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Association of a specific haplotype across the genes MMP1 and MMP3 with radiographic joint destruction in rheumatoid arthritis

The genetic background of rheumatoid arthritis (RA) is only partly understood, and several genes seem to be involved. The matrix metalloproteinases MMP1 (interstitial collagenase) and MMP3 (stromelysin 1) are tho...

Authors: Sylvia Dörr, Nadine Lechtenböhmer, Rolf Rau, Gertraud Herborn, Ulf Wagner, Bertram Müller-Myhsok, Ingo Hansmann and Gernot Keyszer

Citation: Arthritis Res Ther 2004 6:R199

Content type: Research article Published on: 8 March 2004
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Hypoxia: not merely a regulator of angiogenesis?

Authors: Ewa Paleolog

Citation: Arthritis Res Ther 2004 6:75

Content type: Viewpoint Published on: 8 March 2004
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Serum levels of cartilage oligomeric matrix protein are elevated in rheumatoid arthritis, but not in inflammatory rheumatic diseases such as psoriatic arthritis, reactive arthritis, Raynaud's syndrome, scleroderma, systemic lupus erythematosus, vasculitis and Sjögren's syndrome

Authors: Martin Skoumal, Günther Haberhauer, Josef Feyertag, Eva Maria Kittl, Kurt Bauer and Attila Dunky

Citation: Arthritis Res Ther 2004 6:73

Content type: Letter Published on: 8 March 2004
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Endothelial cell phenotypes in the rheumatoid synovium: activated, angiogenic, apoptotic and leaky

Endothelial cells are active participants in chronic inflammatory diseases. These cells undergo phenotypic changes that can be characterised as activated, angiogenic, apoptotic and leaky. In the present review...

Authors: Jim Middleton, Laure Americh, Regis Gayon, Denis Julien, Luc Aguilar, Francois Amalric and Jean-Philippe Girard

Citation: Arthritis Res Ther 2004 6:60

Content type: Review Published on: 8 March 2004
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Kennedy Institute of Rheumatology Division, Imperial College London, 12–13 November 2003: Towards a molecular toolkit for studying lymphocyte function in inflammatory arthritis

T lymphocytes have been implicated in the pathogenesis of inflammatory arthritis for approximately 30 years. Over that period a vast literature has described the phenotype, location and behaviour of T cells de...

Authors: Jeff Faint and Frances Hall

Citation: Arthritis Res Ther 2004 6:55

Content type: Meeting report Published on: 8 March 2004
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Multiple functions for CD28 and cytotoxic T lymphocyte antigen-4 during different phases of T cell responses: implications for arthritis and autoimmune diseases

Chronic T cell responses, as they occur in rheumatoid arthritis, are complex and are likely to involve many mechanisms. There is a growing body of evidence that, in concert with the T cell antigen receptor sig...

Authors: Monika C Brunner-Weinzierl, Holger Hoff and Gerd-R Burmester

Citation: Arthritis Res Ther 2004 6:45

Content type: Review Published on: 3 March 2004
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Increased AP-1 and NF-κB activation and recruitment with the combination of the proinflammatory cytokines IL-1β, tumor necrosis factor alpha and IL-17 in rheumatoid synoviocytes

To determine the contribution of IL-1β, tumor necrosis factor alpha (TNF-α) and IL-17 to AP-1, NF-κB and Egr-1 activation in rheumatoid arthritis, the effect of the cytokines used alone or in combination was m...

Authors: Corinne Granet, Wova Maslinski and Pierre Miossec

Citation: Arthritis Res Ther 2004 6:R190

Content type: Research article Published on: 26 February 2004
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Drug induced differential gene expression in normal and RA synovial fibroblasts cell lines

Authors: M Yahyawi, C Kaps, C Lübke, J Ringe, T Rohrlach, H Augst, G-R Burmester, T Häupl and M Sittinger

Citation: Arthritis Res Ther 2004 6(Suppl 1):106

Content type: Meeting abstract Published on: 25 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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Clinical and serological study of 26 patients with anti-SL (Ki) autoantibodies

Authors: I Cavazzana, F Franceschini, C Vassalini, M Quinzanini, L Andreoli and R Cattaneo

Citation: Arthritis Res Ther 2004 6(Suppl 1):105

Content type: Meeting abstract Published on: 25 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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The role of a defective clearance in the pathogenesis of systemic lupus erythematosus

Authors: S Franz, US Gaipl, U Appelt, P Heyder, RE Voll, JR Kalden and M Herrmann

Citation: Arthritis Res Ther 2004 6(Suppl 1):104

Content type: Meeting abstract Published on: 25 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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A new approach to study angiogenesis in rheumatoid arthritis by power Doppler sonography and serum vascular endothelial growth factor level measurement

