Busija L, Bridgett L, Williams SR, Osborne RH, Buchbinder R, March L, Fransen M: Osteoarthritis. Best Pract Clin Rheumatol. 2010, 24: 757-768. 10.1016/j.berh.2010.11.001.
Article
Google Scholar
Lotz MK, Fraus VB: New developments in osteoarthritis. Arthritis Res Ther. 2010, 12: 211-220. 10.1186/ar3046. Erratum in Arthritis Res Ther 2010, 12:408. Kraus, Virginia B [added]
Article
PubMed Central
PubMed
Google Scholar
Sun HB: Mechanical loading, cartilage degradation, and arthritis. Ann NY Acad Sci. 2010, 1211: 37-50. 10.1111/j.1749-6632.2010.05808.x.
Article
CAS
PubMed
Google Scholar
Fisher MC, Ferrari D, Yincui L, Shepard JB, Patterson SE, Anderson N, Dealy CN: The potential of human embryonic stem cells for articular cartilage repair and osteoarthritis treatment. Rheumatol Curr Res. 2012, S3-
Google Scholar
Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L: Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med. 1994, 331: 889-895. 10.1056/NEJM199410063311401.
Article
CAS
PubMed
Google Scholar
Gomoll AH: Microfracture and augments. J Knee Surg. 2012, 25: 9-15.
Article
PubMed
Google Scholar
Benthien JP, Schwaninger M, Behrens P: We do not have evidence based methods for the treatment of cartilage defects in the knee. Knee Surg Sports Traumatol Arthrosc. 2011, 19: 543-552. 10.1007/s00167-010-1271-5.
Article
PubMed
Google Scholar
Aigner T, Söder S, Gebhard PM, McAlinden A, Haag J: Mechanisms of disease: role of chondrocytes in the pathogenesis of osteoarthritis-structure, chaos and senescence. Nat Clin Pract Rheumatol. 2007, 3: 391-399. 10.1038/ncprheum0534.
Article
CAS
PubMed
Google Scholar
Estes BT, Diekman BO, Gimble JM, Guilak F: Isolation of adipose derived stem cells and their induction to a chondrogenic phenotype. Nat Protoc. 2010, 5: 1294-1311. 10.1038/nprot.2010.81.
Article
PubMed Central
CAS
PubMed
Google Scholar
LaPrade RF, Bursch LS, Olson EJ, Havlas V, Carlson CS: Histologic and immunohistochemical characteristics of failed articular cartilage resurfacing procedures for osteochondritis of the knee: a case series. Am J Sports Med. 2008, 36: 360-368. 10.1177/0363546507308359.
Article
PubMed
Google Scholar
Dealy CN: Chondrogenic progenitors for cartilage repair and osteoarthritis treatment. Rheumatol Curr Res. 2012, S3-
Google Scholar
McCarthy HE, Bara JJ, Brakspear K, Singhrao SK, Archer CW: The comparison of equine articular cartilage progenitor cells and bone marrow-derived stromal cells as potential cell sources for cartilage repair in the horse. Vet J. 2012, 192: 345-351. 10.1016/j.tvjl.2011.08.036.
Article
CAS
PubMed
Google Scholar
Hattori S, Oxford C, Reddi AH: Identification of superficial zone articular chondrocyte stem/progenitor cells. Biochem Biophys Res Comm. 2007, 358: 99-103. 10.1016/j.bbrc.2007.04.142.
Article
PubMed Central
CAS
PubMed
Google Scholar
Pretzel D, Linss S, Rochler S, Endres M, Kaps C, Alsalameh S, Kinne RW: Relative percentage and zonal distribution of mesenchymal progenitor cells in human osteoarthritic and normal cartilage. Arthritis Res Ther. 2011, 13: R64-10.1186/ar3320.
