Turk B: Targeting proteases: successes, failures and future prospects. Nat Rev Drug Discov. 2006, 5: 785-799. 10.1038/nrd2092.
Article
CAS
PubMed
Google Scholar
Lah TT, Duran Alonso MB, Van Noorden CJ: Antiprotease therapy in cancer: hot or not?. Expert Opin Biol Ther. 2006, 6: 257-79. 10.1517/14712598.6.3.257.
Article
CAS
PubMed
Google Scholar
Dickinson DP: Cysteine peptidases of mammals: their biological roles and potential effects in the oral cavity and other tissues in health and disease. Crit Rev Oral Biol Med. 2002, 13: 238-275.
Article
CAS
PubMed
Google Scholar
Turk D, Guncar G: Lysosomal cysteine proteases (cathepsins): promising drug targets. Acta Crystallogr D Biol Crystal-logr. 2003, 59: 203-213. 10.1107/S0907444902021479.
Article
Google Scholar
Barrett AJ: The many forms and functions of cellular proteinases. Fed Proc. 1980, 39: 9-14.
CAS
PubMed
Google Scholar
Cawston TE, Wilson AJ: Understanding the role of tissue degrading enzymes and their inhibitors in development and disease. Best Pract Res Clin Rheumatol. 2006, 20: 983-1002. 10.1016/j.berh.2006.06.007.
Article
CAS
PubMed
Google Scholar
Fusek M, Vetvicka V: Dual role of cathepsin D: ligand and protease. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005, 149: 43-50.
Article
CAS
PubMed
Google Scholar
Chapman HA: Endosomal proteases in antigen presentation. Curr Opin Immunol. 2006, 18: 78-84. 10.1016/j.coi.2005.11.011.
Article
CAS
PubMed
Google Scholar
Lkhider M, Castino R, Bouguyon E, Isidoro C, Ollivier-Bousquet M: Cathepsin D released by lactating rat mammary epithelial cells is involved in prolactin cleavage under physiological conditions. J Cell Sci. 2004, 117: 5155-5164. 10.1242/jcs.01396.
Article
CAS
PubMed
Google Scholar
Turk V, Turk B, Turk D: Lysosomal cysteine proteases: facts and opportunities. EMBO J. 2001, 3: 4629-4633. 10.1093/emboj/20.17.4629.
Article
Google Scholar
Yasuda Y, Kaleta J, Bromme D: The role of cathepsins in osteoporosis and arthritis: rationale for the design of new therapeutics. Adv Drug Deliv Rev. 2005, 57: 973-993. 10.1016/j.addr.2004.12.013.
Article
CAS
PubMed
Google Scholar
Mitsiades CS, Mitsiades N, Hideshima T, Richardson PG, Anderson KC: Proteasome inhibition as a new therapeutic principle in hematological malignancies. Curr Drug Targets. 2006, 7: 1341-1347. 10.2174/138945006778559247.
Article
CAS
PubMed
Google Scholar
Wang J, Maldonado MA: The ubiquitin-proteasome system and its role in inflammatory and autoimmune diseases. Cell Mol Immunol. 2006, 3: 255-261.
CAS
PubMed
Google Scholar
Pham CT: Neutrophil serine proteases: specific regulators of inflammation. Nat Rev Immunol. 2006, 6: 541-550. 10.1038/nri1841.
Article
CAS
PubMed
Google Scholar
Walker B, Lynas JF: Strategies for the inhibition of serine proteases. Cell Mol Life Sci. 2001, 58: 596-624. 10.1007/PL00000884.
Article
CAS
PubMed
Google Scholar
Jin T, Tarkowski A, Carmeliet P, Bokarewa M: Urokinase, a constitutive component of the inflamed synovial fluid, induces arthritis. Arthritis Res Ther. 2003, 5: R9-R17. 10.1186/ar606.
Article
PubMed Central
CAS
PubMed
Google Scholar
Burrage PS, Mix KS, Brinckerhoff CE: Matrix metalloproteinases: role in arthritis. Front Biosci. 2006, 11: 529-543. 10.2741/1817.
