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Average findings of uric acid in blood in patients with gout with different categories of hyperglycemia
https://doi.org/10.1186/ar3633
© Kayumov et al.; licensee BioMed Central Ltd. 2012
- Published: 29 February 2012
Keywords
- Metabolic Syndrome
- Uric Acid
- Glucose Tolerance
- Hyperglycemia
- Gout
Along with a huge amount of works about the importance of a metabolic syndrome in development of cardiovascular diseases, within last decade in the literature there was a series of reports on a pathogenetic role of this syndrome in formation and more serious current of some other diseases of an internal. In process of doctrine development about a metabolic syndrome [1], there was new data about existence at gout of various signs insulin resistance [2]. At the same time, there are insufficiently studied questions on a role of various categories of a hyperglycemia (a hyperglycemia on an empty stomach and a postloading hyperglycemia) in a pathogenesis and gout and hyperuricemia clinic.
Method of the inquiry
120 males with gout at age 30-69 were examined to investigate the connection between different categories of hyperglycemia and level of uric acid in patients with gout. Gout was revealed on the basis of criteria of American Rheumatic Association. Glucose tolerance condition was revealed by carrying out standard test of glucose tolerance (TGT) with revealing of glycemia on an empty stomach, and also in one and two hours after taking 75 gr glucose by the examined patients.
The results
According to the revealed findings average levels of uric acid in patients with gout with normal glucose tolerance had 531,56 ± 0,38 mcmol/l. With damaged glucose tolerance on an empty stomach and in two hours after glucose loading, levels of uric acid were more higher(658,18 ± 0,27 mcmol/l and 656,22 ± 0,34 mcmol/l correspondingly). At the same time on damaged glucose tolerance in an hour after glucose loading average level of uric acid was 501,16 ± 0,33 mcmol/l. We should draw attention that the difference of average levels of uric acid among people with disorders glucose tolerance on an empty stomach and in two hours after glucose loading was more differ from level of uric acid among people with glucose tolerance disorder in an hour after glucose loading (p*<0,05).
Conclusion
Average findings of uric acid in blood in patients with different categories of hyperglycemia
Categories of hyperglycemia | n | M | ± m |
|---|---|---|---|
Normal tolerance | 13 | 531,56 | 0,38 |
Hyperglycemia on an empty stomach | 11 | 658,18 * | 0,27 |
Hyperglycemia after 1 hour | 20 | 501,16 | 0,33 |
Hyperglycemia after 2 hours | 76 | 656,22 * | 0,34 |
Authors’ Affiliations
References
- McNeill AM, Rosamond WD, Girman CJ, et al: The metabolic syndrome and 11-year risk of incident cardiovascular disease in the atherosclerosis risk in Communities Study. Diabetes Care. 2005, 28 (2): 385-390. 10.2337/diacare.28.2.385.View ArticlePubMedGoogle Scholar
- Vázquez-Mellado J, et al: Metabolic syndrome and ischemic heart disease in gout. J Clin Reumatol. 2004, 10 (3): 105-109.View ArticleGoogle Scholar
Copyright
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
