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  1. The origin and role of IL-17, a T-cell derived cytokine, in cartilage and bone destruction during rheumatoid arthritis (RA) remain to be clarified. In human ex vivo models, addition of IL-17 enhanced IL-6 product...

    Authors: Martine Chabaud, Erik Lubberts, Leo Joosten, Wim van den Berg and Pierre Miossec
    Citation: Arthritis Research & Therapy 2001 3:168
  2. Authors: J Raats, W Degen, S Litjens, I Bulduk, G Mans, E Wijnen, S Zampieri, W Roeffen, F Van den Hoogen and WJ van Venrooij
    Citation: Arthritis Research & Therapy 2001 3(Suppl 2):P116

    This article is part of a Supplement: Volume 3 Supplement 2

  3. In our study we characterised the immunophenotype of monocytes that migrated through an endothelial cell (EC) monolayer in vitro. We found that monocyte migration led to an enhanced expression of CD11a, CD33, CD4...

    Authors: Johannes Grisar, Philipp Hahn, Susanne Brosch, Meinrad Peterlik, Josef S Smolen and Peter Pietschmann
    Citation: Arthritis Research & Therapy 2001 3:127
  4. This review focuses on the mechanisms of stress response in the synovial tissue of rheumatoid arthritis. The major stress factors, such as heat stress, shear stress, proinflammatory cytokines and oxidative str...

    Authors: Georg Schett, Makiyeh Tohidast-Akrad, Günter Steiner and Josef Smolen
    Citation: Arthritis Research & Therapy 2001 3:80
  5. Macrophages that accumulate in the synovium of rheumatoid arthritis patients play an important role in the pathogenesis of this inflammatory disease. However, the mechanism by which macrophages are attracted i...

    Authors: Kenji Hayashida, Toshihiro Nanki, Hermann Girschick, Sule Yavuz, Takahiro Ochi and Peter E Lipsky
    Citation: Arthritis Research & Therapy 2001 3:118
  6. The causes of rheumatoid arthritis (RA) are largely unknown. However, RA is most probably a multifactorial disease with contributions from genetic and environmental factors. Searches for genes that influence R...

    Authors: Johan Jirholt, Anna-Karin B Lindqvist and Rikard Holmdahl
    Citation: Arthritis Research & Therapy 2000 3:87
  7. The underlying molecular defect resulting in the abnormal calcification observed in ank/ank mice has been identified. The responsible nonsense mutation affects the protein product of ank, resulting in diminished ...

    Authors: Lawrence M Ryan
    Citation: Arthritis Research & Therapy 2000 3:77
  8. Most anti-inflammatory drugs have been associated with an increased risk of serious upper gastrointestinal complications. Epidemiological studies have estimated the magnitude of the risk for specific anti-infl...

    Authors: Luis Alberto García Rodríguez and Sonia Hernández-Díaz
    Citation: Arthritis Research & Therapy 2000 3:98
  9. To reduce culture artifacts by conventional repeated passaging and long-term culture in vitro, the isolation of synovial fibroblasts (SFB) was attempted from rheumatoid arthritis (RA) synovial membranes by trypsi...

    Authors: Thomas Zimmermann, Elke Kunisch, Robert Pfeiffer, Astrid Hirth, Hans-Detlev Stahl, Ulrich Sack, Anke Laube, Eckehard Liesaus, Andreas Roth, Ernesta Palombo-Kinne, Frank Emmrich and Raimund W Kinne
    Citation: Arthritis Research & Therapy 2000 3:72

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