Heijde van der DM, van Leeuwen MA, van Riel PL, Koster AM, van't Hof MA, van Rijswijk MH, Putte van de LB: Biannual radiographic assessments of hands and feet in a three-year prospective followup of patients with early rheumatoid arthritis. Arthritis Rheum. 1992, 35: 26-34. 10.1002/art.1780350105.
Article
PubMed
Google Scholar
Plant MJ, Jones PW, Saklatvala J, Ollier WE, Dawes PT: Patterns of radiological progression in early rheumatoid arthritis: results of an 8 year prospective study. J Rheumatol. 1998, 25: 417-426.
CAS
PubMed
Google Scholar
Masi AT: Articular patterns in the early course of rheumatoid arthritis. Am J Med. 1983, 75 (6A): 16-26. 10.1016/0002-9343(83)90471-0.
Article
CAS
PubMed
Google Scholar
Steiner G, Smolen JS: Autoantibodies in rheumatoid arthritis. Rheumatoid Arthritis. Edited by: Firestein GS, Panayi GS, Wollheim FA. 2006, Oxford: Oxford University Press, 193-198. 2
Google Scholar
Pincus T, Brooks RH, Callahan LF: Prediction of long-term mortality in patients with rheumatoid arthritis according to simple questionnaire and joint count measures. Ann Intern Med. 1994, 120: 26-34.
Article
CAS
PubMed
Google Scholar
Drossaers-Bakker KW, de Buck M, van Zeben D, Zwinderman AH, Breedveld FC, Hazes JM: Long-term course and outcome of functional capacity in rheumatoid arthritis: the effect of disease activity and radiologic damage over time. Arthritis Rheum. 1999, 42: 1854-1860. 10.1002/1529-0131(199909)42:9<1854::AID-ANR9>3.0.CO;2-F.
Article
CAS
PubMed
Google Scholar
Aletaha D, Smolen J, Ward MM: Measuring function in rheumatoid arthritis: identifying reversible and irreversible components. Arthritis Rheum. 2006, 54: 2784-2792. 10.1002/art.22052.
Article
PubMed
Google Scholar
Lassere MN, Johnson KR, Boers M, Tugwell P, Brooks P, Simon L, Strand V, Conaghan PG, Ostergaard M, Maksymowych WP, Landewe R, Bresnihan B, Tak PP, Wakefield R, Mease P, Bingham CO, Hughes M, Altman D, Buyse M, Galbraith S, Wells G: Definitions and validation criteria for biomarkers and surrogate endpoints: development and testing of a quantitative hierarchical levels of evidence schema. J Rheumatol. 2007, 34: 607-615.
PubMed
Google Scholar
Aletaha D, Smolen JS: The definition and measurement of disease modification in inflammatory rheumatic diseases. Rheum Dis Clin North Am. 2006, 32: 9-44. 10.1016/j.rdc.2005.09.005.
Article
PubMed
Google Scholar
Temple RJ: A regulatory authority's opinion about surrogate endpoints. Clinical Measurement in Drug Evaluation. Edited by: Nimmo WS, Tucker GT. 1995, New York: John Wiley and Sons Inc, 5-23.
Google Scholar
NIH White Paper: Biomarkers, the Osteoarthritis Initiative. 2000, Bethesda: National Institutes of Health
Google Scholar
Lassere MN, Johnson KR, Boers M, Tugwell P, Brooks P, Simon L, Strand V, Conaghan PG, Ostergaard M, Maksymowych WP, Landewe R, Bresnihan B, Tak PP, Wakefield R, Mease P, Bingham CO, Hughes M, Altman D, Buyse M, Galbraith S, Wells G: Definitions and validation criteria for biomarkers and surrogate endpoints: development and testing of a quantitative hierarchical levels of evidence schema. J Rheumatol. 2007, 34: 607-615.
PubMed
Google Scholar
Heijde van der D, Simon L, Smolen J, Strand V, Sharp J, Boers M, Breedveld F, Weisman M, Weinblatt M, Rau R, Lipsky P: How to report radiographic data in randomized clinical trials in rheumatoid arthritis: guidelines from a roundtable discussion. Arthritis Rheum. 2002, 47: 215-218. 10.1002/art.10181.
Article
PubMed
Google Scholar
Landewe R, Geusens P, Boers M, van der HD, Lems W, te KJ, Koppele J, Linden van der S, Garnero P: Markers for type II collagen breakdown predict the effect of disease-modifying treatment on long-term radiographic progression in patients with rheumatoid arthritis. Arthritis Rheum. 2004, 50: 1390-1399. 10.1002/art.20222.
