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  1. Recent evidence highlights the role of low-grade synovial inflammation in the progression of osteoarthritis (OA). Inflamed synovium of OA joints detected by imaging modalities are associated with subsequent pr...

    Authors: Kwanghoon Lee, Soheil Niku, Sonya J. Koo, Ernest Belezzuoli and Monica Guma
    Citation: Arthritis Research & Therapy 2024 26:25
    Content type: Review Published on:

  2. Ankylosing spondylitis (AS) is one of several disorders known as seronegative spinal arthritis (SpA), the origin of which is unknown. Existing epidemiological data show that inflammatory and immunological fact...

    Authors: Yuchang Fei, Huan Yu, Yulun Wu and Shanshan Gong
    Citation: Arthritis Research & Therapy 2024 26:24
    Content type: Research Published on:

  3. Involvement of B cells in the pathogenesis of rheumatoid arthritis (RA) is supported by the presence of disease-specific autoantibodies and the efficacy of treatment directed against B cells. B cells that expr...

    Authors: Katrin Thorarinsdottir, Sarah McGrath, Kristina Forslind, Monica Leu Agelii, Anna-Karin Hultgård Ekwall, Lennart T. H. Jacobsson, Anna Rudin, Inga-Lill Mårtensson and Inger Gjertsson
    Citation: Arthritis Research & Therapy 2024 26:23
    Content type: Research Published on:

  5. Patients with rheumatoid arthritis (RA) showed impaired immune tolerance characterized by reduced follicular regulatory T (Tfr) cells, and they also exhibited altered gut microbiotas and their metabolites in R...

    Authors: Ruihe Wu, Dongming Wang, Liyun Cheng, Rui Su, Baochen Li, Chunxue Fan, Chong Gao and Caihong Wang
    Citation: Arthritis Research & Therapy 2024 26:21
    Content type: Research Published on:

  6. Osteoarthritis (OA) is a degenerative joint disease that affects elderly populations worldwide, causing pain and disability. Alteration of the fibroblast-like synoviocytes (FLSs) phenotype leads to an imbalanc...

    Authors: Kai Chen, Huaqiang Tao, Pengfei Zhu, Miao Chu, Xueyan Li, Yi Shi, Liyuan Zhang, Yaozeng Xu, Shujun Lv, Lixin Huang, Wei Huang and Dechun Geng
    Citation: Arthritis Research & Therapy 2024 26:20
    Content type: Research Published on:

  7. Despite existing extensive literature, a comprehensive and clinically relevant classification system for osteoarthritis (OA) has yet to be established. In this study, we aimed to further characterize four knee...

    Authors: Joan Calvet, Antoni Berenguer-Llergo, Cristóbal Orellana, María García-Manrique, Menna Rusiñol, Silvia Garcia-Cirera, Maria Llop, Marta Arévalo, Alba Garcia-Pinilla, Carlos Galisteo, Cristina Aymerich, Rafael Gómez, Alejandra Serrano, Anna Carreras and Jordi Gratacós
    Citation: Arthritis Research & Therapy 2024 26:19
    Content type: Research Published on:

  8. Inflammatory arthritis encompasses a group of immune-mediated diseases characterized by chronic joint inflammation. Despite having pathogenic mechanisms in common, the prognosis of rheumatoid arthritis (RA), p...

    Authors: Ana Belén Azuaga, Andrea Cuervo, Raquel Celis, Beatriz Frade-Sosa, Juan C. Sarmiento-Monroy, Virginia Ruiz-Esquide, José A. Gómez-Puerta, Raimon Sanmartí and Julio Ramírez
    Citation: Arthritis Research & Therapy 2024 26:18
    Content type: Research Published on:

  9. Variations in bone morphology in patients with hip osteoarthritis (HOA) can be broadly categorized into three types: atrophic, normotrophic, and hypertrophic. Despite the investigations examining clinical elem...

