Maroudas A, Stockwell RA, Nachemson A, Urban J: Factors involved in the nutrition of the human lumbar intervertebral disc: cellularity and diffusion of glucose in vitro. J Anat. 1975, 120: 113-130.
PubMed Central
CAS
PubMed
Google Scholar
Gruber HE, Hanley EN: Analysis of aging and degeneration of the human intervertebral disc. Comparison of surgical specimens with normal controls. Spine. 1998, 23: 751-757. 10.1097/00007632-199804010-00001.
Article
CAS
PubMed
Google Scholar
Boos N, Weissbach S, Rohrbach H, Weiler C, Spratt KF, Nerlich AG: Classification of age-related changes in lumbar intervertebral discs: 2002 Volvo Award in basic science. Spine. 2002, 27: 2631-2644. 10.1097/00007632-200212010-00002.
Article
PubMed
Google Scholar
Johnson WE, Eisenstein SM, Roberts S: Cell cluster formation in degenerate lumbar intervertebral discs is associated with increased disc cell proliferation. Connect Tissue Res. 2001, 42: 197-207. 10.3109/03008200109005650.
Article
CAS
PubMed
Google Scholar
Johnson WE, Roberts S: Human intervertebral disc cell morphology and cytoskeletal composition: a preliminary study of regional variations in health and disease. J Anat. 2003, 203: 605-612. 10.1046/j.1469-7580.2003.00249.x.
Article
PubMed Central
CAS
PubMed
Google Scholar
Roberts S, Evans EH, Kletsas D, Jaffray DC, Eisenstein SM: Senescence in human intervertebral discs. Eur Spine J. 2006, 15: S312-316. 10.1007/s00586-006-0126-8.
Article
PubMed
Google Scholar
Gruber HE, Ingram JA, Norton HJ, Hanley EN: Senescence in cells of the aging and degenerating intervertebral disc: immunolocalization of senescence-associated beta-galactosidase in human and sand rat discs. Spine. 2007, 32: 321-327. 10.1097/01.brs.0000253960.57051.de.
Article
PubMed
Google Scholar
Le Maitre CL, Freemont AJ, Hoyland JA: Accelerated cellular senescence in degenerate intervertebral discs: a possible role in the pathogenesis of intervertebral disc degeneration. Arthritis Res Ther. 2007, 9: R45-10.1186/ar2198.
Article
PubMed Central
PubMed
Google Scholar
Urban JP, Smith S, Fairbank JC: Nutrition of the intervertebral disc. Spine. 2004, 29: 2700-2709. 10.1097/01.brs.0000146499.97948.52.
Article
PubMed
Google Scholar
Grunhagen T, Wilde G, Soukane DM, Shirazi-Adl SA, Urban JP: Nutrient supply and intervertebral disc metabolism. J Bone Joint Surg Am. 2006, 88: 30-35. 10.2106/JBJS.E.01290.
Article
PubMed
Google Scholar
Kauppila LI, McAlindon T, Evans S, Wilson PW, Kiel D, Felson DT: Disc degeneration/back pain and calcification of the abdominal aorta. A 25-year follow-up study in Framingham. Spine. 1997, 22: 1642-1647. 10.1097/00007632-199707150-00023.
Article
CAS
PubMed
Google Scholar
Holm S, Nachemson A: Nutrition of the intervertebral disc: acute effects of cigarette smoking. An experimental animal study. Ups J Med Sci. 1988, 93: 91-99.
CAS
PubMed
Google Scholar
Ziv I, Moskowitz RW, Kraise I, Adler JH, Maroudas A: Physicochemical properties of the aging and diabetic sand rat intervertebral disc. J Orthop Res. 1992, 10: 205-210. 10.1002/jor.1100100207.
Article
CAS
PubMed
Google Scholar
Robinson D, Mirovsky Y, Halperin N, Evron Z, Nevo Z: Changes in proteoglycans of intervertebral disc in diabetic patients. A possible cause of increased back pain. Spine. 1998, 23: 849-855. 10.1097/00007632-199804150-00001.
Article
CAS
PubMed
Google Scholar
Videman T, Battié MC, Gibbons LE, Kaprio J, Koskenvuo M, Kannus P, Raininko R, Manninen H: Disc degeneration and bone density in monozygotic twins discordant for insulin-dependent diabetes mellitus. J Orthop Res. 2000, 18: 768-772. 10.1002/jor.1100180514.
Article
CAS
PubMed
Google Scholar
Roberts S, Urban JP, Evans H, Eisenstein SM: Transport properties of the human cartilage endplate in relation to its composition and calcification. Spine. 1996, 21: 415-420. 10.1097/00007632-199602150-00003.
Article
CAS
PubMed
Google Scholar
Kauppila LI: Ingrowth of blood vessels in disc degeneration. Angiographic and histological studies of cadaveric spines. J Bone Joint Surg Am. 1995, 77: 26-31.
CAS
PubMed
Google Scholar
Johnson WE, Evans H, Menage J, Eisenstein SM, El Haj A, Roberts S: Immunohistochemical detection of Schwann cells in innervated and vascularized human intervertebral discs. Spine. 2001, 26: 2550-2557. 10.1097/00007632-200112010-00007.
Article
CAS
PubMed
Google Scholar
Nerlich AG, Schaaf R, Wälchli B, Boos N: Temporo-spatial distribution of blood vessels in human lumbar intervertebral discs. Eur Spine J. 2007, 16: 547-555. 10.1007/s00586-006-0213-x.
