Woolf AD, Pfleger B: Burden of major musculoskeletal conditions. Bull World Health Organ. 2003, 81: 646-656.
PubMed Central
PubMed
Google Scholar
Bonnet CS, Walsh DA: Osteoarthritis, angiogenesis and inflammation. Rheumatology. 2005, 44: 7-16. 10.1093/rheumatology/keh344.
Article
CAS
PubMed
Google Scholar
Haywood L, McWilliams DF, Pearson CI, Gill SE, Ganesan A, Wilson D, Walsh DA: Inflammation and angiogenesis in osteoarthritis. Arthritis Rheum. 2003, 48: 2173-2177. 10.1002/art.11094.
Article
CAS
PubMed
Google Scholar
Sowers M, Jannausch M, Stein E, Jamadar D, Hochberg M, Lachance L: C-reactive protein as a biomarker of emergent osteoarthritis. Osteoarthr Cartil. 2002, 10: 595-601. 10.1053/joca.2002.0800.
Article
PubMed
Google Scholar
Spector TD, Hart DJ, Nandra D, Doyle DV, Mackillop N, Gallimore JR, Pepys MB: Low-level increases in serum C-reactive protein are present in early osteoarthritis of the knee and predict progressive disease. Arthritis Rheum. 1997, 40: 723-727. 10.1002/art.1780400419.
Article
CAS
PubMed
Google Scholar
Lee DM, Weinblatt ME: Rheumatoid arthritis. Lancet North Am Ed. 2001, 358: 903-911.
Article
CAS
Google Scholar
Feldmann M, Brennan FM, Maini RN: Role of cytokines in rheumatoid arthritis. Annu Rev Immunol. 1996, 14: 397-440. 10.1146/annurev.immunol.14.1.397.
Article
CAS
PubMed
Google Scholar
Mackie K: Cannabinoid receptors as therapeutic targets. Annu Rev Pharmacol Toxicol. 2006, 46: 101-122. 10.1146/annurev.pharmtox.46.120604.141254.
Article
CAS
PubMed
Google Scholar
Croxford JL, Yamamura T: Cannabinoids and the immune system: potential for the treatment of inflammatory diseases?. J Neuroimmunol. 2005, 166: 3-18. 10.1016/j.jneuroim.2005.04.023.
Article
CAS
PubMed
Google Scholar
Elmes SJR, Jhaveri MD, Smart D, Kendall DA, Chapman V: Cannabinoid CB2 receptor activation inhibits mechanically evoked responses of wide dynamic range dorsal horn neurons in naive rats and in rat models of inflammatory and neuropathic pain. Eur J Neurosci. 2004, 20: 2311-2320. 10.1111/j.1460-9568.2004.03690.x.
Article
PubMed
Google Scholar
Elmes SJR, Winyard LA, Medhurst SJ, Clayton NM, Wilson AW, Kendall DA, Chapman V: Activation of CB1 and CB2 receptors attenuates the induction and maintenance of inflammatory pain in the rat. Pain. 2005, 118: 327-335. 10.1016/j.pain.2005.09.005.
Article
CAS
PubMed
Google Scholar
Nackley AG, Zvonok AM, Makriyannis A, Hohmann AG: Activation of cannabinoid CB2 receptors suppresses C-fiber responses and windup in spinal wide dynamic range neurons in the absence and presence of inflammation. J Neurophysiol. 2004, 92: 3562-3574. 10.1152/jn.00886.2003.
Article
CAS
PubMed
Google Scholar
Quartilho A, Mata HP, Ibrahim MM, Vanderah TW, Porreca F, Makriyannis A, Malan TP: Inhibition of inflammatory hyperalgesia by activation of peripheral CB2 cannabinoid receptors. Anesthesiology. 2003, 99: 955-960. 10.1097/00000542-200310000-00031.
Article
CAS
PubMed
Google Scholar
Smith FL, Fujimori K, Lowe J, Welch SP: Characterization of [Delta]9-tetrahydrocannabinol and anandamide antinociception in nonarthritic and arthritic rats. Pharmacol Biochem Behav. 1998, 60: 183-191. 10.1016/S0091-3057(97)00583-2.
