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  1. Lenabasum is a cannabinoid type 2 receptor (CB2R) reverse agonist that demonstrates anti-inflammatory effects in vivo and in vitro in dermatomyositis (DM) and is currently being investigated for therapeutic po...

    Authors: Spandana Maddukuri, Jay Patel, De Anna Diaz, Kristen L. Chen, Maria Wysocka, Christina Bax, Yubin Li, Adarsh Ravishankar, Madison Grinnell, Majid Zeidi, Nithin Reddy, Josef Symon S. Concha, Muhammad M. Bashir, Joyce Okawa, Barbara White and Victoria P. Werth
    Citation: Arthritis Research & Therapy 2022 24:12

    The Correction to this article has been published in Arthritis Research & Therapy 2022 24:69

  2. The effects of filgotinib on patient-reported outcomes (PROs) from 3 trials in patients with active rheumatoid arthritis were investigated.

    Authors: Clifton O. Bingham III, David Walker, Peter Nash, Susan J. Lee, Lei Ye, Hao Hu, Javaria Mona Khalid and Bernard Combe
    Citation: Arthritis Research & Therapy 2022 24:11
  3. This study aimed to investigate the effect of glucocorticoid doses on adverse pregnancy outcomes (APOs) in women complicated by systemic lupus erythematosus (SLE).

    Authors: Hiromi Shimada, Risa Wakiya, Kenji Kanenishi, Nobuyuki Miyatake, Shusaku Nakashima, Mai Mahmoud Fahmy Mansour, Mikiya Kato, Taichi Miyagi, Koichi Sugihara, Yusuke Ushio, Rina Mino, Mao Mizusaki, Tomohiro Kameda, Norimitsu Kadowaki and Hiroaki Dobashi
    Citation: Arthritis Research & Therapy 2022 24:10
  4. Seronegative antiphospholipid syndrome (SN-APS) is often defined as the presence of APS criteria manifestations, negative antiphospholipid antibodies (aPL), and coexistence of APS non-criteria manifestations. ...

    Authors: Gilberto Pires da Rosa, Bernardo Sousa-Pinto, Ester Ferreira, Olga Araújo, Giuseppe Barilaro, Paulo Bettencourt, Ricard Cervera and Gerard Espinosa
    Citation: Arthritis Research & Therapy 2022 24:9
  5. Hip osteoarthritis is a common disabling condition of the hip joint and is associated with a substantial health burden. We assessed the epidemiological patterns of hip osteoarthritis from 1990 to 2019 by sex, ...

    Authors: Ming Fu, Hongming Zhou, Yushi Li, Hai Jin and Xiqing Liu
    Citation: Arthritis Research & Therapy 2022 24:8
  6. Adult-onset Still’s disease (AOSD) is a rare systemic autoinflammatory disease which encompasses patients with heterogenous presentation and a wide range of clinical courses. In this study, we aimed to identif...

    Authors: Takahiro Sugiyama, Shunsuke Furuta, Masaki Hiraguri, Kei Ikeda, Yosuke Inaba, Shin-ichiro Kagami, Yasuhiko Kita, Kei Kobayashi, Yoshihisa Kobayashi, Kazuhiro Kurasawa, Daiki Nakagomi, Yasushi Nawata, Yohei Kawasaki, Yuki Shiko, Takao Sugiyama and Hiroshi Nakajima
    Citation: Arthritis Research & Therapy 2022 24:7
  7. Hydroxychloroquine (HCQ) has been recommended as a basic treatment for lupus nephritis (LN) during this decade based on its ability to improve LN-related renal immune-mediated inflammatory lesions. As a classi...

    Authors: Ning An, Chen Yang, Hong-Luan Wu, Yun Guo, Xi-Jie Huang, Tong-Sheng Huang, Zhi-Hong Wu, Jing Xue, Rui-Hong Chen, Zhi-Hang Li, Qing-Jun Pan and Hua-Feng Liu
    Citation: Arthritis Research & Therapy 2022 24:6
  8. Systemic lupus erythematosus (SLE) is a chronic and complex multi-system autoimmune disorder. Higher risks of hematological malignancies (HM) were observed in SLE patients, which was associated with higher mor...

    Authors: Yuqi Zhang, Wei Li, Panpan Zhang, Jinyan Guo, Jinlei Sun, Jiameng Lu and Shengyun Liu
    Citation: Arthritis Research & Therapy 2022 24:5
  9. Rheumatoid arthritis (RA) is a heterogeneous disease, as evidenced by the differences in long-term outcomes. This applies especially to anti-citrullinated protein antibodies (ACPA)-negative RA, where a proport...

