- Oral presentation
- Open Access
Fcγ receptor targeting in RA
© Takai et al.; licensee BioMed Central Ltd. 2012
- Published: 29 February 2012
- Inflammatory Disease
- Murine Model
- Potential Therapeutic Target
- Binding Ability
- Allergic Response
The activation threshold of cells in the immune system is often tuned by cell surface molecules. Among these, Fc receptors expressed on various hematopoietic cells constitute critical elements for activating or down-modulating immune responses.
IgGFc receptors (FcγRs) were originally identified as B cell surface molecules. For more than 40 years, FcγRs have continued to attract the interest of many basic researchers and clinicians due to their intriguing IgG binding ability, which provides a critical link between the humoral and cellular branches of the immune system.
Several activating-type FcγRs, which associate with homodimeric Fc receptor common γ subunits, are crucial for the onset and exacerbation of inflammatory diseases. In contrast, a unique inhibitory FcγR, FcγRIIB, plays a critical role in keeping immune cells silent. Murine models for allergic responses and autoimmune diseases including RA illustrate the indispensable roles of activating-type FcγRs and the inhibitory FcγRIIB in the initiation and suppression of inflammation, respectively [1–5].
The ultimate goals of FcγR research are to accomplish our understanding of this molecular family and to delineate novel therapeutic strategies toward the conquest of allergic and autoimmune diseases, infectious diseases, immunodeficiency, transplantation-associated immune disorders, and malignant tumors. Although many lines of evidence indicate that a part of the intravenous Ig (IVIg)-mediated anti-inflammatory effects can be attributable to the blocking of activating-type FcγRs, recent studies have pointed out an indispensable role of FcγRIIB in therapeutic benefits of IVIg in several murine models of inflammatory diseases including RA . In this session, we will give a brief summary of recent knowledge on antibody biomedicine including IVIgto you, in light of exploiting FcγRs as potential therapeutic targets for various inflammatory diseases, along with the comparison withnon-FcγR-mediated mechanisms of IVIg.
- Nakamura A, Kubo T, Takai T: Fc receptor targeting in the treatment of allergy, autoimmune diseases and cancer. Adv Exp Med Biol. 2008, 640: 220-233. 10.1007/978-0-387-09789-3_17.View ArticlePubMedGoogle Scholar
- Nakamura A, Nukiwa T, Takai T: Deregulation of peripheral B-cell development in enhanced severity of collagen-induced arthritis in FcgammaRIIB-deficient mice. J Autoimmun. 2003, 20: 227-236. 10.1016/S0896-8411(03)00034-9.View ArticlePubMedGoogle Scholar
- Takai T: Roles of Fc receptors in autoimmunity. Nat Rev Immunol. 2002, 2: 580-592.PubMedGoogle Scholar
- Yuasa T, Kubo S, Yoshino T, Ujike A, Matsumura K, Ono M, Ravetch JV, Takai T: Deletion of Fcγ receptor IIB renders H-2b mice susceptible to collagen-induced arthritis. J Exp Med. 1999, 189: 187-194. 10.1084/jem.189.1.187.PubMed CentralView ArticlePubMedGoogle Scholar
- Takai T, Ono M, Hikida M, Ohmori H, Ravetch JV: Augmented humoral and anaphylactic responses in FcγRII-deficient mice. Nature. 1996, 379: 346-349. 10.1038/379346a0.View ArticlePubMedGoogle Scholar
- Anthony RM, Kobayashi T, Wermeling F, Ravetch JV: Intravenous gammaglobulin suppresses inflammation through a novel TH2 pathway. Nature. 2011, 475: 110-113. 10.1038/nature10134.PubMed CentralView ArticlePubMedGoogle Scholar
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