Article
CAS
PubMed
Google Scholar
Landewe RB, Geusens P, Heijde Van der DM, Boers M, Linden van der SJ, Garnero P: Arthritis instantaneously causes collagen type I and type II degradation in patients with early rheumatoid arthritis: a longitudinal analysis. Ann Rheum Dis. 2006, 65: 40-44. 10.1136/ard.2004.035196.
Article
PubMed Central
CAS
PubMed
Google Scholar
Visvanathan S, Marini JC, Smolen JS, Clair EW, Pritchard C, Shergy W, Pendley C, Baker D, Bala M, Gathany T, Han J, Wagner C: Changes in biomarkers of inflammation and bone turnover and associations with clinical efficacy following infliximab plus methotrexate therapy in patients with early rheumatoid arthritis. J Rheumatol. 2007, 34: 1465-1474.
CAS
PubMed
Google Scholar
Young-Min S, Cawston T, Marshall N, Coady D, Christgau S, Saxne T, Robins S, Griffiths I: Biomarkers predict radiographic progression in early rheumatoid arthritis and perform well compared with traditional markers. Arthritis Rheum. 2007, 56: 3236-3247. 10.1002/art.22923.
Article
CAS
PubMed
Google Scholar
den Broeder AA, Joosten LA, Saxne T, Heinegård D, Fenner H, Miltenburg AM, Frasa WL, van Tits LJ, Buurman WA, van Riel PL, Putte van de LB, Barrera P: Long term anti-tumour necrosis factor alpha monotherapy in rheumatoid arthritis: effect on radiological course and prognostic value of markers of cartilage turnover and endothelial activation. Ann Rheum Dis. 2002, 61: 311-318. 10.1136/ard.61.4.311.
Article
PubMed Central
CAS
PubMed
Google Scholar
Pettit AR, Ji H, von Stechow D, Muller R, Goldring SR, Choi Y, Benoist C, Gravallese EM: TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis. Am J Pathol. 2001, 159: 1689-1699.
Article
PubMed Central
CAS
PubMed
Google Scholar
Redlich K, Hayer S, Ricci R, David JP, Tohidast-Akrad M, Kollias G, Steiner G, Smolen JS, Wagner EF, Schett G: Osteoclasts are essential for TNF-alpha-mediated joint destruction. J Clin Invest. 2002, 110: 1419-1427.
Article
PubMed Central
CAS
PubMed
Google Scholar
Teitelbaum SL: Bone resorption by osteoclasts. Science. 2000, 289: 1504-1508. 10.1126/science.289.5484.1504.
Article
CAS
PubMed
Google Scholar
Geusens PP, Landewé RB, Garnero P, Chen D, Dunstan CR, Lems WF, Stinissen P, Heijde van der DM, Linden van der S, Boers M: The ratio of circulating osteoprotegerin to RANKL in early rheumatoid arthritis predicts later joint destruction. Arthritis Rheum. 2006, 54: 1772-1777. 10.1002/art.21896.
Article
CAS
PubMed
Google Scholar
Skoumal M, Haberhauer G, Kolarz G, Hawa G, Woloszczuk W, Klingler A: Serum cathepsin K levels of patients with long-standing rheumatoid arthritis: correlation with radiological destruction. Arthritis Res Ther. 2005, 7: R65-R70. 10.1186/ar1461.
Article
PubMed Central
CAS
PubMed
Google Scholar
Grisar J, Kapral T, Gonda G, Stamm T, Smolen JS, Aletaha D: Short term responsiveness of biomarkers to prednisolone in patients with active rheumatoid arthritis [abstract]. Ann Rheum Dis. 2006, 65 (Suppl II): 171-
Google Scholar
Gertz BJ, Shao P, Hanson DA, Quan H, Harris ST, Genant HK, Chesnut CH, Eyre DR: Monitoring bone resorption in early postmenopausal women by an immunoassay for cross-linked collagen peptides in urine. J Bone Miner Res. 1994, 9: 135-142.
Article
CAS
PubMed
Google Scholar
Gertz BJ, Clemens JD, Holland SD, Yuan W, Greenspan S: Application of a new serum assay for type I collagen cross-linked N-telopeptides: assessment of diurnal changes in bone turnover with and without alendronate treatment. Calcif Tissue Int. 1998, 63: 102-106. 10.1007/s002239900497.