    Authors: M. Verstappen, H. W. van Steenbergen, P. H. P. de Jong and A. H. M. van der Helm-van Mil
    Citation: Arthritis Research & Therapy 2022 24:4
  10. To assay salivary anti-nuclear antibody (ANA) and its isotypes in patients with systemic lupus erythematosus (SLE) and to investigate relevant clinical associations.

    Authors: Ting Zhang, Yong Du, Qingqing Wu, Hao Li, Thao Nguyen, Gabriel Gidley, Valeria Duran, Daniel Goldman, Michelle Petri and Chandra Mohan
    Citation: Arthritis Research & Therapy 2022 24:3
  11. Interstitial lung disease (ILD) is an important problem for patients with rheumatoid arthritis (RA). However, current approaches to ILD case finding in real-world data have been evaluated only in limited setti...

    Authors: M. Meehan, A. Shah, J. Lobo, J. Oates, C. Clinton, N. Annapureddy, F. Xie, J. Zhuo, M. I. Danila, B. R. England and J. R. Curtis
    Citation: Arthritis Research & Therapy 2022 24:2
  12. Ankylosing spondylitis is a progressive, disabling joint disease that affects millions worldwide. Given its unclear etiology, studies of ankylosing spondylitis relied heavily on drug-induced or transgenic rode...

    Authors: Huanhuan Jia, Meili Chen, Yanzhen Cai, Xiaoling Luo, Gang Hou, Yongfeng Li, Chunmei Cai, Jun Chen, Qingnan Li, Kai-Kei Miu, Sin-Hang Fung, Zhangting Wang, Ren Huang, Huiyong Shen and Li Lu
    Citation: Arthritis Research & Therapy 2022 24:1
  13. In rheumatoid arthritis (RA), macrophages play an important role in modulating the immunoinflammatory response through their polarisation into “classically” (M1) or “alternatively activated” (M2) phenotypes. I...

    Authors: Maurizio Cutolo, Stefano Soldano, Emanuele Gotelli, Paola Montagna, Rosanna Campitiello, Sabrina Paolino, Carmen Pizzorni, Alberto Sulli, Vanessa Smith and Samuele Tardito
    Citation: Arthritis Research & Therapy 2021 23:306
  14. To determine the diagnostic accuracy of major salivary gland ultrasonography (SGUS) in primary Sjögren’s syndrome (pSS) using the novel Outcome Measures in Rheumatology Clinical Trials (OMERACT) scoring system...

    Authors: Xia Zhang, Ruiling Feng, Jinxia Zhao, Yu Wang, Juan He, Li Liu, Yongjing Cheng, Haihong Yao, Sumei Tang, Jiali Chen, Shanshan Zhang, Zhiyi Zhang, Qingwen Wang, Jing He and Zhanguo Li
    Citation: Arthritis Research & Therapy 2021 23:305
  15. Previous studies have shown that the incidence and risk factors of gout differs according to sex. However, little research has been done on the association between reproductive factors and gout. We conducted a...

    Authors: Yeonghee Eun, In-Young Kim, Kyungdo Han, Kyu Na Lee, Dong-Yun Lee, Dong Wook Shin, Seonyoung Kang, Seulkee Lee, Hoon-Suk Cha, Eun-Mi Koh, Jaejoon Lee and Hyungjin Kim
    Citation: Arthritis Research & Therapy 2021 23:304
  16. There have been lacking reliable serum biomarkers in assessing the disease activity of Takayasu’s arteritis (TAK). This study aimed to assess the disease activity of TAK by assayed gene expression levels in pe...

    Authors: Yixiao Tian, Jing Li, Xinping Tian and Xiaofeng Zeng
    Citation: Arthritis Research & Therapy 2021 23:303
  17. The single nucleotide polymorphism (SNP) rs62324212, located in IL21 antisense RNA 1 (IL21-AS1), has been identified as a genetic risk variant associated with systemic lupus erythematosus (SLE). We aimed to pr...

    Authors: He Hao, Shingo Nakayamada, Naoaki Ohkubo, Kaoru Yamagata, Mingzeng Zhang, Yu Shan, Shigeru Iwata, Tong Zhang and Yoshiya Tanaka
    Citation: Arthritis Research & Therapy 2021 23:302
  18. WNT16 is critical for bone homeostasis, but the effect of WNT16 in ankylosing spondylitis (AS) is still unknown. Here, we investigated whether WNT16 influences bone formation and pathophysiological changes of ...