Article
CAS
PubMed
Google Scholar
Blake DR, Robson P, Ho M, Jubb RW, McCabe CS: Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis. Rheumatology. 2006, 45: 50-52. 10.1093/rheumatology/kei183.
Article
CAS
PubMed
Google Scholar
Pertwee RG, Ross RA: Cannabinoid receptors and their ligands. Prostaglandins Leukot Essent Fatty Acids. 2002, 66: 101-121. 10.1054/plef.2001.0341.
Article
CAS
PubMed
Google Scholar
Klein TW, Lane B, Newton CA, Friedman H: The cannabinoid system and cytokine network. Exp Biol Med. 2000, 225: 1-8. 10.1046/j.1525-1373.2000.22501.x.
Article
CAS
Google Scholar
Devane WA, Hanus L, Breuer A, Pertwee RG, Stevenson LA, Griffin G, Gibson D, Mandelbaum A, Etinger A, Mechoulam R: Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science. 1992, 258: 1946-1949. 10.1126/science.1470919.
Article
CAS
PubMed
Google Scholar
Sugiura T, Kondo S, Sukagawa A, Nakane S, Sindo A, Itoh K, Yamashita A, Waku K: 2-arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain. Biochem Biophys Res Commun. 1995, 215: 89-97. 10.1006/bbrc.1995.2437.
Article
CAS
PubMed
Google Scholar
Mechoulam R, Fride E, Di Marzo V: Endocannabinoids. Eur J Pharmacol. 1998, 359: 1-18. 10.1016/S0014-2999(98)00649-9.
Article
CAS
PubMed
Google Scholar
Lambert DM, Di Marzo V: The palmitoylethanolamide and oleamide enigmas: are these two fatty acid amides cannabimimetic?. Curr Med Chem. 1999, 6: 757-773.
CAS
PubMed
Google Scholar
Cravatt BF, Demarest K, Patricelli MP, Bracey MH, Giang DK, Martin BR, Lichtman AH: Supersensitivity to anandamide and enhanced endogenous cannabinoid signalling in mice lacking fatty acid amide hydrolase. Proc Natl Acad Sci USA. 2001, 98: 9371-9376. 10.1073/pnas.161191698.
Article
PubMed Central
CAS
PubMed
Google Scholar
Jhaveri MD, Richardson D, Chapman V: Endocannabinoid metabolism and uptake: novel targets for neuropathic and inflammatory pain. Br J Pharmacol. 2007, 152: 624-632. 10.1038/sj.bjp.0707433.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ofek O, Karsak M, Leclerc N, Fogel M, Frenkel B, Wright K, Tam J, Attar-Namdar M, Kram V, Shohami E, Mechoulam R, Zimmer A, Bab I: Peripheral cannabinoid receptor, CB2, regulates bone mass. Proc Natl Acad Sci USA. 2006, 103: 696-701. 10.1073/pnas.0504187103.
Article
PubMed Central
CAS
PubMed
Google Scholar
Idris AI, van 't Hof RJ, Greig IR, Ridge SA, Baker D, Ross RA, Ralston SH: Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors. Nat Med. 2005, 11: 774-779. 10.1038/nm1255.
Article
PubMed Central
CAS
PubMed
Google Scholar
Fowler CJ, Holt S, Tiger G: Acidic nonsteroidal anti-inflammatory drugs inhibit rat brain fatty acid amide hydrolase in a pH-dependent manner. J Enzyme Inhib Med Chem. 2003, 18: 55-58. 10.1080/1475636021000049726.
Article
CAS
PubMed
Google Scholar
Fowler CJ, Janson U, Johnson RM, Wahlstrom G, Stenstrom A, Norstrom K, Tiger G: Inhibition of anandamide hydrolysis by the enantiomers of ibuprofen, ketorolac, and flurbiprofen. Arch Biochem Biophys. 1999, 362: 191-196. 10.1006/abbi.1998.1025.
Article
CAS
PubMed
Google Scholar
Guindon J, Beaulieu P: Antihyperalgesic effects of local injections of anandamide, ibuprofen, rofecoxib and their combinations in a model of neuropathic pain. Neuropharmacology. 2006, 50: 814-823. 10.1016/j.neuropharm.2005.12.002.
