Catrina AI, Trollmo C, af Klint E, Engstrom M, Lampa J, Hermansson Y, Klareskog L, Ulfgren AK: Evidence that anti-tumor necrosis factor therapy with both etanercept and infliximab induces apoptosis in macrophages, but not lymphocytes, in rheumatoid arthritis joints: extended report. Arthritis Rheum. 2005, 52: 61-72. 10.1002/art.20764.
Article
CAS
PubMed
Google Scholar
Yanni G, Whelan A, Feighery C, Bresnihan B: Synovial tissue macrophages and joint erosion in rheumatoid arthritis. Ann Rheum Dis. 1994, 53: 39-44.
Article
PubMed Central
CAS
PubMed
Google Scholar
Mulherin D, Fitzgerald O, Bresnihan B: Synovial tissue macrophage populations and articular damage in rheumatoid arthritis. Arthritis Rheum. 1996, 39: 115-124. 10.1002/art.1780390116.
Article
CAS
PubMed
Google Scholar
Liu H, Pope RM: Apoptosis in rheumatoid arthritis: friend or foe. Rheum Dis Clin North Am. 2004, 30: 603-625. 10.1016/j.rdc.2004.04.010.
Article
PubMed
Google Scholar
Matsumoto S, Muller-Ladner U, Gay RE, Nishioka K, Gay S: Ultrastructural demonstration of apoptosis, Fas and Bcl-2 expression of rheumatoid synovial fibroblasts. J Rheum. 1996, 23: 1345-1352.
CAS
PubMed
Google Scholar
Sugiyama M, Tsukazaki T, Yonekura A, Matsuzaki S, Yamashita S, Iwasaki K: Localization of apoptosis and expression of apoptosis related proteins in the synovium of patients with rheumatoid arthritis. Ann Rheum Dis. 1996, 55: 442-449.
Article
PubMed Central
CAS
PubMed
Google Scholar
Miagkov AV, Kovalenko DV, Brwon C, Didsbury JR, Cogswell JP, Stimpson SA, Baldwin AS, Makarov SS: NF-kB activation provides the potential link between inflammation and hyperplasia in the arthritic joint. Proc Natl Acad Sci USA. 1998, 95: 13859-13864. 10.1073/pnas.95.23.13859.
Article
PubMed Central
CAS
PubMed
Google Scholar
Fujisawa K, Asahara H, Okamoto K, Aono H, Hasunuma T, Kobata T, Iwakura Y, Yonehara S, Sumida T, Nishioka N: Therapeutic effect of the anti-Fas antibody on arthritis in HTLV-1 tax transgenic mice. J Clin Invest. 1996, 98: 271-278.
Article
PubMed Central
CAS
PubMed
Google Scholar
Zhang H, Yang Y, Horton JL, Samoilova EB, Judge TA, Turka LA, Wilson JM, Chen Y: Amelioration of collagen-induced arthritis by CD-95 (Apo-1/Fas)-ligand gene transfer. J Clin Invest. 1997, 100: 1951-1957.
Article
PubMed Central
CAS
PubMed
Google Scholar
Harjacek M, Diaz-Cano S, De Miguel M, Wolfe H, Maldonado CA, Rabinovich GA: Expression of galectins-1 and -3 correlates with defective mononuclear cell apoptosis in patients with juvenile idiopathic arthritis. J Rheumatol. 2001, 28: 1914-1922.
CAS
PubMed
Google Scholar
Adams JM, Cory S: The Bcl-2 protein family: arbiters of cell survival. Science. 1998, 281: 1322-1326. 10.1126/science.281.5381.1322.
Article
CAS
PubMed
Google Scholar
Opferman JT, Korsmeyer SJ: Apoptosis in the development and maintenance of the immune system. Nat Immunol. 2003, 4: 410-415. 10.1038/ni0503-410.