Article
CAS
PubMed
Google Scholar
Rannou F, Francois M, Corvol MT, Berenbaum F: Cartilage breakdown in rheumatoid arthritis. Joint Bone Spine. 2006, 73: 29-36. 10.1016/j.jbspin.2004.12.013.
Article
CAS
PubMed
Google Scholar
Martel-Pelletier J, Welsch DJ, Pelletier JP: Metalloproteases and inhibitors in arthritic diseases. Best Pract Res Clin Rheumatol. 2001, 15: 805-829. 10.1053/berh.2001.0195.
Article
CAS
PubMed
Google Scholar
Murphy G, Knauper V, Atkinson S, Butler G, English W, Hutton M, Stracke J, Clark I: Matrix metalloproteinases in arthritic disease. Arthritis Res. 2002, 4 (Suppl 3): S39-S49. 10.1186/ar572.
Article
PubMed Central
PubMed
Google Scholar
Chakraborti S, Mandal M, Das S, Mandal A, Chakraborti T: Regulation of matrix metalloproteinases: an overview. Mol Cell Biochem. 2003, 253: 269-285. 10.1023/A:1026028303196.
Article
CAS
PubMed
Google Scholar
Visse R, Nagase H: Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry. Circ Res. 2003, 92: 827-839. 10.1161/01.RES.0000070112.80711.3D.
Article
CAS
PubMed
Google Scholar
Lambert E, Dasse E, Haye B, Petitfrere E: TIMPs as multifacial proteins. Crit Rev Oncol Hematol. 2004, 49: 187-198. 10.1016/j.critrevonc.2003.09.008.
Article
PubMed
Google Scholar
Baker AH, Edwards DR, Murphy G: Metalloproteinase inhibitors: biological actions and therapeutic opportunities. J Cell Sci. 2002, 115: 3719-3727. 10.1242/jcs.00063.
Article
CAS
PubMed
Google Scholar
Huovila AP, Turner AJ, Pelto-Huikko M, Karkkainen I, Ortiz RM: Shedding light on ADAM metalloproteinases. Trends Biochem Sci. 2005, 30: 413-422. 10.1016/j.tibs.2005.05.006.
Article
CAS
PubMed
Google Scholar
Nagase H, Kashiwagi M: Aggrecanases and cartilage matrix degradation. Arthritis Res Ther. 2003, 5: 94-103. 10.1186/ar630.
Article
PubMed Central
CAS
PubMed
Google Scholar
Arner EC: Aggrecanase-mediated cartilage degradation. Curr Opin Pharmacol. 2002, 2: 322-329. 10.1016/S1471-4892(02)00148-0.
Article
CAS
PubMed
Google Scholar
Longpre JM, Leduc R: Identification of prodomain determinants involved in ADAMTS-1 biosynthesis. J Biol Chem. 2004, 279: 33237-33245. 10.1074/jbc.M313151200.
Article
CAS
PubMed
Google Scholar
Milner JM, Rowan AD, Cawston TE, Young DA: Metalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis. Arthritis Res Ther. 2006, 8: R142-10.1186/ar2034.
Article
PubMed Central
PubMed
Google Scholar
Luyten FP, Lories RJ, Verschueren P, de Vlam K, Westhovens R: Contemporary concepts of inflammation, damage and repair in rheumatic diseases. Best Pract Res Clin Rheumatol. 2006, 20: 829-848. 10.1016/j.berh.2006.06.009.
Article
CAS
PubMed
Google Scholar
Poole AR, Kojima T, Yasuda T, Mwale F, Kobayashi M, Laverty S: Composition and structure of articular cartilage: a template for tissue repair. Clin Orthop Relat Res. 2001, 391 (Suppl): S26-S33. 10.1097/00003086-200110001-00004.
Article
PubMed
Google Scholar
Poole AR, Kobayashi M, Yasuda T, Laverty S, Mwale F, Kojima T, Sakai T, Wahl C, El-Maadawy S, Webb G, et al: Type II collagen degradation and its regulation in articular cartilage in osteoarthritis. Ann Rheum Dis. 2002, 61 (Suppl 2): ii78-ii81.
