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  1. Certain circRNAs could be used as biomarkers to determine the risk of development and/or severity of systemic lupus erythematosus, and their new function in the regulation of gene expression has motivated us t...

    Authors: Xingwang Zhao, Rui Dong, Longlong Zhang, Junkai Guo, Ying Shi, Lan Ge, Juan Wang, Zhiqiang Song, Bing Ni and Yi You
    Citation: Arthritis Research & Therapy 2022 24:37
    Content type: Research article Published on:

  2. Analyses of lymphoid organs are required to further elucidate the pathogenesis of inflammatory diseases like rheumatoid arthritis (RA). Yet, invasive tissue collection methods are scarcely applied, because the...

    Authors: Renée H. Fiechter, Janne W. Bolt, Marleen G. H. van de Sande, Caroline J. Aalbers, Robert B. M. Landewé, Mario Maas, Sander W. Tas and Lisa G. M. van Baarsen
    Citation: Arthritis Research & Therapy 2022 24:36
    Content type: Research article Published on:

  3. Rheumatoid arthritis is a chronic systemic autoimmune disease characterized by synovial hyperplasia, inflammatory cell infiltration, and proliferation of inflammatory tissue (angiogranuloma). The destruction o...

    Authors: Yuan-yuan Wu, Xiao-feng Li, Sha Wu, Xue-ni Niu, Su-qin Yin, Cheng Huang and Jun Li
    Citation: Arthritis Research & Therapy 2022 24:35
    Content type: Review Published on:

  4. To describe the longitudinal associations between the morphological parameters of proximal tibiofibular joint (PTFJ) and joint structural changes in tibiofemoral compartments in patients with knee osteoarthrit...

    Authors: Jun Chang, Tianyu Chen, Yizhu Yan, Zhaohua Zhu, Weiyu Han, Yi Zhao, Benny Antony, Anita Wluka, Tania Winzenberg, Flavia Cicuttini and Changhai Ding
    Citation: Arthritis Research & Therapy 2022 24:34
    Content type: Research article Published on:

  5. From this retrospective study, we aimed to (1) describe the prevalence and characteristics of non-criteria features in primary antiphospholipid syndrome (p-APS) and (2) determine their prognostic value.

    Authors: Alexis F. Guédon, Jennifer Catano, Laure Ricard, Charlotte Laurent, Claire de Moreuil, Geoffrey Urbanski, Sophie Deriaz, Grigorios Gerotziafas, Ismail Elalamy, Alexandra Audemard, Francois Chasset, Sonia Alamowitch, Jérémie Sellam, François Maillot, Jean Jacques Boffa, Ariel Cohen…
    Citation: Arthritis Research & Therapy 2022 24:33
    Content type: Research article Published on:

  6. Patients with gout frequently have low urinary pH, which is associated with the nephrolithiasis. However, the specific distribution of urinary pH and potential relationship of acidic urine pH to broader manife...

    Authors: Yuwei He, Xiaomei Xue, Robert Terkeltaub, Nicola Dalbeth, Tony R. Merriman, David B. Mount, Zhe Feng, Xinde Li, Lingling Cui, Zhen Liu, Yan Xu, Ying Chen, Hailong Li, Aichang Ji, Xiaopeng Ji, Xuefeng Wang…
    Citation: Arthritis Research & Therapy 2022 24:32
    Content type: Research article Published on:

  7. To examine how female patients with RA form decisions about having children, pregnancy, and medication use.

    Authors: Nevena Rebić, Sarah Munro, Ria Garg, Glen Hazlewood, Neda Amiri, Corisande Baldwin, Stephanie Ensworth, Laurie Proulx and Mary A. De Vera
    Citation: Arthritis Research & Therapy 2022 24:31
    Content type: Research article Published on:

  8. To evaluate the influence of the disease activity on radiographic progression in axial spondyloarthritis (axSpA) patients treated with TNF inhibitors (TNFi).

    Authors: Maria Llop, Mireia Moreno, Victoria Navarro-Compán, Xavier Juanola, Eugenio de Miguel, Raquel Almodóvar, Eduardo Cuende Quintana, Jesús Sanz Sanz, Emma Beltrán, M. Dolores Ruiz Montesinos, Joan Calvet, Antoni Berenguer-Llergo and Jordi Gratacós
    Citation: Arthritis Research & Therapy 2022 24:30
    Content type: Research article Published on:

  9. In patients with axial spondyloarthritis (axSpA), magnetic resonance imaging (MRI) is used to detect bone marrow edema (BME) in sacroiliac joints (SIJ) but SIJ BME are also detected in the population. Not much...