Article
CAS
PubMed
Google Scholar
Andersson ML, Petersson IF, Karlsson KE, Jonsson EN, Mansson B, Heinegard D, Saxne T: Diurnal variation in serum levels of cartilage oligomeric matrix protein in patients with knee osteoarthritis or rheumatoid arthritis. Ann Rheum Dis. 2006, 65: 1490-1494. 10.1136/ard.2005.051292.
Article
PubMed Central
CAS
PubMed
Google Scholar
Manicourt DH, Poilvache P, Nzeusseu A, van EA, Devogelaer JP, Lenz ME, Thonar EJ: Serum levels of hyaluronan, antigenic keratan sulfate, matrix metalloproteinase 3, and tissue inhibitor of metalloproteinases 1 change predictably in rheumatoid arthritis patients who have begun activity after a night of bed rest. Arthritis Rheum. 1999, 42: 1861-1869. 10.1002/1529-0131(199909)42:9<1861::AID-ANR10>3.0.CO;2-I.
Article
CAS
PubMed
Google Scholar
Engstrom-Laurent A: Changes in hyaluronan concentration in tissues and body fluids in disease states. Ciba Found Symp. 1989, 143: 233-240.
CAS
PubMed
Google Scholar
Williams FM, Andrew T, Saxne T, Heinegard D, Spector TD, Mac-Gregor AJ: The heritable determinants of cartilage oligomeric matrix protein. Arthritis Rheum. 2006, 54: 2147-2151. 10.1002/art.21931.
Article
CAS
PubMed
Google Scholar
Charni-Ben Tabassi N, Garnero P: Monitoring cartilage turnover. Curr Rheumatol Rep. 2007, 9: 16-24. 10.1007/s11926-007-0017-y.
Article
CAS
PubMed
Google Scholar
Scott DL, Grindulis KA, Struthers GR, Coulton BL, Popert AJ, Bacon PA: Progression of radiological changes in rheumatoid arthritis. Ann Rheum Dis. 1984, 43: 8-17.
Article
PubMed Central
CAS
PubMed
Google Scholar
Brennan P, Harrison B, Barrett E, Chakravarty K, Scott D, Silman AJ: A simple algorithm to predict the development of radiological erosions in patients with early rheumatoid arthritis: prospective cohort study. BMJ. 1996, 313: 471-476.
Article
PubMed Central
CAS
PubMed
Google Scholar
Bukhari M, Lunt M, Harrison BJ, Scott DG, Symmons DP, Silman AJ: Rheumatoid factor is the major predictor of increasing severity of radiographic erosions in rheumatoid arthritis: results from the Norfolk Arthritis Register Study, a large inception cohort. Arthritis Rheum. 2002, 46: 906-912. 10.1002/art.10167.
Article
CAS
PubMed
Google Scholar
Rantapaa-Dahlqvist S: Diagnostic and prognostic significance of autoantibodies in early rheumatoid arthritis. Scand J Rheumatol. 2005, 34: 83-96. 10.1080/03009740510017689.
Article
CAS
PubMed
Google Scholar
Nell V, Machold KP, Stamm TA, Eberl G, Heinzl H, Uffmann M, Smolen JS, Steiner G: Autoantibody profiling as early diagnostic and prognostic tool for rheumatoid arthritis. Ann Rheum Dis. 2005, 64: 1731-1736. 10.1136/ard.2005.035691.
Article
PubMed Central
CAS
PubMed
Google Scholar
van Gaalen FA, van Aken J, Huizinga TW, Schreuder GM, Breedveld FC, Zanelli E, van Venrooij WJ, Verweij CL, Toes RE, de Vries RR: Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCPs) influences the severity of rheumatoid arthritis. Arthritis Rheum. 2004, 50: 2113-2121. 10.1002/art.20316.
Article
CAS
PubMed
Google Scholar
De Rycke L, Verhelst X, Kruithof E, Bosch van den F, Hoffman IE, Veys EM, de Keyser F: Rheumatoid factor, but not anti-cyclic citrullinated peptide antibodies, is modulated by infliximab treatment in rheumatoid arthritis. Ann Rheum Dis. 2005, 64: 299-302. 10.1136/ard.2004.023523.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kavanaugh A, Rosengren S, Lee SJ, Hammaker D, Firestein GS, Kalunian K, Wei N, Boyle DL: Assessment of rituximab's immunomodulatory synovial effects (the ARISE trial). I: clinical and synovial biomarker results. Ann Rheum Dis. 2007, 67: 402-408. 10.1136/ard.2007.074229.
