Hooyman JR, Melton LJ, Nelson AM, O'Fallon WM, Riggs BL: Fractures after rheumatoid arthritis. A population-based study. Arthritis Rheum. 1984, 27: 1353-1361.
Article
CAS
PubMed
Google Scholar
Spector TD, Hall GM, McCloskey EV, Kanis JA: Risk of vertebral fracture in women with rheumatoid arthritis. BMJ. 1993, 306: 558-
Article
PubMed Central
CAS
PubMed
Google Scholar
Rehman Q, Lane NE: Bone loss. Therapeutic approaches for preventing bone loss in inflammatory arthritis. Arthritis Res. 2001, 3: 221-227. 10.1186/ar305.
Article
PubMed Central
CAS
PubMed
Google Scholar
Sinigaglia L, Nervetti A, Mela Q, Bianchi G, Del Puente A, Di Munno O, Frediani B, Cantatore F, Pellerito R, Bartolone S, et al: A multicenter cross sectional study on bone mineral density in rheumatoid arthritis. Italian Study Group on Bone Mass in Rheumatoid Arthritis. J Rheumatol. 2000, 27: 2582-2589.
CAS
PubMed
Google Scholar
Forsblad D'Elia H, Larsen A, Waltbrand E, Kvist G, Mellstrom D, Saxne T, Ohlsson C, Nordborg E, Carlsten H: Radiographic joint destruction in postmenopausal rheumatoid arthritis is strongly associated with generalised osteoporosis. Ann Rheum Dis. 2003, 62: 617-623. 10.1136/ard.62.7.617.
Article
PubMed
Google Scholar
Riggs BL, Khosla S, Melton LJ: A unitary model for involutional osteoporosis: estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men. J Bone Miner Res. 1998, 13: 763-773.
Article
CAS
PubMed
Google Scholar
Cauley JA, Seeley DG, Ensrud K, Ettinger B, Black D, Cummings SR: Estrogen replacement therapy and fractures in older women. Ann Int Med. 1995, 122: 9-16.
Article
CAS
PubMed
Google Scholar
Cauley JA, Robbins J, Chen Z, Cummings SR, Jackson RD, LaCroix AZ, LeBoff M, Lewis CE, McGowan J, Neuner J, et al: Effects of estrogen plus progestin on risk of fracture and bone mineral density: the Women's Health Initiative randomized trial. JAMA. 2003, 290: 1729-1738. 10.1001/jama.290.13.1729.
Article
CAS
PubMed
Google Scholar
Hall GM, Daniels M, Doyle DV, Spector TD: Effect of hormone replacement therapy on bone mass in rheumatoid arthritis patients treated with and without steroids. Arthritis Rheum. 1994, 37: 1499-1505.
Article
CAS
PubMed
Google Scholar
D'Elia HF, Larsen A, Mattsson LA, Waltbrand E, Kvist G, Mellstrom D, Saxne T, Ohlsson C, Nordborg E, Carlsten H: Influence of hormone replacement therapy on disease progression and bone mineral density in rheumatoid arthritis. J Rheumatol. 2003, 30: 1456-1463.
PubMed
Google Scholar
Eriksen EF, Colvard DS, Berg NJ, Graham ML, Mann KG, Spelsberg TC, Riggs BL: Evidence of estrogen receptors in normal human osteoblast-like cells. Science. 1988, 241: 84-86.
Article
CAS
PubMed
Google Scholar
Oursler MJ, Osdoby P, Pyfferoen J, Riggs BL, Spelsberg TC: Avian osteoclasts as estrogen target cells. Proc Natl Acad Sci USA. 1991, 88: 6613-6617.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ushiyama T, Ueyama H, Inoue K, Ohkubo I, Hukuda S: Expression of genes for estrogen receptors alpha and beta in human articular chondrocytes. Osteoarthritis Cartilage. 1999, 7: 560-566. 10.1053/joca.1999.0260.
Article
CAS
PubMed
Google Scholar
Hughes DE, Dai A, Tiffee JC, Li HH, Mundy GR, Boyce BF: Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-beta. Nat Med. 1996, 2: 1132-1136. 10.1038/nm1096-1132.