Article
PubMed Central
CAS
PubMed
Google Scholar
Goldring SR: Pathogenesis of bone and cartilage destruction in rheumatoid arthritis. Rheumatology (Oxford). 2003, 42 (Suppl 2): ii11-ii16.
CAS
Google Scholar
Mandelin J, Hukkanen M, Li TF, Korhonen M, Liljestrom M, Sillat T, Hanemaaijer R, Salo J, Santavirta S, Konttinen YT: Human osteoblasts produce cathepsin K. Bone. 2006, 38: 769-777. 10.1016/j.bone.2005.10.017.
Article
CAS
PubMed
Google Scholar
Walsh NC, Crotti TN, Goldring SR, Gravallese EM: Rheumatic diseases: the effects of inflammation on bone. Immunol Rev. 2005, 208: 228-251. 10.1111/j.0105-2896.2005.00338.x.
Article
CAS
PubMed
Google Scholar
Delaisse JM, Andersen TL, Engsig MT, Henriksen K, Troen T, Blavier L: Matrix metalloproteinases (MMP) and cathepsin K contribute differently to osteoclastic activities. Microsc Res Tech. 2003, 61: 504-513. 10.1002/jemt.10374.
Article
CAS
PubMed
Google Scholar
Anandarajah AP, Schwarz EM: Anti-RANKL therapy for inflammatory bone disorders: mechanisms and potential clinical applications. J Cell Biochem. 2006, 97: 226-232. 10.1002/jcb.20674.
Article
CAS
PubMed
Google Scholar
Mandal M, Mandal A, Das S, Chakraborti T, Sajal C: Clinical implications of matrix metalloproteinases. Mol Cell Biochem. 2003, 252: 305-329. 10.1023/A:1025526424637.
Article
CAS
PubMed
Google Scholar
Malemud CJ: Matrix metalloproteinases (MMPs) in health and disease: an overview. Front Biosci. 2006, 11: 1696-1701. 10.2741/1915.
Article
CAS
PubMed
Google Scholar
Huet G, Flipo RM, Colin C, Janin A, Hemon B, Collyn-d'Hooghe M, Lafyatis R, Duquesnoy B, Degand P: Stimulation of the secretion of latent cysteine proteinase activity by tumor necrosis factor alpha and interleukin-1. Arthritis Rheum. 1993, 36: 772-780. 10.1002/art.1780360606.
Article
CAS
PubMed
Google Scholar
Lemaire R, Huet G, Zerimech F, Grard G, Fontaine C, Duquesnoy B, Flipo RM: Selective induction of the secretion of cathepsins B and L by cytokines in synovial fibroblast-like cells. Br J Rheumatol. 1997, 36: 735-743. 10.1093/rheumatology/36.7.735.
Article
CAS
PubMed
Google Scholar
Kaneko M, Tomita T, Nakase T, Ohsawa Y, Seki H, Takeuchi E, Takano H, Shi K, Takahi K, Kominami E, et al: Expression of proteinases and inflammatory cytokines in subchondral bone regions in the destructive joint of rheumatoid arthritis. Rheumatology (Oxford). 2001, 40: 247-255. 10.1093/rheumatology/40.3.247.
Article
CAS
Google Scholar
Trabandt A, Gay RE, Fassbender HG, Gay S: Cathepsin B in synovial cells at the site of joint destruction in rheumatoid arthritis. Arthritis Rheum. 1991, 34: 1444-1451.
Article
CAS
PubMed
Google Scholar
Hashimoto Y, Kakegawa H, Narita Y, Hachiya Y, Hayakawa T: Significance of cathepsin B accumulation in synovial fluid of rheumatoid arthritis. Biochem Biophys Res Commun. 2001, 283: 334-339. 10.1006/bbrc.2001.4787.
