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  1. The antigenic specificity of an unusual antinuclear antibody pattern in three patient sera was identified after separating HeLa-cell nuclear extracts by two-dimensional (2D) gel electrophoresis and localizing ...

    Authors: Niels HH Heegaard, Martin R Larsen, Terri Muncrief, Allan Wiik and Peter Roepstorff
    Citation: Arthritis Research & Therapy 2000 2:407
  2. IL-10, IL-13, IFN-γ, tumor necrosis factor (TNF)-α, LT-α, CD154, and TNF-related activation-induced cytokine (TRANCE) were expressed by 2-20% of rheumatoid arthritis (RA) synovial tissue CD4+ memory T cells, wher...

    Authors: Toshihiro Nanki and Peter E Lipsky
    Citation: Arthritis Research & Therapy 2000 2:415
  3. We propose that the phenomenon of X-chromosome inactivation in females may constitute a risk factor for loss of T-cell tolerance; specifically that skewed X-chromosome inactivation in the thymus may lead to in...

    Authors: Smita Chitnis, Joanita Monteiro, David Glass, Brian Apatoff, Jane Salmon, Patrick Concannon and Peter K Gregersen
    Citation: Arthritis Research & Therapy 2000 2:399

    The Erratum to this article has been published in Arthritis Research & Therapy 2001 3:E001

  4. Leukocyte ingress into the synovium is a key process in the pathogenesis of rheumatoid arthritis and other inflammatory conditions. In this review, the role of endothelial cells in leukocyte extravasation will...

    Authors: Zoltan Szekanecz and Alisa E Koch
    Citation: Arthritis Research & Therapy 2000 2:368
  5. The substantial progress in our understanding of molecular and cellular biology has allowed us to design biological therapeutics ('biologicals') with defined targets and effector functions. These biologicals h...

    Authors: Hendrik Schulze-Koops and Joachim R Kalden
    Citation: Arthritis Research & Therapy 2000 2:337
  6. Anti-neutrophil cytoplasmic antibodies (ANCA) have become important diagnostic markers of small vessel vasculitides characterized by focal necrotizing lesions of vessel walls and accumulation of lymphocytes an...

    Authors: Allan Wiik
    Citation: Arthritis Research & Therapy 2000 2:252
  7. Fibroblast-like cells in the synovial lining (type B lining cells), stroma and pannus tissue are targeted by many signals, such as the following: ligands binding to cell surface receptors; lipid soluble, small...

    Authors: Yrjö T Konttinen, Tian-Fang Li, Mika Hukkanen, Jian Ma, Jing-Wen Xu and Ismo Virtanen
    Citation: Arthritis Research & Therapy 2000 2:348
  8. Autoimmune diseases that are resistant to conventional treatment cause severe morbidity and even mortality. In the present study we demonstrate that complete remissions can be achieved in refractory polychondr...

    Authors: Oliver Rosen, Andreas Thiel, Gero Massenkeil, Falk Hiepe, Thomas Häupl, Hartmut Radtke, Gerd R Burmester, Erika Gromnica-Ihle, Andreas Radbruch and Renate Arnold
    Citation: Arthritis Research & Therapy 2000 2:327
  9. The immunodominant T-cell epitope that is involved in collagen-induced arthritis (CIA) is the glycosylated type II collagen (CII) peptide 256-270. In CII transgenic mice, which express the immunodominant CII 2...

    Authors: Vivianne Malmström, Johan Bäcklund, Liselotte Jansson, Jan Kihlberg and Rikard Holmdahl
    Citation: Arthritis Research & Therapy 2000 2:315
  10. Studies on immunological reconstitution after immune ablation and stem-cell therapy may yield important clues to our understanding of the pathogenesis of human autoimmune disease, due to the profound effects o...

    Authors: Jacob M van Laar
    Citation: Arthritis Research & Therapy 2000 2:270
  11. To determine whether IL-4 is therapeutic in treating established experimental arthritis, a recombinant adenovirus carrying the gene that encodes murine IL-4 (Ad-mIL-4) was used for periarticular injection into...

    Authors: Seon Hee Kim, Christopher H Evans, Sunyoung Kim, Thomas Oligino, Steven C Ghivizzani and Paul D Robbins
    Citation: Arthritis Research & Therapy 2000 2:293
  12. In the present study 55 IgVH genes amplified from three different anatomical regions of a rheumatoid arthritis (RA) patient were analyzed, adding further information on synovial B-cell maturation and recircula...

    Authors: Maria M Souto-Carneiro, Veit Krenn, Ralph Hermann, Achim König and Hans-Konrad Müller-Hermelink
    Citation: Arthritis Research & Therapy 2000 2:303
  13. Recent studies have described the spontaneous development of arthritis or vasculitis in IL-1 receptor antagonist (IL-1Ra) knockout mice bred on specific and different genetic backgrounds. The levels of both se...

    Authors: William P Arend and Cem Gabay
    Citation: Arthritis Research & Therapy 2000 2:245

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