    Authors: J. Braun, X. Baraliakos, R. Bülow, C. O. Schmidt and A. Richter
    Citation: Arthritis Research & Therapy 2022 24:29
    Content type: Research article Published on:

  10. Psoriasis patients developing psoriatic arthritis (PsA) are thought to go through different phases. Understanding the underlying events in these phases is crucial to diagnose PsA early. Here, we have character...

    Authors: Hannah den Braanker, Wida Razawy, Kim Wervers, Anne-Marie C. Mus, Nadine Davelaar, Marc R. Kok and Erik Lubberts
    Citation: Arthritis Research & Therapy 2022 24:28
    Content type: Research article Published on:

  11. Penfluridol, isolated from an FDA-approved small-molecule drug library as an inhibitor of tumor necrosis factor α (TNFα)-stimulated NF-κB activation, is clinically used to treat chronic schizophrenia and relat...

    Authors: Yue-hong Chen, Rong-han Liu, Ya-zhou Cui, Aubryanna Hettinghouse, Wen-yu Fu, Lei Zhang, Chen Zhang and Chuan-ju Liu
    Citation: Arthritis Research & Therapy 2022 24:27
    Content type: Research article Published on:

  12. Musculoskeletal (MSK) symptoms are among the commonest reasons for primary care assessments; however, few individuals will be diagnosed with an inflammatory arthritis (IA) within the following year. The purpos...

    Authors: Leticia Garcia-Montoya, Jacqueline L. Nam, Laurence Duquenne, Catalina Villota-Eraso, Andrea Di Matteo, Collette Hartley, Kulveer Mankia and Paul Emery
    Citation: Arthritis Research & Therapy 2022 24:26
    Content type: Research article Published on:

  13. Intervertebral disc (IVD) herniation is characterized by annulus fibrosus failure (AF) in containing the nucleus pulposus (NP). IVD herniation involves cellular and extracellular matrix (ECM) alterations that ...

    Authors: A. L. Castro, C. Ribeiro-Machado, C. M. Oliveira, G. Q. Teixeira, C. Neidlinger-Wilke, P. Pereira, R. Vaz, M. A. Barbosa and R. M. Gonçalves
    Citation: Arthritis Research & Therapy 2022 24:25
    Content type: Research article Published on:

  14. Neutrophils are present in the early phases of spondyloarthritis-related uveitis, skin and intestinal disease, but their role in enthesitis, a cardinal musculoskeletal lesion in spondyloarthritis, remains unkn...

    Authors: Zheni Stavre, Charles Bridgewood, Qiao Zhou, Yukiko Maeda, Ting-ting Huang, Jozsef Karman, Almas Khan, Sami Giryes, Kassem Sharif, Dennis McGonagle and Ellen M. Gravallese
    Citation: Arthritis Research & Therapy 2022 24:24
    Content type: Research article Published on:

  15. Anti-citrullinated protein antibodies (ACPAs) are highly specific for rheumatoid arthritis (RA). In vivo, ACPAs target peptidyl-citrulline epitopes (cit-) in a variety of proteins (cit-prot-ACPAs) and derived ...

    Authors: Natalia Regine de França, Henri André Ménard, Maximilien Lora, Zhijie Zhou, Joyce Rauch, Carol Hitchon, Luís Eduardo Coelho Andrade and Inés Colmegna
    Citation: Arthritis Research & Therapy 2022 24:23
    Content type: Research article Published on:

  16. The prevalence of psoriatic arthritis (PsA) is the same in men and women; however, the latter experience a higher burden of disease and are affected more frequently by polyarthritis. Here, we performed an earl...

    Authors: E. Passia, M. Vis, L. C. Coates, A. Soni, I. Tchetverikov, A. H. Gerards, M. R. Kok, P. A. J. M. Vos, L. Korswagen, F. Fodili, Y. P. M. Goekoop-Ruiterman, J. van der Kaap, M. van Oosterhout and J. J. Luime
    Citation: Arthritis Research & Therapy 2022 24:22
    Content type: Research article Published on:

  17. Little is known about the safety of SARS-CoV-2 vaccination in patients with rheumatic musculoskeletal disease (RMD). We evaluated the occurrence of adverse events following immunization (AEFI) in RMD patients ...

