Reparon-Schuijt CC, van Esch WJ, van Kooten C, Schellekens GA, de Jong BA, van Venrooij WJ, Breedveld FC, Verweij CL: Secretion of anti-citrulline-containing peptide antibody by B lymphocytes in rheumatoid arthritis. Arthritis Rheum. 2001, 44: 41-47. 10.1002/1529-0131(200101)44:1<41::AID-ANR6>3.0.CO;2-0.
Article
CAS
PubMed
Google Scholar
Rantapaa-Dahlqvist S, de Jong BA, Berglin E, Hallmans G, Wadell G, Stenlund H, Sundin U, van Venrooij WJ: Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum. 2003, 48: 2741-2749. 10.1002/art.11223.
Article
PubMed
Google Scholar
Newkirk MM: Rheumatoid factors: host resistance or autoimmunity?. Clin Immunol. 2002, 104: 1-13. 10.1006/clim.2002.5210.
Article
CAS
PubMed
Google Scholar
Burkhardt H, Sehnert B, Bockermann R, Engstrom A, Kalden JR, Holmdahl R: Humoral immune response to citrullinated collagen type II determinants in early rheumatoid arthritis. Eur J Immunol. 2005, 35: 1643-1652. 10.1002/eji.200526000.
Article
CAS
PubMed
Google Scholar
Stuart JM, Dixon FJ: Serum transfer of collagen-induced arthritis in mice. J Exp Med. 1983, 158: 378-392. 10.1084/jem.158.2.378.
Article
CAS
PubMed
Google Scholar
Holmdahl R, Rubin K, Klareskog L, Larsson E, Wigzell H: Characterization of the antibody response in mice with type II collagen-induced arthritis, using monoclonal anti-type II collagen antibodies. Arthritis Rheum. 1986, 29: 400-410. 10.1002/art.1780290314.
Article
CAS
PubMed
Google Scholar
Nandakumar KS, Svensson L, Holmdahl R: Collagen type II-specific monoclonal antibody-induced arthritis in mice: description of the disease and the influence of age, sex, and genes. Am J Pathol. 2003, 163: 1827-1837. 10.1016/S0002-9440(10)63542-0.
Article
PubMed Central
CAS
PubMed
Google Scholar
Uysal H, Bockermann R, Nandakumar KS, Sehnert B, Bajtner E, Engstrom A, Serre G, Burkhardt H, Thunnissen MM, Holmdahl R: Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis. J Exp Med. 2009, 206: 449-462. 10.1084/jem.20081862.
Article
PubMed Central
CAS
PubMed
Google Scholar
Gellrich S, Muche JM, Wilks A, Jasch KC, Voit C, Fischer T, Audring H, Sterry W: Systemic eight-cycle anti-CD20 monoclonal antibody (rituximab) therapy in primary cutaneous B-cell lymphomas--an applicational observation. Br J Dermatol. 2005, 153: 167-173. 10.1111/j.1365-2133.2005.06659.x.
Article
CAS
PubMed
Google Scholar
Edwards JC, Szczepanski L, Szechinski J, Filipowicz-Sosnowska A, Emery P, Close DR, Stevens RM, Shaw T: Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. N Engl J Med. 2004, 350: 2572-2581. 10.1056/NEJMoa032534.
Article
CAS
PubMed
Google Scholar
Hedbom E, Antonsson P, Hjerpe A, Aeschlimann D, Paulsson M, Rosa-Pimentel E, Sommarin Y, Wendel M, Oldberg A, Heinegard D: Cartilage matrix proteins. An acidic oligomeric protein (COMP) detected only in cartilage. J Biol Chem. 1992, 267: 6132-6136.
CAS
PubMed
Google Scholar
Halasz K, Kassner A, Morgelin M, Heinegard D: COMP acts as a catalyst in collagen fibrillogenesis. J Biol Chem. 2007, 282: 31166-31173. 10.1074/jbc.M705735200.