Article
CAS
PubMed
Google Scholar
Cunnane G, FitzGerald O, Hummel KM, Gay RE, Gay S, Bresnihan B: Collagenase, cathepsin B and cathepsin L gene expression in the synovial membrane of patients with early inflammatory arthritis. Rheumatology (Oxford). 1999, 38: 34-42. 10.1093/rheumatology/38.1.34.
Article
CAS
Google Scholar
Cunnane G, FitzGerald O, Hummel KM, Youssef PP, Gay RE, Gay S, Bresnihan B: Synovial tissue protease gene expression and joint erosions in early rheumatoid arthritis. Arthritis Rheum. 2001, 44: 1744-1753. 10.1002/1529-0131(200108)44:8<1744::AID-ART309>3.0.CO;2-K.
Article
CAS
PubMed
Google Scholar
Hou WS, Li W, Keyszer G, Weber E, Levy R, Klein MJ, Gravallese EM, Goldring SR, Bromme D: Comparison of cathepsins K and S expression within the rheumatoid and osteoarthritic synovium. Arthritis Rheum. 2002, 46: 663-674. 10.1002/art.10114.
Article
CAS
PubMed
Google Scholar
Hummel KM, Petrow PK, Franz JK, Muller-Ladner U, Aicher WK, Gay RE, Bromme D, Gay S: Cysteine proteinase cathepsin K mRNA is expressed in synovium of patients with rheumatoid arthritis and is detected at sites of synovial bone destruction. J Rheumatol. 1998, 25: 1887-1894.
CAS
PubMed
Google Scholar
Hou WS, Li Z, Gordon RE, Chan K, Klein MJ, Levy R, Keysser M, Keyszer G, Bromme D: Cathepsin k is a critical protease in synovial fibroblast-mediated collagen degradation. Am J Pathol. 2001, 159: 2167-2177.
Article
PubMed Central
CAS
PubMed
Google Scholar
Tchetverikov I, Ronday HK, Van El B, Kiers GH, Verzijl N, TeKoppele JM, Huizinga TW, DeGroot J, Hanemaaijer R: MMP profile in paired serum and synovial fluid samples of patients with rheumatoid arthritis. Ann Rheum Dis. 2004, 63: 881-883. 10.1136/ard.2003.013243.
Article
PubMed Central
CAS
PubMed
Google Scholar
Konttinen YT, Ainola M, Valleala H, Ma J, Ida H, Mandelin J, Kinne RW, Santavirta S, Sorsa T, Lopez-Otin C, et al: Analysis of 16 different matrix metalloproteinases (MMP-1 to MMP-20) in the synovial membrane: different profiles in trauma and rheumatoid arthritis. Ann Rheum Dis. 1999, 58: 691-697.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ainola MM, Mandelin JA, Liljestrom MP, Li TF, Hukkanen MV, Konttinen YT: Pannus invasion and cartilage degradation in rheumatoid arthritis: involvement of MMP-3 and interleukin-1beta. Clin Exp Rheumatol. 2005, 23: 644-650.
CAS
PubMed
Google Scholar
Fiedorczyk M, Klimiuk PA, Sierakowski S, Gindzienska-Sieskiewicz E, Chwiecko J: Serum matrix metalloproteinases and tissue inhibitors of metalloproteinases in patients with early rheumatoid arthritis. J Rheumatol. 2006, 33: 1523-1529.
CAS
PubMed
Google Scholar
Pap T, Meinecke I, Muller-Ladner U, Gay S: Are fibroblasts involved in joint destruction?. Ann Rheum Dis. 2005, 64 (Suppl 4): iv52-iv54. 10.1136/ard.2005.042424.
PubMed Central
CAS
PubMed
Google Scholar
Karouzakis E, Neidhart M, Gay RE, Gay S: Molecular and cellular basis of rheumatoid joint destruction. Immunol Lett. 2006, 106: 8-13. 10.1016/j.imlet.2006.04.011.
Article
CAS
PubMed
Google Scholar
Muller-Ladner U, Gay S: MMPs and rheumatoid synovial fibroblasts : Siamese twins in joint destruction?. Ann Rheum Dis. 2002, 61: 957-959. 10.1136/ard.61.11.957.