    Authors: Sungsin Jo, Subin Weon, Bora Nam, Mi-Ae Jang, Hyundeok Kang, Tae-Jong Kim, Ye-Soo Park and Tae-Hwan Kim
    Citation: Arthritis Research & Therapy 2021 23:301
  19. To determine the usefulness of power Doppler (PD) ultrasound (US) to predict rheumatoid arthritis (RA) development in patients with clinically suspect arthralgia (CSA).

    Authors: Juan Molina Collada, Katerine López Gloria, Isabel Castrejón, Juan Carlos Nieto-González, Javier Rivera, Fernando Montero, Carlos González and José María Álvaro-Gracia
    Citation: Arthritis Research & Therapy 2021 23:299
  20. Besides anti-citrullinated protein antibodies (ACPA), rheumatoid arthritis patients (RA) often display autoantibody reactivities against other post-translationally modified (PTM) proteins, more specifically ca...

    Authors: M. Volkov, A. S. B. Kampstra, K. A. van Schie, A. Kawakami, M. Tamai, S. Kawashiri, T. Maeda, T. W. J. Huizinga, R. E. M. Toes and D. van der Woude
    Citation: Arthritis Research & Therapy 2021 23:298
  21. Establishing an optimal animal model for intervertebral disc (IVD) degeneration is essential for developing new IVD therapies. The intra-articular injection of monosodium iodoacetate (MIA), which is commonly u...

    Authors: Takao Sudo, Koji Akeda, Koki Kawaguchi, Takahiro Hasegawa, Junichi Yamada, Nozomu Inoue, Koichi Masuda and Akihiro Sudo
    Citation: Arthritis Research & Therapy 2021 23:297
  22. Features of new bone formation (NBF) are common in tophaceous gout. The aim of this project was to develop a plain radiographic scoring system for NBF in gout.

    Authors: Chang-Nam Son, Ken Cai, Sarah Stewart, John Ferrier, Karen Billington, Yun-Jung Jack Tsai, Thomas Bardin, Anne Horne, Lisa K. Stamp, Anthony Doyle and Nicola Dalbeth
    Citation: Arthritis Research & Therapy 2021 23:296
  23. Systemic sclerosis (SSc) is associated with a variability of mortality rates in the literature.

    Authors: Sébastien De Almeida Chaves, Tiphaine Porel, Mickael Mounié, Laurent Alric, Léonardo Astudillo, Antoine Huart, Olivier Lairez, Martin Michaud, Grégoire Prévot, David Ribes, Laurent Sailler, Francis Gaches, Daniel Adoue and Gregory Pugnet
    Citation: Arthritis Research & Therapy 2021 23:295
  24. The use of interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor as a treatment for the inflammatory joint disease is a promising method. However, its underlying mechanism in osteoarthritis (OA) remains...

    Authors: Muzhe Li, Huiyun Li, Xun Ran, Han Yin, Xuling Luo and Zhiwei Chen
    Citation: Arthritis Research & Therapy 2021 23:294
  25. Pulmonary artery involvement (PAI) in Takayasu arteritis (TAK) can lead to severe complications, but the relationship between the two has not been fully clarified.

    Authors: Hiroki Mukoyama, Mirei Shirakashi, Nozomi Tanaka, Takeshi Iwasaki, Toshiki Nakajima, Hideo Onizawa, Hideaki Tsuji, Koji Kitagori, Shuji Akizuki, Ran Nakashima, Kosaku Murakami, Masao Tanaka, Akio Morinobu and Hajime Yoshifuji
    Citation: Arthritis Research & Therapy 2021 23:293
  26. Humidity was an unfavorable factor for patients with rheumatoid arthritis (RA). RA disease activity was severe in high humidity conditions. However, there is no evidence to demonstrate the effects of humidity ...

    Authors: Mingzhu Wang, Jiao Chen, Xiaoying Lin, Lin Huang, Haichang Li, Chengping Wen and Zhixing He
    Citation: Arthritis Research & Therapy 2021 23:292
  27. We performed expression quantitative trait locus (eQTL) analysis in single classical (CL) and non-classical (NCL) monocytes from patients with systemic lupus erythematosus (SLE) to quantify the impact of well-...

    Authors: Yogita Ghodke-Puranik, Zhongbo Jin, Kip D. Zimmerman, Hannah C. Ainsworth, Wei Fan, Mark A. Jensen, Jessica M. Dorschner, Danielle M. Vsetecka, Shreyasee Amin, Ashima Makol, Floranne Ernste, Thomas Osborn, Kevin Moder, Vaidehi Chowdhary, Carl D. Langefeld and Timothy B. Niewold
    Citation: Arthritis Research & Therapy 2021 23:290
  28. Sjögren’s syndrome is a systemic autoimmune disease characterized by immune cells predominantly infiltrating the exocrine glands and frequently forming ectopic lymphoid structures. These structures drive a loc...