Article
PubMed Central
PubMed
Google Scholar
Pai RR, D'sa B, Raghuveer CV, Kamath A: Neovascularization of nucleus pulposus. A diagnostic feature of intervertebral disc prolapse. Spine. 1999, 24: 739-741. 10.1097/00007632-199904150-00002.
Article
CAS
PubMed
Google Scholar
Ozaki S, Muro T, Ito S, Mizushima M: Neovascularization of the outermost area of herniated lumbar intervertebral discs. J Orthop Sci. 1999, 4: 286-292. 10.1007/s007760050105.
Article
CAS
PubMed
Google Scholar
Johnson WE, Wootton A, El Haj A, Eisenstein SM, Curtis AS, Roberts S: Topographical guidance of intervertebral disc cell growth in vitro : towards the development of tissue repair strategies for the anulus fibrosus. Eur Spine J. 2006, 15: S389-396. 10.1007/s00586-006-0125-9.
Article
PubMed
Google Scholar
Benya PD, Shaffer JD: Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels. Cell. 1982, 30: 215-224. 10.1016/0092-8674(82)90027-7.
Article
CAS
PubMed
Google Scholar
Gargiulo BJ, Cragg P, Richardson JB, Ashton BA, Johnson WE: Phenotypic modulation of human articular chondrocytes by bistratene A. Eur Cell Mater. 2002, 3: 9-18.
CAS
PubMed
Google Scholar
Poole CA, Brookes NH, Clover GM: Keratocyte networks visualised in the living cornea using vital dyes. J Cell Sci. 1993, 106: 685-691.
PubMed
Google Scholar
Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, Medrano EE, Linskens M, Rubelj I, Pereira-Smith O, Peacocke M, Campisi J: A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA. 1995, 92: 9363-9367. 10.1073/pnas.92.20.9363.
Article
PubMed Central
CAS
PubMed
Google Scholar
Preston GA, Lang JE, Maronpot RR, Barrett JC: Regulation of apoptosis by low serum in cells of different stages of neoplastic progression: enhanced susceptibility after loss of a senescence gene and decreased susceptibility after loss of a tumor suppressor gene. Cancer Res. 1994, 54: 4214-4223.
CAS
PubMed
Google Scholar
Gos M, Miloszewska J, Swoboda P, Trembacz H, Skierski J, Janik P: Cellular quiescence induced by contact inhibition or serum withdrawal in C3H10T1/2 cells. Cell Prolif. 2005, 38: 107-116. 10.1111/j.1365-2184.2005.00334.x.
Article
CAS
PubMed
Google Scholar
Kumar CC: Signaling by integrin receptors. Oncogene. 1998, 17: 1365-1373. 10.1038/sj.onc.1202172.
Article
CAS
PubMed
Google Scholar
Qi J, Fox AM, Alexopoulos LG, Chi L, Bynum D, Guilak F, Banes AJ: IL-1beta decreases the elastic modulus of human tenocytes. J Appl Physiol. 2006, 101: 189-195. 10.1152/japplphysiol.01128.2005.
Article
CAS
PubMed
Google Scholar
Gruber HE, Norton HJ, Hanley EN: Anti-apoptotic effects of IGF-1 and PDGF on human intervertebral disc cells in vitro. Spine. 2000, 25: 2153-2157. 10.1097/00007632-200009010-00002.
Article
CAS
PubMed
Google Scholar
Zhao CQ, Liu D, Li H, Jiang LS, Dai LY: Interleukin-1beta enhances the effect of serum deprivation on rat annular cell apoptosis. Apoptosis. 2007, 12: 2155-2161. 10.1007/s10495-007-0137-x.
Article
CAS
PubMed
Google Scholar
Li H, Zou X, Baatrup A, Lind M, Bünger C: Cytokine profiles in conditioned media from cultured human intervertebral disc tissue. Implications of their effect on bone marrow stem cell metabolism. Acta Orthop. 2005, 76: 115-121. 10.1080/00016470510030436.
Article
PubMed
Google Scholar
Risbud MV, Guttapalli A, Stokes DG, Hawkins D, Danielson KG, Schaer TP, Albert TJ, Shapiro IM: Nucleus pulposus cells express HIF-1alpha under normoxic culture conditions: a metabolic adaptation to the intervertebral disc microenvironment. J Cell Biochem. 2006, 98: 152-159. 10.1002/jcb.20765.
Article
CAS
PubMed
Google Scholar
Lee DC, Adams CS, Albert TJ, Shapiro IM, Evans SM, Koch CJ: In situ oxygen utilization in the rat intervertebral disc. J Anat. 2007, 210: 294-303. 10.1111/j.1469-7580.2007.00692.x.
Article
PubMed Central
CAS
PubMed
Google Scholar
Bartels EM, Fairbank JC, Winlove CP, Urban JP: Oxygen and lactate concentrations measured in vivo in the intervertebral discs of patients with scoliosis and back pain. Spine. 1998, 23: 1-7. 10.1097/00007632-199801010-00001.
Article
CAS
PubMed
Google Scholar
Takuma S, Hirashima C, Piret JM: Dependence on glucose limitation of the pCO2 influences on CHO cell growth, metabolism and IgG production. Biotechnol Bioeng. 2007, 97: 1479-1488. 10.1002/bit.21376.
Article
CAS
PubMed
Google Scholar
Hehenberger K, Hansson A: High glucose-induced growth factor resistance in human fibroblasts can be reversed by antioxidants and protein kinase C-inhibitors. Cell Biochem Funct. 1997, 15: 197-201. 10.1002/(SICI)1099-0844(199709)15:3<197::AID-CBF740>3.0.CO;2-7.
Article
CAS
PubMed
Google Scholar