    Authors: Francesca Romana Spinelli, Ennio Giulio Favalli, Cristina Garufi, Martina Cornalba, Serena Colafrancesco, Fabrizio Conti and Roberto Caporali
    Citation: Arthritis Research & Therapy 2022 24:21
    Content type: Research article Published on:

  19. Interstitial lung disease (ILD) is a common organ manifestation in systemic sclerosis (SSc) and is the leading cause of death in patients with SSc. A decline in forced vital capacity (FVC) is an indicator of I...

    Authors: Michael Kreuter, Francesco Del Galdo, Corinna Miede, Dinesh Khanna, Wim A. Wuyts, Laura K. Hummers, Margarida Alves, Nils Schoof, Christian Stock and Yannick Allanore
    Citation: Arthritis Research & Therapy 2022 24:19
    Content type: Research article Published on:

  20. Synovial fluid (SF) is commonly used for diagnostic and research purposes, as it is believed to reflect the local inflammatory environment. Owing to its complex composition and especially the presence of hyalu...

    Authors: Hilde Brouwers, Johannes Hendrick von Hegedus, Enrike van der Linden, Rachid Mahdad, Margreet Kloppenburg, René Toes, Martin Giera and Andreea Ioan-Facsinay
    Citation: Arthritis Research & Therapy 2022 24:18
    Content type: Research article Published on:

  21. Methotrexate (MTX) has a protective effect against cardiovascular diseases (CVD), but the mechanism is unclear.

    Authors: Bing Wang, Hui Deng, Yao Hu, Ling Han, Qiong Huang, Xu Fang, Ke Yang, Siyuan Wu, Zhizhong Zheng, Nikhil Yawalkar, Zhenghua Zhang and Kexiang Yan
    Citation: Arthritis Research & Therapy 2022 24:17
    Content type: Research article Published on:

  22. Although the risk of cardiovascular disease has been discussed extensively in both psoriasis (PsO) and psoriatic arthritis (PsA), very few studies have addressed the occurrence of venous thromboembolic (VTE) e...

    Authors: Tal Gazitt, Jacob Pesachov, Idit Lavi, Muna Elias, Amir Haddad, Ilan Feldhamer, Arnon Dov Cohen, Walid Saliba and Devy Zisman
    Citation: Arthritis Research & Therapy 2022 24:16
    Content type: Research article Published on:

  23. The currently known risk loci could explain a small proportion of the heritability of ankylosing spondylitis (AS). Epigenetics might account for the missing heritability. We aimed to seek more novel AS-associa...

    Authors: Min Xiao, Xuqi Zheng, Xiaomin Li, Xinyu Wu, Yefei Huang, Qiujing Wei, Shuangyan Cao and Jieruo Gu
    Citation: Arthritis Research & Therapy 2022 24:15
    Content type: Research article Published on:

  24. The relationship between IgG4-related disease (IgG4-RD) and the risk of malignancy is still controversial. This article focused on assessing the risk of cancer in patients with IgG4-RD by meta-analysis.

    Authors: Tingfeng Yu, Yaxian Wu, Jia Liu, Yanyan Zhuang, Xiaoyan Jin and Lingyun Wang
    Citation: Arthritis Research & Therapy 2022 24:14
    Content type: Research article Published on:

    The Correspondence to this article has been published in Arthritis Research & Therapy 2022 24:122

  25. Uncontrolled immune response with T cell activation has a key role in the pathogenesis of systemic sclerosis (SSc), a disorder that is characterized by generalized fibrosis affecting particularly the lungs and...

    Authors: Cindy Orvain, Anne Cauvet, Alexis Prudent, Christophe Guignabert, Raphaël Thuillet, Mina Ottaviani, Ly Tu, Fanny Duhalde, Carole Nicco, Frédéric Batteux, Jérôme Avouac, NingXin Wang, Michelle A. Seaberg, Stacey R. Dillon and Yannick Allanore
    Citation: Arthritis Research & Therapy 2022 24:13
    Content type: Research article Published on:

  26. Lenabasum is a cannabinoid type 2 receptor (CB2R) reverse agonist that demonstrates anti-inflammatory effects in vivo and in vitro in dermatomyositis (DM) and is currently being investigated for therapeutic po...

