Expression patterns and function of chromatin protein HMGB2 during mesenchymal stem cell differentiation
© Taniguchi et al.; licensee BioMed Central Ltd. 2012
Published: 29 February 2012
The superficial zone (SZ) of articular cartilage is critical in maintaining tissue function and homeostasis and represents the site of the earliest changes in osteoarthritis (OA). The expression of chromatin protein HMGB2 is restricted to the SZ, which contains cells expressing mesenchymal stem cell (MSC) markers . Aging-related loss of HMGB2 and gene deletion are associated with reduced SZ cellularity and early onset OA . This study addressed HMGB2 expression patterns in MSC and its role during differentiation.
These results demonstrate that HMGB2 expression is inversely correlated with the differentiation status of MSC and that HMGB2 suppresses chondrogenic differentiation. The aging-related loss of HMGB2 in articular cartilage may represent a mechanism responsible for the decline in adult cartilage stem cell populations.
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