    Authors: Estelle Gerossier, Saba Nayar, Sylvie Froidevaux, Charlotte G. Smith, Celine Runser, Valentina Iannizzotto, Enrico Vezzali, Gabin Pierlot, Ulrich Mentzel, Mark J. Murphy, Marianne M. Martinic and Francesca Barone
    Citation: Arthritis Research & Therapy 2021 23:289
  29. Pulmonary arterial hypertension (PAH) is a severe complication of connective tissue disease (CTD), causing death in systemic sclerosis (SSc). The past decade has yielded many scientific insights into microRNA ...

    Authors: Bei Xu, Guanhua Xu, Ye Yu and Jin Lin
    Citation: Arthritis Research & Therapy 2021 23:288
  30. Osteoarthritis (OA) subsequent to acute joint injury accounts for a significant proportion of all arthropathies. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of myeloid progenitor ce...

    Authors: Lixia Zhang, Cameron L. Kirkwood, Jiho Sohn, Ashley Lau, Mary Bayers-Thering, Supinder Kour Bali, Sridhar Rachala, John M. Marzo, Mark J. Anders, Frank Beier and Keith L. Kirkwood
    Citation: Arthritis Research & Therapy 2021 23:287
  31. Gasdermin D (GSDMD) is cleaved by several proteases including by caspase-1, a component of intracellular protein complexes called inflammasomes. Caspase-1 also converts pro-interleukin-1β (pro-IL-1β) and pro-I...

    Authors: Tong Yang, Kai Sun, Chun Wang, Gaurav Swarnkar, Songtao Quan, Dustin Kress, Jianqiu Xiao, Yael Alippe, Hongjun Zheng, Robert H Brophy, Dingjun Hao, Audrey McAlinden, Yousef Abu-Amer, Jie Shen and Gabriel Mbalaviele
    Citation: Arthritis Research & Therapy 2021 23:286
  32. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Michaël Doumen, Diederik De Cock, Sofia Pazmino, Delphine Bertrand, Johan Joly, René Westhovens and Patrick Verschueren
    Citation: Arthritis Research & Therapy 2021 23:285

    The original article was published in Arthritis Research & Therapy 2021 23:269

  33. This study aimed to classify the distinct group of patients with axial spondyloarthritis (SpA) on tumour necrosis factor alpha inhibitors (TNFi) according to the baseline characteristics using a clustering alg...

    Authors: Seulkee Lee, Seonyoung Kang, Yeonghee Eun, Hong-Hee Won, Hyungjin Kim, Hoon-Suk Cha, Eun-Mi Koh and Jaejoon Lee
    Citation: Arthritis Research & Therapy 2021 23:284
  34. We have recently demonstrated that serum CCL20 levels positively correlate with mean pulmonary arterial pressure in patients with systemic sclerosis (SSc). Considering a proangiogenic effect of CCL20 on endoth...

    Authors: Tetsuya Ikawa, Takuya Miyagawa, Yuki Fukui, Satoshi Toyama, Jun Omatsu, Kentaro Awaji, Yuta Norimatsu, Yusuke Watanabe, Ayumi Yoshizaki, Shinichi Sato and Yoshihide Asano
    Citation: Arthritis Research & Therapy 2021 23:283
  35. Authors: Francesca Ometto, Augusta Ortolan, Davide Farber, Mariagrazia Lorenzin, Giulia Dellamaria, Giacomo Cozzi, Marta Favero, Romina Valentini, Andrea Doria and Roberta Ramonda
    Citation: Arthritis Research & Therapy 2021 23:282

    The original article was published in Arthritis Research & Therapy 2021 23:219

  36. To assess the first-year features of patients with chronic nonbacterial osteomyelitis (CNO).

    Authors: Christiane Reiser, Jens Klotsche, Anton Hospach, Rainer Berendes, Anja Schnabel, Annette F. Jansson, Markus Hufnagel, Nadine Grösch, Martina Niewerth, Kirsten Minden and Hermann Girschick
    Citation: Arthritis Research & Therapy 2021 23:281
  37. Anterior cruciate ligament (ACL) and meniscus tears are common knee injuries. Despite the high rate of post-traumatic osteoarthritis (PTOA) following these injuries, the contributing factors remain unclear. In...