Authors: J Strunk, E Heinemann and U Lange

Citation: Arthritis Res Ther 2004 6(Suppl 1):103

Content type: Meeting abstract Published on: 25 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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Three-dimensional power Doppler sonographic visualization of synovial vasculature: an 'in vivo' model to study angiogenesis in rheumatoid arthritis

Authors: J Strunk, K Strube, P Klingenberger and U Lange

Citation: Arthritis Res Ther 2004 6(Suppl 1):102

Content type: Meeting abstract Published on: 25 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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Serum MRP8/MRP14 as a biomarker for inflammation in autoimmune arthritis

Authors: L De Rycke, D Baeten, D Foell, E Kruithof, EM Veys, J Roth and F De Keyser

Citation: Arthritis Res Ther 2004 6(Suppl 1):101

Content type: Meeting abstract Published on: 25 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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Statins have no effect on collagen-induced arthritis in mice

Authors: G Palmer, V Chobaz, D Talabot, S Taylor, A So, C Gabay and N Busso

Citation: Arthritis Res Ther 2004 6(Suppl 1):100

Content type: Meeting abstract Published on: 25 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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Salivary gland epithelial cells (SGEC) express a novel alternate transcript of the B7.2 costimulatory molecule that lacks the CD28/CTLA4-binding IgV-like domain

Authors: EK Kapsogeorgou, HM Moutsopoulos and MN Manoussakis

Citation: Arthritis Res Ther 2004 6(Suppl 1):99

Content type: Meeting abstract Published on: 25 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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Effects of anti-rheumatic treatments on expression of microsomal prostaglandin E synthase-1 in rheumatoid arthritis synovium

Authors: M Korotkova, M Westman, E af Klint, A-K Ulfgren, L Klareskog and P-J Jakobsson

Citation: Arthritis Res Ther 2004 6(Suppl 1):98

Content type: Meeting abstract Published on: 25 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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Aberrant expression of the co-chaperone HDJ2 in rheumatoid arthritis

Authors: A Zgaga-Griesz, S Haak, K Retzlaff, C Schick, R Rzepka and I Melchers

Citation: Arthritis Res Ther 2004 6(Suppl 1):97

Content type: Meeting abstract Published on: 25 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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Cross-reaction between the major epitope of Ro60 protein (pep216–232) and a homologous peptide of Coxsackievirus 3C protease

Authors: EA Stathopoulou, JG Routsias, HA Stea, HM Moutsopoulos and AG Tzioufas

Citation: Arthritis Res Ther 2004 6(Suppl 1):96

Content type: Meeting abstract Published on: 25 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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Allogeneic bone marrow transplantation can suppress established and otherwise chronic collagen-induced arthritis after a nonmyeloablative conditioning regimen employing anti-CD40 ligand monoclonal antibody

Authors: R Flierman, L Morgan, L van Duivenvoorde, RRP de Vries, WE Fibbe, TJW Huizinga, REM Toes and JM van Laar

Citation: Arthritis Res Ther 2004 6(Suppl 1):95

Content type: Meeting abstract Published on: 25 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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Anti-TNF-α antibody Infliximab and glucocorticoids reduce serum vascular endothelial growth factor (VEGF) levels in patients with rheumatoid arthritis: a pilot study

Authors: J Strunk, E Heinemann and U Lange

Citation: Arthritis Res Ther 2004 6(Suppl 1):94

Content type: Meeting abstract Published on: 25 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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The effect of infliximab on skin lesions in a patient with scleroderma (CREST)

Authors: L De Rycke, D Baeten, F Van den Bosch, H Mielants, F De Keyser and EM Veys

Citation: Arthritis Res Ther 2004 6(Suppl 1):93

Content type: Meeting abstract Published on: 25 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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Prediagnosis radiological progression in rheumatoid arthritis: a novel tool to study the effects of early DMARD therapy

Authors: MC Wick, RJ Weiss, L Klareskog and RF van Vollenhoven

Citation: Arthritis Res Ther 2004 6(Suppl 1):92

Content type: Meeting abstract Published on: 25 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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Epstein–Barr virus load follow up in rheumatoid arthritis patients treated with TNF-α inhibitors

Authors: N Balandraud, JB Meynard, I Auger, H Sovran, B Mugnier, D Reviron, J Roudier and C Roudier

Citation: Arthritis Res Ther 2004 6(Suppl 1):91

Content type: Meeting abstract Published on: 25 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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Effects of anti-TNF therapy on endothelial function and intima–media thickness of common carotid artery in patients with rheumatoid arthritis

Authors: P Siakka, A Kalikaki, K Pagonidis, P Sidiropoulos, H Kritikos, E Ganotakis, D Tsetis and DT Boumpas