Article
PubMed Central
CAS
PubMed
Google Scholar
Fickert S, Fiedler J, Brenner RE: Identification of subpopulations with characteristics of mesenchymal progenitor cells from human osteoarthritic cartilage using triple staining for cell surface markers. Arthritis Res Ther. 2004, 6: R422-R432. 10.1186/ar1210.
Article
PubMed Central
CAS
PubMed
Google Scholar
Dowthwaithe GP, Bishop JC, Redman SN, Khan IM, Rooney P, Evans DJR, Haughton L, Bayram Z, Boyer S, Thomson B, Wolfe MS, Archer CW: The surface of articular cartilage contains a progenitor population. J Cell Sci. 2004, 117: 889-897. 10.1242/jcs.00912.
Article
Google Scholar
Williams R, Khan IM, Richardson K, Nelson L, McCarthy HE, Analbelsi T, Singhrao SK, Dowthwithe GP, Jones RE, Baird DM, Lewis H, Roberts S, Shaw HM, Dudhia J, Fariclough J, Briggs T, Archer CW: Identification and clonal characterization of a progenitor cell sub-population in normal human articular cartilage. PLoS One. 2010, 5: e513246-
Article
Google Scholar
Yasuhara R, Ohta Y, Yuasa T, Kondo N, Hoang T, Addya S, Fortina P, Pacifici M, Iwamoto M, Enomoto-Iwamoto M: Role of β-catenin signaling in phenotypic expression and proliferation of articular cartilage superficial zone cells. Lab Invest. 2011, 91: 1739-1752. 10.1038/labinvest.2011.144.
Article
PubMed Central
CAS
PubMed
Google Scholar
Grogan SP, Miyaki S, Asahara H, D'Lima DD, Lotz MK: Mesenchymal progenitor cell markers in human articular cartilage: normal distribution and changes in osteoarthritis. Arthritis Res Ther. 2009, 11: R85-10.1186/ar2719.
Article
PubMed Central
PubMed
Google Scholar
Koelling S, Kruegel J, Immer M, Path JR, Sadowski B, Miro X, Miosge N: Migratory chondrogenic progenitor cells from repair tissue during the later stages of human osteoarthritis. Cell Stem Cell. 2009, 4: 324-335. 10.1016/j.stem.2009.01.015.
Article
CAS
PubMed
Google Scholar
Martin JA, Buckwalter JA: The role of chondrocyte senescence in the pathogenesis of osteoarthritis and in limiting cartilage repair. J Bone Joint Surg Am. 2003, 85: 106-110.
PubMed
Google Scholar
Chang HX, Yang L, Li Z, Chen G, Dai G: Age-related biological characterization of mesenchymal progenitor cells in human articular cartilage. Orthopedics. 2011, 34: e382-8.
PubMed
Google Scholar
Adkisson HD, Martin JA, Amendola RL, Milliman C, Mauch KA, Katwal AB, Syedin M, Amendola A, Streeter PR, Buckwalter JA: The potential of human allogenic juvenile chondrocytes for restoration of articular cartilage. Am J Sports Med. 2010, 38: 1324-1333. 10.1177/0363546510361950.
Article
PubMed Central
PubMed
Google Scholar
Zhang X, Siclari VA, Lan S, Zhu J, Koyama E, Dupuis HL, Enomoto-Iwamoto M, Beier F, Qin L: The critical role of the epidermal growth factor receptor in endochondral ossification. J Bone Miner Res. 2011, 11: 2622-2633.
Article
Google Scholar
Schneider MR, Sibilia M, Erben RG: The EGFR network in bone biology and pathology. Trends Endocrinol Metab. 2009, 20: 517-524. 10.1016/j.tem.2009.06.008.
Article
CAS
PubMed
Google Scholar
Zhang YW, Su Y, Lanning N, Swiatek PJ, Bronson RT, Sigler R, Martin RW, Vande Woude GF: Targeted disruption of Mig-6 in the mouse genome leads to early onset degenerative joint disease. Proc Natl Acad Sci USA. 2005, 102: 11740-11745. 10.1073/pnas.0505171102.
