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Articles
Page 126 of 156
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Citation: Arthritis Res Ther 2004 6(Suppl 3):92
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Antibody-initiated organ injury: apoptosis, inflammation and fibrosis in neonatal lupus
Citation: Arthritis Res Ther 2004 6(Suppl 3):31 -
Biochemical markers of bone and cartilage in osteoarthritis
Citation: Arthritis Res Ther 2004 6(Suppl 3):29 -
Biology of recently discovered cytokines: Discerning the pro- and anti-inflammatory properties of interleukin-27
IL-27 is a recently identified heterodimeric cytokine produced in response to microbial and host derived inflammatory cues. Initial studies indicated that IL-27 promotes the generation of Th1 responses require...
Citation: Arthritis Res Ther 2004 6:225 -
Critical role of the major histocompatibility complex and IL-10 in matrilin-1-induced relapsing polychondritis in mice
Relapsing polychondritis (RP) is an autoimmune disease that affects extra-articular cartilage. Matrilin-1-induced relapsing polychondritis (MIRP) is a model for RP and is useful for studies of the pathogenic m...
Citation: Arthritis Res Ther 2004 6:R484 -
Biomarkers for systemic lupus erythematosus: has the right time finally arrived?
Citation: Arthritis Res Ther 2004 6:223 -
Antibodies against the CB10 fragment of type II collagen in rheumatoid arthritis
Antibodies against intact type II collagen (CII) are a feature of rheumatoid arthritis (RA) but have limited diagnostic value. Here we assess whether either of the two major cyanogen bromide fragments of CII, ...
Citation: Arthritis Res Ther 2004 6:R477 -
Regulating the immune system: the induction of regulatory T cells in the periphery
The immune system has evolved a variety of mechanisms to achieve and maintain tolerance both centrally and in the periphery. Central tolerance is achieved through negative selection of autoreactive T cells, wh...
Citation: Arthritis Res Ther 2004 6:215 -
Improved cartilage integration and interfacial strength after enzymatic treatment in a cartilage transplantation model
The objective of the present study was to investigate whether treatment of articular cartilage with hyaluronidase and collagenase enhances histological and mechanical integration of a cartilage graft into a de...
Citation: Arthritis Res Ther 2004 6:R469 -
Hormone replacement therapy, calcium and vitamin D3 versus calcium and vitamin D3alone decreases markers of cartilage and bone metabolism in rheumatoid arthritis: a randomized controlled trial [ISRCTN46523456]
This study aimed to evaluate the effects of hormone replacement therapy (HRT), known to prevent osteoporosis and fractures, on markers of bone and cartilage metabolism. Furthermore, we assessed whether changes...
Citation: Arthritis Res Ther 2004 6:R457 -
Emerging mechanisms of immune regulation: the extended B7 family and regulatory T cells
Whereas B7-1/B7-2 and CD28/cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) serve as the main switches regulating the clonal composition of activated naive T cells, other B7 family members fine-tune the ex...
Citation: Arthritis Res Ther 2004 6:208 -
Increased circulating levels and salivary gland expression of interleukin-18 in patients with Sjögren's syndrome: relationship with autoantibody production and lymphoid organization of the periductal inflammatory infiltrate
IL-18, an immunoregulatory and proinflammatory cytokine, has been shown to play an important pathogenic role in Th1-driven autoimmune disorders. In this study, we evaluated the circulating levels and salivary-...
Citation: Arthritis Res Ther 2004 6:R447 -
Report on the Molecular Approaches to Osteoarthritis Symposium, Imperial College London, UK, 18–20 April 2004
Citation: Arthritis Res Ther 2004 6:203 -
The current status of targeting BAFF/BLyS for autoimmune diseases
It is increasingly recognized that B cells have multiple functions that contribute to the pathogenesis of autoimmunity. Specific targeting of B cells might therefore be an appropriate therapeutic intervention....
Citation: Arthritis Res Ther 2004 6:197 -
Gene therapy in animal models of rheumatoid arthritis: are we ready for the patients?