Citation: Arthritis Res Ther 2004 6(Suppl 1):90

Content type: Meeting abstract Published on: 25 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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Addition of cyclosporine-A (Neoral^®) in patients on anti-TNF and methotrexate therapy improves disease activity: an open-label, pilot study

Authors: P Sidiropoulos, P Siakka, M Mamoulaki, H Kouroumali, H Kritikos and DT Boumpas

Citation: Arthritis Res Ther 2004 6(Suppl 1):89

Content type: Meeting abstract Published on: 25 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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Impact of cellular therapies on autoreactive, long-lived plasma cells in autoimmune diseases (AID)

Authors: F Hiepe, R Manz, B Hoyer, A Thiel, T Alexander, G-R Burmester, G Massenkeil, R Arnold and A Radbruch

Citation: Arthritis Res Ther 2004 6(Suppl 1):88

Content type: Meeting abstract Published on: 25 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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Multidrug resistance proteins and DMARD efficacy in rheumatoid arthritis

Authors: G Jansen, R Oerlemans, J van der Heijden, WF Lems, GL Scheffer, RJ Scheper and BAC Dijkmans

Citation: Arthritis Res Ther 2004 6(Suppl 1):87

Content type: Meeting abstract Published on: 24 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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Zoledronic acid protects from local and systemic bone loss in TNF-mediated arthritis

Authors: J Zwerina, P Herrak, B Goertz, S Hayer, K Redlich, E Reiter, J Gasser, H Bergmeister, G Kollias, JS Smolen and G Schett

Citation: Arthritis Res Ther 2004 6(Suppl 1):85

Content type: Meeting abstract Published on: 24 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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Application of regulatable vectors in gene therapy of experimental arthritis

Authors: DJ Gould and Y Chernajovsky

Citation: Arthritis Res Ther 2004 6(Suppl 1):83

Content type: Meeting abstract Published on: 24 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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IL-22 gene transfer in collagen-induced arthritis

Authors: F Apparailly, J Dudler, J-C Renauld, P Plence, L Dumoutier, F Djouad, D Noel, AK So, J Sany and C Jorgensen

Citation: Arthritis Res Ther 2004 6(Suppl 1):81

Content type: Meeting abstract Published on: 24 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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Switching of serotype can improve local AAV-mediated gene therapy in RA

Authors: J Adriaansen, M Vervoordeldonk, P Plence, A Bakker, E Gicquel, C Jorgensen, PP Tak and F Apparailly

Citation: Arthritis Res Ther 2004 6(Suppl 1):79

Content type: Meeting abstract Published on: 24 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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Fibroblast-like synoviocytes derived from patients with rheumatoid arthritis show the imprint of synovial tissue heterogeneity: evidence for the existence of distinctive pathways relevant to disease

Authors: PV Kasperkovitz, NL Verbeet, T Smeets, PP Tak, TWJ Huizinga, B Baltus, T Timmer, E Pieterman, M Fero, GS Firestein, AA Alizadeh, TCTM van der Pouw Kraan and CL Verweij

Citation: Arthritis Res Ther 2004 6(Suppl 1):77

Content type: Meeting abstract Published on: 24 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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Toll-like receptor 4 polymorphism influences susceptibility to but not severity and outcome of rheumatoid arthritis

Authors: TRDJ Radstake, B Franke, S Hanssen, P Welsing, LAB Joosten, PLCM van Riel, P Barrera and WB van den Berg

Citation: Arthritis Res Ther 2004 6(Suppl 1):75

Content type: Meeting abstract Published on: 24 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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Requirement of local synovial IL-17 receptor signaling in the progression of chronic synovitis and bone erosion in arthritis

Authors: E Lubberts, W Huang, P Schwarzenberger, J Schurr, J Peschon, WB van den Berg and JK Kolls

Citation: Arthritis Res Ther 2004 6(Suppl 1):58

Content type: Meeting abstract Published on: 24 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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Neutralizing synovial RANKL by local OPG gene therapy in collagen-induced arthritis prevents cartilage erosion through induction of a non-destructive type 2 synovitis

Authors: E Lubberts, MI Koenders, B Oppers-Walgreen, M Wagenmans, L van den Bersselaar, LAB Joosten, J Schurr, JK Kolls and WB van den Berg

Citation: Arthritis Res Ther 2004 6(Suppl 1):55

Content type: Meeting abstract Published on: 24 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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Differential gene expression and protein expression levels of MMP and TIMP molecules in response to glucocorticoid treatment in arthritic patients

Authors: T Andersson, E af Klint, S Strobel, U Andersson, A Stark, R Gelinas, J Lundeberg, L Klareskog and A-K Ulfgren

Citation: Arthritis Res Ther 2004 6(Suppl 1):53

Content type: Meeting abstract Published on: 24 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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The effects of NF-κB inhibition by a NEMO binding domain peptide in vitro and in vivo