Article
PubMed Central
PubMed
Google Scholar
Heijde Van der DM, van Riel PL, van Leeuwen MA, van 't Hof MA, van Rijswijk MH, Putte van de LB: Prognostic factors for radiographic damage and physical disability in early rheumatoid arthritis. A prospective follow-up study of 147 patients. Br J Rheumatol. 1992, 31: 519-525. 10.1093/rheumatology/31.8.519.
Article
PubMed
Google Scholar
Rooney M, Condell D, Quinlan W, Daly L, Whelan A, Feighery C, Bresnihan B: Analysis of the histologic variation of synovitis in rheumatoid arthritis. Arthritis Rheum. 1988, 31: 956-963. 10.1002/art.1780310803.
Article
CAS
PubMed
Google Scholar
Bresnihan B, Tak PP: Synovial tissue analysis in rheumatoid arthritis. Baillieres Best Pract Res Clin Rheumatol. 1999, 13: 645-659. 10.1053/berh.1999.0051.
Article
CAS
PubMed
Google Scholar
Bresnihan B, Gerlag DM, Rooney T, Smeets TJ, Wijbrandts CA, Boyle D, Fitzgerald O, Kirkham BW, McInnes IB, Smith M, Ulfgren AK, Veale DJ, Tak PP: Synovial macrophages as a biomarker of response to therapeutic intervention in rheumatoid arthritis: standardization and consistency across centers. J Rheumatol. 2007, 34: 620-622.
PubMed
Google Scholar
Haringman JJ, Gerlag DM, Zwinderman AH, Smeets TJ, Kraan MC, Baeten D, McInnes IB, Bresnihan B, Tak PP: Synovial tissue macrophages: a sensitive biomarker for response to treatment in patients with rheumatoid arthritis. Ann Rheum Dis. 2005, 64: 834-838. 10.1136/ard.2004.029751.
Article
PubMed Central
CAS
PubMed
Google Scholar
Gerlag DM, Haringman JJ, Smeets TJ, Zwinderman AH, Kraan MC, Laud PJ, Morgan S, Nash AF, Tak PP: Effects of oral prednisolone on biomarkers in synovial tissue and clinical improvement in rheumatoid arthritis. Arthritis Rheum. 2004, 50: 3783-3791. 10.1002/art.20664.
Article
CAS
PubMed
Google Scholar
Haringman JJ, Gerlag DM, Smeets TJ, Baeten D, Bosch van den F, Bresnihan B, Breedveld FC, Dinant HJ, Legay F, Gram H, Loetscher P, Schmouder R, Woodworth T, Tak PP: A randomized controlled trial with an anti-CCL2 (anti-monocyte chemotactic protein 1) monoclonal antibody in patients with rheumatoid arthritis. Arthritis Rheum. 2006, 54: 2387-2392. 10.1002/art.21975.
Article
CAS
PubMed
Google Scholar
Vos K, Thurlings RM, Wijbrandts CA, van SD, Gerlag DM, Tak PP: Early effects of rituximab on the synovial cell infiltrate in patients with rheumatoid arthritis. Arthritis Rheum. 2007, 56: 772-778. 10.1002/art.22400.
Article
CAS
PubMed
Google Scholar
Kraan MC, Versendaal H, Jonker M, Bresnihan B, Post WJ, t Hart BA, Breedveld FC, Tak PP: Asymptomatic synovitis precedes clinically manifest arthritis. Arthritis Rheum. 1998, 41: 1481-1488. 10.1002/1529-0131(199808)41:8<1481::AID-ART19>3.0.CO;2-O.
Article
CAS
PubMed
Google Scholar
Haupl T, Yahyawi M, Lubke C, Ringe J, Rohrlach T, Burmester GR, Sittinger M, Kaps C: Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs. J Biomol Screen. 2007, 12: 328-340. 10.1177/1087057107299261.
Article
PubMed
Google Scholar
Gerlag DM, Boyle DL, Rosengren S, Nash T, Tak PP, Firestein GS: Real-time quantitative PCR to detect changes in synovial gene expression in rheumatoid arthritis after corticosteroid treatment. Ann Rheum Dis. 2007, 66: 545-547. 10.1136/ard.2006.059790.