Article
CAS
PubMed
Google Scholar
Kameda T, Mano H, Yuasa T, Mori Y, Miyazawa K, Shiokawa M, Nakamaru Y, Hiroi E, Hiura K, Kameda A, et al: Estrogen inhibits bone resorption by directly inducing apoptosis of the bone-resorbing osteoclasts. J Exp Med. 1997, 186: 489-495. 10.1084/jem.186.4.489.
Article
PubMed Central
CAS
PubMed
Google Scholar
Chow J, Tobias JH, Colston KW, Chambers TJ: Estrogen maintains trabecular bone volume in rats not only by suppression of bone resorption but also by stimulation of bone formation. J Clin Invest. 1992, 89: 74-78.
Article
PubMed Central
CAS
PubMed
Google Scholar
Hall GM, Spector TD, Delmas PD: Markers of bone metabolism in postmenopausal women with rheumatoid arthritis. Effects of corticosteroids and hormone replacement therapy. Arthritis Rheum. 1995, 38: 902-906.
Article
CAS
PubMed
Google Scholar
Garnero P, Jouvenne P, Buchs N, Delmas PD, Miossec P: Uncoupling of bone metabolism in rheumatoid arthritis patients with or without joint destruction: assessment with serum type I collagen breakdown products. Bone. 1999, 24: 381-385. 10.1016/S8756-3282(98)00193-8.
Article
CAS
PubMed
Google Scholar
Gough A, Sambrook P, Devlin J, Huissoon A, Njeh C, Robbins S, Nguyen T, Emery P: Osteoclastic activation is the principal mechanism leading to secondary osteoporosis in rheumatoid arthritis. J Rheumatol. 1998, 25: 1282-1289.
CAS
PubMed
Google Scholar
Garnero P, Landewe R, Boers M, Verhoeven A, Van Der Linden S, Christgau S, Van Der Heijde D, Boonen A, Geusens P: Association of baseline levels of markers of bone and cartilage degradation with long-term progression of joint damage in patients with early rheumatoid arthritis: the COBRA study. Arthritis Rheum. 2002, 46: 2847-2856. 10.1002/art.10616.
Article
CAS
PubMed
Google Scholar
Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS, et al: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988, 31: 315-324.
Article
CAS
PubMed
Google Scholar
Christgau S, Rosenquist C, Alexandersen P, Bjarnason NH, Ravn P, Fledelius C, Herling C, Qvist P, Christiansen C: Clinical evaluation of the Serum CrossLaps One Step ELISA, a new assay measuring the serum concentration of bone-derived degradation products of type I collagen C-telopeptides. Clin Chem. 1998, 44: 2290-2300.
CAS
PubMed
Google Scholar
Rosenquist C, Fledelius C, Christgau S, Pedersen BJ, Bonde M, Qvist P, Christiansen C: Serum CrossLaps One Step ELISA. First application of monoclonal antibodies for measurement in serum of bone-related degradation products from C-terminal telopeptides of type I collagen. Clin Chem. 1998, 44: 2281-2289.
CAS
PubMed
Google Scholar
Saxne T, Zunino L, Heinegard D: Increased release of bone sialoprotein into synovial fluid reflects tissue destruction in rheumatoid arthritis. Arthritis Rheum. 1995, 38: 82-90.
Article
CAS
PubMed
Google Scholar
Christgau S, Garnero P, Fledelius C, Moniz C, Ensig M, Gineyts E, Rosenquist C, Qvist P: Collagen type II C-telopeptide fragments as an index of cartilage degradation. Bone. 2001, 29: 209-215. 10.1016/S8756-3282(01)00504-X.
Article
CAS
PubMed
Google Scholar
Saxne T, Heinegard D: Cartilage oligomeric matrix protein: a novel marker of cartilage turnover detectable in synovial fluid and blood. Br J Rheumatol. 1992, 31: 583-591.
Article
CAS
PubMed
Google Scholar
Larsen A: How to apply Larsen score in evaluating radiographs of rheumatoid arthritis in long-term studies. J Rheumatol. 1995, 22: 1974-1975.