Authors: SW Tas, EC de Jong, MJ Vervoordeldonk, KA Reedquist, M May, S Ghosh and PP Tak

Citation: Arthritis Res Ther 2004 6(Suppl 1):51

Content type: Meeting abstract Published on: 24 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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Phenotypic and functional deficiencies of monocyte derived dendritic cells in systemic lupus erythematosus patients

Authors: C Scheinecker, M Köller, B Zwölfer and JS Smolen

Citation: Arthritis Res Ther 2004 6(Suppl 1):49

Content type: Meeting abstract Published on: 24 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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Differential dendritic cell expression in chronic inflammatory arthritis: implications for their maturation, recruitment and involvement in disease

Authors: S Jongbloed, A Fraser, JA Gracie and IB McInnes

Citation: Arthritis Res Ther 2004 6(Suppl 1):47

Content type: Meeting abstract Published on: 24 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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RANK and RANKL expression in rheumatoid arthritis synovium and lymph nodes as markers of dendritic cell – T cell interactions

Authors: G Page and P Miossec

Citation: Arthritis Res Ther 2004 6(Suppl 1):45

Content type: Meeting abstract Published on: 24 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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Increased expression of chemokines DC-CK1, ELC and TARC by dendritic cells and in synovium from patients with rheumatoid arthritis

Authors: T Radstake, R van der Voort, A Sloetjes, C Figdor, W van den Berg, P Barrera and G Adema

Citation: Arthritis Res Ther 2004 6(Suppl 1):43

Content type: Meeting abstract Published on: 24 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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The presence of deiminated fibrin in the synovial membrane is not specific for rheumatoid arthritis

Authors: S Chapuy-Regaud, M Sebbag, D Baeten, C Clavel, F De Keyser and G Serre

Citation: Arthritis Res Ther 2004 6(Suppl 1):20

Content type: Meeting abstract Published on: 24 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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Citrullinated proteins in arthritis: presence in joints and effects on immunogenicity

Authors: K Lundberg, S Nijenhuis, E Vossenaar, L Klareskog, WJ van Venrooij and H Erlandsson Harris

Citation: Arthritis Res Ther 2004 6(Suppl 1):18

Content type: Meeting abstract Published on: 24 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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False positivity of rheumatoid factor and antibodies to citrullinated peptides in systemic lupus erythematosus

Authors: IEA Hoffman, I Peene, A Union, L Meheus, T Huizinga, L Cebecauer, D Isenberg, K De Bosschere, F Hulstaert, EM Veys and F De Keyser

Citation: Arthritis Res Ther 2004 6(Suppl 1):16

Content type: Meeting abstract Published on: 24 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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VIDAS-EDRA fully automated testing of autoantibodies to citrullinated proteins for the diagnosis of rheumatoid arthritis

Authors: L Nogueira, A Foussadier, C Vincent, C Clavel, N Moinard, M Jolivet and G Serre

Citation: Arthritis Res Ther 2004 6(Suppl 1):14

Content type: Meeting abstract Published on: 24 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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Two B cell populations differentially expressing IgVH mRNAs in human RA synovium

Authors: S Ruzickova, O Krystufkova, L Sedova, J Niederlova, Z Cimburek, T Dörner and J Vencovsky

Citation: Arthritis Res Ther 2004 6(Suppl 1):12

Content type: Meeting abstract Published on: 24 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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Immune complexes from RA patients induce FcγRII-dependent and RF-correlated TNF-α and IL-8 production from healthy PBMC

Authors: L Mathsson, J Lampa, M Mullazehi and J Rönnelid

Citation: Arthritis Res Ther 2004 6(Suppl 1):10

Content type: Meeting abstract Published on: 24 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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Multiplex analysis of antinuclear antibodies by flow cytometry using FIDIS

Authors: PJ Charles

Citation: Arthritis Res Ther 2004 6(Suppl 1):8

Content type: Meeting abstract Published on: 24 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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Association of anti-ribosomal P protein antibodies with neuropsychiatric systemic lupus erythematosus

Authors: A Ambrozic, B Bozic, B Rozman, B Lestan and T Kveder

Citation: Arthritis Res Ther 2004 6(Suppl 1):6

Content type: Meeting abstract Published on: 24 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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Concomitant appearance of anti-cardiolipin, anti-β₂-glycoprotein I, anti-prothrombin and anti-annexin V antibodies

Authors: S Cucnik, N Gaspersic, T Kveder and B Bozic

Citation: Arthritis Res Ther 2004 6(Suppl 1):4

Content type: Meeting abstract Published on: 24 February 2004

This article is part of a Supplement: Volume 6 Supplement 1
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