McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. N Engl J Med. 2011;365:2205–19.
Article
CAS
PubMed
Google Scholar
Parikh-Patel A, White RH, Allen M, Cress R. Risk of cancer among rheumatoid arthritis patients in California. Cancer Causes Control. 2009;20:1001–10.
Article
PubMed Central
PubMed
Google Scholar
Jessica A, Stanich JDC, Whittum-Hudson J, Hudson AP. Rheumatoid arthritis: disease or syndrome? Open Access Rheumatol Res Rev. 2009;1:179–92.
Google Scholar
Lewder JN. Diagnostic use of in the management HLA-B27 in the management of seronegative spondyloarthropathies: methods for detection. Clin Immunol Newslett. 1996;16:1–32.
Article
Google Scholar
Eaton WW, Byrne M, Ewald H, Mors O, Chen CY, Agerbo E, et al. Association of schizophrenia and autoimmune diseases: linkage of Danish national registers. Am J Psychiatry. 2006;163:521–8.
Article
PubMed
Google Scholar
Thomas G, Jacobs KB, Yeager M, Kraft P, Wacholder S, Orr N, et al. Multiple loci identified in a genome-wide association study of prostate cancer. Nat Genet. 2008;40:310–5.
Article
CAS
PubMed
Google Scholar
Veeriah S, Taylor BS, Meng S, Fang F, Yilmaz E, Vivanco I, et al. Somatic mutations of the Parkinson’s disease-associated gene PARK2 in glioblastoma and other human malignancies. Nat Genet. 2010;42:77–82.
Article
CAS
PubMed Central
PubMed
Google Scholar
Khurana R, Wolf R, Berney S, Caldito G, Hayat S, Berney SM. Risk of development of lung cancer is increased in patients with rheumatoid arthritis: a large case control study in US veterans. J Rheumatol. 2008;35:1704–8.
PubMed
Google Scholar
Isomaki HA, Hakulinen T, Joutsenlahti U. Excess risk of lymphomas, leukemia and myeloma in patients with rheumatoid arthritis. J Chronic Dis. 1978;31:691–6.
Article
CAS
PubMed
Google Scholar
Michaud K, Wolfe F. Comorbidities in rheumatoid arthritis. Best Pract Res Clin Rheumatol. 2007;21:885–906.
Article
PubMed
Google Scholar
Young A, Koduri G, Batley M, Kulinskaya E, Gough A, Norton S, et al. Mortality in rheumatoid arthritis. Increased in the early course of disease, in ischaemic heart disease and in pulmonary fibrosis. Rheumatology. 2007;46:350–7.
Article
CAS
PubMed
Google Scholar
Tsuchiya Y, Takayanagi N, Sugiura H, Miyahara Y, Tokunaga D, Kawabata Y, et al. Lung diseases directly associated with rheumatoid arthritis and their relationship to outcome. Eur Respir J. 2011;37:1411–7.
Article
CAS
PubMed
Google Scholar
Goh KI, Cusick ME, Valle D, Childs B, Vidal M, Barabasi AL. The human disease network. Proc Natl Acad Sci U S A. 2007;104:8685–90.
Article
CAS
PubMed Central
PubMed
Google Scholar
Barrenas F, Chavali S, Holme P, Mobini R, Benson M. Network properties of complex human disease genes identified through genome-wide association studies. PLoS One. 2009;4:e8090.
Article
PubMed Central
PubMed
Google Scholar
Park J, Lee DS, Christakis NA, Barabasi AL. The impact of cellular networks on disease comorbidity. Mol Syst Biol. 2009;5:262.
Article
PubMed Central
PubMed
Google Scholar
Chavali S, Barrenas F, Kanduri K, Benson M. Network properties of human disease genes with pleiotropic effects. BMC Syst Biol. 2010;4:78.
Article
PubMed Central
PubMed
Google Scholar
Valentonyte R, Hampe J, Huse K, Rosenstiel P, Albrecht M, Stenzel A, et al. Sarcoidosis is associated with a truncating splice site mutation in BTNL2. Nat Genet. 2005;37:357–64.
Article
CAS
PubMed
Google Scholar
Thorsby E, Lie BA. HLA associated genetic predisposition to autoimmune diseases: Genes involved and possible mechanisms. Transpl Immunol. 2005;14:175–82.
Article
CAS
PubMed
Google Scholar
Zanelli E, Breedveld FC, de Vries RR. HLA association with autoimmune disease: a failure to protect? Rheumatology. 2000;39:1060–6.
Article
CAS
PubMed
Google Scholar
Sirota M, Schaub MA, Batzoglou S, Robinson WH, Butte AJ. Autoimmune disease classification by inverse association with SNP alleles. PLoS Genet. 2009;5:e1000792.
Article
PubMed Central
PubMed
Google Scholar
Sivakumaran S, Agakov F, Theodoratou E, Prendergast JG, Zgaga L, Manolio T, et al. Abundant pleiotropy in human complex diseases and traits. Am J Hum Genet. 2011;89:607–18.