Article
CAS
PubMed
Google Scholar
Letai A, Bassik MC, Walensky LD, Sorcinelli MD, Weiler S, Korsmeyer SJ: Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell. 2002, 2: 183-192. 10.1016/S1535-6108(02)00127-7.
Article
CAS
PubMed
Google Scholar
Certo M, Moore Vdel G, Nishino M, Wei G, Korsmeyer S, Armstrong SA, Letai A: Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. Cancer Cell. 2006, 9: 351-365. 10.1016/j.ccr.2006.03.027.
Article
CAS
PubMed
Google Scholar
Chen L, Willis SN, Wei A, Smith BJ, Fletcher JI, Hinds MG, Colman PM, Day CL, Adams JM, Huang DC: Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol Cell. 2005, 17: 393-403. 10.1016/j.molcel.2004.12.030.
Article
CAS
PubMed
Google Scholar
Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI, Adams JM, Huang DC: Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins. Genes Dev. 2005, 19: 1294-1305. 10.1101/gad.1304105.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kuwana T, Bouchier-Hayes L, Chipuk JE, Bonzon C, Sullivan BA, Green DR, Newmeyer DD: BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly. Mol Cell. 2005, 17: 525-535. 10.1016/j.molcel.2005.02.003.
Article
CAS
PubMed
Google Scholar
Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, Peng T-I, Jones DP, Wang X: Prevention of apoptosis by Bcl-2: Release of cytochrome c from mitochondria blocked. Science. 1997, 275: 1129-1132. 10.1126/science.275.5303.1129.
Article
CAS
PubMed
Google Scholar
Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD: The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis. Science. 1997, 275: 1132-1136. 10.1126/science.275.5303.1132.
Article
CAS
PubMed
Google Scholar
Kuida K, Haydar TF, Kuan C, Gu Y, Taya C, Karasuyama H, Su MS, Rakic P, Flavell RA: Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell. 1998, 94: 325-337. 10.1016/S0092-8674(00)81476-2.
Article
CAS
PubMed
Google Scholar
Rao L, White E: Bcl-2 and the ICE family of apoptotic regulators: making a connection. Curr Opin Genet Dev. 1997, 7: 52-58. 10.1016/S0959-437X(97)80109-8.
Article
CAS
PubMed
Google Scholar
Strasser A: The role of BH3-only proteins in the immunesystem. Nat Rev Immunol. 2005, 5: 189-200. 10.1038/nri1568.
Article
CAS
PubMed
Google Scholar
Green DR: Apoptotic pathways: The roads to ruin. Cell. 1998, 94: 695-698. 10.1016/S0092-8674(00)81728-6.
Article
CAS
PubMed
Google Scholar
Luo X, Budihardjo I, Zou H, Slaughter C, Wang X: Bid, a Bcl-2 interacting protein mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell. 1998, 94: 481-490. 10.1016/S0092-8674(00)81589-5.
Article
CAS
PubMed
Google Scholar
Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X: Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell. 1997, 91: 479-489. 10.1016/S0092-8674(00)80434-1.
Article
CAS
PubMed
Google Scholar
Wang K, Yin XM, Chao DT, Milliman CL, Korsmeyer SJ: BID, a novel BH3 domain only death agonist. Genes Dev. 1996, 10: 2859-2869. 10.1101/gad.10.22.2859.
Article
CAS
PubMed
Google Scholar
Brown NJ, Hutcheson J, Bickel E, Scatizzi JC, Albee LD, Haines GK, Eslick J, Bradley K, Taricone E, Perlman H: Fas death receptor signaling represses monocyte numbers and macrophage activation in vivo. J Immunol. 2004, 173: 7584-7593.
Article
CAS
PubMed
Google Scholar
Scatizzi JC, Bickel E, Hutcheson J, Haines GK, Perlman H: Bim deficiency leads to exacerbation and prolongation of joint inflammation in experimental arthritis. Arthritis Rheum. 2006, 54: 3182-3193. 10.1002/art.22133.
