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  1. Patient-reported outcomes (PROs) are increasingly used to track symptoms and to assess disease activity, quality of life, and treatment effectiveness. It is therefore important to understand which PROs patient...

    Authors: W. Benjamin Nowell, Kelly Gavigan, Carol L. Kannowski, Zhihong Cai, Theresa Hunter, Shilpa Venkatachalam, Julie Birt, Jennifer Workman and Jeffrey R. Curtis

    Citation: Arthritis Research & Therapy 2021 23:53

    Content type: Research article

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  2. A20 haploinsufficiency (HA20) is an early-onset autoinflammatory disease caused by mutations in the TNFAIP3 gene, which encodes the protein A20. Numerous truncating mutations in the TNFAIP3 gene have been reporte...

    Authors: Saori Kadowaki, Kunio Hashimoto, Toyoki Nishimura, Kenichi Kashimada, Tomonori Kadowaki, Norio Kawamoto, Kohsuke Imai, Satoshi Okada, Hirokazu Kanegane and Hidenori Ohnishi

    Citation: Arthritis Research & Therapy 2021 23:52

    Content type: Research article

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  3. To demonstrate equivalent efficacy of the proposed high-concentration (100 mg/ml), citrate-free adalimumab biosimilar CT-P17 to European Union-approved adalimumab (EU-adalimumab) in subjects with active rheuma...

    Authors: Jonathan Kay, Janusz Jaworski, Rafal Wojciechowski, Piotr Wiland, Anna Dudek, Marek Krogulec, Slawomir Jeka, Agnieszka Zielinska, Jakub Trefler, Katarzyna Bartnicka-Maslowska, Magdalena Krajewska-Wlodarczyk, Piotr A. Klimiuk, Sang Joon Lee, Yun Ju Bae, Go Eun Yang, Jae Kyoung Yoo…

    Citation: Arthritis Research & Therapy 2021 23:51

    Content type: Research article

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  4. Cartilage defects frequently occur around the knee joint yet cartilage has limited self-repair abilities. Hydrogel scaffolds have excellent potential for use in tissue engineering. Therefore, the aim of the pr...

    Authors: Yuan Li, Yanping Liu and Qiang Guo

    Citation: Arthritis Research & Therapy 2021 23:50

    Content type: Research article

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  5. We hypothesized that Behçet’s disease (BD) consists of several clinical subtypes with different severity, resulting in heterogeneity of the disease. Here, we conducted a study to identify clinical clusters of BD.

    Authors: Yutaro Soejima, Yohei Kirino, Mitsuhiro Takeno, Michiko Kurosawa, Masaki Takeuchi, Ryusuke Yoshimi, Yumiko Sugiyama, Shigeru Ohno, Yukiko Asami, Akiko Sekiguchi, Toshihisa Igarashi, Shohei Nagaoka, Yoshiaki Ishigatsubo, Hideaki Nakajima and Nobuhisa Mizuki

    Citation: Arthritis Research & Therapy 2021 23:49

    Content type: Research article

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  6. Subclinical synovitis by ultrasound is a frequent finding in rheumatoid arthritis (RA) patients in remission and has been shown to be related to erosive progression, risk of flare and unsuccessful drug taperin...

    Authors: Lene Terslev, Cecilie Heegaard Brahe, Mikkel Østergaard, Viktoria Fana, Mads Ammitzbøll-Danielsen, Torsten Møller, Simon Krabbe, Merete Lund Hetland and Uffe Møller Døhn

    Citation: Arthritis Research & Therapy 2021 23:48

    Content type: Research article

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  7. Chondrocyte apoptosis plays a vital role in osteoarthritis (OA) progression. Angelica sinensis polysaccharide (ASP), a traditional Chinese medicine, possesses anti-inflammatory and anti-apoptotic properties in ch...

