Brunsberg U, Gustafsson K, Jansson L: Expression of a transgenic class II Ab gene confers susceptibility to collagen-induced arthritis. Eur J Immunol. 1994, 24: 1698-1702.
Article
PubMed
CAS
Google Scholar
Michaëlsson E, Andersson M, Engström A, Holmdahl R: Identification of an immunodominant type-II collagen peptide recognized by T cells in H-2q mice: self tolerance at the level of determinant selection. Eur J Immunol. 1992, 22: 1819-1825.
Article
PubMed
Google Scholar
Brand DD, Myers LK, Terato K: Characterization of the T cell determinants in the induction of autoimmune arthritis by bovine alpha 1(II)-CB11 in H-2q mice. J Immunol. 1994, 152: 3088-3097.
PubMed
CAS
Google Scholar
Holmdahl R, Andersson M, Goldschmidt TJ: Type II collagen autoimmunity in animals and provocations leading to arthritis. Immunol Rev. 1990, 118: 193-232.
Article
PubMed
CAS
Google Scholar
Andersson EC, Hansen BE, Jacobsen H: Definition of MHC and T cell receptor contacts in the HLA-DR4 restricted immunodominant epitope in type II collagen and characterization of collagen-induced arthritis in HLA-DR4 and human CD4 transgenic mice. Proc Natl Acad Sci USA. 1998, 95: 7574-7569.
Article
PubMed
CAS
PubMed Central
Google Scholar
Rosloniec EF, Brand DD, Myers LK: An HLA-DR1 transgene confers susceptibility to collagen-induced arthritis elicited with human type II collagen. J Exp Med. 1997, 185: 1113-1122.
Article
PubMed
CAS
PubMed Central
Google Scholar
Vingsbo C, Sahlstrand P, Brun JG, Jonsson R, Saxne T, Holmdahl R: Pristane-induced arthritis in rats: a new model for rheumatoid arthritis with a chronic disease course influenced by both major histocompatibility complex and non-major histocompatibility complex genes. Am J Pathol. 1996, 149: 1675-1683.
PubMed
CAS
PubMed Central
Google Scholar
Kawahito Y, Cannon GW, Gulko PS: Localization of quantitative trait loci regulating adjuvant-induced arthritis in rats: evidence for genetic factors common to multiple autoimmune diseases. J Immunol. 1998, 161: 4411-4419.
PubMed
CAS
Google Scholar
Matsumoto I, Staub A, Benoist C, Mathis D: Arthritis provoked by linked T and B cell recognition of a glycolytic enzyme. Science. 1999, 286: 1732-1735. 10.1126/science.286.5445.1732.
Article
PubMed
CAS
Google Scholar
Iwakura Y, Tosu M, Yoshida E: Induction of inflammatory arthropathy resembling rheumatoid arthritis in mice transgenic for HTLV-I. Science. 1991, 253: 1026-1028.
Article
PubMed
CAS
Google Scholar
Yamazaki H, Ikeda H, Ishizu A: A wide spectrum of collagen vascular and autoimmune diseases in transgenic rats carrying the env-pX gene of human T lymphocyte virus type I. Int Immunol. 1997, 9: 339-346.
Article
PubMed
CAS
Google Scholar
Weyand CM, McCarthy TG, Goronzy JJ: Correlation between disease phenotype and genetic heterogeneity in rheumatoid arthritis. J Clin Invest. 1995, 95: 2120-2126.
Article
PubMed
CAS
PubMed Central
Google Scholar
Kotzin BL, Falta MT, Crawford F: Use of soluble peptide-DR4 tetramers to detect synovial T cells specific for cartilage antigens in patients with rheumatoid arthritis. Proc Natl Acad Sci USA. 2000, 97: 291-296.
Article
PubMed
CAS
PubMed Central
Google Scholar
Malmström V, Michaëlsson E, Burkhardt H, Mattsson R, Vuorio E, Holmdahl R: Systemic versus cartilage-specific expression of a type II collagen-specific T-cell epitope determines the level of tolerance and susceptibility to arthritis. Proc Natl Acad Sci USA. 1996, 93: 4480-4485.