Article
PubMed Central
CAS
PubMed
Google Scholar
van Leeuwen MA, Westra J, Limburg PC, van Riel PL, van Rijswijk MH: Clinical significance of interleukin-6 measurement in early rheumatoid arthritis: relation with laboratory and clinical variables and radiological progression in a three year prospective study. Ann Rheum Dis. 1995, 54: 674-677.
Article
PubMed Central
CAS
PubMed
Google Scholar
Eastgate JA, Symons JA, Wood NC, Grinlinton FM, diGiovine FS, Duff GW: Correlation of plasma interleukin-1 levels with disease activity in rheumatoid arthritis. Lancet. 1988, 2: 706-709. 10.1016/S0140-6736(88)90185-7.
Article
CAS
PubMed
Google Scholar
Knudsen LS, Christensen IJ, Lottenburger T, Svendsen MN, Nielsen HJ, Nielsen L, Hørslev-Petersen K, Jensen JE, Kollerup G, Johansen JS: Pre-analytical and biological variability in circulating interleukin 6 in healthy subjects and patients with rheumatoid arthritis. Biomarkers. 2008, 13: 59-78. 10.1080/13547500701615017.
Article
CAS
PubMed
Google Scholar
Weyand CM, Klimiuk PA, Goronzy JJ: Heterogeneity of rheumatoid arthritis: from phenotypes to genotypes. Springer Semin Immunopathol. 1998, 20: 5-22. 10.1007/BF00831996.
Article
CAS
PubMed
Google Scholar
Tak PP: Analyzing synovial tissue samples. What can we learn about early rheumatoid arthritis, the heterogeneity of the disease, and the effects of treatment?. J Rheumatol. 2005, 32 (Suppl 72): 25-26.
Google Scholar
Veale DJ, Ritchlin C, Fitzgerald O: Immunopathology of psoriasis and psoriatic arthritis. Ann Rheum Dis. 2005, 64 (Suppl 2): ii26-ii29. 10.1136/ard.2004.031740.
PubMed Central
PubMed
Google Scholar
Francois RJ, Neure L, Sieper J, Braun J: Immunohistological examination of open sacroiliac biopsies of patients with ankylosing spondylitis: detection of tumour necrosis factor alpha in two patients with early disease and transforming growth factor beta in three more advanced cases. Ann Rheum Dis. 2006, 65: 713-720. 10.1136/ard.2005.037465.
Article
PubMed Central
CAS
PubMed
Google Scholar
Partsch G, Steiner G, Leeb BF, Dunky A, Broll H, Smolen JS: Highly increased levels of tumor necrosis factor-alpha and other proinflammatory cytokines in psoriatic arthritis synovial fluid. J Rheumatol. 1997, 24: 518-523.
CAS
PubMed
Google Scholar
Steiner G, Tohidast-Akrad M, Witzmann G, Vesely M, Studnicka-Benke A, Gal A, Kunaver M, Zenz P, Smolen JS: Cytokine production by synovial T cells in rheumatoid arthritis. Rheumatology (Oxford). 1999, 38: 202-213. 10.1093/rheumatology/38.3.202.
Article
CAS
Google Scholar
Raza K, Falciani F, Curnow SJ, Ross EJ, Lee CY, Akbar AN, Raza K, Falciani F, Curnow SJ, Ross EJ, Lee CY, Akbar AN, Lord JM, Gordon C, Buckley CD, Salmon M: Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin. Arthritis Res Ther. 2005, 7: R784-R795. 10.1186/ar1733.
Article
PubMed Central
CAS
PubMed
Google Scholar
Gabay C, Silacci P, Genin B, Mentha G, Le CC, Guerne PA: Soluble interleukin-6 receptor strongly increases the production of acute-phase protein by hepatoma cells but exerts minimal changes on human primary hepatocytes. Eur J Immunol. 1995, 25: 2378-2383. 10.1002/eji.1830250838.
Article
CAS
PubMed
Google Scholar
Dawes PT, Fowler PD, Clarke S, Fisher J, Lawton A, Shadforth MF: Rheumatoid arthritis: treatment which controls the C-reactive protein and erythrocyte sedimentation rate reduces radiological progression. Br J Rheumatol. 1986, 25: 44-49. 10.1093/rheumatology/25.1.44.
Article
CAS
PubMed
Google Scholar
Aletaha D, Nell VPK, Stamm T, Uffmann M, Pflugbeil S, Machold K, Smolen JS: Acute phase reactants add little to composite disease activity indices for rheumatoid arthritis: validation of a clinical activity score. Arthritis Res. 2005, 7: R796-R806. 10.1186/ar1740.