Article
CAS
PubMed
Google Scholar
Kellgren JH, Lawrence JS: Osteo-arthrosis and disk degeneration in an urban population. Ann Rheum Dis. 1958, 17: 388-397.
Article
PubMed Central
CAS
PubMed
Google Scholar
Larsen A: How to apply Larsen score in evaluating radiographs of rheumatoid arthritis in long-term studies. J Rheumatol. 1995, 22: 1974-1975.
CAS
PubMed
Google Scholar
Richardson D, Ortori CA, Chapman V, Kendall DA, Barrett DA: Quantitative profiling of endocannabinoids and related compounds in rat brain using liquid chromatography-tandem electrospray ionization mass spectrometry. Anal Biochem. 2007, 360: 216-226. 10.1016/j.ab.2006.10.039.
Article
CAS
PubMed
Google Scholar
Lowry OH, Rosebrough NJ, Farr AL, Randall RJ: Protein measurement with the folin phenol reagent. J Biol Chem. 1951, 193: 265-275.
CAS
PubMed
Google Scholar
Boldrup L, Wilson SJ, Barbier AJ, Fowler CJ: A simple stopped assay for fatty acid amide hydrolase avoiding the use of a chloroform extraction phase. J Biochem Biophys Methods. 2004, 60: 171-177. 10.1016/j.jbbm.2004.04.020.
Article
CAS
PubMed
Google Scholar
Holt S, Comelli F, Costa B, Fowler CJ: Inhibitors of fatty acid amide hydrolase reduce carrageenan-induced hind paw inflammation in pentobarbital-treated mice: comparison with indomethacin and possible involvement of cannabinoid receptors. Br J Pharmacol. 2005, 146: 467-476. 10.1038/sj.bjp.0706348.
Article
PubMed Central
CAS
PubMed
Google Scholar
Don RH, Cox PT, Wainwright BJ, Baker K, Mattick JS: 'Touchdown' PCR to circumvent spurious priming during gene amplification. Nucleic Acids Res. 1991, 19: 4008-10.1093/nar/19.14.4008.
Article
PubMed Central
CAS
PubMed
Google Scholar
Matias I, Pochard P, Orlando P, Salzet M, Pestel J, Di Marzo V: Presence and regulation of the endocannabinoid system in human dendritic cells. Eur J Biochem. 2002, 269: 3771-3778. 10.1046/j.1432-1033.2002.03078.x.
Article
CAS
PubMed
Google Scholar
Porcella A, Marchese G, Casu MA, Rocchitta A, Lai ML, Gessa GL, Pani L: Evidence for functional CB1 cannabinoid receptor expressed in the rat thyroid. Eur J Endocrinol. 2002, 147: 255-261. 10.1530/eje.0.1470255.
Article
CAS
PubMed
Google Scholar
Song C, Howlett AC: Rat brain cannabinoid receptors are N-linked glycosylated proteins. Life Sci. 1995, 56: 1983-1989. 10.1016/0024-3205(95)00179-A.
Article
CAS
PubMed
Google Scholar
Wager-Miller J, Westenbroek R, Mackie K: Dimerization of G protein-coupled receptors: CB1 cannabinoid receptors as an example. Chem Phys Lipids. 2002, 121: 83-89. 10.1016/S0009-3084(02)00151-2.
Article
CAS
PubMed
Google Scholar
Van Sickle MD, Duncan M, Kingsley PJ, Mouihate A, Urbani P, Mackie K, Stella N, Makriyannis A, Piomelli D, Davison JS, Marnett LJ, Di Marzo V, Pittman QJ, Patel KD, Sharkey KA: Identification and functional characterization of brainstem cannabinoid CB2 receptors. Science. 2005, 310: 329-332. 10.1126/science.1115740.
Article
CAS
PubMed
Google Scholar
Klegeris A, Bissonnette CJ, McGeer PL: Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor. Br J Pharmacol. 2003, 139: 775-786. 10.1038/sj.bjp.0705304.