Article
PubMed
PubMed Central
Google Scholar
Svensson L, Jirholt J, Holmdahl R, Jansson L: B cell-deficient mice do not develop type II collagen-induced arthritis (CIA). Clin Exp Immunol. 1998, 111: 521-526.
Article
PubMed
CAS
PubMed Central
Google Scholar
Vingsbo C, Larsson P, Andersson M, Holmdahl R: Association of pepsin with type II collagen (CII) breaks control of CII autoimmunity and triggers development of arthritis in rats. Scand J Immunol. 1993, 37: 337-342.
Article
PubMed
CAS
Google Scholar
Weston SA, Parish CR: New fluorescent dyes for lymphocyte migration studies. Analysis by flow cytometry and fluorescence microscopy. J Immunol Methods. 1990, 133: 87-97.
Article
PubMed
CAS
Google Scholar
Corthay A, Bäcklund J, Broddefalk J: Epitope glycosylation plays a critical role for T cell recognition of type II collagen in collagen-induced arthritis. Eur J Immunol. 1998, 28: 2580-2590. 10.1002/(SICI)1521-4141(199808)28:08<2580::AID-IMMU2580>3.3.CO;2-O.
Article
PubMed
CAS
Google Scholar
Snowden N, Reynolds I, Morgan K, Holt L: T cell responses to human type II collagen in patients with rheumatoid arthritis and healthy controls. Arthritis Rheum. 1997, 40: 1210-1218.
Article
PubMed
CAS
Google Scholar
Kim HY, Kim WU, Cho ML: Enhanced T cell proliferative response to type II collagen and synthetic peptide CII (255-274) in patients with rheumatoid arthritis. Arthritis Rheum . 1999, 42: 2085-2093.
Article
PubMed
CAS
Google Scholar
Berg L, Rönnelid J, Sanjeevi CB, Lampa J, Klareskog L: Interferon gamma production in response to in vitro stimulation with collagen type II in rheumatoid arthritis is associated with HLA-DRB1*0401 and DQ8. Arthritis Res. 2000, 2: 75-84.
Article
PubMed
CAS
PubMed Central
Google Scholar
Holmdahl R, Andersson EC, Andersen CB, Svejgaard A, Fugger L: Transgenic mouse models of rheumatoid arthritis. Immunol Rev. 1999, 169: 161-173.
Article
PubMed
CAS
Google Scholar
Rönnelid J, Lysholm J, Engström-Laurent A, Klareskog L, Heyman B: Local anti-type II collagen antibody production in rheumatoid arthritis synovial fluid. Evidence for an HLA-DR4-restricted IgG response. Arthritis Rheum. 1994, 37: 1023-1029.
Article
PubMed
Google Scholar
Cook AD, Stockman A, Brand CA: Antibodies to type II collagen and HLA disease susceptibility markers in rheumatoid arthritis. Arthritis Rheum. 1999, 42: 2569-2576.
Article
PubMed
CAS
Google Scholar
Holmdahl R: Another pathway towards arthritis. Curr Biol. 1999, 9: 528-530.
Article
Google Scholar
Zinkernagel RM, Callahan GN, Althage A, Cooper S, Klein PA, Klein J: On the thymus in the differentiation of 'H-2 self recognition' by T-cells: evidence for dual recognition. J Exp Med. 1978, 147: 882-896.
Article
PubMed
CAS
Google Scholar
Kappler JW, Staerz U, White J, Marrack PC: Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex. Nature. 1988, 332: 35-40.
Article
PubMed
CAS
Google Scholar
Rooke R, Waltzinger C, Benoist C, Mathis D: Targeted complementation of MHC class II deficiency by intrathymic delivery of recombinant adenoviruses. Immunity. 1997, 7: 123-134.
Article
PubMed
CAS
Google Scholar
Ignatowicz L, Rees W, Pacholczyk R: T cells can be activated by peptides that are unrelated in sequence to their selecting peptide. Immunity. 1997, 7: 179-186.
Article
PubMed
CAS
Google Scholar
Ohashi PS, Oehen S, Buerki K: Ablation of 'tolerance' and induction of diabetes by virus infection in viral antigen transgenic mice. Cell. 1991, 65: 305-317.
Article
PubMed
CAS
Google Scholar
Tanchot C, Lemonnier FA, Perarnau B, Freitas AA, Rocha B: Differential requirements for survival and proliferation of CD8 naive or memory T cells. Science. 1997, 276: 2057-2062.