    Authors: Yang Yang, Hideyuki Koga, Yusuke Nakagawa, Tomomasa Nakamura, Hiroki Katagiri, Ryohei Takada, Mai Katakura, Kunikazu Tsuji, Ichiro Sekiya and Kazumasa Miyatake
    Citation: Arthritis Research & Therapy 2024 26:17
    Content type: Research Published on:

  10. Advances in rheumatoid arthritis (RA) treatment, highlighted by biological disease-modifying antirheumatic drugs (bDMARDs) and targeted synthetic DMARDs (tsDMARDs), have altered the paradigm of RA treatment in...

    Authors: Takayuki Fujii, Koichi Murata, Hideo Onizawa, Akira Onishi, Masao Tanaka, Kosaku Murakami, Kohei Nishitani, Moritoshi Furu, Ryu Watanabe, Motomu Hashimoto, Hiromu Ito, Takao Fujii, Tsuneyo Mimori, Akio Morinobu and Shuichi Matsuda
    Citation: Arthritis Research & Therapy 2024 26:16
    Content type: Research Published on:

  11. Tacrolimus is one of the major treatment options for systemic lupus erythematosus (SLE) and is considered to be a pregnancy-compatible medication. Since little is known about tacrolimus safety during pregnancy...

    Authors: Takehiro Nakai, Nanase Honda, Eri Soga, Sho Fukui, Ayako Kitada, Naoto Yokogawa and Masato Okada
    Citation: Arthritis Research & Therapy 2024 26:15
    Content type: Research Published on:

  12. A consistent connection has been increasingly reported between rheumatoid arthritis (RA), insulin resistance (IR), and type 2 diabetes (T2D). The β-cell apoptosis induced by pro-inflammatory cytokines, which c...

    Authors: Claudia Di Muzio, Ilenia Di Cola, Azadeh Shariat Panahi, Francesco Ursini, Annamaria Iagnocco, Roberto Giacomelli, Paola Cipriani and Piero Ruscitti
    Citation: Arthritis Research & Therapy 2024 26:14
    Content type: Research Published on:

  13. To investigate the usefulness of 18F-FDG PET-CT for assessing large-vessel (LV) involvement in patients with suspected giant cell arteritis (GCA) and a negative temporal artery biopsy (TAB).

    Authors: Javier Narváez, Paula Estrada, Paola Vidal-Montal, Iván Sánchez-Rodríguez, Aida Sabaté-Llobera, Joan Miquel Nolla and Montserrat Cortés-Romera
    Citation: Arthritis Research & Therapy 2024 26:13
    Content type: Research Published on:

  14. Low back pain is a leading cause of disability worldwide and is frequently attributed to intervertebral disc (IVD) degeneration. Though the contributions of the adjacent cartilage endplates (CEP) to IVD degene...

    Authors: Kyle Kuchynsky, Patrick Stevens, Amy Hite, William Xie, Khady Diop, Shirley Tang, Maciej Pietrzak, Safdar Khan, Benjamin Walter and Devina Purmessur
    Citation: Arthritis Research & Therapy 2024 26:12
    Content type: Research Published on:

  15. The biological function of Acanthopanax sessiliflorus Harm (ASH) has been investigated on various diseases; however, the effects of ASH on arthritis have not been investigated so far. This study investigates t...

    Authors: Dahye Kim, Yunji Heo, Mangeun Kim, Godagama Gamaarachchige Dinesh Suminda, Umar Manzoor, Yunhui Min, Minhye Kim, Jiwon Yang, Youngjun Park, Yaping Zhao, Mrinmoy Ghosh and Young-Ok Son
    Citation: Arthritis Research & Therapy 2024 26:11
    Content type: Research Published on:

  16. Overlapping cases of systemic lupus erythematosus (SLE) and primary biliary cirrhosis (PBC) are rare and have not yet been fully proven to be accidental or have a common genetic basis.

    Authors: Linyong Wu, Songhua Li, Chaojun Wu, Shaofeng Wu, Yan Lin and Dayou Wei
    Citation: Arthritis Research & Therapy 2024 26:10
    Content type: Research Published on:

  17. Anti-melanoma differentiation-associated gene five antibody positive (MDA5+) dermatomyositis (DM) is significantly associated with rapidly progressive interstitial lung disease (RP-ILD). Early detection of RP-ILD...