Article
PubMed Central
CAS
PubMed
Google Scholar
De Bank PA, Kendall DA, Alexander SP: A spectrophotometric assay for fatty acid amide hydrolase suitable for high-throughput screening. Biochem Pharmacol. 2005, 69: 1187-1193. 10.1016/j.bcp.2005.01.012.
Article
CAS
PubMed
Google Scholar
Mor M, Rivara S, Lodola A, Plazzi PV, Tarzia G, Duranti A, Tontini A, Piersanti G, Kathuria S, Piomelli D: Cyclohexylcarbamic acid 3'- or 4'-substituted biphenyl-3-yl esters as fatty acid amide hydrolase inhibitors: synthesis, quantitative structure-activity relationships, and molecular modeling studies. J Med Chem. 2004, 47: 4998-5008. 10.1021/jm031140x.
Article
CAS
PubMed
Google Scholar
Baeten D, Demetter P, Cuvelier C, Bosch Van den F, Kruithof E, Van Damme N, Verbruggen G, Mielants H, Veys EM, De Keyser F: Comparative study of the synovial histology in rheumatoid arthritis, spondyloarthropathy, and osteoarthritis: influence of disease duration and activity. Ann Rheum Dis. 2000, 59: 945-953. 10.1136/ard.59.12.945.
Article
PubMed Central
CAS
PubMed
Google Scholar
Bresnihan B, Cunnane G, Youssef P, Yanni G, Fitzgerald O, Mulherin D: Microscopic measurement of synovial membrane inflammation in rheumatoid arthritis: proposals for the evaluation of tissue samples by quantitative analysis. Br J Rheumatol. 1998, 37: 636-642. 10.1093/rheumatology/37.6.636.
Article
CAS
PubMed
Google Scholar
Farahat MN, Yanni G, Poston R, Panayi GS: Cytokine expression in synovial membranes of patients with rheumatoid arthritis and osteoarthritis. Ann Rheum Dis. 1993, 52: 870-875.
Article
PubMed Central
CAS
PubMed
Google Scholar
Tak PP, Thurkow EW, Daha MR, Kluin PM, Smeets TJM, Meinders AE, Breedveld FC: Expression of adhesion molecules in early rheumatoid synovial tissue. Clin Immunol Immunopathol. 1995, 77: 236-242. 10.1006/clin.1995.1149.
Article
CAS
PubMed
Google Scholar
Maini RN, Taylor PC, Szechinski J, Pavelka K, Bröll J, Balint G, Emery P, Raemen F, Petersen J, Smolen J, Thomson D, Kishimoto T, CHARISMA Study Group: Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate. Arthritis Rheum. 2006, 54: 2817-2829. 10.1002/art.22033.
Article
CAS
PubMed
Google Scholar
Kotake S, Sato K, Kim KJ, Takahashi N, Udagawa N, Nakamura I, Yamaguchi A, Kishimoto T, Suda T, Kashiwazaki S: Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation. J Bone Miner Res. 1996, 11: 88-95.
Article
CAS
PubMed
Google Scholar
Manicourt DH, Poilvache P, Van Egeren A, Devogelaer JP, Lenz ME, Thonar EJ: Synovial fluid levels of tumor necrosis factor alpha and oncostatin M correlate with levels of markers of the degradation of crosslinked collagen and cartilage aggrecan in rheumatoid arthritis but not in osteoarthritis. Arthritis Rheum. 2000, 43: 281-288. 10.1002/1529-0131(200002)43:2<281::AID-ANR7>3.0.CO;2-7.
Article
CAS
PubMed
Google Scholar
Raza K, Falciani F, Curnow SJ, Ross E, Lee CY, Akbar A, Lord J, Gordon C, Buckley C, Salmon M: Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin. Arthritis Res Ther. 2005, 7: R784-795. 10.1186/ar1733.
Article
PubMed Central
CAS
PubMed
Google Scholar
McNearney T, Baethge BA, Cao S, Alam R, Lisse JR, Westlund KN: Excitatory amino acids, TNF-alpha, and chemokine levels in synovial fluids of patients with active arthropathies. Clin Exp Immunol. 2004, 137: 621-627. 10.1111/j.1365-2249.2004.02563.x.