    Authors: Chao Xu, Su Ni, Chao Zhuang, Chenkai Li, Gongyin Zhao, Shijie Jiang, Liangliang Wang, Ruixia Zhu, Andre J. van Wijnen and Yuji Wang

    Citation: Arthritis Research & Therapy 2021 23:47

    Content type: Research article

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  8. Fine-mapping of human leukocyte antigen (HLA) region for rheumatoid arthritis (RA) risk factors has identified several HLA alleles and its corresponding amino acid residues as independent signals (i.e., HLA-A, HL...

    Authors: Lay Kim Tan, Chun Lai Too, Lina Marcela Diaz-Gallo, Sulaiman Wahinuddin, Ing Soo Lau, Hussein Heselynn, Shahril Nor-Shuhaila, Suk Chyn Gun, Mageswaran Eashwary, Mohamed Said Mohd-Shahrir, Mohd Mokhtar Ainon, Rosman Azmillah, Othman Muhaini, Murad Shahnaz, Lars Alfredsson, Lars Klareskog…

    Citation: Arthritis Research & Therapy 2021 23:46

    Content type: Research article

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  9. Behcet’s syndrome (BS) is a complex, heterogeneous disorder. However, classification of its subgroups is still debated. The purpose of this study was to investigate the clinical features and aggregation of pat...

    Authors: Jun Zou, Jian-feng Luo, Yan Shen, Jian-fei Cai and Jian-long Guan

    Citation: Arthritis Research & Therapy 2021 23:45

    Content type: Research article

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  10. Persistence of biologic therapy in psoriatic arthritis (PsA) patients is an important factor in individualized patient treatment planning and healthcare policy and guideline development.

    Authors: Amir Haddad, Tal Gazitt, Ilan Feldhamer, Joy Feld, Arnon Dov Cohen, Idit Lavi, Faten Tatour, Irena Bergman and Devy Zisman

    Citation: Arthritis Research & Therapy 2021 23:44

    Content type: Research article

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  11. Limited information is available on the impact of treatment with a tumor necrosis factor inhibitor (TNFi) on structural lesions in patients with recent-onset axial spondyloarthritis (axSpA). We compared 2-year...

    Authors: Walter P. Maksymowych, Pascal Claudepierre, Manouk de Hooge, Robert G. Lambert, Robert Landewé, Anna Molto, Désirée van der Heijde, Jack F. Bukowski, Heather Jones, Ron Pedersen, Annette Szumski, Bonnie Vlahos and Maxime Dougados

    Citation: Arthritis Research & Therapy 2021 23:43

    Content type: Research article

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  12. The efficacy and safety of ixekizumab (IXE) with and without continuous concomitant methotrexate (MTX), for up to 52 weeks of treatment, were evaluated in patients with active psoriatic arthritis (PsA).

    Authors: Bernard Combe, Tsen-Fang Tsai, J. Eugene Huffstutter, Aubrey Trevelin Sprabery, Chen-Yen Lin, So Young Park, Andris Kronbergs, Matthew M. Hufford and Peter Nash

    Citation: Arthritis Research & Therapy 2021 23:41

    Content type: Research article

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  13. The goal of the study was to assess the diagnostic and prognostic utility of survivin in patients with juvenile idiopathic arthritis (JIA).

    Authors: Joanna Lipinska, Marcin Kaszkowiak, Beata Malachowska, Joanna Swidrowska-Jaros and Elzbieta Smolewska

    Citation: Arthritis Research & Therapy 2021 23:40

    Content type: Research article

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  14. Curcumin (CUR), vitamin D3 (D3), and omega-3-fatty acids (O3FA) individually modulate inflammation and pain in arthritis. Although these supplements are widely used, their combinatorial effects have not been defi...

    Authors: Mahadevappa Hemshekhar, Vidyanand Anaparti, Hani El-Gabalawy and Neeloffer Mookherjee

    Citation: Arthritis Research & Therapy 2021 23:39

    Content type: Research article

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  15. To identify rheumatoid arthritis (RA)-associated susceptibility genes and pathways through integrating genome-wide association study (GWAS) and gene expression profile data.