CAS
PubMed
Google Scholar
Prevoo ML, van't Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB, van Riel PL: Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum. 1995, 38: 44-48.
Article
CAS
PubMed
Google Scholar
Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, Jackson RD, Beresford SA, Howard BV, Johnson KC, et al: Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA. 2002, 288: 321-333. 10.1001/jama.288.3.321.
Article
CAS
PubMed
Google Scholar
Sattar N, McCarey DW, Capell H, McInnes IB: Explaining how "high-grade" systemic inflammation accelerates vascular risk in rheumatoid arthritis. Circulation. 2003, 108: 2957-2963. 10.1161/01.CIR.0000099844.31524.05.
Article
PubMed
Google Scholar
Delmas PD, Eastell R, Garnero P, Seibel MJ, Stepan J: The use of biochemical markers of bone turnover in osteoporosis. Committee of Scientific Advisors of the International Osteoporosis Foundation. Osteoporos Int. 2000, 11: S2-17. 10.1007/s001980070002.
Article
PubMed
Google Scholar
Garnero P, Rousseau JC, Delmas PD: Molecular basis and clinical use of biochemical markers of bone, cartilage, and synovium in joint diseases. Arthritis Rheum. 2000, 43: 953-968. 10.1002/1529-0131(200005)43:5<953::AID-ANR1>3.0.CO;2-Q.
Article
CAS
PubMed
Google Scholar
Garnero P, Delmas PD: Biochemical markers of bone turnover. Applications for osteoporosis. Endocrinol Metab Clin North Am. 1998, 27: 303-323.
Article
CAS
PubMed
Google Scholar
Garnero P, Borel O, Byrjalsen I, Ferreras M, Drake FH, McQueney MS, Foged NT, Delmas PD, Delaisse JM: The collagenolytic activity of cathepsin K is unique among mammalian proteinases. J Biol Chem. 1998, 273: 32347-32352. 10.1074/jbc.273.48.32347.
Article
CAS
PubMed
Google Scholar
Ravn P, Clemmesen B, Riis BJ, Christiansen C: The effect on bone mass and bone markers of different doses of ibandronate: a new bisphosphonate for prevention and treatment of postmenopausal osteoporosis: a 1-year, randomized, double-blind, placebo-controlled dose-finding study. Bone. 1996, 19: 527-533. 10.1016/S8756-3282(96)00229-3.
Article
CAS
PubMed
Google Scholar
Garnero P, Gineyts E, Christgau S, Finck B, Delmas PD: Association of baseline levels of urinary glucosyl-galactosyl-pyridinoline and type II collagen C-telopeptide with progression of joint destruction in patients with early rheumatoid arthritis. Arthritis Rheum. 2002, 46: 21-30. 10.1002/1529-0131(200201)46:1<21::AID-ART10061>3.0.CO;2-Q.
Article
CAS
PubMed
Google Scholar
Christgau S, Bitsch-Jensen O, Hanover Bjarnason N, Gamwell Henriksen E, Qvist P, Alexandersen P, Bang Henriksen D: Serum CrossLaps for monitoring the response in individuals undergoing antiresorptive therapy. Bone. 2000, 26: 505-511. 10.1016/S8756-3282(00)00248-9.
Article
CAS
PubMed
Google Scholar
Lems WF, van den Brink HR, Gerrits MI, van Rijn HJ, Bijlsma JW: Effect of hormone replacement therapy on markers of bone metabolism in RA. Ann Rheum Dis. 1993, 52: 835-836.
Article
PubMed Central
CAS
PubMed
Google Scholar
Al-Awadhi A, Olusi S, Al-Zaid N, Prabha K: Serum concentrations of interleukin 6, osteocalcin, intact parathyroid hormone, and markers of bone resorption in patients with rheumatoid arthritis. J Rheumatol. 1999, 26: 1250-1256.
CAS
PubMed
Google Scholar
Cortet B, Flipo RM, Pigny P, Duquesnoy B, Boersma A, Marchandise X, Delcambre B: Is bone turnover a determinant of bone mass in rheumatoid arthritis?. J Rheumatol. 1998, 25: 2339-2344.
