- Poster presentation
- Open Access
Peripheral tolerance induced by apoptotic cells and PD-1+ CD8 T cells
https://doi.org/10.1186/ar3635
© Kazama et al.; licensee BioMed Central Ltd. 2012
- Published: 29 February 2012
Keywords
- Public Health
- Immune Response
- Arthritis
- Autoimmune Disease
- Apoptotic Cell
PD-1 is essential for tolerance induced by apoptotic cells. TNP-apoptotic cells were injected intravenously into PD-1 hetero- or homo- deficient mice. The mice were immunized with TNP (Filled bar) or preconditioned with apoptotic cells before immunization with TNP (open bar).
Declarations
Acknowledgements
We were kindly provided the neutralizing antibodies to PD-1 and PD-L2 by Dr. Hideo Yagita (Juntendo University) and hybridoma to PD-L1 from Dr. Miyuki Azuma (Tokyo Medical and Dental University).
Authors’ Affiliations
Copyright
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.