    Authors: Cuiyan Wu, Sijian Tan, Li Liu, Shiqiang Cheng, Peilin Li, Wenyu Li, Huan Liu, Feng’e Zhang, Sen Wang, Yujie Ning, Yan Wen and Feng Zhang

    Citation: Arthritis Research & Therapy 2021 23:38

    Content type: Research article

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  16. Investigating the pathophysiological mechanisms of early osteoarthritis (OA) is of utmost interest since this stage holds the strongest promise for therapeutic interventions. The aims of this study were to ana...

    Authors: Nils Rosshirt, Richard Trauth, Hadrian Platzer, Elena Tripel, Timo A. Nees, Hanns-Martin Lorenz, Theresa Tretter and Babak Moradi

    Citation: Arthritis Research & Therapy 2021 23:37

    Content type: Research article

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  17. Subchondral bone marrow lesions (BMLs) detected on MRI in knee osteoarthritis (OA) are associated with knee pain. The prevalence and progression of subchondral BMLs are increased by mechanical knee load. Howev...

    Authors: Koji Aso, Seyed Mohsen Shahtaheri, Daniel F. McWilliams and David A. Walsh

    Citation: Arthritis Research & Therapy 2021 23:35

    Content type: Research article

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  18. Pain is a frequent, yet inadequately explored challenge in patients with systemic sclerosis (SSc). This study aimed to conduct an extensive pain assessment, examining pain chronification and its association wi...

    Authors: Caroline Evers, Suzana Jordan, Britta Maurer, Mike Oliver Becker, Carina Mihai, Rucsandra Dobrota, Petra Hoederath and Oliver Distler

    Citation: Arthritis Research & Therapy 2021 23:34

    Content type: Research article

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  19. Anti-Jo-1 autoantibodies which recognize histidyl-tRNA synthetase identify patients with the rare rheumatologic disease, anti-histidyl-tRNA synthetase syndrome (Jo-1 ARS), a phenotypically distinct subset of i...

    Authors: Jennifer Young-Glazer, Alberto Cisneros III, Erin M. Wilfong, Scott A. Smith, Leslie J. Crofford and Rachel H. Bonami

    Citation: Arthritis Research & Therapy 2021 23:33

    Content type: Research article

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  20. Proprotein convertase subtilisin kexin 9 (PCSK9) targets the LDL-receptor (LDLR) which raises LDL-levels. In addition, PCSK9 has proinflammatory immunological effects. Here, we investigate the role of PCSK9 in...

    Authors: Johan Frostegård, Sabbir Ahmed, Ingiäld Hafström, Sofia Ajeganova and Mizanur Rahman

    Citation: Arthritis Research & Therapy 2021 23:32

    Content type: Research article

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  21. Rheumatoid arthritis (RA) is an autoimmune disease of inflammatory joint damage, wherein C-reactive protein and autoantibodies including rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP) ...

    Authors: Sora Mun, Jiyeong Lee, Mira Park, Jieun Shin, Mi-Kyoung Lim and Hee-Gyoo Kang

    Citation: Arthritis Research & Therapy 2021 23:31

    Content type: Research article

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  22. To evaluate our hypotheses that, when rheumatoid arthritis (RA) flares postpartum, gene expression patterns are altered compared to (a) healthy women, (b) RA women whose disease activity is low or in remission...

    Authors: Matthew Wright, Mette K. Smed, J. Lee Nelson, Jørn Olsen, Merete L. Hetland, Vibeke Zoffmann and Damini Jawaheer

    Citation: Arthritis Research & Therapy 2021 23:30

    Content type: Research article

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  23. Type I interferons (IFNs) play an important role in the pathophysiology of systemic lupus erythematosus (SLE). While cross-sectional data suggest an association between IFN-induced gene expression and SLE dise...

    Authors: Lloyd Mai, Arundip Asaduzzaman, Babak Noamani, Paul R. Fortin, Dafna D. Gladman, Zahi Touma, Murray B. Urowitz and Joan Wither

    Citation: Arthritis Research & Therapy 2021 23:29

    Content type: Research article

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  24. To assess through systematic review and meta-analysis whether plasma exchange (PE) is associated with prognosis in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) patients.