    Authors: Spandana Maddukuri, Jay Patel, De Anna Diaz, Kristen L. Chen, Maria Wysocka, Christina Bax, Yubin Li, Adarsh Ravishankar, Madison Grinnell, Majid Zeidi, Nithin Reddy, Josef Symon S. Concha, Muhammad M. Bashir, Joyce Okawa, Barbara White and Victoria P. Werth
    Citation: Arthritis Research & Therapy 2022 24:12
    Content type: Research article Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2022 24:69

  27. The effects of filgotinib on patient-reported outcomes (PROs) from 3 trials in patients with active rheumatoid arthritis were investigated.

    Authors: Clifton O. Bingham III, David Walker, Peter Nash, Susan J. Lee, Lei Ye, Hao Hu, Javaria Mona Khalid and Bernard Combe
    Citation: Arthritis Research & Therapy 2022 24:11
    Content type: Research article Published on:

  28. This study aimed to investigate the effect of glucocorticoid doses on adverse pregnancy outcomes (APOs) in women complicated by systemic lupus erythematosus (SLE).

    Authors: Hiromi Shimada, Risa Wakiya, Kenji Kanenishi, Nobuyuki Miyatake, Shusaku Nakashima, Mai Mahmoud Fahmy Mansour, Mikiya Kato, Taichi Miyagi, Koichi Sugihara, Yusuke Ushio, Rina Mino, Mao Mizusaki, Tomohiro Kameda, Norimitsu Kadowaki and Hiroaki Dobashi
    Citation: Arthritis Research & Therapy 2022 24:10
    Content type: Research article Published on:

  29. Seronegative antiphospholipid syndrome (SN-APS) is often defined as the presence of APS criteria manifestations, negative antiphospholipid antibodies (aPL), and coexistence of APS non-criteria manifestations. ...

    Authors: Gilberto Pires da Rosa, Bernardo Sousa-Pinto, Ester Ferreira, Olga Araújo, Giuseppe Barilaro, Paulo Bettencourt, Ricard Cervera and Gerard Espinosa
    Citation: Arthritis Research & Therapy 2022 24:9
    Content type: Research article Published on:

  30. Hip osteoarthritis is a common disabling condition of the hip joint and is associated with a substantial health burden. We assessed the epidemiological patterns of hip osteoarthritis from 1990 to 2019 by sex, ...

    Authors: Ming Fu, Hongming Zhou, Yushi Li, Hai Jin and Xiqing Liu
    Citation: Arthritis Research & Therapy 2022 24:8
    Content type: Research article Published on:

  31. Adult-onset Still’s disease (AOSD) is a rare systemic autoinflammatory disease which encompasses patients with heterogenous presentation and a wide range of clinical courses. In this study, we aimed to identif...

    Authors: Takahiro Sugiyama, Shunsuke Furuta, Masaki Hiraguri, Kei Ikeda, Yosuke Inaba, Shin-ichiro Kagami, Yasuhiko Kita, Kei Kobayashi, Yoshihisa Kobayashi, Kazuhiro Kurasawa, Daiki Nakagomi, Yasushi Nawata, Yohei Kawasaki, Yuki Shiko, Takao Sugiyama and Hiroshi Nakajima
    Citation: Arthritis Research & Therapy 2022 24:7
    Content type: Research article Published on:

  32. Hydroxychloroquine (HCQ) has been recommended as a basic treatment for lupus nephritis (LN) during this decade based on its ability to improve LN-related renal immune-mediated inflammatory lesions. As a classi...

    Authors: Ning An, Chen Yang, Hong-Luan Wu, Yun Guo, Xi-Jie Huang, Tong-Sheng Huang, Zhi-Hong Wu, Jing Xue, Rui-Hong Chen, Zhi-Hang Li, Qing-Jun Pan and Hua-Feng Liu
    Citation: Arthritis Research & Therapy 2022 24:6
    Content type: Research article Published on:

  33. Systemic lupus erythematosus (SLE) is a chronic and complex multi-system autoimmune disorder. Higher risks of hematological malignancies (HM) were observed in SLE patients, which was associated with higher mor...

