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  1. Human leucocyte antigen (HLA) class II molecules have been shown to be associated with predisposition to rheumatoid arthritis (RA). We generated HLA-DR and DQ transgenic mice that lacked endogenous class II mo...

    Authors: Veena Taneja and Chella S David
    Citation: Arthritis Research & Therapy 2000 2:205
  2. The abundance and activation of macrophages in the inflamed synovial membrane/pannus significantly correlates with the severity of rheumatoid arthritis (RA). Although unlikely to be the 'initiators' of RA (if ...

    Authors: Raimund W Kinne, Rolf Bräuer, Bruno Stuhlmüller, Ernesta Palombo-Kinne and Gerd-R Burmester
    Citation: Arthritis Research & Therapy 2000 2:189
  3. Results and new hypotheses in animal models often stimulate development of new paradigms in how we view rheumatoid arthritis (RA). The complexity of RA does, however, eventually lead to the rejection of these ...

    Authors: Rikard Holmdahl
    Citation: Arthritis Research & Therapy 2000 2:169
  4. An inception cohort of 238 patients having peripheral joint synovitis of less than 12 months duration was evaluated clinically and followed prospectively for 1 year to determine the clinical significance of a ...

    Authors: Raphaela Goldbach-Mansky, Jennifer Lee, Angela McCoy, Joseph Hoxworth, Cheryl Yarboro, Josef S Smolen, Günter Steiner, Antony Rosen, Cindy Zhang, Henri A Ménard, Zhi Jie Zhou, Timo Palosuo, Walther J Van Venrooij, Ronald L Wilder, John H Klippel, H Ralph Schumacher Jr…
    Citation: Arthritis Research & Therapy 2000 2:236
  5. The kinetics of apoptosis and the apoptosis-regulating gene p53 in adjuvant arthritis (AA) were investigated to assess the value of the AA rat model for testing apoptosis-inducing therapies. Very few terminal deo...

    Authors: Paul P Tak, Maartje S Klapwijk, Sophie FM Broersen, Deliana A van de Geest, Marieke Overbeek and Gary S Firestein
    Citation: Arthritis Research & Therapy 2000 2:229
  6. Acute-phase serum amyloid A (A-SAA) is a major component of the acute-phase response. A sustained acute-phase response in rheumatoid arthritis (RA) is associated with increased joint damage. A-SAA mRNA express...

    Authors: Rosemary O'Hara, Evelyn P Murphy, Alexander S Whitehead, Oliver FitzGerald and Barry Bresnihan
    Citation: Arthritis Research & Therapy 2000 2:142
  7. Normally the immune response is restricted to the peripheral secondary lymphoid organs. However, additional ectopic lymphoid tissue may develop at chronic sites of inflammation. In the synovium of rheumatoid a...

    Authors: Hye-Jung Kim and Claudia Berek
    Citation: Arthritis Research & Therapy 2000 2:126
  8. Osteoarthritis is complex in genetics, pathogenesis, monitoring and treatment. Current treatment of osteoarthritis does not influence progression. Much could be gained by more effective 'low-tech-low-cost' tre...

    Authors: L Stefan Lohmander
    Citation: Arthritis Research & Therapy 2000 2:95
  9. Serum and synovial tissue expression of the matrix metalloproteinase (MMP)-2 and -9 and their molecular regulators, MMP-14 and TIMP-2 was examined in 28 patients with inflammatory early synovitis and 4 healthy...

    Authors: Raphaela Goldbach-Mansky, Jennifer M Lee, Joseph M Hoxworth, David Smith II, Paul Duray, H Ralph Schumacher Jr, Cheryl H Yarboro, John Klippel, David Kleiner and Hani S El-Gabalawy
    Citation: Arthritis Research & Therapy 2000 2:145
  10. Autoantibodies present in the serum of patients with a variety of inflammatory diseases have proven useful as diagnostic markers and as probes with which to elucidate biochemical and signaling pathways. The me...

    Authors: Paul J Utz,, Timothy J Gensler and Paul Anderson
    Citation: Arthritis Research & Therapy 2000 2:101
  11. A chance observation has led to the development of a new murine model for inflammatory arthritis. Arthritis is induced, and transferred, by T-cell-dependent antibodies to glucose-6-phosphate isomerase. This en...

    Authors: Hugh McDevitt
    Citation: Arthritis Research & Therapy 2000 2:85
  12. CD8+ T cells dominate the lymphocyte population insynovial fluid in chronic inflammatory arthritis. It is known that theseCD8+ T cells are often clonally or oligoclonally expanded, but theirspecificity and their ...

    Authors: Linda C Tan, Alastair G Mowat, Chrysoula Fazou, Tim Rostron, Helen Roskell, P Rod Dunbar, Claire Tournay, François Romagné, Marie-Alix Peyrat, Elisabeth Houssaint, Marc Bonneville, Alan B Rickinson, Andrew J McMichael and Margaret FC Callan
    Citation: Arthritis Research & Therapy 2000 2:154

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