    Authors: Sophia Y. Kim-Wang, Abigail G. Holt, Alyssa M. McGowan, Stephanie T. Danyluk, Adam P. Goode, Brian C. Lau, Alison P. Toth, Jocelyn R. Wittstein, Louis E. DeFrate, John S. Yi and Amy L. McNulty
    Citation: Arthritis Research & Therapy 2021 23:280
  38. Dysregulation of T cells mediated immune responses is a hallmark in the development of systemic lupus erythematosus (SLE). Recent genome wide association study (GWAS) revealed the genetic contribution of varia...

    Authors: Yuan-yuan Qi, Xin-yu Zhao, Xin-ran Liu, Yan-na Wang, Ya-ling Zhai, Xiao-xue Zhang, Xiao-yang Wang, Li-jie Zhang, Ya-fei Zhao, Yan Cui, Xiang-hui Ning and Xu-jie Zhou
    Citation: Arthritis Research & Therapy 2021 23:279
  39. Clinical trials show intensive treatment to induce remission is effective in patients with highly active rheumatoid arthritis (RA). The TITRATE trial showed that the benefits of intensive treatment also extend...

    Authors: Sook Yan Lee, Fowzia Ibrahim, Brian D. M. Tom, Elena Nikiphorou, Frances M. K. Williams, Heidi Lempp and David L. Scott
    Citation: Arthritis Research & Therapy 2021 23:278
  40. Articular cartilage repair is a critical issue in osteoarthritis (OA) treatment. The insulin-like growth factor (IGF) signaling pathway has been implicated in articular cartilage repair. IGF-1 is a member of a...

    Authors: Caining Wen, Limei Xu, Xiao Xu, Daping Wang, Yujie Liang and Li Duan
    Citation: Arthritis Research & Therapy 2021 23:277
  41. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Marwa Qadri, Gregory D. Jay, Ling X. Zhang, Tannin A. Schmidt, Jennifer Totonchy and Khaled A. Elsaid
    Citation: Arthritis Research & Therapy 2021 23:276

    The original article was published in Arthritis Research & Therapy 2021 23:241

  42. To clarify the frequency and outcome of patients with systemic lupus erythematosus (SLE) who achieved the clinical state as serologically active clinically quiescent (SACQ) and to identify factors associated w...

    Authors: Hong Huang, Lin Mu, Zhuoli Zhang, Dai Gao, Yanjie Hao and Wei Zhou
    Citation: Arthritis Research & Therapy 2021 23:275
  43. Identification of predictive clinical factors of long-term treatment response may contribute to improved management of non-radiographic axSpA (nr-axSpA) patients. This analysis aims to identify whether any bas...

    Authors: Walter P. Maksymowych, Thomas Kumke, Simone E. Auteri, Bengt Hoepken, Lars Bauer and Martin Rudwaleit
    Citation: Arthritis Research & Therapy 2021 23:274
  44. Central nervous system (CNS)-mediated symptoms, such as fatigue, depression, and hyperalgesia, are common complications among patients with rheumatoid arthritis (RA). However, it remains unclear how the periph...

    Authors: Takayuki Matsushita, Kazuhiro Otani, Yohsuke Oto, Yukari Takahashi, Daitaro Kurosaka and Fusao Kato
    Citation: Arthritis Research & Therapy 2021 23:273
  45. Autoantibody production is a hallmark of rheumatoid arthritis (RA). Anti-citrullinated protein antibodies (ACPA) are highly disease-specific, and their presence is associated with more severe disease and poor ...

    Authors: H. Koppejan, M. Hameetman, G. Beyrend, V. van Unen, J. C. Kwekkeboom, A. H. van der Helm-van Mil, R. E. M. Toes and F. A. van Gaalen
    Citation: Arthritis Research & Therapy 2021 23:272
  46. Hydroxychloroquine (HCQ) is a cornerstone therapy for systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). However, reports of its use and subsequent fatal arrhythmias in patients with coronavirus...

    Authors: Elizabeth Park, Jon T. Giles, Thania Perez-Recio, Paloma Pina, Christopher Depender, Yevgeniya Gartshteyn, Anca D. Askanase, Joan Bathon and Laura Geraldino-Pardilla
    Citation: Arthritis Research & Therapy 2021 23:271
  47. Self-efficacy, or patients’ confidence in their ability to control disease and its consequences, was recently prioritised in EULAR recommendations for inflammatory arthritis self-management strategies. However...

    Authors: Michaël Doumen, Diederik De Cock, Sofia Pazmino, Delphine Bertrand, Johan Joly, René Westhovens and Patrick Verschueren
    Citation: Arthritis Research & Therapy 2021 23:269

    The Correction to this article has been published in Arthritis Research & Therapy 2021 23:285

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