Article
CAS
PubMed
Google Scholar
Holden P, Meadows RS, Chapman KL, Grant ME, Kadler KE, Briggs MD: Cartilage oligomeric matrix protein interacts with type IX collagen, and disruptions to these interactions identify a pathogenetic mechanism in a bone dysplasia family. J Biol Chem. 2001, 276: 6046-6055. 10.1074/jbc.M009507200.
Article
CAS
PubMed
Google Scholar
Briggs MD, Hoffman SM, King LM, Olsen AS, Mohrenweiser H, Leroy JG, Mortier GR, Rimoin DL, Lachman RS, Gaines ES: Pseudoachondroplasia and multiple epiphyseal dysplasia due to mutations in the cartilage oligomeric matrix protein gene. Nat Genet. 1995, 10: 330-336. 10.1038/ng0795-330.
Article
CAS
PubMed
Google Scholar
Hecht JT, Nelson LD, Crowder E, Wang Y, Elder FF, Harrison WR, Francomano CA, Prange CK, Lennon GG, Deere M: Mutations in exon 17B of cartilage oligomeric matrix protein (COMP) cause pseudoachondroplasia. Nat Genet. 1995, 10: 325-329. 10.1038/ng0795-325.
Article
CAS
PubMed
Google Scholar
Carlsen S, Hansson AS, Olsson H, Heinegard D, Holmdahl R: Cartilage oligomeric matrix protein (COMP)-induced arthritis in rats. Clin Exp Immunol. 1998, 114: 477-484. 10.1046/j.1365-2249.1998.00739.x.
Article
PubMed Central
CAS
PubMed
Google Scholar
Carlsen S, Nandakumar KS, Backlund J, Holmberg J, Hultqvist M, Vestberg M, Holmdahl R: Cartilage oligomeric matrix protein induction of chronic arthritis in mice. Arthritis Rheum. 2008, 58: 2000-2011. 10.1002/art.23554.
Article
CAS
PubMed
Google Scholar
Souto-Carneiro MM, Burkhardt H, Muller EC, Hermann R, Otto A, Kraetsch HG, Sack U, Konig A, Heinegard D, Muller-Hermelink HK, Krenn V: Human monoclonal rheumatoid synovial B lymphocyte hybridoma with a new disease-related specificity for cartilage oligomeric matrix protein. J Immunol. 2001, 166: 4202-4208.
Article
CAS
PubMed
Google Scholar
Mo JA, Holmdahl R: The B cell response to autologous type II collagen: biased V gene repertoire with V gene sharing and epitope shift. J Immunol. 1996, 157: 2440-2448.
CAS
PubMed
Google Scholar
Svensson L, Aszodi A, Heinegard D, Hunziker EB, Reinholt FP, Fassler R, Oldberg A: Cartilage oligomeric matrix protein-deficient mice have normal skeletal development. Mol Cell Biol. 2002, 22: 4366-4371. 10.1128/MCB.22.12.4366-4371.2002.
Article
PubMed Central
CAS
PubMed
Google Scholar
Hultqvist M, Olofsson P, Holmberg J, Backstrom BT, Tordsson J, Holmdahl R: Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene. Proc Natl Acad Sci USA. 2004, 101: 12646-12651. 10.1073/pnas.0403831101.
Article
PubMed Central
CAS
PubMed
Google Scholar
Geng H, Carlsen S, Nandakumar KS, Holmdahl R, Aspberg A, Oldberg A, Mattsson R: Cartilage oligomeric matrix protein deficiency promotes early onset and the chronic development of collagen-induced arthritis. Arthritis Res Ther. 2008, 10: R134-10.1186/ar2551.
Article
PubMed Central
PubMed
Google Scholar
Cao D, Khmaladze I, Jia H, Bajtner E, Nandakumar KS, Blom T, Mo JA, Holmdahl R: Pathogenic autoreactive B cells are not negatively selected toward matrix protein collagen II. J Immunol. 2011, 187: 4451-4458. 10.4049/jimmunol.1101378.
