Volume 6 Supplement 1

24th European Workshop for Rheumatology Research

Open Access

CD25+regulatory T cells can be used therapeutically in collagen-induced arthritis

  • ME Morgan1,
  • R Flierman1,
  • HJ Witteveen1,
  • TWJ Huizinga1,
  • RRP de Vries2 and
  • REM Toes1
Arthritis Res Ther20046(Suppl 1):40

https://doi.org/10.1186/ar1082

Received: 16 January 2004

Published: 24 February 2004

Background

Naturally occurring CD4+CD25+ T cells have been shown to suppress immune responses both in vivo and in vitro. Finding a way to harness their regulatory abilities is of particular value in both transplantation and autoimmunity, where unwanted immune reactions need to be eliminated. Tantalizing evidence for their future potential is demonstrated by their ability to cure T cell mediated colitis induced in SCID mice [1]. However, many autoimmune diseases display a strong humoral component, such as rheumatoid arthritis. It is unknown whether CD4+CD25+ T cells are effective in these B cell-mediated autoimmune diseases.

Objective

We tested the ability of CD4+CD25+ T cells to modulate collagen-induced arthritis (CIA), a disease dependent on the presence of B cells [2].

Methods

In order to determine the role of endogenous CD25+ T cells in CIA, CD25+ cells were first depleted in mice before immunizations to induce CIA. The therapeutic value of these cells was assessed by adoptively transferring preactivated CD4+CD25+ T cells into mice during the onset of disease.

Results

Depletion of CD25+ cells before CIA induction lead to a hastened severe disease in comparison with nondepleted control mice. If CD4+CD25+ T cells were transferred to mice therapeutically, the mice had a significantly milder disease.

Conclusion

CD4+CD25+ T cells can treat chronic arthritis and probably have the potential to treat a wide spectrum of autoimmune diseases, including those that are mainly mediated by B cells.

Authors’ Affiliations

(1)
Department of Rheumatology, Leiden University Medical Center
(2)
Department of Immunohematology and Blood Transfusion, Leiden University Medical Center

References

  1. Mottet C, Uhlig HH, Powrie F: Cutting edge: cure of colitis by CD4+CD25+ regulatory T cells. J Immunol. 2003, 170: 3939-3943.View ArticlePubMedGoogle Scholar
  2. Svensson L, Jirholt J, Holmdahl R, Jansson L: B cell-deficient mice do not develop type II collagen-induced arthritis (CIA). Clin Exp Immunol. 1998, 111: 521-526. 10.1046/j.1365-2249.1998.00529.x.PubMed CentralView ArticlePubMedGoogle Scholar

Copyright

© The Author(s) 2004

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