Article
PubMed Central
CAS
PubMed
Google Scholar
Dealy CN, Scranton V, Cheng H-C: Roles of transforming growth factor-α and epidermal growth factor in chick limb development. Dev Biol. 1998, 202: 43-55. 10.1006/dbio.1998.8988.
Article
CAS
PubMed
Google Scholar
Yoon YM, Oh CD, Kim DY, Lee YS, Park JW, Hub TL, Kang SS, Chun JS: Epidermal growth factor negatively regulates chondrogenesis of mesenchymal cells by modulating the protein kinase c-alpha, Erk1 and p38MAPK signaling pathways. J Biol Chem. 2000, 275: 12353-12359. 10.1074/jbc.275.16.12353.
Article
CAS
PubMed
Google Scholar
Verschure PJ, Joosten LA, van der Kraan PM, Van den Berg WB: Responsiveness of articular cartilage from normal and inflamed mouse knee joints to various growth factors. Ann Rheum Dis. 1994, 53: 455-460. 10.1136/ard.53.7.455.
Article
PubMed Central
CAS
PubMed
Google Scholar
Klooster A, Bernier SM: Tumor necrosis factor alpha and epidermal growth factor act additively to inhibit matrix gene expression by chondrocytes. Arthritis Res Theory. 2005, 7: R127-R138. 10.1186/ar1464.
Article
CAS
Google Scholar
Usmani SE, Appleton CT, Beier F: Transforming growth factor-alpha induces endothelin receptor-A expression in osteoarthritis. J Orthp Res. 2012, 30: 1391-1397. 10.1002/jor.22099.
Article
CAS
Google Scholar
Appleton CT, Usmani SE, Bernier SM, Aigner T, Beier F: Transforming growth factor alpha suppression of articular chondrocyte phenotype and Sox9 expression in a rat model of osteoarthritis. Arthritis Rheum. 2007, 56: 3693-3705. 10.1002/art.22968.
Article
PubMed
Google Scholar
Jakob M, Demarteau O, Schafer D, Hintermann B, Dick W, Heberer M, Martin I: Specific growth factors during the expansion and redifferentiation of adult human articular chondrocytes enhance chondrogenesis and cartilaginous tissue formation in vitro. J Cell Biochem. 2001, 81: 368-377. 10.1002/1097-4644(20010501)81:2<368::AID-JCB1051>3.0.CO;2-J.
Article
CAS
PubMed
Google Scholar
Huh Y-H, Kim S-H, Kim S-J, Chun J-S: Differentiation status-dependent regulation of cyclooxygenase-2 expression and prostaglandin E2 production by epidermal growth factor via mitogen-activated protein kinase in articular chondrocytes. J Biol Chem. 2003, 278: 9691-9697. 10.1074/jbc.M211360200.
Article
CAS
PubMed
Google Scholar
Takeda H, Inoue H, Kutsuna T, Matsushita N, Takahashi T, Watanabe S, Higashiyama S, Yamamoto H: Activation of epidermal growth factor receptor gene is involved in transforming growth factor-β-mediated fibronectin expression in a chondrogenic progenitor cell line. Int J Mol Med. 2010, 25: 593-600.
CAS
PubMed
Google Scholar
Appleton CT, McErlain DD, Henry JL, Holdsworth DW, Beier F: Molecular and histological analysis of a new rat model of experimental knee osteoarthritis. Ann NY Acad Sci. 2007, 1117: 165-174. 10.1196/annals.1402.022.
Article
PubMed
Google Scholar
Hackel PO, Gishizky M, Ullrich A: Mig6 is a negative regulator of the Epidermal Growth Factor Receptor signal. Biol Chem. 2001, 382: 1649-1662.
