Volume 16 Supplement 1
A comprehensive approach to identify approved drugs and treatments for repositioning as therapies for systemic lupus erythematosus
© Grammer et al.; licensee BioMed Central Ltd. 2014
Published: 18 September 2014
Development of new systemic lupus erythematosus (SLE) treatments has been slow. To accelerate the pace, an evidence-based approach was developed to find new lupus therapies amongst 6,800 compounds FDA approved for human use.
The Lupus Treatment List (LRxL) was constructed with intense input from the entire lupus community, including patients, and was used to prioritize therapies to be tested in small focused, biomarker-rich clinical trials (SLE Treatment Acceleration Trials (STAT)). All drugs widely used for lupus or known to be in development for lupus by Pharma/Biotech were excluded. Details of the project can be viewed online . A novel evidence-based composite scoring system was developed to rank the identified drugs/therapies numerically by scientific rationale, experience in lupus mice/human cells, previous clinical experience in autoimmunity, drug properties and adverse event profile.
Of the 157 therapies initially screened, more than 25 have an appropriate set of characteristics to consider for testing in clinical trials in lupus, including drugs targeting cellular metabolism, kinases, the immune system, HDACs, complement as well as cellular therapies and nondrug interventions.
This approach has not only identified unique candidates that could be useful in SLE and possibly other autoimmune/inflammatory conditions, but has also yielded a rigorous evidence-based process by which therapies can be usefully rated for possible clinical application to treat these conditions, thereby mitigating risk in drug development.
- LrXL STAT. [http://www.linkedin.com/in/lrxlstat]
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.