Rheumatoid arthritis (RA) is a chronic inflammatory disease of the synovial joints, with progressive destruction of cartilage and bone. Anti-tumour necrosis factor-α therapies (e.g. soluble tumour necrosis fac...
Citation: Arthritis Res Ther 2004 6:183 -
Direct Toll-like receptor 2 mediated co-stimulation of T cells in the mouse system as a basis for chronic inflammatory joint disease
The pathogenesis of chronic inflammatory joint diseases such as adult and juvenile rheumatoid arthritis and Lyme arthritis is still poorly understood. Central to the various hypotheses in this respect is the n...
Citation: Arthritis Res Ther 2004 6:R433 -
Identification of subpopulations with characteristics of mesenchymal progenitor cells from human osteoarthritic cartilage using triple staining for cell surface markers
We first identified and isolated cellular subpopulations with characteristics of mesenchymal progenitor cells (MPCs) in osteoarthritic cartilage using fluorescence-activated cell sorting (FACS). Cells from ost...
Citation: Arthritis Res Ther 2004 6:R422 -
Estrogen receptor-α gene haplotype is associated with primary knee osteoarthritis in Korean population
Estrogen and estrogen receptors (ERs) are known to play important roles in the pathophysiology of osteoarthritis (OA). To investigate ER-α gene polymorphisms for its associations with primary knee OA, we condu...
Citation: Arthritis Res Ther 2004 6:R415 -
A proinflammatory role for Fas in joints of mice with collagen-induced arthritis
Collagen-induced arthritis (CIA) is a chronic inflammatory disease bearing all the hallmarks of rheumatoid arthritis, e.g. polyarthritis, synovitis, and subsequent cartilage/bone erosions. One feature of the d...
Citation: Arthritis Res Ther 2004 6:R404 -
Pharmacological disruption of insulin-like growth factor 1 binding to IGF-binding proteins restores anabolic responses in human osteoarthritic chondrocytes
Insulin-like growth factor 1 (IGF-1) has poor anabolic efficacy in cartilage in osteoarthritis (OA), partly because of its sequestration by abnormally high levels of extracellular IGF-binding proteins (IGFBPs)...
Citation: Arthritis Res Ther 2004 6:R393 -
Articles selected from Faculty of 1000 in June 2004
Citation: Arthritis Res Ther 2004 6:E4 -
Lymphopenia and autoimmune diseases
Citation: Arthritis Res Ther 2004 6:178 -
Targeting the interleukin-15/interleukin-15 receptor system in inflammatory autoimmune diseases
Interleukin (IL)-15 is a dangerous inflammatory cytokine that induces tumor-necrosis factor-α, IL-1β and inflammatory chemokines. It inhibits self-tolerance mediated by IL-2 mediated activation-induced cell de...
Citation: Arthritis Res Ther 2004 6:174 -
Strong inhibition of TNF-α production and inhibition of IL-8 and COX-2 mRNA expression in monocyte-derived macrophages by RWJ 67657, a p38 mitogen-activated protein kinase (MAPK) inhibitor
In inflammatory processes, the p38 mitogen-activated protein kinase (MAPK) signal transduction route regulates production and expression of cytokines and other inflammatory mediators. Tumor necrosis factor α (...
Citation: Arthritis Res Ther 2004 6:R384 -
Role of RUNX in autoimmune diseases linking rheumatoid arthritis, psoriasis and lupus
Recent studies investigating the genetic susceptibility of systemic lupus erythematosus, rheumatoid arthritis and psoriasis have revealed a potential role for the RUNX proteins in the development of autoimmune...
Citation: Arthritis Res Ther 2004 6:169 -
Signaling by STATs
A variety of cytokines and growth factors use the Janus kinase (Jak)–STAT signaling pathway to transmit extracellular signals to the nucleus. STATs (signal transducers and activators of transcription) are late...