Article
CAS
PubMed
Google Scholar
Logan M, Martin JF, Nagy A, Lobe C, Olson EN, Tabin CJ: Expression of Cre Recombinase in the developing mouse limb bud driven by a Prx1 enhancer. Genesis. 2002, 33: 77-80. 10.1002/gene.10092.
Article
CAS
PubMed
Google Scholar
Jin N, Gilbert JL, Broaddus RR, DeMayo FJ, Jeong J-W: Generation of a Mig6-conditional null allele. Genesis. 2007, 45: 716-721. 10.1002/dvg.20348.
Article
CAS
PubMed
Google Scholar
Fisher M, Meyer C, Garber G, Dealy CN: Role of IGFBP2, IGF-I and IGF-II in regulating long bone growth. Bone. 2005, 37: 741-750. 10.1016/j.bone.2005.07.024.
Article
CAS
PubMed
Google Scholar
Watkins DJ, Zhou Y, Chen CL, Darbyshire A, Besner GE: Heparan-binding epidermal growth factor like-growth factor protects mesenchymal stem cells. J Surg Res. 2012, 177: 359-364. 10.1016/j.jss.2012.05.016.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kerpedjieva SS, Kim DS, Barbeau DJ, Tamama K: EGFR ligands drive multipotential stromal cells to produce multiple growth factors and cytokines via early growth response-1. Stem Cells. 2012, 21: 2541-2551. 10.1089/scd.2011.0711.
Article
CAS
Google Scholar
Omi M, Maihle NJ, Fisher M, Dealy CN: Studies on EGF receptor signaling in vertebrate limb patterning. Dev Dyn. 2005, 233: 288-300. 10.1002/dvdy.20353.
Article
CAS
PubMed
Google Scholar
Fisher MC, Clinton GM, Maihle NJ, Dealy CN: Requirement for ErbB2/ErbB signaling in developing cartilage and bone. Dev Growth Differ. 2007, 49: 503-513. 10.1111/j.1440-169X.2007.00941.x.
Article
CAS
PubMed
Google Scholar
Dexheimer V, Frank S, Richter W: Proliferation as a requirement for in vitro chondrogenesis of human mesenchymal stem cells. Stem Cells Dev. 2012, 21: 2160-2169. 10.1089/scd.2011.0670.
Article
PubMed Central
CAS
PubMed
Google Scholar
Karlsson C, Thornemo M, Henricksson HB, Lindahl A: Identification of a stem cell niche in the zone of Ranvier. J Anat. 2009, 215: 355-363. 10.1111/j.1469-7580.2009.01115.x.
Article
PubMed Central
PubMed
Google Scholar
Dy P, Smits P, Silvester A, Penzo-Méndez A, Dumitriu B, Han Y, de la Motte CA, Kingsley DM, Lefebvre V: Synovial joint morphogenesis requires the chondrogenic action of Sox5 and Sox6 in growth plate and articular cartilage. Dev Biol. 2010, 341: 346-359. 10.1016/j.ydbio.2010.02.024.
Article
PubMed Central
CAS
PubMed
Google Scholar
Koyama E, Shibukawa Y, Nagayama M, Sugito H, Young B, Yuasa T, Okabe T, Ochiai T, Kamiya N, Rountree RB, Kingsley DM, Iwamoto M, Enomoto-Iwamoto M, Pacifici M: A distinct cohort of progenitor cells participates in synovial joint and articular cartilage formation during mouse limb skeletogenesis. Dev Biol. 2008, 316: 62-73. 10.1016/j.ydbio.2008.01.012.
Article
PubMed Central
CAS
PubMed
Google Scholar
van der Kraan PM, Blaney Davidson EN, Van den Berg WB: A role for age-related changes in TGFβ signaling in aberrant chondrocyte differentiation and osteoarthritis. Arthritis Res Ther. 2010, 12: 201-10.1186/ar2896.