Article
CAS
Google Scholar
van Leeuwen MA, van Rijswijk MH, Sluiter WJ, van Riel PL, Kuper IH, Putte van de LB, Pepys MB, Limburg PC: Individual relationship between progression of radiological damage and the acute phase response in early rheumatoid arthritis. Towards development of a decision support system. J Rheumatol. 1997, 24: 20-27.
CAS
PubMed
Google Scholar
Smolen JS, Heijde Van Der DM, St Clair EW, Emery P, Bathon JM, Keystone E, Maini RN, Kalden JR, Schiff M, Baker D, Han C, Han J, Bala M, Active-Controlled Study of Patients Receiving Infliximab for the Treatment of Rheumatoid Arthritis of Early Onset (ASPIRE) Study Group: Predictors of joint damage in patients with early rheumatoid arthritis treated with high-dose methotrexate without or with concomitant infliximab. Results from the ASPIRE trial. Arthritis Rheum. 2006, 54: 702-710. 10.1002/art.21678.
Article
CAS
PubMed
Google Scholar
St Clair EW, Wagner CL, Fasanmade AA, Wang B, Schaible T, Kavanaugh A, Keystone EC: The relationship of serum infliximab concentrations to clinical improvement in rheumatoid arthritis: results from ATTRACT, a multicenter, randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 2002, 46: 1451-1459. 10.1002/art.10302.
Article
CAS
PubMed
Google Scholar
Duff GW: Cytokines and acute phase proteins in rheumatoid arthritis. Scand J Rheumatol Suppl. 1994, 100: 9-19. 10.3109/03009749409095197.
Article
CAS
PubMed
Google Scholar
Otterness IG: The value of C-reactive protein measurement in rheumatoid arthritis. Semin Arthritis Rheum. 1994, 24: 91-104. 10.1016/S0049-0172(05)80003-4.
Article
CAS
PubMed
Google Scholar
Charles P, Elliott MJ, Davis D, Potter A, Kalden JR, Antoni C, Breedveld FC, Smolen JS, Eberl G, deWoody K, Feldmann M, Maini RN: Regulation of cytokines, cytokine inhibitors, and acute-phase proteins following anti-TNF-alpha therapy in rheumatoid arthritis. J Immunol. 1999, 163: 1521-1528.
CAS
PubMed
Google Scholar
Barrera P, Boerbooms AM, Putte van de LB, Meer van der JW: Effects of antirheumatic agents on cytokines. Semin Arthritis Rheum. 1996, 25: 234-253. 10.1016/S0049-0172(96)80035-7.
Article
CAS
PubMed
Google Scholar
Lassere MN, Johnson KR, Boers M, Tugwell P, Brooks P, Simon L, Strand V, Conaghan PG, Ostergaard M, Maksymowych WP, Landewe R, Bresnihan B, Tak PP, Wakefield R, Mease P, Bingham CO, Hughes M, Altman D, Buyse M, Galbraith S, Wells G: Definitions and validation criteria for biomarkers and surrogate endpoints: development and testing of a quantitative hierarchical levels of evidence schema. J Rheumatol. 2007, 34: 607-615.
PubMed
Google Scholar
American College of Rheumatology Committee to Reevaluate Improvement Criteria: A proposed revision to the ACR20: the hybrid measure of ACR response [abstract]. Arthritis Rheum. 2007, 57: 193-202. 10.1002/art.22552.
Article
Google Scholar
Soubrier M, Zerkak D, Gossec L, Ayral X, Roux C, Dougados M: Which variables best predict change in rheumatoid arthritis therapy in daily clinical practice?. J Rheumatol. 2006, 33: 1243-1246.
PubMed
Google Scholar
Kobayashi K, Takahashi N, Jimi E, Udagawa N, Takami M, Kotake S, Nakagawa N, Kinosaki M, Yamaguchi K, Shima N, Yasuda H, Morinaga T, Higashio K, Martin TJ, Suda T: Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction. J Exp Med. 2000, 191: 275-286. 10.1084/jem.191.2.275.
Article
PubMed Central
CAS
PubMed
Google Scholar
Devlin RD, Reddy SV, Savino R, Ciliberto G, Roodman GD: IL-6 mediates the effects of IL-1 or TNF, but not PTHrP or 1,25(OH)2D3, on osteoclast-like cell formation in normal human bone marrow cultures. J Bone Miner Res. 1998, 13: 393-399. 10.1359/jbmr.1998.13.3.393.