Article
CAS
PubMed
Google Scholar
Kouskoff V, Korganow AS, Duchatelle V, Degott C, Benoist C, Mathis D: Organ-specific disease provoked by systemic autoimmunity. Cell. 1996, 87: 811-822. 10.1016/S0092-8674(00)81989-3.
Article
CAS
PubMed
Google Scholar
Korganow AS, Ji H, Mangialaio S, Duchatelle V, Pelanda R, Martin T, Degott C, Kikutani H, Rajewsky K, Pasquali JL, Benoist C, Mathis D: From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins. Immunity. 1999, 10: 451-461. 10.1016/S1074-7613(00)80045-X.
Article
CAS
PubMed
Google Scholar
Ji H, Gauguier D, Ohmura K, Gonzalez A, Duchatelle V, Danoy P, Garchon HJ, Degott C, Lathrop M, Benoist C, Mathis D: Genetic influences on the end-stage effector phase of arthritis. J Exp Med. 2001, 194: 321-330. 10.1084/jem.194.3.321.
Article
PubMed Central
CAS
PubMed
Google Scholar
Scatizzi JC, Hutcheson J, Bickel E, Woods JM, Klosowska K, Moore TL, Haines GK, Perlman H: p21Cip1 is required for the development of monocytes and their response to serum transfer-induced arthritis. Am J Pathol. 2006, 168: 1531-1541. 10.2353/ajpath.2006.050555.
Article
PubMed Central
CAS
PubMed
Google Scholar
Pettit AR, Ji H, von Stechow D, Muller R, Goldring SR, Choi Y, Benoist C, Gravallese EM: TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis. Am J Pathol. 2001, 159: 1689-1699.
Article
PubMed Central
CAS
PubMed
Google Scholar
Scatizzi JC, Hutcheson J, Bickel E, Woods JM, Klosowska K, Moore TL, Haines GK, Perlman H: p21Cip1 is required for the development of monocytes and their response to serum transfer-induced arthritis. Am J Pathol. 2006, 168: 1531-1541. 10.2353/ajpath.2006.050555.
Article
PubMed Central
CAS
PubMed
Google Scholar
McKnight AJ, Macfarlane AJ, Dri P, Turley L, Willis AC, Gordon S: Molecular cloning of F4/80, a murine macrophage-restricted cell surface glycoprotein with homology to the G-protein-linked transmembrane 7 hormone receptor family. J Biol Chem. 1996, 271: 486-489. 10.1074/jbc.271.50.31869.
Article
CAS
PubMed
Google Scholar
Nabel EG, Gordon D, Yang ZY, Xu L, San H, Plautz GE, Wu BY, Gao X, Huang L, Nabel GJ: Gene transfer in vivo with DNA-liposome complexes: lack of autoimmunity and gonadal localization. Hum Gene Ther. 1992, 3: 649-656.
Article
CAS
PubMed
Google Scholar
Hirsch S, Austyn JM, Gordon S: Expression of the macrophage-specific antigen F4/80 during differentiation of mouse bone marrow cells in culture. J Exp Med. 1981, 154: 713-725. 10.1084/jem.154.3.713.
Article
CAS
PubMed
Google Scholar
Akiyama T, Miyazaki T, Bouillet P, Nakamura K, Strasser A, Tanaka S: In vitro and in vivo assays for osteoclast apoptosis. Biol Proced Online. 2005, 7: 48-59. 10.1251/bpo105.
Article
PubMed Central
CAS
PubMed
Google Scholar
Schaller E, Macfarlane AJ, Rupec RA, Gordon S, McKnight AJ, Pfeffer K: Inactivation of the F4/80 glycoprotein in the mouse germ line. Mol Cell Biol. 2002, 22: 8035-8043. 10.1128/MCB.22.22.8035-8043.2002.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ditzel HJ: The K/BxN mouse: a model of human inflammatory arthritis. Trends Mol Med. 2004, 10: 40-45. 10.1016/j.molmed.2003.11.004.