Article
PubMed Central
PubMed
Google Scholar
Lee SY, Nakagawa T, Reddi AH: Induction of chondrogenesis and superficial zone protein (SZP)/lubricin expression by mesenchymal progenitors in the infrapatellar fat pad of the knee joint treated with TGF-β1 and BMP-7. Biochem Biophy Res Comm. 2008, 376: 148-153. 10.1016/j.bbrc.2008.08.138.
Article
CAS
Google Scholar
Zhu M, Tang D, Wu Q, Hao S, Chen M, Xie C, Rosier RN, O'Keefe RJ, Zuscik M, Chen D: Activation of β-catenin signaling in articular chondrocytes leads to an osteoarthritic like phenotype in adult beta catenin conditional activation mice. J Bone Miner Res. 2009, 24: 12-21. 10.1359/jbmr.080901.
Article
PubMed Central
CAS
PubMed
Google Scholar
Yuasa T, Kondo N, Yasuhara R, Shimono K, Mackem S, Pacifici M, Iwamoto M, Enomoto-Iwamoto M: Transient activation of Wnt/beta-catenin signaling induces abnormal growth plate closure and articular cartilage thickening in postnatal mice. Am J Pathol. 2009, 175: 1933-2003.
Article
Google Scholar
Uchiyama-Tanaka Y, Matsubara H, Mori Y, Kosaki A, Kishimoto N, Amano K, Higashiyama S, Iwasaka T: Involvement of the HB-EGF and EGF receptor transactivation in TGF-beta mediated fibronectin expression in mesangial cells. Kidney Int. 2002, 62: 799-808. 10.1046/j.1523-1755.2002.00537.x.
Article
CAS
PubMed
Google Scholar
Wendt MK, Smith JA, Schiemann WP: Transforming growth factor-β-induced epithelial-mesenchymal transition facilitates epidermal growth factor dependent breast cancer progression. Oncogene. 2010, 29: 6485-6498. 10.1038/onc.2010.377.
Article
PubMed Central
CAS
PubMed
Google Scholar
Hu T, Li C: Convergence between Wnt-β-catenin and EGFR signaling in cancer. Mol Cancer. 2010, 9: 236-
Article
PubMed Central
PubMed
Google Scholar
Yue X, Lan F, Yang W, Yang Y, Han L, Zhang A, Liu J, Zeng H, Jiang T, Pu P, Kang C: Interruption of β-catenin suppresses the EGFR pathway by blocking multiple oncogenic targets in human glioma cells. Brain Res. 2010, 1366: 27-37.
Article
CAS
PubMed
Google Scholar
Guteri KK, Mandal T, Chatterjee A, Sarkar M, Bhattacharya S, Chatterjee U, Ghosh MK: Mechanism of β-catenin mediated transcriptional regulation of epidermal growth factor receptor expression in glycogen synthase kinase 2 B-inactivated prostate cancer cells. J Biol Chem. 2012, 287: 18287-18296. 10.1074/jbc.M111.324798.
Article
Google Scholar
Segatto O, Anastasi S, Alema S: Regulation of epidermal growth factor receptor signaling by inducible feedback inhibitors. J Cell Sci. 2011, 124: 1785-1793. 10.1242/jcs.083303.
Article
CAS
PubMed
Google Scholar
Zhang Y-W, Vande Woude GF: Mig-6, signal transduction, stress response and cancer. Cell Cycle. 2007, 6: 507-513. 10.4161/cc.6.5.3928.
Article
CAS
PubMed
Google Scholar
Wilken JA, Badri T, Cross S, Raji R, Santin AD, Schwartz P, Branscum AJ, Baron AT, Sakhitab AI, Maihle NJ: EGFR/HER-targeted therapeutics in ovarian cancer. Future Med Chem. 2012, 4: 447-469. 10.4155/fmc.12.11.