    Authors: Yosuke Yamada, Makoto Harada, Yuuta Hara, Ryohei Iwabuchi, Koji Hashimoto, Shuhei Yamamoto and Yuji Kamijo

    Citation: Arthritis Research & Therapy 2021 23:28

    Content type: Review

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  25. Radiographic damage in rheumatoid arthritis (RA) includes erosions and joint space narrowing (JSN). Different mechanisms may underlie their development. The objective of this study was to evaluate predictors o...

    Authors: Emil Rydell, Kristina Forslind, Jan-Åke Nilsson, Magnus Karlsson, Kristina E. Åkesson, Lennart T. H. Jacobsson and Carl Turesson

    Citation: Arthritis Research & Therapy 2021 23:27

    Content type: Research article

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  26. There are numerous non-biologic and biologic disease-modifying anti-rheumatic drugs (bDMARDs) for rheumatoid arthritis (RA). Typical sequences of bDMARDs are not clear. Future treatment policies and trials sho...

    Authors: Daniel H. Solomon, Chang Xu, Jamie Collins, Seoyoung C. Kim, Elena Losina, Vincent Yau and Fredrik D. Johansson

    Citation: Arthritis Research & Therapy 2021 23:26

    Content type: Research article

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  27. Biologic therapies have greatly improved outcomes in rheumatoid arthritis (RA) and psoriatic arthritis (PsA). Yet, our ability to predict long-term remission and persistence or continuation of therapy remains ...

    Authors: Kieran Murray, Matthew Turk, Yousef Alammari, Francis Young, Phil Gallagher, Tajvur Saber, Ursula Fearon and Douglas J. Veale

    Citation: Arthritis Research & Therapy 2021 23:25

    Content type: Research article

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  28. Lupus nephritis (LN) is one of the most severe complications of systemic lupus erythematosus (SLE). Circular RNAs (circRNAs) can act as competitive endogenous RNAs (ceRNAs) to regulate gene transcription, whic...

    Authors: Chunyi Zhang, Congcong Gao, Xueqi Di, Siwan Cui, Wenfang Liang, Wenbo Sun, Menghui Yao, Shengyun Liu and Zhaohui Zheng

    Citation: Arthritis Research & Therapy 2021 23:24

    Content type: Research article

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  29. Over the past decades, circular RNAs (circRNAs) have emerged as a hot spot and sparked intensive interest. Initially considered as the transcriptional noises, further studies have indicated that circRNAs are c...

    Authors: Wenchao Zhang, Lin Qi, Ruiqi Chen, Jieyu He, Zhongyue Liu, Wanchun Wang, Chao Tu and Zhihong Li

    Citation: Arthritis Research & Therapy 2021 23:23

    Content type: Review

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  30. Systemic sclerosis starts with an early phase characterized by Raynaud’s phenomenon, puffy fingers/hands, autoantibodies, and a scleroderma nailfold microscopic pattern. Alterations in the nailfold microscopic...

    Authors: Khalid Daoudi, Brigit E. Kersten, Cornelia H. M. van den Ende, Frank H. J. van den Hoogen, Madelon C. Vonk and Chris L. de Korte

    Citation: Arthritis Research & Therapy 2021 23:22

    Content type: Research article

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  31. Systemic sclerosis (SSc) is an acquired autoimmune disorder characterized by excessive accumulation of collagen and progressive tissue fibrosis. Although interstitial lung disease (ILD) complicates the majorit...

    Authors: Yiqun Li, Jing Huang, Chaojun Hu, Jiaxin Zhou, Dong Xu, Yong Hou, Chanyuan Wu, Jiuliang Zhao, Mengtao Li, Xiaofeng Zeng, Changzheng Liu, Qian Wang and Yan Zhao

    Citation: Arthritis Research & Therapy 2021 23:21

    Content type: Research article

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  32. Scarring alopecia in systemic lupus erythematosus (SLE) patients caused reduced life quality and prolonged disease course. This case-control study aims to survey the prevalence of scarring alopecia during the ...