Article
PubMed Central
CAS
PubMed
Google Scholar
Green MJ, Gough AK, Devlin J, Smith J, Astin P, Taylor D, Emery P: Serum MMP-3 and MMP-1 and progression of joint damage in early rheumatoid arthritis. Rheumatology (Oxford). 2003, 42: 83-88. 10.1093/rheumatology/keg037.
Article
CAS
Google Scholar
Yamanaka H, Matsuda Y, Tanaka M, Sendo W, Nakajima H, Taniguchi A, Kamatani N: Serum matrix metalloproteinase 3 as a predictor of the degree of joint destruction during the six months after measurement, in patients with early rheumatoid arthritis. Arthritis Rheum. 2000, 43: 852-858. 10.1002/1529-0131(200004)43:4<852::AID-ANR16>3.0.CO;2-7.
Article
CAS
PubMed
Google Scholar
Litinsky I, Paran D, Levartovsky D, Wigler I, Kaufman I, Yaron I, Yaron M, Caspi D, Elkayam O: The effects of leflunomide on clinical parameters and serum levels of IL-6, IL-10, MMP-1 and MMP-3 in patients with resistant rheumatoid arthritis. Cytokine. 2006, 33: 106-110. 10.1016/j.cyto.2005.12.009.
Article
CAS
PubMed
Google Scholar
Catrina AI, Lampa J, Ernestam S, af Klint E, Bratt J, Klareskog L, Ulfgren AK: Anti-tumour necrosis factor (TNF)-alpha therapy (etanercept) down-regulates serum matrix metalloproteinase (MMP)-3 and MMP-1 in rheumatoid arthritis. Rheumatology (Oxford). 2002, 41: 484-489. 10.1093/rheumatology/41.5.484.
Article
CAS
Google Scholar
Klimiuk PA, Sierakowski S, Domyslawska I, Chwiecko J: Effect of repeated infliximab therapy on serum matrix metallopro-teinases and tissue inhibitors of metalloproteinases in patients with rheumatoid arthritis [abstract]. J Rheumatol. 2004, 31: 238-242.
CAS
PubMed
Google Scholar
Kurz B, Lemke AK, Fay J, Pufe T, Grodzinsky AJ, Schunke M: Pathomechanisms of cartilage destruction by mechanical injury. Ann Anat. 2005, 187: 473-485.
Article
CAS
PubMed
Google Scholar
Smith GN: The role of collagenolytic matrix metalloproteinases in the loss of articular cartilage in osteoarthritis. Front Biosci. 2006, 11: 3081-3095. 10.2741/2034.
Article
CAS
PubMed
Google Scholar
Yasuda T: Cartilage destruction by matrix degradation products. Mod Rheumatol. 2006, 16: 197-205. 10.1007/s10165-006-0490-6.
Article
PubMed Central
CAS
PubMed
Google Scholar
Wu CW, Tchetina EV, Mwale F, Hasty K, Pidoux I, Reiner A, Chen J, Van Wart HE, Poole AR: Proteolysis involving matrix metalloproteinase 13 (collagenase-3) is required for chondrocyte differentiation that is associated with matrix mineralization. J Bone Miner Res. 2002, 17: 639-651. 10.1359/jbmr.2002.17.4.639.
Article
CAS
PubMed
Google Scholar
Kevorkian L, Young DA, Darrah C, Donell ST, Shepstone L, Porter S, Brockbank SM, Edwards DR, Parker AE, Clark IM: Expression profiling of metalloproteinases and their inhibitors in cartilage. Arthritis Rheum. 2004, 50: 131-141. 10.1002/art.11433.
Article
CAS
PubMed
Google Scholar
Malemud CJ, Islam N, Haqqi TM: Pathophysiological mechanisms in osteoarthritis lead to novel therapeutic strategies. Cells Tissues Organs. 2003, 174: 34-48. 10.1159/000070573.