CAS
PubMed
Google Scholar
Forsblad d'Elia H, Mattsson L-A, Ohlsson C, Nordborg E, Carlsten H: Hormone replacement therapy in rheumatoid arthritis is associated with lower serum levels of soluble IL-6 receptor and higher insulin-like growth factor. Arthritis Res Ther. 2003, 5: R202-R209. 10.1186/ar761.
Article
Google Scholar
Franzen A, Heinegard D: Isolation and characterization of two sialoproteins present only in bone calcified matrix. Biochem J. 1985, 232: 715-724.
Article
PubMed Central
CAS
PubMed
Google Scholar
Stork S, Stork C, Angerer P, Kothny W, Schmitt P, Wehr U, von Schacky C, Rambeck W: Bone sialoprotein is a specific biochemical marker of bone metabolism in postmenopausal women: a randomized 1-year study. Osteoporos Int. 2000, 11: 790-796. 10.1007/s001980070058.
Article
CAS
PubMed
Google Scholar
Lehmann HJ, Mouritzen U, Christgau S, Cloos PA, Christiansen C: Effect of bisphosphonates on cartilage turnover assessed with a newly developed assay for collagen type II degradation products. Ann Rheum Dis. 2002, 61: 530-533. 10.1136/ard.61.6.530.
Article
PubMed Central
CAS
PubMed
Google Scholar
Van Offel JF, Schuerwegh AJ, Bridts CH, Stevens WJ, De Clerck LS: Effect of bisphosphonates on viability, proliferation, and dexamethasone-induced apoptosis of articular chondrocytes. Ann Rheum Dis. 2002, 61: 925-928. 10.1136/ard.61.10.925.
Article
PubMed Central
CAS
PubMed
Google Scholar
Hasegawa J, Nagashima M, Yamamoto M, Nishijima T, Katsumata S, Yoshino S: Bone resorption and inflammatory inhibition efficacy of intermittent cyclical etidronate therapy in rheumatoid arthritis. J Rheumatol. 2003, 30: 474-479.
CAS
PubMed
Google Scholar
Mouritzen U, Christgau S, Lehmann HJ, Tanko LB, Christiansen C: Cartilage turnover assessed with a newly developed assay measuring collagen type II degradation products: influence of age, sex, menopause, hormone replacement therapy, and body mass index. Ann Rheum Dis. 2003, 62: 332-336. 10.1136/ard.62.4.332.
Article
PubMed Central
CAS
PubMed
Google Scholar
Hedbom E, Antonsson P, Hjerpe A, Aeschlimann D, Paulsson M, Rosa-Pimentel E, Sommarin Y, Wendel M, Oldberg A, Heinegard D: Cartilage matrix proteins. An acidic oligomeric protein (COMP) detected only in cartilage. J Biol Chem. 1992, 267: 6132-6136.
CAS
PubMed
Google Scholar
Recklies AD, Baillargeon L, White C: Regulation of cartilage oligomeric matrix protein synthesis in human synovial cells and articular chondrocytes. Arthritis Rheum. 1998, 41: 997-1006. 10.1002/1529-0131(199806)41:6<997::AID-ART6>3.0.CO;2-G.
Article
CAS
PubMed
Google Scholar
Forslind K, Eberhardt K, Jonsson A, Saxne T: Increased serum concentrations of cartilage oligomeric matrix protein. A prognostic marker in early rheumatoid arthritis. Br J Rheumatol. 1992, 31: 593-598.
Article
CAS
PubMed
Google Scholar
Lindqvist E, Eberhardt K, Heinegard D, Saxne T: Serum COMP for risk assessement of joint destruction in early rheumatoid arthritis, EULAR abstract, Stockholm [abstract]. Ann Rheum Dis. 2002, Suppl 1: 81-
Google Scholar
Crnkic M, Mansson B, Larsson L, Geborek P, Heinegard D, Saxne T: Serum cartilage oligomeric matrix protein (COMP) decreases in rheumatoid arthritis patients treated with infliximab or etanercept. Arthritis Res Ther. 2003, 5: R181-185. 10.1186/ar760.
Article
PubMed Central
CAS
PubMed
Google Scholar