Article
PubMed
CAS
Google Scholar
Tanchot C, Rocha B: Peripheral selction of T cell repertoires; the role of continuous thymus output. J Exp Med. 1997, 186: 1099-1106.
Article
PubMed
CAS
PubMed Central
Google Scholar
Hämmerling GJ, Schönrich G, Ferber I, Arnold B: Peripheral tolerance as a multi-step mechanism. Immunol Rev. 1993, 133: 93-104.
Article
PubMed
Google Scholar
Goverman J, Woods A, Larson L, Weiner LP, Hood L, Zaller DM: Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity. Cell. 1993, 72: 551-560.
Article
PubMed
CAS
Google Scholar
Lafaille JJ, Nagashima K, Katsuki M, Tonegawa S: High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice. Cell. 1994, 78: 399-408.
Article
PubMed
CAS
Google Scholar
Wooley PH, Luthra HS, Stuart JM, David CS: Type II collagen induced arthritis in mice. I. Major histocompatibility complex (I-region) linkage and antibody correlates. J Exp Med. 1981, 154: 688-700.
Article
PubMed
CAS
Google Scholar
Stastny P: Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. N Engl J Med. 1978, 298: 869-871.
Article
PubMed
CAS
Google Scholar
Gregersen PK, Silver J, Winchester RJ: The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum. 1987, 30: 1205-1213.
Article
PubMed
CAS
Google Scholar
Fugger L, Rothbard JB, Sonderstrup-McDevitt G: Specificity of an HLA-DRB1*0401-restricted T cell response to type II collagen. Eur J Immunol. 1996, 26: 928-933.
Article
PubMed
CAS
Google Scholar
Dessen A, Lawrence CM, Cupo S, Zaller DM, Wiley DC: X-ray crystal structure of HLA-DR4 (DRA*0101, DRB1*0401) complexed with a peptide from human collagen II. Immunity. 1997, 7: 473-481.
Article
PubMed
CAS
Google Scholar
Rosloniec EF, Brand DD, Myers LK: Induction of autoimmune arthritis in HLA-DR4 (DRB1*0401) transgenic mice by immunization with human and bovine type II collagen. J Immunol. 1998, 160: 2573-2578.
PubMed
CAS
Google Scholar
Ranges GE, Sriram S, Cooper SM: Prevention of type II collagen-induced arthritis by in vivo treatment with anti-L3T4. J Exp Med. 1985, 162: 1105-1110.
Article
PubMed
CAS
Google Scholar
Holmdahl R, Klareskog L, Rubin K, Larsson E, Wigzell H: T lymphocytes in collagen II-induced arthritis in mice. Characterization of arthritogenic collagen II-specific T cell lines and clones. Scand J Immunol. 1985, 22: 295-306.
Article
PubMed
CAS
Google Scholar
Mauri C, Chu CQ, Woodrow D, Mori L, Londei M: Treatment of a newly established transgenic model of chronic arthritis with nondepleting anti-CD4 monoclonal antibody. J Immunol. 1997, 159: 5032-5041.
PubMed
CAS
Google Scholar
Metsäranta M, Toman D, de Crombrugghe B, Vuorio E: Mouse type II collagen gene. Complete nucleotide sequence, exon structure, and alternative splicing. J Biol Chem. 1991, 266: 16862-16869.
PubMed
Google Scholar
Malmström V, Kjéllen P, Holmdahl R: Type II collagen in cartilage evokes peptide-specific tolerance and skews the immune response. J Autoimmun. 1998, 11: 213-221. 10.1006/jaut.1998.0198.
Article
PubMed
Google Scholar
Ishioka GY, Lamont AG, Thomson D: MHC interaction and T cell recognition of carbohydrates and glycopeptides. J Immunol. 1992, 148: 2446-2451.
PubMed
CAS
Google Scholar
Deck B, Elofsson M, Kihlberg J, Unanue ER: Specificity of glycopeptide-specific T cells. J Immunol. 1995, 155: 1074-1078.
PubMed
CAS
Google Scholar
Haurum JS, Arsequell G, Lellouch AC: Recognition of carbohydrate by major histocompatibility complex class I-restricted, glycopeptide-specific cytotoxic T lymphocytes. J Exp Med. 1994, 180: 739-744.
