu, Anxin Wang and Yanxia Luo
    Citation: Arthritis Research & Therapy 2022 24:149
  33. Calpains are a family of calcium-dependent thiol proteases that participate in a wide variety of biological activities. In our recent study, calpain is increased in the sera of scleroderma or systemic sclerosi...

    Authors: Li Zhang, Dong Zheng, Yuemei Yan, Yong Yu, Ruizhen Chen, Zheng Li, Peter A. Greer, Tianqing Peng and Qiang Wang
    Citation: Arthritis Research & Therapy 2022 24:148
  34. The aetiology of ANCA-associated vasculitis (AAV) and triggers of relapse are poorly understood. Vitamin D (vitD) is an important immunomodulator, potentially responsible for the observed latitudinal differenc...

    Authors: Jennifer Scott, Enock Havyarimana, Albert Navarro-Gallinad, Arthur White, Jason Wyse, Jos van Geffen, Michiel van Weele, Antonia Buettner, Tamara Wanigasekera, Cathal Walsh, Louis Aslett, John D. Kelleher, Julie Power, James Ng, Declan O’Sullivan, Lucy Hederman…
    Citation: Arthritis Research & Therapy 2022 24:147
  35. Echocardiography (2DE) is integral for screening and longitudinal evaluation of pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc). In the present study, we sought to establish the reliability, ...

    Authors: Monica Mukherjee, Valentina Mercurio, Aparna Balasubramanian, Ami A. Shah, Steven Hsu, Catherine E. Simpson, Rachel Damico, Todd M. Kolb, Paul M. Hassoun and Stephen C. Mathai
    Citation: Arthritis Research & Therapy 2022 24:146
  36. Osteoarthritis (OA) is one of the costliest and most disabling forms of arthritis, and it poses a major public health burden; however, its detailed etiology, pathophysiology, and metabolism remain unclear. The...

    Authors: Eiji Sasaki, Hiroyuki Yamamoto, Toru Asari, Rira Matsuta, Seiya Ota, Yuka Kimura, Shizuka Sasaki, Kyota Ishibashi, Yuji Yamamoto, Kenjiro Kami, Masataka Ando, Eiichi Tsuda and Yasuyuki Ishibashi
    Citation: Arthritis Research & Therapy 2022 24:145
  37. While low-dose oral glucocorticoids (GCs) are recommended in the management of early arthritis, their impact on mortality is unclear. The aim of this study is to evaluate the effect of GCs on mortality in pati...

    Authors: Garifallia Sakellariou, Carlo Alberto Scirè, Federica Rumi, Greta Carrara, Anna Zanetti, Carlo Cerra, Simona Migliazza, Serena Bugatti and Carlomaurizio Montecucco
    Citation: Arthritis Research & Therapy 2022 24:144
  38. Prognostic biomarkers of treatment response to distinct biologic disease-modifying anti-rheumatic drugs (b-DMARDs) are still lacking within the management of rheumatoid arthritis (RA).

    Authors: Elisa Gremese, Barbara Tolusso, Luca Petricca, Clara Di Mario, Maria Rita Gigante, Gianfranco Ferraccioli and Stefano Alivernini
    Citation: Arthritis Research & Therapy 2022 24:143

    The Correction to this article has been published in Arthritis Research & Therapy 2022 24:177

  39. Systemic lupus erythematosus (SLE) can cause placental dysfunctions, which may result in pregnancy complications. Long noncoding RNAs (lncRNAs) are actively involved in the regulation of immune responses durin...

    Authors: Hui-hui Li, Lin-tao Sai, Yuan Liu, Colman I. Freel, Kai Wang, Chi Zhou, Jing Zheng, Qiang Shu and Ying-jie Zhao
    Citation: Arthritis Research & Therapy 2022 24:142
  40. Antiphospholipid syndrome (APS) is an autoimmune disease characterized by persistent antiphospholipid antibodies (aPLs) positivity with a wide manifestation spectrum. A risk stratification is needed for manage...

    Authors: Wanting Qi, Jiuliang Zhao, Can Huang, Nan Jiang, Jing Li, Chanyuan Wu, Shangzhu Zhang, Chaojun Hu, Dong Xu, Qian Wang, Mengtao Li, Xinping Tian, Yan Zhao and Xiaofeng Zeng
    Citation: Arthritis Research & Therapy 2022 24:140
  41. Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by a large production of autoantibodies and deficient clearance of cellular waste. The disease typically oscillates between episodes of...