Article
CAS
PubMed
Google Scholar
Holmdahl RCS, Mikulowska A, Vestberg M, Brunsberg U, Hansson A-S, Sundvall M, Jansson L, Pettersson U: Genetic analysis of mouse models for rheumatoid arthritis. Human Genome Methods. Edited by: Adolph KW. 1998, New York: CRC Press, 215-238.
Google Scholar
Klaus GG, Pepys MB, Kitajima K, Askonas BA: Activation of mouse complement by different classes of mouse antibody. Immunology. 1979, 38: 687-695.
PubMed Central
CAS
PubMed
Google Scholar
Neuberger MS, Rajewsky K: Activation of mouse complement by monoclonal mouse antibodies. Eur J Immunol. 1981, 11: 1012-1016. 10.1002/eji.1830111212.
Article
CAS
PubMed
Google Scholar
Laver WG, Air GM, Webster RG, Smith-Gill SJ: Epitopes on protein antigens: misconceptions and realities. Cell. 1990, 61: 553-556. 10.1016/0092-8674(90)90464-P.
Article
CAS
PubMed
Google Scholar
Davies DR, Cohen GH: Interactions of protein antigens with antibodies. Proc Natl Acad Sci USA. 1996, 93: 7-12. 10.1073/pnas.93.1.7.
Article
PubMed Central
CAS
PubMed
Google Scholar
Estienne V, Duthoit C, Vinet L, Durand-Gorde JM, Carayon P, Ruf J: A conformational B-cell epitope on the C-terminal end of the extracellular part of human thyroid peroxidase. J Biol Chem. 1998, 273: 8056-8062. 10.1074/jbc.273.14.8056.
Article
CAS
PubMed
Google Scholar
Plotz PH: The autoantibody repertoire: searching for order. Nat Rev Immunol. 2003, 3: 73-78. 10.1038/nri976.
Article
CAS
PubMed
Google Scholar
Saxne T, Heinegard D: Cartilage oligomeric matrix protein: a novel marker of cartilage turnover detectable in synovial fluid and blood. Br J Rheumatol. 1992, 31: 583-591. 10.1093/rheumatology/31.9.583.
Article
CAS
PubMed
Google Scholar
Neidhart M, Hauser N, Paulsson M, DiCesare PE, Michel BA, Hauselmann HJ: Small fragments of cartilage oligomeric matrix protein in synovial fluid and serum as markers for cartilage degradation. Br J Rheumatol. 1997, 36: 1151-1160. 10.1093/rheumatology/36.11.1151.
Article
CAS
PubMed
Google Scholar
Liu CJ, Kong W, Xu K, Luan Y, Ilalov K, Sehgal B, Yu S, Howell RD, Di Cesare PE: ADAMTS-12 associates with and degrades cartilage oligomeric matrix protein. J Biol Chem. 2006, 281: 15800-15808. 10.1074/jbc.M513433200.
Article
PubMed Central
CAS
PubMed
Google Scholar
Luan Y, Kong L, Howell DR, Ilalov K, Fajardo M, Bai XH, Di Cesare PE, Goldring MB, Abramson SB, Liu CJ: Inhibition of ADAMTS-7 and ADAMTS-12 degradation of cartilage oligomeric matrix protein by alpha-2-macroglobulin. Osteoarthritis Cartilage. 2008, 16: 1413-1420. 10.1016/j.joca.2008.03.017.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kashiwagi M, Enghild JJ, Gendron C, Hughes C, Caterson B, Itoh Y, Nagase H: Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing. J Biol Chem. 2004, 279: 10109-10119.
Article
CAS
PubMed
Google Scholar
Di Cesare PE, Carlson CS, Stolerman ES, Hauser N, Tulli H, Paulsson M: Increased degradation and altered tissue distribution of cartilage oligomeric matrix protein in human rheumatoid and osteoarthritic cartilage. J Orthop Res. 1996, 14: 946-955. 10.1002/jor.1100140615.