Citation: Arthritis Res Ther 2004 6:159 -
Closing remarks
Citation: Arthritis Research & Therapy 2004 6(Suppl 2):S44 -
Expanding the armamentarium for the spondyloarthropathies
Ankylosing spondylitis (AS) is a member of the family of spondyloarthropathies, which are inflammatory arthritides largely involving the axial skeleton and commonly accompanied by peripheral arthritis. Genetic...
Citation: Arthritis Research & Therapy 2004 6(Suppl 2):S36 -
Treating psoriatic arthritis: how effective are TNF antagonists?
Psoriatic arthritis (PsA) is a seronegative spondyloarthropathy that commonly appears after the onset of the characteristic cutaneous lesions. This complication affects about 40% of patients with moderate to s...
Citation: Arthritis Research & Therapy 2004 6(Suppl 2):S31 -
Effective use of TNF antagonists
Tumor necrosis factor (TNF) antagonists are biologic response modifiers that have significantly improved functional outcomes in patients with rheumatoid arthritis (RA). RA is a progressive disease in which str...
Citation: Arthritis Research & Therapy 2004 6(Suppl 2):S24 -
Does route of administration affect the outcome of TNF antagonist therapy?
The tumor necrosis factor (TNF) antagonists are parenterally administered biologic response modifiers indicated for the management of rheumatoid arthritis. Although infliximab, etanercept, and adalimumab are a...
Citation: Arthritis Research & Therapy 2004 6(Suppl 2):S19 -
Does safety make a difference in selecting the right TNF antagonist?
Tumor necrosis factor (TNF) antagonists are biologic response modifiers that have significantly improved the outcomes in patients with rheumatoid arthritis (RA). At this report, safety data were collected on a...
Citation: Arthritis Research & Therapy 2004 6(Suppl 2):S12 -
Do anti-TNF agents have equal efficacy in patients with rheumatoid arthritis?
Tumor necrosis factor (TNF) antagonists have dramatically improved the outcomes of rheumatoid arthritis (RA). Three agents currently available in the USA – infliximab, etanercept, and adalimumab – have been de...
Citation: Arthritis Research & Therapy 2004 6(Suppl 2):S3 -
Current and new antitumor necrosis factor agents in perspective
Citation: Arthritis Research & Therapy 2004 6(Suppl 2):S1 -
4th meeting of the EU research network EUROME: From the identification of genes and cellular networks in murine models of arthritis to novel therapeutic intervention strategies in rheumatoid arthritis, London, UK, 9 March 2004
Rheumatoid arthritis (RA) is a common human disease with a prevalence of about 1% in most parts of the world. At the time of symptom onset it is difficult to predict the severity of subsequent disease course. ...
Citation: Arthritis Res Ther 2004 6:155 -
Diosgenin, a plant steroid, induces apoptosis in human rheumatoid arthritis synoviocytes with cyclooxygenase-2 overexpression
In the present study, we have shown for the first time that a plant steroid, diosgenin, causes an inhibition of the growth of fibroblast-like synoviocytes from human rheumatoid arthritis, with apoptosis induct...
Citation: Arthritis Res Ther 2004 6:R373 -
Autoantibody profile in systemic lupus erythematosus with psychiatric manifestations: a role for anti-endothelial-cell antibodies
This study was performed to determine the correlation between psychiatric manifestations and several autoantibodies that might participate in the pathogenesis of psychiatric disorders in the course of systemic...
Citation: Arthritis Res Ther 2004 6:R366 -
Membrane-associated prostaglandin E synthase-1 is upregulated by proinflammatory cytokines in chondrocytes from patients with osteoarthritis
Prostaglandin E synthase (PGES) including isoenzymes of membrane-associated PGES (mPGES)-1, mPGES-2, and cytosolic PGES (cPGES) is the recently identified terminal enzyme of the arachidonic acid cascade. PGES ...
Citation: Arthritis Res Ther 2004 6:R355 -
Altered expression of inflammatory cytokines in primary osteoarthritis by human T lymphotropic virus type I retrovirus infection: a cross-sectional study
Human T cell leukaemia virus type I (HTLV-I) is known to be involved in late-onset chronic polyarthritis as HTLV-I-associated arthropathy. However, it is unclear whether HTLV-I infection could modify the patho...