    Authors: Jesper Karlsson, Jonas Wetterö, Maria Weiner, Johan Rönnelid, Rafael Fernandez-Botran and Christopher Sjöwall
    Citation: Arthritis Research & Therapy 2022 24:139
  42. Rheumatic heart disease (RHD) is a critical public health issue worldwide, and its epidemiological patterns have changed over the decades. This article aimed to estimate the global trends of RHD, and attributa...

    Authors: Zejin Ou, Danfeng Yu, Yuanhao Liang, Jinhua Wu, Huan He, Yongzhi Li, Wenqiao He, Yuhan Gao, Fei Wu and Qing Chen
    Citation: Arthritis Research & Therapy 2022 24:138
  43. Post-traumatic osteoarthritis (PTOA) does not currently have clinical prognostic biomarkers or disease-modifying drugs, though promising candidates such as dexamethasone (Dex) exist. Many challenges in studyin...

    Authors: Rebecca Mae Black, Lisa L. Flaman, Karin Lindblom, Susan Chubinskaya, Alan J. Grodzinsky and Patrik Önnerfjord
    Citation: Arthritis Research & Therapy 2022 24:137
  44. To evaluate the efficacy and safety of HLX01, a rituximab biosimilar, as combination therapy with methotrexate in Chinese patients with active rheumatoid arthritis who had inadequate responses to methotrexate.

    Authors: Xiaofeng Zeng, Ju Liu, Xiumei Liu, Lijun Wu, Yi Liu, Xiangping Liao, Huaxiang Liu, Jiankang Hu, Xin Lu, Linjie Chen, Jian Xu, Zhenyu Jiang, Fu-ai Lu, Huaxiang Wu, Ying Li, Qingyu Wang…
    Citation: Arthritis Research & Therapy 2022 24:136
  45. Infection is one of the primary concerns during treatment for rheumatoid arthritis (RA) in elderly patients. However, infection risk of patients with RA receiving targeted therapy (TT) including biological dis...

    Authors: Ryoko Sakai, Eiichi Tanaka, Masako Majima and Masayoshi Harigai
    Citation: Arthritis Research & Therapy 2022 24:135
  46. Methotrexate (MTX) is an anchor drug for the treatment of rheumatoid arthritis (RA). However, the precise mechanisms by which MTX stalls RA progression and alleviates the ensuing disease effects remain unknown...

    Authors: Jumpei Shoda, Shigeru Tanaka, Keishi Etori, Koto Hattori, Tadamichi Kasuya, Kei Ikeda, Yuko Maezawa, Akira Suto, Kotaro Suzuki, Junichi Nakamura, Yoshiro Maezawa, Minoru Takemoto, Christer Betsholtz, Koutaro Yokote, Seiji Ohtori and Hiroshi Nakajima
    Citation: Arthritis Research & Therapy 2022 24:134
  47. Subcutaneous tocilizumab (TCZ SC) is approved globally for giant cell arteritis (GCA). This phase Ib study investigated the pharmacokinetics, pharmacodynamics, safety, and exploratory efficacy of intravenous (...

    Authors: Christophe Schmitt, Laura Brockwell, Mylène Giraudon, Mauro Zucchetto, Lisa Christ, Bettina Bannert, Thomas Daikeler and Peter M. Villiger
    Citation: Arthritis Research & Therapy 2022 24:133
  48. Rituximab is used for the treatment of active rheumatoid arthritis. In the present study, we examined the long-term flare risk and safety of reduced doses of rituximab.

    Authors: Antonios Bertsias, Nestor Avgoustidis, Ioannis Papalopoulos, Argyro Repa, Nikolaos Kougkas, Eleni Kalogiannaki, Georgios Bertsias, Irini Flouri and Prodromos Sidiropoulos
    Citation: Arthritis Research & Therapy 2022 24:132
  49. To analyse the subsequent clinical course of patients with rheumatoid arthritis (RA) who either continued or discontinued biologic agents after hospitalization for infections.

    Authors: Yusuke Kashiwado, Chikako Kiyohara, Yasutaka Kimoto, Shuji Nagano, Takuya Sawabe, Kensuke Oryoji, Shinichi Mizuki, Hiroaki Nishizaka, Seiji Yoshizawa, Shigeru Yoshizawa, Tomomi Tsuru, Yasushi Inoue, Naoyasu Ueda, Shun-ichiro Ota, Yasuo Suenaga, Tomoya Miyamura…
    Citation: Arthritis Research & Therapy 2022 24:131

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