Article
PubMed
Google Scholar
Dean DD, Martel-Pelletier J, Pelletier JP, Howell DS, Woessner JF: Evidence for metalloproteinase and metalloproteinase inhibitor imbalance in human osteoarthritic cartilage [abstract]. J Clin Invest. 1989, 84: 678-685.
Article
PubMed Central
CAS
PubMed
Google Scholar
Huang W, Schwarz EM: Mechanisms of bone resorption and new bone formation in spondyloarthropathies. Curr Rheumatol Rep. 2002, 4: 513-517. 10.1007/s11926-002-0059-0.
Article
PubMed
Google Scholar
Chen CH, Lin KC, Yu DT, Yang C, Huang F, Chen HA, Liang TH, Liao HT, Tsai CY, Wei JC, et al: Serum matrix metalloproteinases and tissue inhibitors of metalloproteinases in ankylosing spondylitis: MMP-3 is a reproducibly sensitive and specific biomarker of disease activity. Rheumatology (Oxford). 2006, 45: 414-420. 10.1093/rheumatology/kei208.
Article
CAS
Google Scholar
Vandooren B, Kruithof E, Yu DT, Rihl M, Gu J, De Rycke L, Van Den Bosch F, Veys EM, De Keyser F, Baeten D: Involvement of matrix metalloproteinases and their inhibitors in peripheral synovitis and down-regulation by tumor necrosis factor alpha blockade in spondylarthropathy. Arthritis Rheum. 2004, 50: 2942-2953. 10.1002/art.20477.
Article
CAS
PubMed
Google Scholar
Braun J, Baraliakos X, Yelder C, Seemeyer C, Gay R, Boehm H, Gay S, Neidhart M: Clinical and histopathological findings in patients with ankylosing spondylitis before and after surgical treatment for axis correction and erection of the spine [abstract]. Arthritis Rheum. 2006, 54 (Suppl): S466-
Google Scholar
Hidalgo M, Eckhardt SG: Development of matrix metalloproteinase inhibitors in cancer therapy. J Natl Cancer Inst. 2001, 93: 178-193. 10.1093/jnci/93.3.178.
Article
CAS
PubMed
Google Scholar
Murphy G, Lee MH: What are the roles of metalloproteinases in cartilage and bone damage?. Ann Rheum Dis. 2005, 64 (Suppl 4): iv44-iv47. 10.1136/ard.2005.042465.
PubMed Central
CAS
PubMed
Google Scholar
Yip D, Ahmad A, Karapetis CS, Hawkins CA, Harper PG: Matrix metalloproteinase inhibitors: applications in oncology. Invest New Drugs. 1999, 17: 387-399. 10.1023/A:1006386406584.
Article
CAS
PubMed
Google Scholar
Bissett D, O'Byrne KJ, von Pawel J, Gatzemeier U, Price A, Nicolson M, Mercier R, Mazabel E, Penning C, Zhang MH, et al: Phase III study of matrix metalloproteinase inhibitor prinomastat in non-small-cell lung cancer. J Clin Oncol. 2005, 23: 842-849. 10.1200/JCO.2005.03.170.
Article
CAS
PubMed
Google Scholar
Heath EI, Burtness BA, Kleinberg L, Salem RR, Yang SC, et al: Phase II, parallel-design study of preoperative combined modality therapy and the matrix metalloprotease (MMP) inhibitor prinomastat in patients with esophageal adenocarcinoma. Invest New Drugs. 2006, 24: 135-140. 10.1007/s10637-006-5934-5.
Article
CAS
PubMed
Google Scholar
Leighl NB, Paz-Ares L, Douillard JY, Peschel C, Arnold A, Depierre A, Santoro A, Betticher DC, Gatzemeier U, Jassem J, et al: Randomized phase III study of matrix metalloproteinase inhibitor BMS-275291 in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: National Cancer Institute of Canada-Clinical Trials Group Study BR.18. J Clin Oncol. 2005, 23: 2831-2839. 10.1200/JCO.2005.04.044.