Article
CAS
PubMed
Google Scholar
Corr M, Crain B: The role of FcgammaR signaling in the K/B × N serum transfer model of arthritis. J Immunol. 2002, 169: 6604-6609.
Article
CAS
PubMed
Google Scholar
Ji H, Ohmura K, Mahmood U, Lee DM, Hofhuis FM, Boackle SA, Takahashi K, Holers VM, Walport M, Gerard C, et al: Arthritis critically dependent on innate immune system players. Immunity. 2002, 16: 157-168. 10.1016/S1074-7613(02)00275-3.
Article
CAS
PubMed
Google Scholar
Perlman H, Pagliari LJ, Volin MV: Regulation of apoptosis and cell cycle activity in rheumatoid arthritis. Curr Mol Med. 2001, 1: 597-608. 10.2174/1566524013363429.
Article
CAS
PubMed
Google Scholar
Perlman H, Nguyen N, Liu H, Eslick J, Esser S, Walsh K, Moore TL, Pope RM: Rheumatoid arthritis synovial fluid macrophages express decreased tumor necrosis factor-related apoptosis-inducing ligand R2 and increased decoy receptor tumor necrosis factor-related apoptosis-inducing ligand R3. Arthritis Rheum. 2003, 48: 3096-3101. 10.1002/art.11302.
Article
PubMed
Google Scholar
Perlman H, Pagliari LJ, Liu H, Koch AE, Haines GK, Pope RM: Rheumatoid arthritis synovial macrophages express the Fas-associated death domain-like interleukin-1beta-converting enzyme-inhibitory protein and are refractory to Fas-mediated apoptosis. Arthritis Rheum. 2001, 44: 21-30. 10.1002/1529-0131(200101)44:1<21::AID-ANR4>3.0.CO;2-8.
Article
CAS
PubMed
Google Scholar
Perlman H, Georganas C, Pagliari LJ, Koch AE, Haines K, Pope RM: Bcl-2 expression in synovial fibroblasts is essential for maintaining mitochondrial homeostasis and cell viability. J Immunol. 2000, 164: 5227-5235.
Article
CAS
PubMed
Google Scholar
Busteed S, Bennett MW, Molloy C, Houston A, Stone MA, Shanahan F, Molloy MG, O'Connell J: Bcl-x(L) expression in vivo in rheumatoid synovium. Clin Rheumatol. 2006, 25: 789-793. 10.1007/s10067-005-0191-0.
Article
CAS
PubMed
Google Scholar
Hilbers I, Hansen T, Petrow PK, Gaumann A, Brauer R, Salzmann G, Gay RE, Kosmehl H, Kirkpatrick CJ, Gay S, Kriegsmann J: Expression of the apoptosis accelerator Bax in rheumatoid arthritis synovium. Rheumatol Int. 2003, 23: 75-81.
CAS
PubMed
Google Scholar
Cha HS, Rosengren S, Boyle DL, Firestein GS: PUMA regulation and proapoptotic effects in fibroblast-like synoviocytes. Arthritis Rheum. 2006, 54: 587-592. 10.1002/art.21631.
Article
CAS
PubMed
Google Scholar
Chen M, Huang L, Wang J: Deficiency of Bim in dendritic cells contributes to over-activation of lymphocytes and autoimmunity. Blood. 2007, 109: 4360-4367. 10.1182/blood-2006-11-056424.
Article
PubMed Central
CAS
PubMed
Google Scholar
Batliwalla FM, Baechler EC, Xiao X, Li W, Balasubramanian S, Khalili H, Damle A, Ortmann WA, Perrone A, Kantor AB, et al: Peripheral blood gene expression profiling in rheumatoid arthritis. Genes Immun. 2005, 6: 388-397. 10.1038/sj.gene.6364209.