Article
CAS
PubMed Central
PubMed
Google Scholar
Vineis P, Brennan P, Canzian F, Ioannidis JP, Matullo G, Ritchie M, et al. Expectations and challenges stemming from genome-wide association studies. Mutagenesis. 2008;23:439–44.
Article
CAS
PubMed
Google Scholar
Golden Helix GenomeBrowse® visualization tool (Version 2.x) Available from http://goldenhelix.com/.
Claude C, Arshad K, Lemoine NR, SNPnexus. A web database for functional annotation of newly discovered and public domain single nucleotide polymorphisms. Bioinformatics. 2009;25:655–61. Available at http://snp-nexus.org/.
Article
Google Scholar
Hua L, Zhou P, Liu H, Li L, Yang Z, Liu ZC. Mining susceptibility gene modules and disease risk genes from SNP data by combining network topological properties with support vector regression. J Theor Biol. 2011;289:225–36.
Article
CAS
PubMed
Google Scholar
Barabasi AL, Oltvai ZN. Network biology: understanding the cell’s functional organization. Nat Rev Genet. 2004;5:101–13.
Article
CAS
PubMed
Google Scholar
Jiang W, Li X, Rao S, Wang L, Du L, Li C, et al. Constructing disease-specific gene networks using pair-wise relevance metric: application to colon cancer identifies interleukin 8, desmin and enolase 1 as the central elements. BMC Syst Biol. 2008;2:72.
Article
PubMed Central
PubMed
Google Scholar
Torkamani A, Topol EJ, Schork NJ. Pathway analysis of seven common diseases assessed by genome-wide association. Genomics. 2008;92:265–72.
Article
CAS
PubMed Central
PubMed
Google Scholar
Dieude P. Rheumatic diseases: environment and genetics. Joint Bone Spine. 2009;76:602–7.
Article
CAS
PubMed
Google Scholar
Szalay B, Cseh A, Meszaros G, Kovacs L, Balog A, Vasarhelyi B. The impact of DMARD and anti-TNF therapy on functional characterization of short-term T-cell activation in patients with rheumatoid arthritis--a follow-up study. PLoS One. 2014;9:e104298.
Article
PubMed Central
PubMed
Google Scholar
Orozco G, Sanchez E, Gonzalez-Gay MA, Lopez-Nevot MA, Torres B, Caliz R, et al. Association of a functional single-nucleotide polymorphism of PTPN22, encoding lymphoid protein phosphatase, with rheumatoid arthritis and systemic lupus erythematosus. Arthritis Rheum. 2005;52:219–24.
Article
CAS
PubMed
Google Scholar
Zhang X, Li W, Zhang X, Zhao L, Zhang X, Jiang L, et al. Single nucleotide polymorphisms in TNFAIP3 were associated with the risks of rheumatoid arthritis in northern Chinese Han population. BMC Med Genet. 2014;15:56.
Article
CAS
PubMed Central
PubMed
Google Scholar
Kim SK, Choe JY, Bae J, Chae SC, Park DJ, Kwak SG, et al. TNFAIP3 gene polymorphisms associated with differential susceptibility to rheumatoid arthritis and systemic lupus erythematosus in the Korean population. Rheumatology. 2014;53:1009–13.
Article
CAS
PubMed
Google Scholar
Zhernakova A, van Diemen CC, Wijmenga C. Detecting shared pathogenesis from the shared genetics of immune-related diseases. Nat Rev Genet. 2009;10:43–55.
Article
CAS
PubMed
Google Scholar
Aggarwal BB, Shishodia S, Sandur SK, Pandey MK, Sethi G. Inflammation and cancer: how hot is the link? Biochem Pharmacol. 2006;72:1605–21.
Article
CAS
PubMed
Google Scholar
Baranzini SE. The genetics of autoimmune diseases: a networked perspective. Curr Opin Immunol. 2009;21:596–605.
Article
CAS
PubMed
Google Scholar
AlFadhli S, Nanda A. Genetic evidence for the involvement of NOTCH4 in rheumatoid arthritis and alopecia areata. Immunol Lett. 2013;150:130–3.
Article
CAS
PubMed
Google Scholar
Kochi Y, Yamada R, Kobayashi K, Takahashi A, Suzuki A, Sekine A, et al. Analysis of single-nucleotide polymorphisms in Japanese rheumatoid arthritis patients shows additional susceptibility markers besides the classic shared epitope susceptibility sequences. Arthritis Rheum. 2004;50:63–71.
Article
CAS
PubMed
Google Scholar
Nagamatsu I, Onishi H, Matsushita S, Kubo M, Kai M, Imaizumi A, et al. NOTCH4 is a potential therapeutic target for triple-negative breast cancer. Anticancer Res. 2014;34:69–80.
CAS
PubMed
Google Scholar
Zang S, Ji C, Qu X, Dong X, Ma D, Ye J, et al. A study on Notch signaling in human breast cancer. Neoplasma. 2007;54:304–10.
