Objective
In earlier studies we found that FcγRI determines chondrocyte death and matrix metalloproteinase (MMP)-mediated cartilage destruction during interferon gamma (IFN-γ)-regulated immune complex (IC)-mediated arthritis [1]. As binding of ICs to FcγRI leads to oxygen radical production, we now investigate the contribution of oxygen radicals to induction of both parameters of cartilage destruction using P47phox knockout mice. These mice have a defect in NADPH-oxidase activation and fail to produce oxygen radicals.