Article
CAS
PubMed
Google Scholar
Ragab AA, Nalepka JL, Bi Y, Greenfield EM: Cytokines synergistically induce osteoclast differentiation: support by immortalized or normal calvarial cells. Am J Physiol Cell Physiol. 2002, 283: C679-C687.
Article
CAS
PubMed
Google Scholar
Lee ZH, Lee SE, Kim CW, Lee SH, Kim SW, Kwack K, Walsh K, Kim HH: IL-1alpha stimulation of osteoclast survival through the PI 3-kinase/Akt and ERK pathways. J Biochem (Tokyo). 2002, 131: 161-166.
Article
CAS
Google Scholar
Lam J, Takeshita S, Barker JE, Kanagawa O, Ross FP, Teitelbaum SL: TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand. J Clin Invest. 2000, 106: 1481-1488. 10.1172/JCI11176.
Article
PubMed Central
CAS
PubMed
Google Scholar
Smolen JS, Han C, Bala M, Maini RN, Kalden JR, Heijde van der D, Breedveld FC, Furst DE, Lipsky PE, ATTRACT Study Group: Evidence of radiographic benefit of infliximab plus methotrexate in rheumatoid arthritis patients who had no clinical improvement: a detailed subanalysis of the ATTRACT Trial. Arthritis Rheum. 2005, 52: 1020-1030. 10.1002/art.20982.
Article
CAS
PubMed
Google Scholar
Landewe R, Heijde van der D, Klareskog L, van Vollenhoven R, Fatenejad S: Disconnect between inflammation and joint destruction after treatment with etanercept plus methotrexate: results from the trial of etanercept and methotrexate with radiographic and patient outcomes. Arthritis Rheum. 2006, 54: 702-710. 10.1002/art.22143.
Article
Google Scholar
St Clair EW, Heijde van der DM, Smolen JS, Maini RN, Bathon JM, Emery P, Keystone E, Schiff M, Kalden JR, Wang B, Dewoody K, Weiss R, Baker D, Active-Controlled Study of Patients Receiving Infliximab for the Treatment of Rheumatoid Arthritis of Early Onset Study Group: Combination of infliximab and methotrexate therapy for early rheumatoid arthritis: a randomized, controlled trial. Arthritis Rheum. 2004, 50: 3432-3443. 10.1002/art.20568.
Article
CAS
PubMed
Google Scholar
Klareskog L, Heijde van der D, de Jager JP, Gough A, Kalden J, Malaise M, Martín Mola E, Pavelka K, Sany J, Settas L, Wajdula J, Pedersen R, Fatenejad S, Sanda M, TEMPO (Trial of Etanercept and Methotrexate with Radiographic Patient Outcomes) Study Investigators: Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial. Lancet. 2004, 363: 675-681. 10.1016/S0140-6736(04)15640-7.
Article
CAS
PubMed
Google Scholar
Breedveld FC, Weisman MH, Kavanaugh AF, Cohen SB, Pavelka K, van Vollenhoven R, Sharp J, Perez JL, Spencer-Green GT: The PREMIER study – a multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment. Arthritis Rheum. 2006, 54: 26-37. 10.1002/art.21519.
Article
CAS
PubMed
Google Scholar
Redlich K, Görtz B, Hayer S, Zwerina J, Doerr N, Kostenuik P, Bergmeister H, Kollias G, Steiner G, Smolen JS, Schett G: Repair of local bone erosions and reversal of systemic bone loss upon therapy with anti-tumor necrosis factor in combination with osteoprotegerin or parathyroid hormone in tumor necrosis factor-mediated arthritis. Am J Pathol. 2004, 164: 543-555.
Article
PubMed Central
CAS
PubMed
Google Scholar
Diarra D, Stolina M, Polzer K, Zwerina J, Ominsky MS, Dwyer D, Korb A, Smolen J, Hoffmann M, Scheinecker C, Heide van der D, Landewe R, Lacey D, Richards WG, Schett G: Dickkopf-1 is a master regulator of joint remodeling [abstract]. Nat Med. 2007, 13: 156-163. 10.1038/nm1538.
Article
CAS
PubMed
Google Scholar
Smolen JS, Han C, Heijde van der D, Emery P, Bathon JM, Keystone E, Maini RN, Kalden JR, Aletaha D, Baker D, Han J, Bala M, St Clair EW: Infliximab inhibits radiographic progression regardless of disease activity at baseline and following treatment in patients with early active rheumatoid arthritis [abstract]. Arthritis Rheum. 2006, 54 (Suppl): S231-
Google Scholar
Aletaha D, Funovits J, Keystone EC, Smolen JS: Disease activity early in the course of treatment predicts response to therapy after one year in rheumatoid arthritis patients. Arthritis Rheum. 2007, 56: 3226-3235. 10.1002/art.22943.