    Authors: Yulu Qiu, Xiaoke Feng, Chang Liu, Yumeng Shi, Lingxiao Xu, Hanxiao You, Lei Wang, Chengyin Lv, Fang Wang and Wenfeng Tan
    Citation: Arthritis Research & Therapy 2024 26:9
    Content type: Research Published on:

  18. Autoimmune congenital heart block (ACHB) is a passively acquired immune-mediated disease characterized by the presence of maternal antibodies against components of the Ro/SSA and La/SSB ribonucleoprotein compl...

    Authors: Ying Huang, Jialin Deng, Jinghua Liu, Fangyuan Yang and Yi He
    Citation: Arthritis Research & Therapy 2024 26:8
    Content type: Review Published on:

  19. NAT10 is the firstly recognized RNA acetyltransferase that participates in multiple cellular biological processes and human disease. However, the role of N-acetyltransferase 10 (NAT10) in ankylosing spondyliti...

    Authors: Qing Luo, Juxiang Zhu, Shiqian Wang, Peng fu, Biqi Fu, Zikun Huang and Junming Li
    Citation: Arthritis Research & Therapy 2024 26:7
    Content type: Research Published on:

  20. Hypertrophic cranial pachymeningitis (HCP) is uncommon but a poorly understood complication of granulomatosis with polyangiitis (GPA).

    Authors: Yiran Chen, Lijuan Gou, Li Wang, Min Qian, Qingjun Wu, Wenjie Zheng, Mengtao Li, Xiaofeng Zeng and Fengchun Zhang
    Citation: Arthritis Research & Therapy 2024 26:6
    Content type: Research Published on:

  21. There is mounting proof that rheumatoid arthritis (RA) and cognitive decline are related. These studies, however, have not all been uniform, and others have not discovered such a correlation. It is essential t...

    Authors: Lincheng Duan, Shiyin Li, Haoming Li, Yue Shi, Xiaolong Xie and Yue Feng
    Citation: Arthritis Research & Therapy 2024 26:5
    Content type: Research Published on:

  22. Antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) is a group of illnesses that cause inflammation and alterations to small vessels in the body. Some of the most common and detrimental mani...

    Authors: Megan M. Sullivan, Andy Abril, Nabeel Aslam, Colleen T. Ball and Florentina Berianu
    Citation: Arthritis Research & Therapy 2024 26:4
    Content type: Research Published on:

  23. Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation in multiple articular joints, causing pain, joint damage, and loss of joint function. Despite the successful development ...

    Authors: Christian S. Thudium, Peder Frederiksen, Morten A. Karsdal and Anne-Christine Bay-Jensen
    Citation: Arthritis Research & Therapy 2024 26:3
    Content type: Research Published on:

  24. This study aims to investigate the potential anti-inflammatory effects of exosomes engineered to carry super-repressor IκB (Exo-srIκB), an exosome-based NF-κB inhibitor, in the context of RA.

    Authors: Hae-In Lee, Min-Joo Ahn, Jae-Kwang Yoo, So-Hee Ahn, Seon Young Park, Hyangmi Seo, Moon-Ju Kim, Yu Jeong Lee, Hyun Hee Jang, Seung Cheol Shim, Eun Jeong Won, Cheolhyoung Park, Chulhee Choi and Tae-Jong Kim
    Citation: Arthritis Research & Therapy 2024 26:2
    Content type: Research Published on:

  25. The biological mechanisms underlying the differential response to abatacept in patients with rheumatoid arthritis (RA) are unknown. Here, we aimed to identify cellular, transcriptomic, and proteomic features t...