Article
CAS
PubMed
Google Scholar
Iwahashi M, Yamamura M, Aita T, Okamoto A, Ueno A, Ogawa N, Akashi S, Miyake K, Godowski PJ, Makino H: Expression of Toll-like receptor 2 on CD16+ blood monocytes and synovial tissue macrophages in rheumatoid arthritis. Arthritis Rheum. 2004, 50: 1457-1467. 10.1002/art.20219.
Article
CAS
PubMed
Google Scholar
Kawanaka N, Yamamura M, Aita T, Morita Y, Okamoto A, Kawashima M, Iwahashi M, Ueno A, Ohmoto Y, Makino H: CD14+, CD16+ blood monocytes and joint inflammation in rheumatoid arthritis. Arthritis Rheum. 2002, 46: 2578-2586. 10.1002/art.10545.
Article
CAS
PubMed
Google Scholar
van den Berg WB, van Lent PLEM: The role of macrophages in chronic arthritis. Immunobiology. 1996, 195: 614-623.
Article
CAS
PubMed
Google Scholar
Choy EH, Panayi GS: Cytokine pathways and joint inflammation in rheumatoid arthritis. N Engl J Med. 2001, 344: 907-916. 10.1056/NEJM200103223441207.
Article
CAS
PubMed
Google Scholar
Feldmann M, Brennan FM, Maini RN: Role of cytokines in rheumatoid arthritis. Annu Rev Immunol. 1996, 14: 397-440. 10.1146/annurev.immunol.14.1.397.
Article
CAS
PubMed
Google Scholar
Nuki G, Bresnihan B, Bear MB, McCabe D: Long-term safety and maintenance of clinical improvement following treatment with anakinra (recombinant human interleukin-1 receptor antagonist) in patients with rheumatoid arthritis: Extension phase of a randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 2002, 46: 2838-2846. 10.1002/art.10578.
Article
CAS
PubMed
Google Scholar
Genovese MC, Bathon JM, Martin RW, Fleischmann RM, Tesser JR, Schiff MH, Keystone EC, Wasko MC, Moreland LW, Weaver AL, et al: Etanercept versus methotrexate in patients with early rheumatoid arthritis: two-year radiographic and clinical outcomes. Arthritis Rheum. 2002, 46: 1443-1450. 10.1002/art.10308.
Article
CAS
PubMed
Google Scholar
De Rycke L, Baeten D, Foell D, Kruithof E, Veys EM, Roth J, De Keyser F: Differential expression and response to anti-TNFalpha treatment of infiltrating versus resident tissue macrophage subsets in autoimmune arthritis. J Pathol. 2005, 206: 17-27. 10.1002/path.1758.
Article
CAS
PubMed
Google Scholar
Campbell IK, Rich MJ, Bischof RJ, Hamilton JA: The colony-stimulating factors and collagen-induced arthritis: exacerbation of disease by M-CSF and G-CSF and requirement for endogenous M-CSF. J Leukoc Biol. 2000, 68: 144-150.
CAS
PubMed
Google Scholar
Yang YH, Hamilton JA: Dependence of interleukin-1-induced arthritis on granulocyte-macrophage colony-stimulating factor. Arthritis Rheum. 2001, 44: 111-119. 10.1002/1529-0131(200101)44:1<111::AID-ANR15>3.0.CO;2-1.
Article
PubMed
Google Scholar
Solomon S, Rajasekaran N, Jeisy-Walder E, Snapper SB, Illges H: A crucial role for macrophages in the pathology of K/B × N serum-induced arthritis. Eur J Immunol. 2005, 35: 3064-3073. 10.1002/eji.200526167.
Article
CAS
PubMed
Google Scholar
Zinkel SS, Ong CC, Ferguson DO, Iwasaki H, Akashi K, Bronson RT, Kutok JL, Alt FW, Korsmeyer SJ: Proapoptotic BID is required for myeloid homeostasis and tumor suppression. Genes Dev. 2003, 17: 229-239. 10.1101/gad.1045603.
Article
PubMed Central
CAS
PubMed
Google Scholar