    Authors: Yirong Xiang, Mengtao Li, Hui Luo, Yanhong Wang, Xinwang Duan, Cheng Zhao, Feng Zhan, Zhenbiao Wu, Hongbin Li, Min Yang, Jian Xu, Wei Wei, Lijun Wu, Hanxiao You, Junyan Qian, Xiaoxi Yang…

    Citation: Arthritis Research & Therapy 2021 23:20

    Content type: Research article

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  33. Mixed connective tissue disease (MCTD) is a rare condition that is distinguished by the presence of specific U1-RNP antibodies. Information about its etiopathology and diagnostics is still unclear. miRNAs such...

    Authors: Barbara Stypińska, Aleksandra Lewandowska, Anna Felis-Giemza, Marzena Olesińska and Agnieszka Paradowska-Gorycka

    Citation: Arthritis Research & Therapy 2021 23:19

    Content type: Research article

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  34. Granulomatosis with polyangiitis (GPA) causes a recurring inflammation in nose and paranasal sinuses that clinically resembles chronic rhinosinusitis (CRS) of other aetiologies. While sinonasal inflammation is...

    Authors: Sigrun Skaar Holme, Karin Kilian, Heidi B. Eggesbø, Jon Magnus Moen and Øyvind Molberg

    Citation: Arthritis Research & Therapy 2021 23:18

    Content type: Research article

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  35. T cell Ig and ITIM domain (TIGIT)/CD226 pathway has a critical role in regulating T cell responses and has come to the forefront in cancer as a promising immunotherapeutic target. However, its role in autoimmu...

    Authors: Wenli Li, Chuiwen Deng, Hanbo Yang, Xin Lu, Shanshan Li, Xia Liu, Fang Chen, Lida Chen, Xiaoming Shu, Lu Zhang, Qingyan Liu, Guochun Wang and Qinglin Peng

    Citation: Arthritis Research & Therapy 2021 23:15

    Content type: Research article

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  36. Giant cell arteritis (GCA) is frequently associated with aortic involvement that is likely to cause life-threatening structural complications (aneurysm, dissection). Few studies have investigated the occurrenc...

    Authors: Olivier Espitia, Gauthier Blonz, Geoffrey Urbanski, Cédric Landron, Jérôme Connault, Christian Lavigne, Pascal Roblot, François Maillot, Alexandra Audemard-Verger, Mathieu Artifoni, Cécile Durant, Béatrice Guyomarch, Mohamed Hamidou, Julie Magnant and Christian Agard

    Citation: Arthritis Research & Therapy 2021 23:14

    Content type: Research article

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  37. Associations between rheumatoid arthritis (RA) and effect of treatment at the tissue levels are poorly understood. We investigated the scope of released extracellular matrix (ECM) metabolites as a consequence ...

    Authors: Patryk J. Drobinski, Anne C. Bay-Jensen, Morten A. Karsdal, Samra Sardar and Anne S. Siebuhr

    Citation: Arthritis Research & Therapy 2021 23:13

    Content type: Research article

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  38. This study measured the magnitude and determinants of clinical and radiological progression in patients with hand osteoarthritis (HOA) over a 2-year prospective follow-up to gain a greater understanding of the...

    Authors: Audrey Neuprez, Jean-François Kaux, Médéa Locquet, Charlotte Beaudart and Jean-Yves Reginster

    Citation: Arthritis Research & Therapy 2021 23:12

    Content type: Research article

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  39. Treat-to-target (T2T) is a widely accepted strategy for patients with rheumatoid arthritis (RA). It recommends attaining a goal of at least low disease activity (LDA) within 6 months; otherwise, the current th...

    Authors: Lucie Nekvindová, Jiří Vencovský, Karel Pavelka, Pavel Horák, Zlatuše Křístková and Jakub Závada

    Citation: Arthritis Research & Therapy 2021 23:11

    Content type: Research article

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  40. Abnormalities in lymphocyte surface markers and functions have been described in systemic sclerosis (SSc), but conflicting results abound, and these studies often examined patients with heterogeneous disease d...