Article
CAS
PubMed
Google Scholar
Schoels M, Funovits J, Muellner J, Smolen JS, Aletaha D: Disease activity at baseline and early treatment response predict long-term success of therapy in rheumatoid arthritis – results from an observational study [abstract]. Arthritis Rheum. 2007, 56 (Suppl): S186-
Google Scholar
Aletaha D, Eberl G, Nell VP, Machold KP, Smolen JS: Attitudes to early rheumatoid arthritis: changing patterns. Results of a survey. Ann Rheum Dis. 2004, 63: 1269-1275. 10.1136/ard.2003.015131.
Article
PubMed Central
CAS
PubMed
Google Scholar
Emery P, Breedveld FC, Dougados M, Kalden JR, Schiff MH, Smolen JS: Early referral recommendation for newly diagnosed rheumatoid arthritis: evidence based development of a clinical guide. Ann Rheum Dis. 2002, 61: 290-297. 10.1136/ard.61.4.290.
Article
PubMed Central
CAS
PubMed
Google Scholar
Goronzy JJ, Matteson EL, Fulbright JW, Warrington KJ, Chang-Miller A, Hunder GG, Mason TG, Nelson AM, Valente RM, Crowson CS, Erlich HA, Reynolds RL, Swee RG, O'Fallon WM, Weyand CM: Prognostic markers of radiographic progression in early rheumatoid arthritis. Arthritis Rheum. 2004, 50: 43-54. 10.1002/art.11445.
Article
PubMed
Google Scholar
Ehrenstein MR, Evans JG, Singh A, Moore S, Warnes G, Isenberg DA, Mauri C: Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy. J Exp Med. 2004, 200: 277-285. 10.1084/jem.20040165.
Article
PubMed Central
CAS
PubMed
Google Scholar
Brown AK, Quinn MA, Karim Z, Conaghan PG, Peterfy CG, Hensor E, Wakefield RJ, O'Connor PJ, Emery P: Presence of significant synovitis in rheumatoid arthritis patients with disease-modifying antirheumatic drug-induced clinical remission: evidence from an imaging study may explain structural progression. Arthritis Rheum. 2006, 54: 3761-3773. 10.1002/art.22190.
Article
CAS
PubMed
Google Scholar
Taylor PC: Serum vascular markers and vascular imaging in assessment of rheumatoid arthritis disease activity and response to therapy. Rheumatology (Oxford). 2005, 44: 721-728. 10.1093/rheumatology/keh524.
Article
CAS
Google Scholar
Wakefield RJ, D'Agostino MA, Iagnocco A, Filippucci E, Backhaus M, Scheel AK, Joshua F, Naredo E, Schmidt WA, Grassi W, Moller I, Pineda C, Klauser A, Szkudlarek M, Terslev L, Balint P, Bruyn GA, Swen WA, Jousse-Joulin S, Kane D, Koski JM, O'Connor P, Milutinovic S, Conaghan PG, OMERACT Ultrasound Group: The OMERACT Ultrasound Group: status of current activities and research directions. J Rheumatol. 2007, 34: 848-851.
PubMed
Google Scholar
Herwig R, Lehrach H: Expression profiling of drug response – from genes to pathways. Dialogues Clin Neurosci. 2006, 8: 283-293.
PubMed Central
PubMed
Google Scholar
Weljie AM, Dowlatabadi R, Miller BJ, Vogel HJ, Jirik FR: An inflammatory arthritis-associated metabolite biomarker pattern revealed by 1H NMR spectroscopy. J Proteome Res. 2007, 6: 3456-3464. 10.1021/pr070123j.
Article
CAS
PubMed
Google Scholar
Smolen JS, Aletaha D: Patients with rheumatoid arthritis in clinical care. Ann Rheum Dis. 2004, 63: 221-225. 10.1136/ard.2003.012575.
Article
PubMed Central
CAS
PubMed
Google Scholar
Firestein GS, Alvaro-Gracia JM, Maki R: Quantitative analysis of cytokine gene expression in rheumatoid arthritis. J Immunol. 1990, 144: 3347-3353.
CAS
PubMed
Google Scholar