Skip to main content
Download PDF

Volume 14 Supplement 1

Proceedings of the 8th Global Arthritis Research Network (GARN) Meeting and 1st Bio-Rheumatology International Congress (BRIC)

Average findings of uric acid in blood in patients with gout with different categories of hyperglycemia

Arthritis Research & Therapy volume 14, Article number: P32 (2012) Cite this article

Along with a huge amount of works about the importance of a metabolic syndrome in development of cardiovascular diseases, within last decade in the literature there was a series of reports on a pathogenetic role of this syndrome in formation and more serious current of some other diseases of an internal. In process of doctrine development about a metabolic syndrome [1], there was new data about existence at gout of various signs insulin resistance [2]. At the same time, there are insufficiently studied questions on a role of various categories of a hyperglycemia (a hyperglycemia on an empty stomach and a postloading hyperglycemia) in a pathogenesis and gout and hyperuricemia clinic.

Method of the inquiry

120 males with gout at age 30-69 were examined to investigate the connection between different categories of hyperglycemia and level of uric acid in patients with gout. Gout was revealed on the basis of criteria of American Rheumatic Association. Glucose tolerance condition was revealed by carrying out standard test of glucose tolerance (TGT) with revealing of glycemia on an empty stomach, and also in one and two hours after taking 75 gr glucose by the examined patients.

The results

According to the revealed findings average levels of uric acid in patients with gout with normal glucose tolerance had 531,56 ± 0,38 mcmol/l. With damaged glucose tolerance on an empty stomach and in two hours after glucose loading, levels of uric acid were more higher(658,18 ± 0,27 mcmol/l and 656,22 ± 0,34 mcmol/l correspondingly). At the same time on damaged glucose tolerance in an hour after glucose loading average level of uric acid was 501,16 ± 0,33 mcmol/l. We should draw attention that the difference of average levels of uric acid among people with disorders glucose tolerance on an empty stomach and in two hours after glucose loading was more differ from level of uric acid among people with glucose tolerance disorder in an hour after glucose loading (p*<0,05).

Conclusion

According to these results we can come to the conclusion that the level of hyperglycemia has connection with existence in patients with hyperglycemia on an empty stomach and two hours after glucose loading. At the same time the problem about connection of uric acid level with hyperglycemia in an hour after glucose loading should be examined farther. Perhaps, that rising of glycemia level in an hour after glucose loading is a compensator mechanism in patients with gout.

Table 1 Average findings of uric acid in blood in patients with different categories of hyperglycemia
Full size table

References

  1. 1.

    McNeill AM, Rosamond WD, Girman CJ, et al: The metabolic syndrome and 11-year risk of incident cardiovascular disease in the atherosclerosis risk in Communities Study. Diabetes Care. 2005, 28 (2): 385-390. 10.2337/diacare.28.2.385.

    Article  PubMed  Google Scholar 

  2. 2.

    Vázquez-Mellado J, et al: Metabolic syndrome and ischemic heart disease in gout. J Clin Reumatol. 2004, 10 (3): 105-109.

    Article  Google Scholar 

Download references

Author information

Affiliations

  1. Tashkent Institute of Postgraduate Medical Education, Tashkent, Uzbekistan

    Ulugbek K Kayumov & Nargiza A Abdukhakimova

  2. Tashkent Medical Academy, Tashkent, Uzbekistan

    Marif Sh Karimov

Authors
  1. Ulugbek K Kayumov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Marif Sh Karimov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Nargiza A Abdukhakimova
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ulugbek K Kayumov.

Rights and permissions

This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

Reprints and Permissions

About this article

Cite this article

Kayumov, U.K., Karimov, M.S. & Abdukhakimova, N.A. Average findings of uric acid in blood in patients with gout with different categories of hyperglycemia. Arthritis Res Ther 14, P32 (2012). https://doi.org/10.1186/ar3633

Download citation

  • Published:

  • DOI: https://doi.org/10.1186/ar3633

Keywords

  • Metabolic Syndrome
  • Uric Acid
  • Glucose Tolerance
  • Hyperglycemia
  • Gout

Arthritis Research & Therapy

ISSN: 1478-6362

Contact us