    Authors: David A. Fox, Steven K. Lundy, Michael L. Whitfield, Veronica Berrocal, Phillip Campbell, Stephanie Rasmussen, Ray Ohara, Alexander Stinson, Mikel Gurrea-Rubio, Evan Wiewiora, Catherine Spino, Erica Bush, Daniel Furst, Shiv Pillai and Dinesh Khanna

    Citation: Arthritis Research & Therapy 2021 23:10

    Content type: Research article

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    The Correction to this article has been published in Arthritis Research & Therapy 2021 23:73

  41. The objective of the study was to evaluate the efficacy and safety of upadacitinib over 84 weeks in Japanese patients with active rheumatoid arthritis (RA) and an inadequate response to conventional synthetic ...

    Authors: Hideto Kameda, Tsutomu Takeuchi, Kunihiro Yamaoka, Motohiro Oribe, Mitsuhiro Kawano, Masayuki Yokoyama, Aileen L. Pangan, Yuko Konishi, Sebastian Meerwein and Yoshiya Tanaka

    Citation: Arthritis Research & Therapy 2021 23:9

    Content type: Research article

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  42. Placebo-controlled clinical trials have demonstrated the efficacy of tocilizumab (TCZ) for remission maintenance and glucocorticoid sparing in patients with giant cell arteritis (GCA). However, limited data ex...

    Authors: Sebastian Unizony, Timothy J. McCulley, Robert Spiera, Jinglan Pei, Paris N. Sidiropoulos, Jennie H. Best, Christine Birchwood, Andrey Pavlov and John H. Stone

    Citation: Arthritis Research & Therapy 2021 23:8

    Content type: Research article

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  43. There are few studies on the hyperuricemia (HUA) and moderate to vigorous intensity physical activity (PA) and also hardly regarding sitting time (ST). The purpose of this study was to examine the independent ...

    Authors: Xiaokang Dong, Yuqian Li, Lulu Zhang, Xiaotian Liu, Runqi Tu, Yikang Wang, Ruiying Li, Linlin Li, Jian Hou, Zhenxing Mao, Wenqian Huo and Chongjian Wang

    Citation: Arthritis Research & Therapy 2021 23:7

    Content type: Research article

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  44. Although treatments have been proposed for calcinosis cutis (CC) in patients with systemic sclerosis (SSc), a standardized and validated method for CC burden quantification is necessary to enable valid clinica...

    Authors: Anita C. Chandrasekaran, Zhicheng Fu, Reid Kraniski, F. Perry Wilson, Shannon Teaw, Michelle Cheng, Annie Wang, Shangping Ren, Imran M. Omar and Monique E. Hinchcliff

    Citation: Arthritis Research & Therapy 2021 23:6

    Content type: Research article

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  45. CD40-CD40L is a key co-stimulatory pathway for B cell activation. As such, its blockade can inhibit pathogenic B cell responses in autoimmune diseases, such as Sjogren’s syndrome (SjS) and systemic lupus eryth...

    Authors: John Marken, Sujatha Muralidharan and Natalia V. Giltiay

    Citation: Arthritis Research & Therapy 2021 23:5

    Content type: Research article

    Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2021 23:36

  46. Individuals with high bone mass (HBM) have a greater odds of prevalent radiographic hip osteoarthritis (OA), reflecting an association with bone-forming OA sub-phenotypes (e.g. osteophytosis, subchondral scler...

    Authors: April Hartley, Sarah A. Hardcastle, Monika Frysz, Jon Parkinson, Lavinia Paternoster, Eugene McCloskey, Kenneth E. S. Poole, Muhammad K. Javaid, Mo Aye, Katie Moss, Martin Williams, Jon H. Tobias and Celia L. Gregson

    Citation: Arthritis Research & Therapy 2021 23:4

    Content type: Research article

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