    Authors: Takeshi Iwasaki, Ryu Watanabe, Hiromu Ito, Takayuki Fujii, Koichiro Ohmura, Hiroyuki Yoshitomi, Koichi Murata, Kosaku Murakami, Akira Onishi, Masao Tanaka, Shuichi Matsuda, Fumihiko Matsuda, Akio Morinobu and Motomu Hashimoto
    Citation: Arthritis Research & Therapy 2024 26:1
    Content type: Research Published on:

  27. Synovial inflammation, which precedes other pathological changes in osteoarthritis (OA), is primarily initiated by activation and M1 polarization of macrophages. While macrophages play a pivotal role in the in...

    Authors: Changchuan Li, Zhuji Ouyang, Yuhsi Huang, Sipeng Lin, Shixun Li, Jing Xu, Taihe Liu, Jionglin Wu, Peidong Guo, Zhong Chen, Haoyu Wu and Yue Ding
    Citation: Arthritis Research & Therapy 2023 25:249
    Content type: Research Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2024 26:22

  28. Lupus mesenteric vasculitis (LMV) as initial presentation is rare, especially in childhood-onset systemic lupus erythematosus (cSLE). It is a critical complication of lupus. At present, the research on cSLE wi...

    Authors: Jia Zhu, Jianming Lai, Xiaohui Liu, Xue Zhao, Ran Tao, Min Kang, Xiaolan Huang, Li Wang, Fengqi Wu, Xiaoping Pan and Gaixiu Su
    Citation: Arthritis Research & Therapy 2023 25:248
    Content type: Research Published on:

  29. Exogenously providing engineered Uox with enhanced half-life is one of the important urate-lowering treatments for gout. The potential of PAT101, a recombinant human albumin (rHA)-conjugated variant, was evalu...

    Authors: Jeonghaeng Cho, Byungseop Yang, Jae Hun Lee, Hyunwoo Kim, Hyeongseok Kim, Eun Byeol Go, Dong-ho Bak, Su Jin Park, Inchan Kwon, Jong-il Choi and Kyunghee Lee
    Citation: Arthritis Research & Therapy 2023 25:247
    Content type: Research Published on:

  30. Rheumatoid arthritis (RA) is a chronic autoimmune disease with complex causes and recurrent attacks that can easily develop into chronic arthritis and eventually lead to joint deformity. Our study aims to eluc...

    Authors: Congcong Jian, Lingli Wei, Tong Wu, Shilin Li, Tingting Wang, Jianghua Chen, Shengjia Chang, Jie Zhang, Binhan He, Jianhong Wu, Jiang Su, Jing Zhu, Min Wu, Yan Zhang and Fanxin Zeng
    Citation: Arthritis Research & Therapy 2023 25:246
    Content type: Research Published on:

  31. This study investigated the clinical implications of peripheral eosinophil count at diagnosis in estimating cross-sectional antineutrophil cytoplasmic antibody-associated vasculitis (AAV) activity and predicti...

    Authors: Jang Woo Ha, Sung Soo Ahn, Jason Jungsik Song, Yong-Beom Park and Sang-Won Lee
    Citation: Arthritis Research & Therapy 2023 25:245
    Content type: Research Published on:

  32. The vasoactive neuropeptide calcitonin gene-related peptide alpha (αCGRP) enhances nociception in primary knee osteoarthritis (OA) and has been shown to disrupt cartilage and joint integrity in experimental rh...

    Authors: Alexander Hildebrandt, Tamara Dietrich, Jérôme Weber, Mara Meyer Günderoth, Sijia Zhou, Florian N. Fleckenstein, Shan Jiang, Tobias Winkler, Georg N. Duda, Serafeim Tsitsilonis, Johannes Keller and Tazio Maleitzke
    Citation: Arthritis Research & Therapy 2023 25:244
    Content type: Research Published on:

  33. Wilforine (WFR) is a monomeric compound of the anti-RA plant Tripterygium wilfordii Hook. f. (TwHF). Whether WFR has anti-RA effect, its molecular mechanism has not been elucidated.

    Authors: Yurong Huang, Yanhui Peng, Hui Li, Chen Li, Yajie Wu, Xiaomei Wang, Jun Chang and Chenggui Miao
    Citation: Arthritis Research & Therapy 2023 25:243
    Content type: Research Published on:

  34. To investigate the causal relationship between low bone mineral density (BMD) and osteoarthritis (OA) using Mendelian randomization (MR) design.

