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Volume 14 Supplement 1

Proceedings of the 8th Global Arthritis Research Network (GARN) Meeting and 1st Bio-Rheumatology International Congress (BRIC)

The functions of the post-translational modifications in rheumatoid arthritis

Arthritis Research & Therapy volume 14, Article number: P45 (2012) Cite this article

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Rheumatoid Arthritis (RA) is a chronic inflammatory joint disease and characterized by synovial hyperplasia. We previously cloned an E3 ubiquitin ligase, Synoviolin, as a regulatory factor of cell proliferation [1]. It suggested that endoplasmic reticulum (ER) associated degradation system (ERAD) via Synoviolin has important roles for overgrowth of synoviocytes [2, 3]. Meanwhile, it is known that autoantibodies to citrullinated proteins are specific for RA and good markers for RA. Peptidyl-Arginine Deiminases 4 (PADI4) is identified as the RA-susceptible gene [3]. However functions of citrulinated proteins are unclear. In this study, we hypothesize that the accumulation of citrullinated proteins in RA synoviocytes could associate for ER stress and explore the crosstalk of ubiquitination and citrullination.

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Affiliations

  1. Institute of Medical Science, Tokyo Medical University, Shinjuku-ku, Tokyo, 160-8402, Japan
    • Satoko Aratani
    • , Teruhisa Kanazawa
    • , Fukami Nakajima
    • , Kusuki Nishioka
    •  & Toshihiro Nakajima
  2. Institute of Medical Science, St. Marianna University School of Medicine, Kawasaki, Kanagawa, 216-8512, Japan
    • Naoko Yagishita
    •  & Yoshihisa Yamano
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Correspondence to Satoko Aratani.

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Aratani, S., Yagishita, N., Kanazawa, T. et al. The functions of the post-translational modifications in rheumatoid arthritis. Arthritis Res Ther 14, P45 (2012). https://doi.org/10.1186/ar3646

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Keywords

  • Rheumatoid Arthritis
  • Arthritis
  • Cell Proliferation
  • Endoplasmic Reticulum
  • Endoplasmic Reticulum Stress

Arthritis Research & Therapy

ISSN: 1478-6362

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