Article
PubMed Central
CAS
PubMed
Google Scholar
Ferby I, Reschke M, Kudlacek O, Knyazev P, Pante G, Amann K, Sommergruber W, Kraut N, Ullrich A, Fassler R, Kelin R: Mig6 is a negative regulator of EGF receptor mediated skin morphogenesis and tumor formation. Nat Med. 2006, 12: 568-573. 10.1038/nm1401.
Article
CAS
PubMed
Google Scholar
Burton-Wurster N, Mateescu RG, Todhunter RJ, Clements KM, Sun Q, Scarpino V, Lust G: Genes in canine articular cartilage that resond to mechanical injury: gene expression studies with Affymetrix canine GeneChip. J Hered. 2005, 96: 821-828. 10.1093/jhered/esi105.
Article
CAS
PubMed
Google Scholar
Gomez-Camarillo MA, Almonte-Becerril M, Vasquez Tort M, Tapia-Ramirez J, Kouri Flores JB: Chondrocyte proliferation in a new culture system. Cell Prolif. 2009, 442: 207-218.
Article
Google Scholar
Beerlie RR, Hynes NE: Epidermal growth factor related peptides activate distinct subsets of ErbB receptors and differ in their biological activities. J Biol Chem. 1996, 271: 6071-6076. 10.1074/jbc.271.11.6071.
Article
Google Scholar
Olayioye MA, Neve RM, Lane HA, Hynes NE: The ErbB signaling network: receptor heterodimerization in development and cancer. EMBO J. 2000, 19: 3159-3167. 10.1093/emboj/19.13.3159.
Article
PubMed Central
CAS
PubMed
Google Scholar
Fiorentino L, Pertica C, Fiorini M, Talora C, Crescenzi M, Castellani L, Alema S, Benedetti P, Segatto O: Inhibition of ErbB2-mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 kinase domain. Mol Cell Biol. 2000, 20: 7735-7750. 10.1128/MCB.20.20.7735-7750.2000.
Article
PubMed Central
CAS
PubMed
Google Scholar
Lin C-L, Du J, Shen WT, Whang EE, Donner DB, Griff N, He F, Moore FD, Clark OH, Ruan DT: Mitogen-inducible gene-6 is a multifunctional adapter protein with tumor suppressor like activity in papillary thyroid cancer. J Clin Endocrinol Metab. 2011, 96: E554-E565. 10.1210/jc.2010-1800.
Article
CAS
PubMed
Google Scholar
Pante G, Thompson J, Lamballe F, Iwata T, Ferby I, Barr FA, Davies AM, Maina F, Klein R: Mitogen-inducible gene-6 is an endogenous inhibitor of HGF/Met-induced cell migration and neurite outgrowth. J Cell Biol. 2005, 171: 337-348. 10.1083/jcb.200502013.
Article
PubMed Central
CAS
PubMed
Google Scholar
Bau B, McKenna LA, Soeder S, Fan Z, Pecht A, Aigner T: Hepatocyte growth factor/scatter factor is not a potent regulator of anabolic and catabolic gene expression in adult normal articular chondrocytes. Biochem Biophys Res Commun. 2004, 316: 984-990. 10.1016/j.bbrc.2004.03.001.
Article
CAS
PubMed
Google Scholar
Hughes LC, Archer CW, ap Gwynn I: The ultrastructure of mouse articular cartilage: collagen orientation and implications for tissue functionality. A polarized light and scanning electron microscope study and review. Eur Cell Mater. 2005, 9: 68-84.
CAS
PubMed
Google Scholar
Goldring MB: Chondrogenesis, chondrocyte differentiation, and articular cartilage metabolism in health and osteoarthritis. Ther Adv Musculoskelet Dis. 2012, 4: 269-285. 10.1177/1759720X12448454.
Article
PubMed Central
CAS
PubMed
Google Scholar
van der Kraan PM, Van den Berg WB: Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration?. Osteoarthritis Cart. 2012, 20: 223-232. 10.1016/j.joca.2011.12.003.
Article
CAS
Google Scholar