CAS
PubMed
Google Scholar
Lambert JC, Mann D, Harris J, Araria-Goumidi L, Chartier-Harlin MC, Cottel D, et al. Association study of Notch 4 polymorphisms with Alzheimer’s disease. J Neurol Neurosurg Psychiatry. 2004;75:377–81.
Article
PubMed Central
PubMed
Google Scholar
Shibata N, Ohnuma T, Higashi S, Higashi M, Usui C, Ohkubo T, et al. Genetic association between Notch4 polymorphisms and Alzheimer’s disease in the Japanese population. J Gerontol A Biol Sci Med Sci. 2007;62:350–1.
Article
PubMed
Google Scholar
Ajayi OO, Adefenwa MA, Agaviezor BO, Ikeobi CO, Wheto M, Okpeku M, et al. A novel TaqI polymorphism in the coding region of the ovine TNXB gene in the MHC class III region: morphostructural and physiological influences. Biochem Genet. 2014;52:1–14.
Article
CAS
PubMed
Google Scholar
Mao JR, Taylor G, Dean WB, Wagner DR, Afzal V, Lotz JC, et al. Tenascin-X deficiency mimics Ehlers-Danlos syndrome in mice through alteration of collagen deposition. Nat Genet. 2002;30:421–5.
Article
CAS
PubMed
Google Scholar
Kamatani Y, Matsuda K, Ohishi T, Ohtsubo S, Yamazaki K, Iida A, et al. Identification of a significant association of a single nucleotide polymorphism in TNXB with systemic lupus erythematosus in a Japanese population. J Hum Genet. 2008;53:64–73.
Article
CAS
PubMed
Google Scholar
Rupert KL, Rennebohm RM, Yu CY. An unequal crossover between the RCCX modules of the human MHC leading to the presence of a CYP21B gene and a tenascin TNXB/TNXA-RP2 recombinant between C4A and C4B genes in a patient with juvenile rheumatoid arthritis. Exp Clin Immunogenet. 1999;16:81–97.
Article
CAS
PubMed
Google Scholar
Yang HC, Liang YJ, Chung CM, Chen JW, Pan WH. Genome-wide gene-based association study. BMC Proc. 2009;7:S135.
Article
Google Scholar
Shiraishi K, Kunitoh H, Daigo Y, Takahashi A, Goto K, Sakamoto H, et al. A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population. Nat Genet. 2012;44:900–3.
Article
CAS
PubMed
Google Scholar
Love T, Solomon DH. The relationship between cancer and rheumatoid arthritis: still a large research agenda. Arthritis Res Ther. 2008;10:109.
Article
PubMed Central
PubMed
Google Scholar
Orozco G, Eerligh P, Sanchez E, Zhernakova S, Roep BO, Gonzalez-Gay MA, et al. Analysis of a functional BTNL2 polymorphism in type 1 diabetes, rheumatoid arthritis, and systemic lupus erythematosus. Hum Immunol. 2005;66:1235–41.
Article
CAS
PubMed
Google Scholar
Fitzgerald LM, Kumar A, Boyle EA, Zhang Y, McIntosh LM, Kolb S, et al. Germline missense variants in the BTNL2 gene are associated with prostate cancer susceptibility. Canc Epidemiol Biomarkers Prev. 2013;22:1520–8.
Article
CAS
Google Scholar
Morris JC, Janik JE, White JD, Fleisher TA, Brown M, Tsudo M, et al. Preclinical and phase I clinical trial of blockade of IL-15 using Mikbeta1 monoclonal antibody in T cell large granular lymphocyte leukemia. Proc Natl Acad Sci U S A. 2006;103:401–6.
Article
CAS
PubMed Central
PubMed
Google Scholar
Raaschou P, Frisell T, Askling J, for the ASG: TNF inhibitor therapy and risk of breast cancer recurrence in patients with rheumatoid arthritis: a nationwide cohort study. Ann Rheum Dis. 2014. 10.1136/annrheumdis-2014-205745.
Li C, Zhang G, Li X, Rao S, Gong B, Jiang W, et al. A systematic method for mapping multiple loci: an application to construct a genetic network for rheumatoid arthritis. Gene. 2008;408:104–11.
Article
CAS
PubMed
Google Scholar
MalaCards: an integrated database of human maladies and their annotations, modeled on the architecture and richness of the popular GeneCards database of human genes. http://www.malacards.org/. Accessed on 1 June 2015.
HuGE Navigator (version 2.0): An integrated, searchable knowledge base of genetic associations and human genome epidemiology. http://www.hugenavigator.net. Accessed on 3 July 2015.
Kundu JK, Surh YJ. Inflammation: gearing the journey to cancer. Mutat Res. 2008;659:15–30.
Article
CAS
PubMed
Google Scholar
Trinchieri G. Innate inflammation and cancer: is it time for cancer prevention? F1000 Med Rep. 2011;3:11.
Article
PubMed Central
PubMed
Google Scholar