    Authors: Yuqi Zhang, Wei Li, Panpan Zhang, Jinyan Guo, Jinlei Sun, Jiameng Lu and Shengyun Liu
    Citation: Arthritis Research & Therapy 2022 24:5
    Content type: Research article Published on:

  34. Rheumatoid arthritis (RA) is a heterogeneous disease, as evidenced by the differences in long-term outcomes. This applies especially to anti-citrullinated protein antibodies (ACPA)-negative RA, where a proport...

    Authors: M. Verstappen, H. W. van Steenbergen, P. H. P. de Jong and A. H. M. van der Helm-van Mil
    Citation: Arthritis Research & Therapy 2022 24:4
    Content type: Research article Published on:

  35. To assay salivary anti-nuclear antibody (ANA) and its isotypes in patients with systemic lupus erythematosus (SLE) and to investigate relevant clinical associations.

    Authors: Ting Zhang, Yong Du, Qingqing Wu, Hao Li, Thao Nguyen, Gabriel Gidley, Valeria Duran, Daniel Goldman, Michelle Petri and Chandra Mohan
    Citation: Arthritis Research & Therapy 2022 24:3
    Content type: Research article Published on:

  36. Interstitial lung disease (ILD) is an important problem for patients with rheumatoid arthritis (RA). However, current approaches to ILD case finding in real-world data have been evaluated only in limited setti...

    Authors: M. Meehan, A. Shah, J. Lobo, J. Oates, C. Clinton, N. Annapureddy, F. Xie, J. Zhuo, M. I. Danila, B. R. England and J. R. Curtis
    Citation: Arthritis Research & Therapy 2022 24:2
    Content type: Research article Published on:

  37. Ankylosing spondylitis is a progressive, disabling joint disease that affects millions worldwide. Given its unclear etiology, studies of ankylosing spondylitis relied heavily on drug-induced or transgenic rode...

    Authors: Huanhuan Jia, Meili Chen, Yanzhen Cai, Xiaoling Luo, Gang Hou, Yongfeng Li, Chunmei Cai, Jun Chen, Qingnan Li, Kai-Kei Miu, Sin-Hang Fung, Zhangting Wang, Ren Huang, Huiyong Shen and Li Lu
    Citation: Arthritis Research & Therapy 2022 24:1
    Content type: Research article Published on:

  38. In rheumatoid arthritis (RA), macrophages play an important role in modulating the immunoinflammatory response through their polarisation into “classically” (M1) or “alternatively activated” (M2) phenotypes. I...

    Authors: Maurizio Cutolo, Stefano Soldano, Emanuele Gotelli, Paola Montagna, Rosanna Campitiello, Sabrina Paolino, Carmen Pizzorni, Alberto Sulli, Vanessa Smith and Samuele Tardito
    Citation: Arthritis Research & Therapy 2021 23:306
    Content type: Research article Published on:

  39. To determine the diagnostic accuracy of major salivary gland ultrasonography (SGUS) in primary Sjögren’s syndrome (pSS) using the novel Outcome Measures in Rheumatology Clinical Trials (OMERACT) scoring system...

    Authors: Xia Zhang, Ruiling Feng, Jinxia Zhao, Yu Wang, Juan He, Li Liu, Yongjing Cheng, Haihong Yao, Sumei Tang, Jiali Chen, Shanshan Zhang, Zhiyi Zhang, Qingwen Wang, Jing He and Zhanguo Li
    Citation: Arthritis Research & Therapy 2021 23:305
    Content type: Research article Published on:

  40. Previous studies have shown that the incidence and risk factors of gout differs according to sex. However, little research has been done on the association between reproductive factors and gout. We conducted a...

    Authors: Yeonghee Eun, In-Young Kim, Kyungdo Han, Kyu Na Lee, Dong-Yun Lee, Dong Wook Shin, Seonyoung Kang, Seulkee Lee, Hoon-Suk Cha, Eun-Mi Koh, Jaejoon Lee and Hyungjin Kim
    Citation: Arthritis Research & Therapy 2021 23:304
    Content type: Research article Published on:

  41. There have been lacking reliable serum biomarkers in assessing the disease activity of Takayasu’s arteritis (TAK). This study aimed to assess the disease activity of TAK by assayed gene expression levels in pe...