Article
CAS
PubMed
Google Scholar
Hirte H, Vergote IB, Jeffrey JR, Grimshaw RN, Coppieters S, Schwartz B, Tu D, Sadura A, Brundage M, Seymour L: A phase III randomized trial of BAY 12–9566 (tanomastat) as maintenance therapy in patients with advanced ovarian cancer responsive to primary surgery and paclitaxel/platinum containing chemotherapy: a National Cancer Institute of Canada Clinical Trials Group Study. Gynecol Oncol. 2006, 102: 300-308. 10.1016/j.ygyno.2005.12.020.
Article
CAS
PubMed
Google Scholar
Brewster M, Lewis EJ, Wilson KL, Greenham AK, Bottomley KM: Ro 32-an orally active collagenase selective inhibitor, prevents structural damage in the STR/ORT mouse model of osteoarthritis [abstract]. Arthritis Rheum. 1998, 41: 1639-1644. 10.1002/1529-0131(199809)41:9<1639::AID-ART15>3.0.CO;2-0.
Article
CAS
PubMed
Google Scholar
Hemmings FJ, Farhan M, Rowland J, Banken L, Jain R: Tolerability and pharmacokinetics of the collagenase-selective inhibitor Trocade in patients with rheumatoid arthritis. Rheumatology (Oxford). 2001, 40: 537-543. 10.1093/rheumatology/40.5.537.
Article
CAS
Google Scholar
Brandt KD, Mazzuca SA, Katz BP, Lane KA, Buckwalter KA, Yocum DE, Wolfe F, Schnitzer TJ, Moreland LW, Manzi S, et al: Effects of doxycycline on progression of osteoarthritis: results of a randomized, placebo-controlled, double-blind trial. Arthritis Rheum. 2005, 52: 2015-2025. 10.1002/art.21122.
Article
CAS
PubMed
Google Scholar
Moritz F, Distler O, Ospelt C, Gay RE, Gay S: Technology insight: gene transfer and the design of novel treatments for rheumatoid arthritis. Nat Clin Pract Rheumatol. 2006, 2: 153-162. 10.1038/ncprheum0117.
Article
PubMed
Google Scholar
Schedel J, Seemayer CA, Pap T, Neidhart M, Kuchen S, Michel BA, Gay RE, Muller-Ladner U, Gay S, Zacharias W: Targeting cathepsin L (CL) by specific ribozymes decreases CL protein synthesis and cartilage destruction in rheumatoid arthritis. Gene Ther. 2004, 11: 1040-1047. 10.1038/sj.gt.3302265.
Article
CAS
PubMed
Google Scholar
Rutkauskaite E, Zacharias W, Schedel J, Muller-Ladner U, Mawrin C, Seemayer CA, Alexander D, Gay RE, Aicher WK, Michel BA: Ribozymes that inhibit the production of matrix metalloproteinase 1 reduce the invasiveness of rheumatoid arthritis synovial fibroblasts. Arthritis Rheum. 2004, 50: 1448-1456. 10.1002/art.20186.
Article
CAS
PubMed
Google Scholar
van der Laan WH, Pap T, Ronday HK, Grimbergen JM, Huisman LG, TeKoppele JM, Breedveld FC, Gay RE, Gay S, Huizinga TW, et al: Cartilage degradation and invasion by rheumatoid synovial fibroblasts is inhibited by gene transfer of a cell surface-targeted plasmin inhibitor. Arthritis Rheum. 2000, 43: 1710-1718. 10.1002/1529-0131(200008)43:8<1710::AID-ANR6>3.0.CO;2-Y.
Article
CAS
PubMed
Google Scholar
van der Laan WH, Quax PH, Seemayer CA, Huisman LG, Pieterman EJ, Grimbergen JM, Verheijen JH, Breedveld FC, Gay S: Cartilage degradation and invasion by rheumatoid synovial fibroblasts is inhibited by gene transfer of TIMP-1 and TIMP-3. Gene Ther. 2003, 10: 234-242. 10.1038/sj.gt.3301871.
Article
CAS
PubMed
Google Scholar