    Authors: Yudun Qu, Shibo Chen, Mengling Han, Ziqi Gu, Yujie Zhang, Tianxiang Fan, Muhui Zeng, Guangfeng Ruan, Peihua Cao, Qian Yang, Changhai Ding, Yan Zhang and Zhaohua Zhu
    Citation: Arthritis Research & Therapy 2023 25:242
    Content type: Research Published on:

  35. While xanthine oxidase inhibitors target uric acid production, renal urate underexcretion is the predominant subtypes in gout. This study was to compare treatment response to the XOI febuxostat in a gout cohor...

    Authors: Han Qi, Mingshu Sun, Robert Terkeltaub, Xiaomei Xue, Xinde Li, Lingling Cui, Yuwei He, Fei Yan, Ruixia Sun, Ying Chen, Zhaotong Jia, Xiaoyu Cheng, Lidan Ma, Tian Liu, Nicola Dalbeth and Changgui Li
    Citation: Arthritis Research & Therapy 2023 25:241
    Content type: Research Published on:

  36. Osteoarthritis (OA) is a degenerative disease related to cholesterol metabolism disorders. However, current therapies for OA are insufficient and no convincing disease-modifying OA drugs exist. Therefore, we a...

    Authors: WeiBing Wang, HaiMin Mai, Huang Xu, BaoSheng Jing, CuiYu Yu, XiaoTing Li, DanGui Chen, Yuan Huang, MeiMang Shao and Tao Pan
    Citation: Arthritis Research & Therapy 2023 25:240
    Content type: Research Published on:

  38. Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by synovial hyperplasia. Maintaining a balance between the proliferation and apoptosis of rheumatoid arthritis synovial fibr...

    Authors: Xiaonan Zhang, Xiaoyu He, Ming Zhang, Tianyu Wu, Xiaojie Liu, Yan Zhang, Zhuobei Xie, Saisai Liu, Tian Xia, Yuanyuan Wang, Fang Wei, Hongtao Wang and Changhao Xie
    Citation: Arthritis Research & Therapy 2023 25:238
    Content type: Research Published on:

  39. While joint immobilization is a useful repair method for intra-articular ligament injury and periarticular fracture, prolonged joint immobilization can cause multiple complications. A better understanding how ...

    Authors: Donghao Gan, Xiaowan Jin, Xiangpeng Wang, Chu Tao, Qinnan Yan, Qingyun Jia, Shaochuan Huo, Di Chen, Qing Yao and Guozhi Xiao
    Citation: Arthritis Research & Therapy 2023 25:237
    Content type: Research Published on:

  40. Our preliminary study indicates that the multi-functional protein, prokineticin 2 (Prok2), is upregulated in osteoarthritic (OA) chondrocytes as a target of the hypoxia-inducible factor (HIF)-2α. This study ai...

    Authors: Jiye Yang, Youngnim Shin, Hwee-Jin Kim, Hyo-Eun Kim and Jang-Soo Chun
    Citation: Arthritis Research & Therapy 2023 25:236
    Content type: Research Published on:

  41. To identify the role of gluconeogenesis in chondrocytes in osteoarthritis (OA).

    Authors: Zhuolun Wang, Xinjie Wang, Liangliang Liu, Xiongtian Guo, Haiyan Zhang, Jianbing Yin, Rengui Lin, Yan Shao and Daozhang Cai
    Citation: Arthritis Research & Therapy 2023 25:235
    Content type: Research Published on:

    The Correction to this article has been published in Arthritis Research & Therapy 2023 25:250

  42. Currently, it is not possible to predict whether patients with hyperuricemia (HUA) will develop gout and how this progression may be affected by urate-lowering treatment (ULT). Our study aimed to evaluate diff...