    Authors: Yixiao Tian, Jing Li, Xinping Tian and Xiaofeng Zeng
    Citation: Arthritis Research & Therapy 2021 23:303
    Content type: Research article Published on:

  42. The single nucleotide polymorphism (SNP) rs62324212, located in IL21 antisense RNA 1 (IL21-AS1), has been identified as a genetic risk variant associated with systemic lupus erythematosus (SLE). We aimed to pr...

    Authors: He Hao, Shingo Nakayamada, Naoaki Ohkubo, Kaoru Yamagata, Mingzeng Zhang, Yu Shan, Shigeru Iwata, Tong Zhang and Yoshiya Tanaka
    Citation: Arthritis Research & Therapy 2021 23:302
    Content type: Research article Published on:

  43. WNT16 is critical for bone homeostasis, but the effect of WNT16 in ankylosing spondylitis (AS) is still unknown. Here, we investigated whether WNT16 influences bone formation and pathophysiological changes of ...

    Authors: Sungsin Jo, Subin Weon, Bora Nam, Mi-Ae Jang, Hyundeok Kang, Tae-Jong Kim, Ye-Soo Park and Tae-Hwan Kim
    Citation: Arthritis Research & Therapy 2021 23:301
    Content type: Research article Published on:

  45. To determine the usefulness of power Doppler (PD) ultrasound (US) to predict rheumatoid arthritis (RA) development in patients with clinically suspect arthralgia (CSA).

    Authors: Juan Molina Collada, Katerine López Gloria, Isabel Castrejón, Juan Carlos Nieto-González, Javier Rivera, Fernando Montero, Carlos González and José María Álvaro-Gracia
    Citation: Arthritis Research & Therapy 2021 23:299
    Content type: Research article Published on:

  46. Besides anti-citrullinated protein antibodies (ACPA), rheumatoid arthritis patients (RA) often display autoantibody reactivities against other post-translationally modified (PTM) proteins, more specifically ca...

    Authors: M. Volkov, A. S. B. Kampstra, K. A. van Schie, A. Kawakami, M. Tamai, S. Kawashiri, T. Maeda, T. W. J. Huizinga, R. E. M. Toes and D. van der Woude
    Citation: Arthritis Research & Therapy 2021 23:298
    Content type: Research article Published on:

  47. Establishing an optimal animal model for intervertebral disc (IVD) degeneration is essential for developing new IVD therapies. The intra-articular injection of monosodium iodoacetate (MIA), which is commonly u...

    Authors: Takao Sudo, Koji Akeda, Koki Kawaguchi, Takahiro Hasegawa, Junichi Yamada, Nozomu Inoue, Koichi Masuda and Akihiro Sudo
    Citation: Arthritis Research & Therapy 2021 23:297
    Content type: Research article Published on:

  48. Features of new bone formation (NBF) are common in tophaceous gout. The aim of this project was to develop a plain radiographic scoring system for NBF in gout.

    Authors: Chang-Nam Son, Ken Cai, Sarah Stewart, John Ferrier, Karen Billington, Yun-Jung Jack Tsai, Thomas Bardin, Anne Horne, Lisa K. Stamp, Anthony Doyle and Nicola Dalbeth
    Citation: Arthritis Research & Therapy 2021 23:296
    Content type: Research article Published on:

  49. Systemic sclerosis (SSc) is associated with a variability of mortality rates in the literature.

    Authors: Sébastien De Almeida Chaves, Tiphaine Porel, Mickael Mounié, Laurent Alric, Léonardo Astudillo, Antoine Huart, Olivier Lairez, Martin Michaud, Grégoire Prévot, David Ribes, Laurent Sailler, Francis Gaches, Daniel Adoue and Gregory Pugnet
    Citation: Arthritis Research & Therapy 2021 23:295
    Content type: Research article Published on:

  50. The use of interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor as a treatment for the inflammatory joint disease is a promising method. However, its underlying mechanism in osteoarthritis (OA) remains...

    Authors: Muzhe Li, Huiyun Li, Xun Ran, Han Yin, Xuling Luo and Zhiwei Chen
    Citation: Arthritis Research & Therapy 2021 23:294
    Content type: Research article Published on:
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