Citation: Arthritis Res Ther 2004 6:R347 -
CD25brightCD4+regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease
CD25+CD4+ regulatory T cells participate in the regulation of immune responses. We recently demonstrated the presence of CD25brightCD4+ regulatory T cells with a capacity to control T cell proliferation in the jo...
Citation: Arthritis Res Ther 2004 6:R335 -
What should be the core outcomes in chronic pain clinical trials?
A consensus conference with representatives from academia, governmental agencies, and the pharmaceutical industry met and concluded that clinical trials designed to assess the efficacy and effectiveness of tre...
Citation: Arthritis Res Ther 2004 6:151 -
Phosphatidylserine receptor and apoptosis: consequences of a non-ingested meal
Apoptosis, a physiological process of controlled cell death, is essential during embryonic development and for the maintenance of tissue homeostasis. In recent years the view has emerged that dying cells can p...
Citation: Arthritis Res Ther 2004 6:147 -
Perspectives and limitations of gene expression profiling in rheumatology: new molecular strategies
The deciphering of the sequence of the human genome has raised the expectation of unravelling the specific role of each gene in physiology and pathology. High-throughput technologies for gene expression profil...
Citation: Arthritis Res Ther 2004 6:140 -
Deactivation of endothelium and reduction in angiogenesis in psoriatic skin and synovium by low dose infliximab therapy in combination with stable methotrexate therapy: a prospective single-centre study
Psoriasis and psoriatic arthritis are inflammatory diseases that respond well to anti-tumour necrosis factor-α therapy. To evaluate the effects of anti-tumour necrosis factor-α treatment on expression of adhes...
Citation: Arthritis Res Ther 2004 6:R326 -
Measurement of global functional performance in patients with rheumatoid arthritis using rheumatology function tests
Outcome assessment in patients with rheumatoid arthritis (RA) includes measurement of physical function. We derived a scale to quantify global physical function in RA, using three performance-based rheumatolog...
Citation: Arthritis Res Ther 2004 6:R315 -
Nifedipine decreases sVCAM-1 concentrations and oxidative stress in systemic sclerosis but does not affect the concentrations of vascular endothelial growth factor or its soluble receptor 1
Microvascular injury, oxidative stress, and impaired angiogenesis are prominent features of systemic sclerosis (SSc). We compared serum markers of these phenomena at baseline and after treatment with nifedipin...
Citation: Arthritis Res Ther 2004 6:R309 -
A combination of autoantibodies to cyclic citrullinated peptide (CCP) and HLA-DRB1 locus antigens is strongly associated with future onset of rheumatoid arthritis
Antibodies against cyclic citrullinated peptide (CCP) and rheumatoid factors (RFs) have been demonstrated to predate the onset of rheumatoid arthritis (RA) by years. A nested case–control study was performed w...
Citation: Arthritis Res Ther 2004 6:R303 -
Ageing, autoimmunity and arthritis: Senescence of the B cell compartment – implications for humoral immunity
Immunosenescence is associated with a decline in both T and B lymphocyte function. Although aged individuals have normal numbers of B cells in the periphery and are capable of mounting robust humoral responses...
Citation: Arthritis Res Ther 2004 6:131 -
Patients with systemic lupus erythematosus have abnormally elevated Epstein–Barr virus load in blood
Various genetic and environmental factors appear to be involved in systemic lupus erythematosus (SLE). Epstein–Barr virus (EBV) is among the environmental factors that are suspected of predisposing to SLE, bas...
Citation: Arthritis Res Ther 2004 6:R295 -
Gene expression signatures for autoimmune disease in peripheral blood mononuclear cells
The relatively new technology of DNA microarrays offers the possibility to probe the human genome for clues to the pathogenesis and treatment of human disease. While early studies using this approach were larg...
Citation: Arthritis Res Ther 2004 6:120