Article
PubMed Central
CAS
PubMed
Google Scholar
Drew LJ, Harris J, Millns PJ, Kendall DA, Chapman V: Activation of spinal cannabinoid 1 receptors inhibits C-fibre driven hyperexcitable neuronal responses and increases [35S]GTPgammaS binding in the dorsal horn of the spinal cord of noninflamed and inflamed rats. Eur J Neurosci. 2000, 12: 2079-2086. 10.1046/j.1460-9568.2000.00101.x.
Article
CAS
PubMed
Google Scholar
Finn DP, Jhaveri MD, Beckett SRG, Roe CH, Kendall DA, Marsden CA, Chapman V: Effects of direct periaqueductal grey administration of a cannabinoid receptor agonist on nociceptive and aversive responses in rats. Neuropharmacology. 2003, 45: 594-604. 10.1016/S0028-3908(03)00235-1.
Article
CAS
PubMed
Google Scholar
Kelly S, Chapman V: Cannabinoid CB1 receptor inhibition of mechanically evoked responses of spinal neurones in control rats, but not in rats with hindpaw inflammation. Eur J Pharmacol. 2003, 474: 209-216. 10.1016/S0014-2999(03)02085-5.
Article
CAS
PubMed
Google Scholar
LoVerme J, Fu J, Astarita G, La Rana G, Russo R, Calignano A, Piomelli D: The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide. Mol Pharmacol. 2005, 67: 15-19. 10.1124/mol.104.006353.
Article
CAS
Google Scholar
Lambert DM, Vandevoorde S, Jonsson KO, Fowler CJ: The palmitoylethanolamide family: a new class of anti-inflammatory agents?. Curr Med Chem. 2002, 9: 663-674.
Article
CAS
PubMed
Google Scholar
Fegley D, Gaetani S, Duranti A, Tontini A, Mor M, Tarzia G, Piomelli D: Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation. J Pharmacol Exp Ther. 2005, 313: 352-358. 10.1124/jpet.104.078980.
Article
CAS
PubMed
Google Scholar
Haynes MK, Hume EL, Smith JB: Phenotypic characterization of inflammatory cells from osteoarthritic synovium and synovial fluids. Clin Immunol. 2002, 105: 315-325. 10.1006/clim.2002.5283.
Article
CAS
PubMed
Google Scholar
Smeets TJ, Dolhain RJ, Breedveld FC, Tak PP: Analysis of the cellular infiltrates and expression of cytokines in synovial tissue from patients with rheumatoid arthritis and reactive arthritis. J Pathol. 1998, 186: 75-81. 10.1002/(SICI)1096-9896(199809)186:1<75::AID-PATH142>3.0.CO;2-B.
Article
CAS
PubMed
Google Scholar
Deutsch DG, Goligorsky MS, Schmid PC, Krebsbach RJ, Schmid HH, Das SK, Dey SK, Arreaza G, Thorup C, Stefano G, Moore LC: Production and physiological actions of anandamide in the vasculature of the rat kidney. J Clin Invest. 1997, 100: 1538-1546. 10.1172/JCI119677.
Article
PubMed Central
CAS
PubMed
Google Scholar
Sugiura T, Kodaka T, Nakane S, Kishimoto S, Kondo S, Waku K: Detection of an endogenous cannabimimetic molecule, 2-Arachidonoylglycerol, and cannabinoid CB1 receptor mRNA in human vascular cells: is 2-Arachidonoylglycerol a possible vasomodulator?. Biochem Biophys Res Commun. 1998, 243: 838-843. 10.1006/bbrc.1998.8187.
Article
CAS
PubMed
Google Scholar
Maruotti N, Cantatore FP, Crivellato E, Vacca A, Ribatti D: Angiogenesis in rheumatoid arthritis. Histol Histopathol. 2006, 21: 557-566.
CAS
PubMed
Google Scholar
Casanova ML, Blázquez C, Martínez-Palacio J, Villanueva C, Fernández-Aceñero MJ, Huffman JW, Jorcano JL, Guzmán M: Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. J Clin Invest. 2003, 111: 43-50.
Article
PubMed Central
CAS
PubMed
Google Scholar