Article
PubMed
CAS
Google Scholar
Abdel-Motal UM, Berg L, Rosen A: Immunization with glycosylated Kb-binding peptides generates carbohydrate-specific, unrestricted cytotoxic T cells. Eur J Immunol. 1996, 26: 544-551.
Article
PubMed
CAS
Google Scholar
Jensen T, Hansen P, Galli-Stampino L: Carbohydrate and peptide specificity of MHC class II-restricted T cell hybridomas raised against an O-glycosylated self peptide. J Immunol. 1997, 158: 3769-3778.
PubMed
CAS
Google Scholar
Michaëlsson E, Malmström V, Reis S, Burkhardt H, Engström Å, Holmdahl R: T cell recognition of carbohydrates on type II collagen. J Exp Med. 1994, 30: 745-749.
Article
Google Scholar
Michaëlsson E, Broddefalk J, Kihlberg J, Engström Å, Holmdahl R: Antigen processing and presentation of a naturally glycosylated protein elicits major histocompatibility complex class II-restricted, carbohydrate-specific T cells. Eur J Immunol. 1996, 26: 1906-1910.
Article
PubMed
Google Scholar
Smith BD, Martin GR, Dorfman A, Swarm R: Nature of the collagen synthesized by a transplanted chondrosarcoma. Arch Biochem Biophys . 1975, 166: 181-186.
Article
PubMed
CAS
Google Scholar
Andersson M, Holmdahl R: Analysis of type II collagen reactive T cells in the mouse. I. Different regulation of autoreactive versus non-autoreactive anti-type II collagen T cells in the DBA/1 mouse. Eur J Immunol. 1990, 20: 1061-1066.
Article
PubMed
CAS
Google Scholar
Broddefalk J, Bäcklund J, Almqvist F, Johansson M, Holmdahl R, Kihlberg J: T cells recognize a glycopeptide derived from type II collagen in a model for rheumatoid arthritis. J Am Chem Soc. 1998, 120: 7676-7683. 10.1021/ja980489k.
Article
CAS
Google Scholar
Holmdahl R, Klareskog L, Andersson M, Hansen C: High antibody response to autologous type II collagen is restricted to H-2q. Immunogenetics. 1986, 24: 84-89.
Article
PubMed
CAS
Google Scholar
Michaëlsson E, Holmdahl M, Engström Å, Burkhardt H, Scheynius A, Holmdahl R: Macrophages but not dendritic cells present collagen to T-cells. Eur J Immunol. 1995, 25: 2234-2241.
Article
PubMed
Google Scholar
Manoury Schwartz B, Chiocchia G, Fournier C: Processing and presentation of type II collagen, a fibrillar autoantigen, by H-2q antigen-presenting cells. Eur J Immunol. 1995, 25: 3235-3242.
Article
PubMed
CAS
Google Scholar
Steinman R: The dendritic cell system and its role in immunogenicity. Annu Rev Immunol. 1991, 9: 271-296.
Article
PubMed
CAS
Google Scholar
Tanchot C, Rocha B: The peripheral T cell repertoire: independent homeostatic regulation of virgin and activated CD8+ T cell pools. Eur J Immunol. 1995, 25: 2127-2136.
Article
PubMed
CAS
Google Scholar
Gray D, Matzinger P: T cell memory is short-lived in the absence of antigen. J Exp Med. 1991, 174: 969-974.
Article
PubMed
CAS
Google Scholar
Mueller DL, Jenkins MK, Schwartz RH: Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy. Ann Rev Immunol. 1989, 7: 445-480.
Article
CAS
Google Scholar
Brocke S, Gaur A, Piercy C: Induction of relapsing paralysis in experimental autoimmune encephalomyelitis by bacterial super-antigen. Nature. 1993, 365: 642-644.
Article
PubMed
CAS
Google Scholar
Potter M, Wax JS: Genetics of susceptibility to pristane-induced plasmacytomas in BALB/cAn: reduced susceptibility in BALB/cJ with a brief description of pristane-induced arthritis. J Immunol. 1981, 127: 1591-1595.
PubMed
CAS
Google Scholar