- Oral presentation
- Open Access
- Published:
Overview of osteoimmunology: What's happened? And what's going on?
Arthritis Research & Therapy volume 14, Article number: O12 (2012)
The interaction between the immune and skeletal systems has long been acknowledged, but molecular mechanisms linking the two systems have not been demonstrated until recently. Investigation into autoimmune arthritis as well as the various bone phenotypes found in mice deficient in immunomodulatory molecules has highlighted the importance of the dynamic interplay between the two systems and brought about a rapid evolution of the field of osteoimmunology [1]. In bone loss in autoimmune arthritis, IL-17-producing helper T (TH17) cells play a major role by inducing RANKL [2]. Maintenance and mobilization of hematopoietic cells are regulated by bone cells. In addition to cellular interactions via cytokines, the immune and skeletal systems share various molecules, including transcription factors, signaling molecules and membrane receptors. RANKL stimulates osteoclastogenesis through NFATc1 in cooperation with immunoglobulin-like receptors. Here I will discuss emerging topics in osteoimmunology including the mechanisms underlying bone cell communication: osteocyte RANKL [3] and inhibition of bone formation by osteoclast Sema4D [4].
References
Nat Rev Immunol. 2007, 7: 292-304.
Nat Rev Rheumatol. 2009, 5: 667-76.
Nat Med. 2011, 17: 1231-34.
Nat Med. 2011, 17: 1473-80.
Author information
Authors and Affiliations
Rights and permissions
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
About this article
Cite this article
Takayanagi, H. Overview of osteoimmunology: What's happened? And what's going on?. Arthritis Res Ther 14 (Suppl 1), O12 (2012). https://doi.org/10.1186/ar3567
Published:
DOI: https://doi.org/10.1186/ar3567
Keywords
- Public Health
- Transcription Factor
- Arthritis
- Molecular Mechanism
- Bone Formation