Article
CAS
PubMed
Google Scholar
Maccioni M, Zeder-Lutz G, Huang H, Ebel C, Gerber P, Hergueux J, Marchal P, Duchatelle V, Degott C, van Regenmortel M, Benoist C, Mathis D: Arthritogenic monoclonal antibodies from K/BxN mice. J Exp Med. 2002, 195: 1071-1077. 10.1084/jem.20011941.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ji H, Ohmura K, Mahmood U, Lee DM, Hofhuis FM, Boackle SA, Takahashi K, Holers VM, Walport M, Gerard C, Ezekowitz A, Carroll MC, Brenner M, Weissleder R, Verbeek JS, Duchatelle V, Degott C, Benoist C, Mathis D: Arthritis critically dependent on innate immune system players. Immunity. 2002, 16: 157-168. 10.1016/S1074-7613(02)00275-3.
Article
CAS
PubMed
Google Scholar
Hietala MA, Nandakumar KS, Persson L, Fahlen S, Holmdahl R, Pekna M: Complement activation by both classical and alternative pathways is critical for the effector phase of arthritis. Eur J Immunol. 2004, 34: 1208-1216. 10.1002/eji.200424895.
Article
CAS
PubMed
Google Scholar
Takai T: Roles of Fc receptors in autoimmunity. Nat Rev Immunol. 2002, 2: 580-592.
CAS
PubMed
Google Scholar
Blom AB, van Lent PL, van Vuuren H, Holthuysen AE, Jacobs C, van de Putte LB, van de Winkel JG, van den Berg WB: Fc gamma R expression on macrophages is related to severity and chronicity of synovial inflammation and cartilage destruction during experimental immune-complex-mediated arthritis (ICA). Arthritis Res. 2000, 2: 489-503. 10.1186/ar131.
Article
PubMed Central
CAS
PubMed
Google Scholar
Lee DM, Friend DS, Gurish MF, Benoist C, Mathis D, Brenner MB: Mast cells: a cellular link between autoantibodies and inflammatory arthritis. Science. 2002, 297: 1689-1692. 10.1126/science.1073176.
Article
CAS
PubMed
Google Scholar
Matsumoto I, Maccioni M, Lee DM, Maurice M, Simmons B, Brenner M, Mathis D, Benoist C: How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease. Nat Immunol. 2002, 3: 360-365. 10.1038/ni772.
Article
CAS
PubMed
Google Scholar
Humby F, Bombardieri M, Manzo A, Kelly S, Blades MC, Kirkham B, Spencer J, Pitzcalis C: Ectopic lymphoid structures support ongoing production of class-switched autoantibodies in rheumatoid synovium. PLoS Med. 2009, 6: e1-
Article
PubMed Central
PubMed
Google Scholar
Morozzi G, Fabbroni M, Bellisai F, Bellisai F, Pucci G, Galeazzi M: Cartilage oligomeric matrix protein level in rheumatic diseases: potential use as a marker for measuring articular cartilage damage and/or the therapeutic efficacy of treatments. Ann NY Acad Sci. 2007, 1108: 398-407. 10.1196/annals.1422.041.
Article
CAS
PubMed
Google Scholar
Turesson C, Bergström U, Jacobsson LT, Truedsson L, Berglund G, Saxne T: Increased cartilage turnover and circulating autoantibodies in different subsets before the clinical onset of rheumatoid arthritis. Ann Rheum Dis. 2010, 70: 520-522.
Article
PubMed
Google Scholar
Kühne SA, Neidhart M, Everson MP, Häntzschel H, Fine PR, Gay S, Häuselmann HJ, RE Gay: Persistent high serum levels of cartilage oligomeric matrix protein in a subgroup of patients with traumatic knee injury. Rheumatol Int. 1998, 18: 21-15. 10.1007/s002960050049.
Article
PubMed
Google Scholar
Happonen KE, Saxne T, Aspberg A, Morgelin M, Heinegard D, Blom A: Regulation of complement by cartilage oligomeric matrix protein allows for a novel molecular diagnostic principle in rheumatoid arthritis. Arthritis Rheum. 2010, 62: 3574-3583. 10.1002/art.27720.
Article
PubMed Central
CAS
PubMed
Google Scholar