    Authors: Aleš Kvasnička, David Friedecký, Radana Brumarová, Markéta Pavlíková, Kateřina Pavelcová, Jana Mašínová, Lenka Hasíková, Jakub Závada, Karel Pavelka, Pavel Ješina and Blanka Stibůrková
    Citation: Arthritis Research & Therapy 2023 25:234
    Content type: Research Published on:

  43. PANoptosis represents a newly identified form of programmed cell death that plays a significant role in the autoimmune diseases. Rheumatoid arthritis (RA) is characterized by the presence of autoantibodies. Ne...

    Authors: Jing Li, Jun Cui, Li Wu, Ya-bing Liu and Qi Wang
    Citation: Arthritis Research & Therapy 2023 25:233
    Content type: Research Published on:

  44. Osteoarthritis (OA) is a joint disease with a heritable component. Genetic loci identified via genome-wide association studies (GWAS) account for an estimated 26.3% of the disease trait variance in humans. Cur...

    Authors: Jacob Kenny, Benjamin H. Mullin, William Tomlinson, Brett Robertson, Jinbo Yuan, Weiwei Chen, Jinmin Zhao, Nathan J. Pavlos, John P. Walsh, Scott G. Wilson, Jennifer Tickner, Grant Morahan and Jiake Xu
    Citation: Arthritis Research & Therapy 2023 25:232
    Content type: Research Published on:

  45. The objective of this study was to investigate the relation between swelling and tenderness of individual finger joints and grip force in patients with early rheumatoid arthritis (RA).

    Authors: Maria Rydholm, Ankita Sharma, Lennart Jacobsson and Carl Turesson
    Citation: Arthritis Research & Therapy 2023 25:231
    Content type: Research Published on:

  46. Innate immunity plays a significant role in the pathogenesis of temporomandibular joint osteoarthritis (TMJOA), which is characterized by synovial inflammation and condylar cartilage degradation. We are urged ...

    Authors: Xin Liu, Huimin Li, Yaping Feng, Huilin Guo, Yingjie Li, Jin Ke and Xing Long
    Citation: Arthritis Research & Therapy 2023 25:230
    Content type: Research Published on:

  47. Human placenta-derived exosomes (pExo) were generated, characterized, and evaluated as a therapeutic candidate for the treatment of osteoarthritis (OA).

    Authors: Chenfei Huang, Yuechao Zhao, Shengchen Lin, Lin Li, Xuan Guo, Sebastian Yumiseba, Jeng-dar Yang, Robert Hariri, Qian Ye, Shuyang He and Adrian Kilcoyne
    Citation: Arthritis Research & Therapy 2023 25:229
    Content type: Research Published on:

  48. Chronic non-bacterial osteomyelitis (CNO) is an autoinflammatory bone-disease of unknown origin. The National Pediatric Rheumatologic Database (NPRD) collects long-term data of children and adolescents with rh...

    Authors: Christiane Reiser, Jens Klotsche, Toni Hospach, Georg Heubner, Daniel Windschall, Ralf Trauzeddel, Nadine Groesch, Martina Niewerth, Kirsten Minden and Hermann Girschick
    Citation: Arthritis Research & Therapy 2023 25:228
    Content type: Research Published on:

  49. Identifying axial spondyloarthritis (axSpA) activity early and accurately is essential for treating physicians to adjust treatment plans and guide clinical decisions promptly. The current literature is mostly ...

    Authors: Peijin Xin, Qizheng Wang, Ruixin Yan, Yongye Chen, Yupeng Zhu, Enlong Zhang, Cui Ren and Ning Lang
    Citation: Arthritis Research & Therapy 2023 25:227
    Content type: Research Published on:

  50. Sarilumab, an IL-6 receptor antagonist, is a first-line biologic disease-modifying anti-rheumatic drug for rheumatoid arthritis. The identification of genetic biomarkers as predictors of response to sarilumab ...

    Authors: Luis Sainz, Pau Riera, Patricia Moya, Sara Bernal, Jordi Casademont, Cesar Díaz-Torné, Ana Milena Millán, Hye Sang Park, Adriana Lasa and Hector Corominas
    Citation: Arthritis Research & Therapy 2023 25:226
    Content type: Research Published on:
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Arthritis Research & Therapy

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